The Human Reference Genome
Source: CTSB⇦⇨ cathepsin B
CTCCCAACCTCACATCTGCCACGAT... Show All
This gene encodes a member of the C1 family
of peptidases. Alternative splicing of this
gene results in multiple transcript variants.
At least one of these variants encodes a
preproprotein that is proteolytically processed
to generate multiple protein products. These
products include the cathepsin B light and
heavy chains, which can dimerize to form
the double chain form of the enzyme. This
enzyme is a lysosomal cysteine protease
with both endopeptidase and exopeptidase
activity that may play a role in protein
turnover. It is also known as amyloid precursor
protein secretase and is involved in the
proteolytic processing of amyloid precursor
protein (APP). Incomplete proteolytic processing
of APP has been suggested to be a causative
factor in Alzheimer's disease, the most
common cause of dementia. Overexpression
of the encoded protein has been associated
with esophageal adenocarcinoma and other
tumors. Multiple pseudogenes of this gene
have been identified.
Expression of cathepsin B has been detected
in thyroid, adipose, lymph node, lung, kidney
and 29 other tissues.
32195026Trifluoperazine prolongs the survival
of experimental brain metastases by
STAT3-dependent lysosomal membrane
32176724 Myocardial cathepsin D is
downregulated in sudden cardiac death.
32175287 Isoforms of Cathepsin B1 in
Neurotropic Schistosomula of Trichobilharzia
regenti Differ in Substrate Preferences and a
Highly Expressed Catalytically Inactive Paralog
32171725 Yeast β-D-glucan exerts antitumour
activity in liver cancer through impairing
autophagy and lysosomal function, promoting
reactive oxygen species production and
32154176 Molecular Mechanisms by Which
S100A4 Regulates the Migration and Invasion
of PGCCs With Their Daughter Cells in Human
30263671 Proteolytic effect of starter culture
during ripening of smoked horse sausage.
30263592 The changes in the proteolysis
activity and the accumulation of free amino
acids during chinese traditional dry-cured loins
30261474 Cathepsin B and S as markers for
cardiovascular risk and all-cause mortality in
patients with stable coronary heart disease
during 10 years: a CLARICOR trial sub-study.
30228307 Proteome analysis reveals a role of
rainbow trout lymphoid organs during Yersinia
ruckeri infection process.
30215090 Cyclopeptidic photosensitizer
prodrugs as proteolytically triggered drug
delivery systems of pheophorbide A: part II -
co-loading of pheophorbide A and black hole
30204757 The vacuolar-type ATPase inhibitor
archazolid increases tumor cell adhesion to
endothelial cells by accumulating extracellular
30194476 A Mild Inhibition of cathepsin K
Paradoxically Stimulates the Resorptive Activity
of Osteoclasts in Culture.
30187035 Primary tumor and pre-metastatic
niches co-targeting "peptides-lego" hybrid
hydroxyapatite nanoparticles for metastatic
breast cancer treatment.
30180270NLRP3 inflammasome activation in
hepatic stellate cells induces murine liver
30179491 Docetaxel-Loaded Hyaluronic
Acid-Cathepsin B Cleavable Peptide-Gold
Nanoparticles for The Treatment of Cancer.
30177970 Expression and Localization of
Cathepsins B, D and G in Cancer Stem Cells in
Liver Metastasis From Colon Adenocarcinoma.
30171718PNPLA3 variant M148 causes
resistance to starvation-mediated lipid droplet
autophagy in human hepatocytes.
30154458 Enhanced autophagy contributes to
excitotoxic lesions in a rat model of preterm
30145925 Identification of compound CA-5f as
a novel late-stage autophagy inhibitor with
potent anti-tumor effect against non-small cell
30138927 Oxidative Stress is the Principal
Contributor to Inflammasome Activation in
Retinal Pigment Epithelium Cells with Defunct
Proteasomes and Autophagy.
30136196 Lysosomal membrane
permeabilization causes secretion of IL-1β in
human vascular smooth muscle cells.
A novel flavonoid from Dulacia egleri with
potential inhibitory activity against cathepsins B
30107168 The role of cathepsin B in autophagy
during obesity: A systematic review.
30105973 Intranasal delivery of a formulation
containing stage-specific recombinant proteins
of Fasciola hepatica cathepsin L5 and
cathepsin B2 triggers an anti-fecundity effect
and an adjuvant-mediated reduction in fluke
burden in sheep.
30099343 Cathepsin B contributes to
radioresistance by enhancing homologous
recombination in glioblastoma.
30091535 Determination of the concentration
of cathepsin B by SPRI biosensor in children
with appendicitis, and its correlation with
30062341 A core-shell
as pH and enzyme dual-recognition switch for
stepwise-responsive imaging in living cells.
30049645 Modeling endophilin-mediated Aβ
disposal in glioma cells.
30046966 Ischemic Postconditioning Alleviates
Cerebral Ischemia-Reperfusion Injury Through
Activating Autophagy During Early Reperfusion
30030080 Transcription factor E3 protects
against Cadmium-induced apoptosis by
maintaining the lysosomal-mitochondrial axis
but not autophagic flux in Neuro-2a cells.
3635138 Effect of the Incoportation of Copper
and Zinc Nanoparticles Into Dental Adhesives
3286062 VM110 in Detection of Microscopic
Tumors: A Phase I Study
2495870 The Acute Effects of Low
Temperature for Long Time Heat Treatment of
Pork Semitendinosus on Satiety
660218 A Phase I/II Study of Radiation
Therapy, Paclitaxel Poliglumex and Cetuximab
in Advanced Head and Neck Cancer
459810 Paclitaxel Poliglumex and Estradiol in
Treating Patients With Stage IV Prostate