*ncbi.life
			The Human Reference Genome

  Source:		ATF2


    		activating transcription factor 2
     
			GTTGTCAGTCCGATCTCGCGAGAGA... Show All

			Summary
			This gene encodes a transcription factor
			that is a member of the leucine zipper family
			of DNA binding proteins. The encoded protein
			has been identified as a moonlighting protein
			based on its ability to perform mechanistically
			distinct functions This protein binds to
			the cAMP-responsive element (CRE), an octameric
			palindrome. It forms a homodimer or a heterodimer
			with c-Jun and stimulates CRE-dependent
			transcription. This protein is also a histone
			acetyltransferase (HAT) that specifically
			acetylates histones H2B and H4 in vitro;
			thus it may represent a class of sequence-specific
			factors that activate transcription by direct
			effects on chromatin components. The encoded
			protein may also be involved in cell's DNA
			damage response independent of its role
			in transcriptional regulation. Several alternatively
			spliced transcript variants have been found
			for this gene

			Expression of activating transcription factor
			2 has been detected in ovary, white blood
			cells, prostate, testes, thyroid and 29
			other tissues.

			Related Genes
			mitogen-activated protein kinase 13 (MAPK13)
			mitogen-activated protein kinase 14 (MAPK14)
			undifferentiated embryonic cell transcription factor 1 (UTF1)
			vaccinia related kinase 1 (VRK1)

			Location
			Chromosome 2

			PubMed
			30229848 Regulation by Pink1 on the
			mitochondrial dysfunction in endothelial cells
			post the hypoxia mimetic agent CoCl2
			treatment.

			30229843 The involvement of p38MAPK in the
			rat model of lower-extremity arterial
			ischemia-reperfusion injury.

			30229828 MiR-451a suppressed cell migration
			and invasion in non-small cell lung cancer
			through targeting ATF2.

			30165978 Identifying Pathophysiological
			Mechanisms in Heart Failure With Reduced
			Versus Preserved Ejection Fraction.

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