The Human Reference Genome
⇦ ⇨ TANK binding kinase 1
GCACCCGCACCGGCGCGCCGGCCGT... Show All
The NF-kappa-B complex of proteins
(NFKB1, NFKB2, RELA, RELB, REL)
is inhibited by I-kappa-B (IKB) proteins,
which inactivate NFKB by trapping it in
the cytoplasm. Phosphorylation of serine
residues on the IKB proteins by IKB kinases
marks them for destruction via the ubiquitination
pathway, thereby allowing activation and
nuclear translocation of the NFKB complex.
The protein encoded by this gene is similar
to IKB kinases and can mediate NFKB activation
in response to certain growth factors.
Expression of TANK binding kinase 1 has
been detected in testes, lung, white blood
cells, lymph node, bone marrow and 29 other
5-azacytidine induced 2 (AZI2)
TBK1 binding protein 1 (TBKBP1)
suppressor of IKBKE 1 (SIKE1)
Amyotrophic lateral sclerosis and/or frontotemporal dementia 1
Herpes simplex encephalitis 1
32185393 CYLD is a causative gene for
frontotemporal dementia -
amyotrophic lateral sclerosis.
30233137 Dingchuan tang essential oil inhibits
the production of inflammatory mediators via
suppressing the IRAK/NF-κB, IRAK/AP-1, and
TBK1/IRF3 pathways in
lipopolysaccharide-stimulated RAW264.7 cells.
30232186 NSs protein of Sandfly fever Sicilian
phlebovirus counteracts interferon induction by
masking the DNA-binding domain of
interferon regulatory factor 3.
30223576 Roles for the IKK-Related Kinases
TBK1 and IKKε in Cancer.
30217950 Functional proteomics and deep
network interrogation reveal a complex
mechanism of action of midostaurin in lung
30205046 Overcoming Resistance to Dual
Innate Immune and MEK Inhibition Downstream
30199924 Hepatitis E Virus Methyltransferase
Inhibits Type I Interferon Induction by Targeting
30193106 Tuning Apoptosis and
Neuroinflammation: TBK1 Restrains RIPK1.
30183071 NLRP2 negatively regulates antiviral
immunity by interacting with TBK1.
30042930 MicroRNA-199a Inhibits Cellular
Autophagy and Downregulates IFN-β Expression
by Targeting TBK1 in Mycobacterium bovis
30021900 Two conserved amino acids within
the NSs of SFTS phlebovirus are essential for
30016790 PLA1A Participates in the Antiviral
Innate Immune Response by Facilitating the
Recruitment of TANK-Binding Kinase 1 to
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