The Human Reference Genome

  Source:		STAT1

    		signal transducer and activator of transcription 1

			The protein encoded by this gene is a member
			of the STAT protein family. In response
			to cytokines and growth factors, STAT family
			members are phosphorylated by the receptor
			associated kinases, and then form homo-
			or heterodimers that translocate to the
			cell nucleus where they act as transcription
			activators. This protein can be activated
			by various ligands including interferon-alpha, interferon gamma, EGF,
			PDGF and IL6. This protein mediates the expression
			of a variety of genes, which is thought
			to be important for cell viability in response
			to different cell stimuli and pathogens.
			Two alternatively spliced transcript variants
			encoding distinct isoforms have been described.

			Expression of signal transducer and activator
			of transcription 1 has been detected in
			lymph node, white blood cells, testes, colon,
			lung and 29 other tissues.

			Related Genes
			MAGE family member H1 (MAGEH1)
			NOS2 5' regulatory region (LOC111365141)
			interferon alpha and beta receptor subunit 1 (IFNAR1)
			interferon alpha and beta receptor subunit 2 (IFNAR2)
			interleukin 21 receptor (IL21R)
			protein inhibitor of activated STAT 1 (PIAS1)
			signal transducer and activator of transcription 2 (STAT2)

			Chromosome 2

			MedGen Concepts
			Disseminated atypical mycobacterial infection
			Candidiasis, familial, 1
			Mycobacterial and viral infections, susceptibility to, autosomal recessive
			Immunodeficiency 31a

			32210958 Disruption of Monocyte and
			Macrophage Homeostasis in Periodontitis.

			32210710 Adipose Tissue-Derived
			Mesenchymal Stem Cells Suppress Growth of
			Huh7 Hepatocellular Carcinoma Cells via
			Interferon (IFN)-β-Mediated JAK/STAT1 Pathway
			in vitro.

			32208488 Interferon-complement loop in
			thrombotic microangiopathy.

			32201535 Transcriptomic analysis reveals the
			oncogenic role of S6K1 in
			hepatocellular carcinoma.

			32194688 Prognostic value of key genes of the
			JAK-STAT signaling pathway in patients with
			cutaneous melanoma.

			32188902 GPNMB is expressed in human
			epidermal keratinocytes but disappears in the
			vitiligo lesional skin.

			32188878 microRNA-875-5p plays critical role
			for mesenchymal condensation in
			epithelial-mesenchymal interaction during tooth

			32169104 Mechanical load-induced H2S
			production by periodontal ligament stem cells
			activates M1 macrophages to promote bone
			remodeling and tooth movement via STAT1.

			32164778 Identification of molecules
			associated with response to abatacept in
			patients with rheumatoid arthritis.

			32161581 Cirrhosis Hampers Early and Rapid
			Normalization of Natural Killer Cell Phenotype
			and Function in Hepatitis C Patients
			Undergoing Interferon-Free Therapy.

			32156810 Barrier-to-Autointegration Factor 1
			Protects against a Basal cGAS-STING

			32152220 Downregulation of RIG-I mediated
			by ITGB3/c-SRC/STAT3 signaling confers
			resistance to interferon-α-induced apoptosis in
			tumor-repopulating cells of melanoma.

			30235866 Deficiency in STAT1 Signaling
			Predisposes Gut Inflammation and Prompts
			Colorectal Cancer Development.

			30231913 Waves of chromatin modifications in
			mouse dendritic cells in response to LPS

			30229666 Monocyte and alveolar macrophage
			skewing is associated with the development of
			pulmonary arterial hypertension (PAH) in a
			primate model of HIV-infection.

			30226605 STAT1‑HDAC4 signaling induces
			epithelial‑mesenchymal transition and sphere
			formation of cancer cells overexpressing the
			oncogene, CUG2.

			30224822 NKILA lncRNA promotes tumor
			immune evasion by sensitizing T cells to
			activation-induced cell death.

			30224514 IL-17A Attenuates IFN-λ Expression
			by Inducing Suppressor of Cytokine Signaling
			Expression in Airway Epithelium.

