The Human Reference Genome

  Source:		TANK

    		TRAF family member associated NFKB activator

			The TRAF (tumor necrosis factor receptor-associated
			factor) family of proteins associate with
			and transduce signals from members of the
			tumor necrosis factor receptor superfamily.
			The protein encoded by this gene is found
			in the cytoplasm and can bind to TRAF1, TRAF2,
			or TRAF3, thereby inhibiting TRAF function
			by sequestering the TRAFs in a latent state
			in the cytoplasm. For example, the protein
			encoded by this gene can block TRAF2 binding
			to LMP1, the Epstein-Barr virus transforming
			protein, and inhibit LMP1-mediated NF-kappa-B
			protein complex (NFKB1, NFKB2, RELA, RELB, REL)
			activation. Three alternatively spliced
			transcript variants encoding different isoforms
			have been found for this gene.

			Expression of TRAF family member associated
			NFKB activator has been detected in white
			blood cells, lung, lymph node, prostate,
			breast and 29 other tissues.

			Chromosome 2

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