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			The Human Reference Genome

  Source:		IRF3


    		interferon regulatory factor 3
     
			GGAAACCCAAAAAAGGGCATAGGGG... Show All

			Summary
			This gene encodes a member of the interferon
			regulatory transcription factor (IRF) family.
			The encoded protein is found in an inactive
			cytoplasmic form that upon serine/threonine
			phosphorylation forms a complex with CREBBP.
			This complex translocates to the nucleus
			and activates the transcription of interferons
			alpha and beta, as well as other interferon-induced
			genes. Alternatively spliced transcript
			variants encoding multiple isoforms have
			been observed for this gene.

			Expression of interferon regulatory factor
			3 has been detected in lymph node, lung,
			adrenal gland, prostate, ovary and 29 other
			tissues.

			Related Genes
			testis specific serine kinase substrate (TSKS)

			Location
			Chromosome 19

			MedGen Concepts
			Herpes simplex encephalitis 1

			PubMed
			32226432 Interaction With 14-3-3 Correlates
			With Inactivation of the RIG-I Signalosome by
			Herpesvirus Ubiquitin Deconjugases.

			32218789 Inhibition of PI3Kδ Enhances Poly
			I:C-Induced Antiviral Responses and Inhibits
			Replication of Human Metapneumovirus in
			Murine Lungs and Human Bronchial Epithelial
			Cells.

			32179480 Positive Selection of a Serine
			Residue in Bat IRF3 Confers Enhanced Antiviral
			Protection.

			32161340 Adaptations of
			Interferon Regulatory Factor 3 with Transition
			from Terrestrial to Aquatic Life.

			32156810 Barrier-to-Autointegration Factor 1
			Protects against a Basal cGAS-STING
			Response.

			32153563 Estrogen Receptor, Inflammatory,
			and FOXO Transcription Factors Regulate
			Expression of Myasthenia Gravis-Associated
			Circulating microRNAs.

			30233137 Dingchuan tang essential oil inhibits
			the production of inflammatory mediators via
			suppressing the IRAK/NF-κB, IRAK/AP-1, and
			TBK1/IRF3 pathways in
			lipopolysaccharide-stimulated RAW264.7 cells.

			30232186 NSs protein of Sandfly fever Sicilian
			phlebovirus counteracts interferon induction by
			masking the DNA-binding domain of interferon
			regulatory factor 3.

			30222725 Triggering microglia through
			toll like receptor 2 pathway induced interferon β
			expression in cell and animal model of
			Alzheimers disease.

			30209176 HOIL1 is essential for the induction
			of type I and III interferons by MDA5 and
			regulates persistent murine norovirus infection.

			30194441 USP4 positively regulates
			RLR-induced NF-κB activation by targeting
			TRAF6 for K48-linked deubiquitination and
			inhibits enterovirus 71 replication.

			30183071 NLRP2 negatively regulates antiviral
			immunity by interacting with TBK1.

			30141161 Antiviral activity of Schizonepeta
			tenuifolia Briquet against noroviruses via
			induction of antiviral interferons.

			30056593 Irf3 from mandarin fish thymus
			initiates interferon transcription.

			30021900 Two conserved amino acids within
			the NSs of SFTS phlebovirus are essential for
			anti-interferon activity.

			30016790 PLA1A Participates in the Antiviral
			Innate Immune Response by Facilitating the
			Recruitment of TANK binding kinase 1 to
			mitochondria.

			30010019 Molecular cloning and functional
			characterisation of NLRX1 in grass carp
			(Ctenopharyngodon idella).

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