The Human Reference Genome
Source: STAT1⇦⇨ signal transducer and activator of transcription 1
GCTGAGCGCGGAGCCGCCCGGTGAT... Show All
The protein encoded by this gene is a member
of the STAT protein family. In response
to cytokines and growth factors, STAT family
members are phosphorylated by the receptor
associated kinases, and then form homo-
or heterodimers that translocate to the
cell nucleus where they act as transcription
activators. This protein can be activated
by various ligands including interferon-alpha, interferon gamma, EGF,
PDGF and IL6. This protein mediates the expression
of a variety of genes, which is thought
to be important for cell viability in response
to different cell stimuli and pathogens.
Two alternatively spliced transcript variants
encoding distinct isoforms have been described.
Expression of signal transducer and activator
of transcription 1 has been detected in
lymph node, white blood cells, testes, colon,
lung and 29 other tissues.
MAGE family member H1 (MAGEH1)
NOS2 5' regulatory region (LOC111365141)
interferon alpha and beta receptor subunit 1 (IFNAR1)
interferon alpha and beta receptor subunit 2 (IFNAR2)
interleukin 21 receptor (IL21R)
protein inhibitor of activated STAT 1 (PIAS1)
signal transducer and activator of transcription 2 (STAT2)
Disseminated atypical mycobacterial infectionCandidiasis, familial, 1Mycobacterial and viral infections, susceptibility to, autosomal recessiveImmunodeficiency 31a
32210958 Disruption of Monocyte and
Macrophage Homeostasis in Periodontitis.
32210710 Adipose Tissue-Derived
Mesenchymal Stem Cells Suppress Growth of
Huh7 Hepatocellular Carcinoma Cells via
Interferon (IFN)-β-Mediated JAK/STAT1 Pathway
32208488Interferon-complement loop in
32201535 Transcriptomic analysis reveals the
oncogenic role of S6K1 in
32194688 Prognostic value of key genes of the
JAK-STAT signaling pathway in patients with
32188902GPNMB is expressed in human
epidermal keratinocytes but disappears in the
32188878microRNA-875-5p plays critical role
for mesenchymal condensation in
epithelial-mesenchymal interaction during tooth
32169104 Mechanical load-induced H2S
production by periodontal ligament stem cells
activates M1 macrophages to promote bone
remodeling and tooth movement via STAT1.
32164778 Identification of molecules
associated with response to abatacept in
patients with rheumatoid arthritis.
32161581Cirrhosis Hampers Early and Rapid
Normalization of Natural Killer Cell Phenotype
and Function in Hepatitis CPatients
Undergoing Interferon-Free Therapy.
32156810Barrier-to-Autointegration Factor 1
Protects against a Basal cGAS-STING
32152220 Downregulation of RIG-I mediated
by ITGB3/c-SRC/STAT3 signaling confers
resistance to interferon-α-induced apoptosis in
tumor-repopulating cells of melanoma.
30235866 Deficiency in STAT1 Signaling
Predisposes Gut Inflammation and Prompts
Colorectal Cancer Development.
30231913 Waves of chromatin modifications in
mouse dendritic cells in response to LPS
30229666 Monocyte and alveolar macrophage
skewing is associated with the development of
pulmonary arterial hypertension (PAH) in a
primate model of HIV-infection.
30226605 STAT1‑HDAC4 signaling induces
epithelial‑mesenchymal transition and sphere
formation of cancer cells overexpressing the
30224822NKILA lncRNA promotes tumor
immune evasion by sensitizing T cells to
activation-induced cell death.
30224514 IL-17A Attenuates IFN-λ Expression
by Inducing Suppressor of Cytokine Signaling
Expression in Airway Epithelium.
30224377 Therapeutically active RIG-I agonist
induces immunogenic tumor cell killing in breast
30222739 Phospho-proteomic analysis of
primary human colon epithelial cells during the
early Trypanosoma cruzi infection phase.
30214460 Growth Hormone Did Not Activate
Its Intracellular Signaling Molecules in Rats Liver
Hepatocytes During Early Life Period.
30214448suppressor of cytokine signaling 1/STAT1
Regulates Renal Inflammation in Mesangial
Proliferative Glomerulonephritis Models.
30210365 Telmisartan Modulates the Oral
Mucositis Induced by 5-Fluorouracil in
30209176 HOIL1 is essential for the induction
of type I and III interferons by MDA5 and
regulates persistent murine norovirus infection.
30203045 Immunological differences between
primary and metastatic breast cancer.
30200742 [Molecular mechanism of Shaofu
Zhuyu decoction in treating endometriosis
dysmenorrhea based on GPER2/MAPK/STAT1
30200670 Topical Plant Polyphenols Prevent
Type I Interferon Signaling in the Skin and
Suppress Contact Hypersensitivity.
30187709 Bronchiectasis and Recurrent
Respiratory Infections with a De Novo STAT1
Gain-of-Function Variant: First Case in Korea.
30182475 Analysis of differentially expressed
genes and the promoters in bovine
endometrium throughout estrus cycle and early
30177680 The osteopontin-CD44 axis in
hepatic cancer stem cells regulates IFN
signaling and HCV replication.
30167870 The effect of maternal type 2
diabetes on fetal endothelial gene expression
30160848 [A Case of Chronic Mucocutaneous
Candidiasis Associated with STAT1 Mutation].
30158934STAT3 Cooperates With
phospholipid scramblase 2 to Suppress Type I
30132863insulin promotes macrophage
phenotype transition through PI3K/Akt and
PPAR-γ signaling during diabetic wound healing.
30126685 Interferon signaling during Hepatitis
B Virus (HBV) infection and HBV-associated
30086151 Network analysis of inflammatory
responses to sepsis by neutrophils and
peripheral blood mononuclear cells.
30078219 Role of STAT signaling and
autocrine action of chemokines during H2 O 2
induced HTR-8/SVneo trophoblastic cells
30061950 In vitro effects of arsenic trioxide,
interferon α and zidovudine in adult T cell
30039429 Honokiol and Magnolol Inhibit
CXCL10 and CXCL11 Production in
IL-27-Stimulated Human Oral Epithelial Cells.
30021913 Blastocyst-induced changes in the
bovine endometrial transcriptome.
30021838 Regulation of monoamine oxidase A
(MAO-A) expression, activity and function in
IL-13-stimulated monocytes and A549 lung
30017387 Silencing of the interferon-inducible
gene Ifi204/p204 induces resistance to
interferon-γ-mediated cell growth arrest of tumor
3387670 Multiple Sclerosis-Simvastatin Trial 2
2225977 Assessing Induction of Type II (M2)
Monocytes/Macrophages in Patients Receiving
2044575 Clock Genes in Patients With
Refractory Septic Shock (SeptiClock) - Pilot
1801670 Impact of Vorinostat on Pruritus
Signaling Pathways - Merck Study
1633346 Regulation of the Immune System in
Response to the Treatment With Tocilizumab in
Rheumatoid Arthritis Patients
1592721 Radiation and Cetuximab Plus
Intratumoral EGFR Antisense DNA in Locally
Advanced Head and Neck Squamous Cell
1460875 Recombinant Interferon Alfa-2b in
Treating Patients With Melanoma
1382511 Simvastatin Treatment of
1788 Genetic Basis of Primary