The Human Reference Genome
Source: IRF3⇦⇨ interferon regulatory factor 3
GGAAACCCAAAAAAGGGCATAGGGG... Show All
This gene encodes a member of the interferon
regulatory transcription factor (IRF) family.
The encoded protein is found in an inactive
cytoplasmic form that upon serine/threonine
phosphorylation forms a complex with CREBBP.
This complex translocates to the nucleus
and activates the transcription of interferons
alpha and beta, as well as other interferon-induced
genes. Alternatively spliced transcript
variants encoding multiple isoforms have
been observed for this gene.
Expression of interferon regulatory factor
3 has been detected in lymph node, lung,
adrenal gland, prostate, ovary and 29 other
testis specific serine kinase substrate (TSKS)
Herpes simplex encephalitis 1
32226432 Interaction With 14-3-3 Correlates
With Inactivation of the RIG-I Signalosome by
Herpesvirus Ubiquitin Deconjugases.
32218789Inhibition of PI3Kδ Enhances Poly
I:C-Induced Antiviral Responses and Inhibits
Replication of Human Metapneumovirus in
Murine Lungs and Human Bronchial Epithelial
32179480Positive Selection of a Serine
Residue in Bat IRF3 Confers Enhanced Antiviral
32161340 Adaptations of
Interferon Regulatory Factor 3 with Transition
from Terrestrial to Aquatic Life.
32156810Barrier-to-Autointegration Factor 1
Protects against a Basal cGAS-STING
32153563Estrogen Receptor, Inflammatory,
and FOXO Transcription Factors Regulate
Expression of Myasthenia Gravis-Associated
30233137 Dingchuan tang essential oil inhibits
the production of inflammatory mediators via
suppressing the IRAK/NF-κB, IRAK/AP-1, and
TBK1/IRF3 pathways in
lipopolysaccharide-stimulated RAW264.7 cells.
30232186 NSs protein of Sandfly fever Sicilian
phlebovirus counteracts interferon induction by
masking the DNA-binding domain of interferon
regulatory factor 3.
30222725 Triggering microglia through
toll like receptor 2 pathway induced interferon β
expression in cell and animal model of
30209176 HOIL1 is essential for the induction
of type I and III interferons by MDA5 and
regulates persistent murine norovirus infection.
30194441USP4 positively regulates
RLR-induced NF-κB activation by targeting
TRAF6 for K48-linked deubiquitination and
inhibits enterovirus 71 replication.
30183071NLRP2 negatively regulates antiviral
immunity by interacting with TBK1.
30141161 Antiviral activity of Schizonepeta
tenuifolia Briquet against noroviruses via
induction of antiviral interferons.
30056593 Irf3 from mandarin fish thymus
initiates interferon transcription.
30021900 Two conserved amino acids within
the NSs of SFTS phlebovirus are essential for
30016790PLA1A Participates in the Antiviral
Innate Immune Response by Facilitating the
Recruitment of TANK binding kinase 1 to
30010019 Molecular cloning and functional
characterisation of NLRX1 in grass carp