The Human Reference Genome
Source: TANK⇦⇨ TRAF family member associated NFKB activator
GTTTGAGCAGCATTGTTAGAGCCTG... Show All
The TRAF (tumor necrosis factor receptor-associated
factor) family of proteins associate with
and transduce signals from members of the
tumor necrosis factor receptor superfamily.
The protein encoded by this gene is found
in the cytoplasm and can bind to TRAF1, TRAF2,
or TRAF3, thereby inhibiting TRAF function
by sequestering the TRAFs in a latent state
in the cytoplasm. For example, the protein
encoded by this gene can block TRAF2 binding
to LMP1, the Epstein-Barr virus transforming
protein, and inhibit LMP1-mediated NF-kappa-B
protein complex (NFKB1, NFKB2, RELA, RELB, REL)
activation. Three alternatively spliced
transcript variants encoding different isoforms
have been found for this gene.
Expression of TRAF family member associated
NFKB activator has been detected in white
blood cells, lung, lymph node, prostate,
breast and 29 other tissues.