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			The Human Reference Genome

  Source:		TMPRSS2


    		transmembrane serine protease 2
     
			GAGTAGGCGCGAGCTAAGCAGGAGG... Show All

			Summary
			This gene encodes a protein that belongs
			to the serine protease family. The encoded
			protein contains a type II transmembrane
			domain, a receptor class A domain, a scavenger
			receptor cysteine-rich domain and a protease
			domain. Serine proteases are known to be
			involved in many physiological and pathological
			processes. This gene was demonstrated to
			be up-regulated by androgenic hormones in
			prostate cancer cells and down-regulated
			in androgen-independent prostate cancer
			tissue. The protease domain of this protein
			is thought to be cleaved and secreted into
			cell media after autocleavage. Alternatively
			spliced transcript variants encoding different
			isoforms have been found for this gene.

			Expression of transmembrane serine protease
			2 has been detected in prostate, colon,
			stomach, small intestine, lung and 28 other
			tissues.

			Related Genes
			ERG, ETS transcription factor breakpoint cluster recombination region (LOC111099028)
			transmembrane protease serine 2 breakpoint cluster recombination region (LOC111099027)

			Location
			Chromosome 21

			PubMed
			30229547 Novel Biomarkers for Prostate
			Cancer Detection and Prognosis.

			30201302 TMPRSS2:ERG gene fusion
			expression regulates bone markers and
			enhances the osteoblastic phenotype of
			prostate cancer bone metastases.

			30084768 Exchange of amino acids in the
			H1-haemagglutinin to H3 residues is required
			for efficient influenza A virus replication and
			pathology in Tmprss2 knock-out mice.

			Clinical Trials
			2770391 ARN-509 and Leuprolide in
			Intermediate and High-risk Prostate Cancer

			2303327 Comparative Study of Radiotherapy
			Treatments to Treat High Risk Prostate Cancer
			Patients

			2288936 Analyze the Predictive Value of Gene
			TMPRSS2-ETS in Response to Enzalutamide in
			Patients With Prostate Cancer

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