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			The Human Reference Genome

  Source:		TBK1


    		TANK binding kinase 1
     
			GCACCCGCACCGGCGCGCCGGCCGT... Show All

			Summary
			The NF-kappa-B complex of proteins
			(NFKB1, NFKB2, RELA, RELB, REL)
			is inhibited by I-kappa-B (IKB) proteins,
			which inactivate NFKB by trapping it in
			the cytoplasm. Phosphorylation of serine
			residues on the IKB proteins by IKB kinases
			marks them for destruction via the ubiquitination
			pathway, thereby allowing activation and
			nuclear translocation of the NFKB complex.
			The protein encoded by this gene is similar
			to IKB kinases and can mediate NFKB activation
			in response to certain growth factors.

			Expression of TANK binding kinase 1 has
			been detected in testes, lung, white blood
			cells, lymph node, bone marrow and 29 other
			tissues.

			Related Genes
			5-azacytidine induced 2 (AZI2)
			TBK1 binding protein 1 (TBKBP1)
			suppressor of IKBKE 1 (SIKE1)

			Location
			Chromosome 12

			MedGen Concepts
			Amyotrophic lateral sclerosis and/or frontotemporal dementia 1
			Herpes simplex encephalitis 1

			PubMed
			32185393 CYLD is a causative gene for
			frontotemporal dementia -
			amyotrophic lateral sclerosis.

			30233137 Dingchuan tang essential oil inhibits
			the production of inflammatory mediators via
			suppressing the IRAK/NF-κB, IRAK/AP-1, and
			TBK1/IRF3 pathways in
			lipopolysaccharide-stimulated RAW264.7 cells.

			30232186 NSs protein of Sandfly fever Sicilian
			phlebovirus counteracts interferon induction by
			masking the DNA-binding domain of
			interferon regulatory factor 3.

			30223576 Roles for the IKK-Related Kinases
			TBK1 and IKKε in Cancer.

			30217950 Functional proteomics and deep
			network interrogation reveal a complex
			mechanism of action of midostaurin in lung
			cancer cells.

			30205046 Overcoming Resistance to Dual
			Innate Immune and MEK Inhibition Downstream
			of KRAS.

			30199924 Hepatitis E Virus Methyltransferase
			Inhibits Type I Interferon Induction by Targeting
			RIG-I.

			30193106 Tuning Apoptosis and
			Neuroinflammation: TBK1 Restrains RIPK1.

			30183071 NLRP2 negatively regulates antiviral
			immunity by interacting with TBK1.

			30042930 MicroRNA-199a Inhibits Cellular
			Autophagy and Downregulates IFN-β Expression
			by Targeting TBK1 in Mycobacterium bovis
			Infected Cells.

			30021900 Two conserved amino acids within
			the NSs of SFTS phlebovirus are essential for
			anti-interferon activity.

			30016790 PLA1A Participates in the Antiviral
			Innate Immune Response by Facilitating the
			Recruitment of TANK-Binding Kinase 1 to
			mitochondria.

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