			30224377 Therapeutically active RIG-I agonist
			induces immunogenic tumor cell killing in breast

			30222739 Phospho-proteomic analysis of
			primary human colon epithelial cells during the
			early Trypanosoma cruzi infection phase.

			30214460 Growth Hormone Did Not Activate
			Its Intracellular Signaling Molecules in Rats Liver
			Hepatocytes During Early Life Period.

			suppressor of cytokine signaling 1/STAT1
			Regulates Renal Inflammation in Mesangial
			Proliferative Glomerulonephritis Models.

			30210365 Telmisartan Modulates the Oral
			Mucositis Induced by 5-Fluorouracil in

			30209176 HOIL1 is essential for the induction
			of type I and III interferons by MDA5 and
			regulates persistent murine norovirus infection.

			30203045 Immunological differences between
			primary and metastatic breast cancer.

			30200742 [Molecular mechanism of Shaofu
			Zhuyu decoction in treating endometriosis
			dysmenorrhea based on GPER2/MAPK/STAT1

			30200670 Topical Plant Polyphenols Prevent
			Type I Interferon Signaling in the Skin and
			Suppress Contact Hypersensitivity.

			30187709 Bronchiectasis and Recurrent
			Respiratory Infections with a De Novo STAT1
			Gain-of-Function Variant: First Case in Korea.

			30182475 Analysis of differentially expressed
			genes and the promoters in bovine
			endometrium throughout estrus cycle and early

			30177680 The osteopontin-CD44 axis in
			hepatic cancer stem cells regulates IFN
			signaling and HCV replication.

			30167870 The effect of maternal type 2
			diabetes on fetal endothelial gene expression
			and function.

			30160848 [A Case of Chronic Mucocutaneous
			Candidiasis Associated with STAT1 Mutation].

			30158934 STAT3 Cooperates With
			phospholipid scramblase 2 to Suppress Type I
			Interferon Response.

			30132863 insulin promotes macrophage
			phenotype transition through PI3K/Akt and
			PPAR-γ signaling during diabetic wound healing.

			30126685 Interferon signaling during Hepatitis
			B Virus (HBV) infection and HBV-associated
			hepatocellular carcinoma.

			30086151 Network analysis of inflammatory
			responses to sepsis by neutrophils and
			peripheral blood mononuclear cells.

			30078219 Role of STAT signaling and
			autocrine action of chemokines during H2 O 2
			induced HTR-8/SVneo trophoblastic cells

			30061950 In vitro effects of arsenic trioxide,
			interferon α and zidovudine in adult T cell
			leukemia/lymphoma cells.

			30039429 Honokiol and Magnolol Inhibit
			CXCL10 and CXCL11 Production in
			IL-27-Stimulated Human Oral Epithelial Cells.

			30021913 Blastocyst-induced changes in the
			bovine endometrial transcriptome.

			30021838 Regulation of monoamine oxidase A
			(MAO-A) expression, activity and function in
			IL-13-stimulated monocytes and A549 lung
			carcinoma cells.

			30017387 Silencing of the interferon-inducible
			gene Ifi204/p204 induces resistance to
			interferon-γ-mediated cell growth arrest of tumor

			Clinical Trials
			3387670 Multiple Sclerosis-Simvastatin Trial 2

			2225977 Assessing Induction of Type II (M2)
			Monocytes/Macrophages in Patients Receiving

			2044575 Clock Genes in Patients With
			Refractory Septic Shock (SeptiClock) - Pilot

			1801670 Impact of Vorinostat on Pruritus
			Signaling Pathways - Merck Study

			1633346 Regulation of the Immune System in
			Response to the Treatment With Tocilizumab in
			Rheumatoid Arthritis Patients

			1592721 Radiation and Cetuximab Plus
			Intratumoral EGFR Antisense DNA in Locally
			Advanced Head and Neck Squamous Cell

			1460875 Recombinant Interferon Alfa-2b in
			Treating Patients With Melanoma

			1382511 Simvastatin Treatment of
			Pachyonychia Congenita

			1788 Genetic Basis of Primary

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