The Human Reference Genome
⇦ ⇨ angiotensin I converting enzyme 2
GTTGTTGTGATCCCATGGCTACAGA... Show All
The protein encoded by this gene belongs
to the angiotensin-converting enzyme family
of dipeptidyl carboxydipeptidases and has
considerable homology to human
angiotensin I converting enzyme (ACE).
This secreted protein catalyzes
the cleavage of angiotensin I into
angiotensin 1-9, and angiotensin II
into the vasodilator angiotensin 1-7. The
organ- and cell-specific expression of this
gene suggests that it may play a role in
the regulation of cardiovascular and renal
function, as well as fertility. In addition,
the encoded protein is a functional receptor
for the spike glycoprotein of the human
coronaviruses SARS and HCoV-NL63.
Expression of angiotensin I converting enzyme
2 has been detected in small intestine,
testes, gall bladder, duodenum, kidney and
28 other tissues.
deleted in lymphocytic leukemia 2 (non-protein coding) (DLEU2)
Angiotensin-converting Enzyme 2 Pathway
Angiotensin-converting Enzyme Inhibitor
Angiotensin-converting Enzyme Inhibitor Fetopathy
32219057 The SARS-CoV-2 Vaccine Pipeline:
32214681 Angiotensin Converting Enzyme-2
(ACE2) and its Possible Roles in Hypertension,
Diabetes and Cardiac Function.
32214680 Angiotensin converting enzyme-2
(ACE2) and its possible roles in hypertension,
diabetes and cardiac function.
32210742 Role of changes in SARS-CoV-2
spike protein in the interaction with the human
ACE2 receptor: An in silico analysis.
32194907 Fugan Wan alleviates hepatic fibrosis
by inhibiting ACE/Ang II/AT-1R
signaling pathway and enhancing ACE2/Ang
1-7/Mas signaling pathway in hepatic fibrosis
32184813 Electroacupuncture Improved
Chronic Cerebral Hypoperfusion-Induced
Anxiety-Like Behavior and Memory Impairments
in Spontaneously Hypertensive Rats by
Downregulating the ACE/Ang II/AT1R Axis and
Upregulating the ACE2/Ang-(1-7)/MasR Axis.
32169119 The origin, transmission and clinical
therapies on coronavirus disease 2019
(COVID-19) outbreak - an update on the status.
32167747 Evidence of the COVID-19 Virus
Targeting the CNS: Tissue Distribution,
Host-Virus Interaction, and Proposed
32144368 Angiotensin-[1-7] attenuates kidney
injury in experimental Alport syndrome.
32138266 Potential Factors Influencing
Repeated SARS Outbreaks in China.
32133153 Comparative genetic analysis of the
novel coronavirus (2019-nCoV/SARS-CoV-2)
receptor ACE2 in different populations.
30227878 ACE2 polymorphisms associated
with cardiovascular risk in Uygurs with type 2
30207087 Angiotensin-converting enzyme 2
deficiency accelerates and angiotensin 1-7
restores age-related muscle weakness in mice.
3489993 FGF23 and Angiotensin-(1-7) in
2409043 Neuronal and Glial Biomarkers in
2348515 Cardiovascular Disease Protection
1597635 The Safety, Tolerability, PK and PD of
GSK2586881 in Patients With Acute Lung
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