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			MedGen

  Source:		MedGen UID: 163722


     		Oseltamivir phosphate

			Definition
			The phosphate salt of oseltamivir, a synthetic
			derivative prodrug of ethyl ester with antiviral
			activity. By blocking neuraminidases on the
			surfaces of influenza viruses, oseltamivir
			interferes with host cell release of complete viral
			particles.

			Related Concepts
			Antiviral product
			Tamiflu
			influenza

			PubMed
			32288966 Severe human infection with a novel
			avian-origin influenza A(H7N4) virus.

			32187230 Targeting glycosphingolipid
			metabolism as a potential therapeutic approach
			for treating disease in female MRL/lpr lupus
			mice.

			31107922 Baloxavir marboxil, a novel
			cap-dependent endonuclease inhibitor potently
			suppresses influenza virus replication and
			represents therapeutic effects in both
			immunocompetent and immunocompromised
			mouse models.

			30962337 Pulmonary Pharmacokinetics of
			Oseltamivir Carboxylate in Rats after
			Nebulization or Intravenous Administration of its
			Prodrug Oseltamivir Phosphate.

			30935767 Efficacy of laninamivir octanoate in
			mice with advanced inflammation stage caused
			by infection of highly lethal influenza virus.

			30834626 Oseltamivir phosphate-Lifting the
			restriction on its use to treat teenagers with
			influenza in Japan.

			30557562 Population Pharmacokinetic and
			Exposure-Response Analyses of Baloxavir
			Marboxil in Adults and Adolescents Including
			Influenza Patients.

			30524598 A case of fulminant myocarditis
			associated with novel N1H1 influenza
			successfully treated by percutaneous
			cardiopulmonary support system.

			30476172 Combination treatment with the
			cap-dependent endonuclease inhibitor baloxavir
			marboxil and a neuraminidase inhibitor in a
			mouse model of influenza A virus infection.

			30442394 Quantitative Raman assays for
			on-site analysis of stockpiled drugs.

			30420605 A Lateral Flow
			Immunochromato-graphic Strip Test for Rapid
			Detection of Oseltamivir Phosphate in Egg and
			Chicken Meat.

			30384353 Compatibility of Baclofen, Carvedilol,
			Hydrochlorothiazide, Mercaptopurine,
			Methadone Hydrochloride, Oseltamivir
			Phosphate, Phenobarbital, Propranolol
			Hydrochloride, Pyrazinamide, Sotalol
			Hydrochloride, Spironolactone, Tacrolimus
			Monohydrate, Ursodeoxycholic Acid, and
			Vancomycin Hydrochloride Oral Suspensions
			Compounded with SyrSpend SF pH4.

			30296193 Multirefractory primary immune
			thrombocytopenia; targeting the decreased
			sialic acid content.

			30282713 Salinomycin Inhibits Influenza Virus
			Infection by Disrupting Endosomal Acidification
			and Viral Matrix Protein 2 Function.

			30210106 Acute Unilateral Isolated Oculomotor
			Nerve Palsy in an Adult Patient with Influenza A.

			30040881 Enantioselective Synthesis of
			Oseltamivir Phosphate (Tamiflu) via the
			Iron-Catalyzed Stereoselective Olefin
			Diazidation.

			29899269 A Simple and Robust Approach for
			Evaluation of Antivirals Using a Recombinant
			Influenza Virus Expressing Gaussia Luciferase.

			29887593 Rhabdomyolysis Following Initiation
			of Antiviral Therapy with Oseltamivir.

			29702353 Reductive amination assistance for
			quantification of oseltamivir phosphate and
			oseltamivir carboxylate by HPLC-MS/MS.

			29560107 Oseltamivir phosphate released from
			injectable Pickering emulsions over an extended
			term disables human pancreatic cancer cell
			survival.

			29403810 Simultaneous quantification of
			prodrug oseltamivir and its metabolite
			oseltamivir carboxylate in human plasma by
			LC-MS/MS to support a bioequivalence study.

			29277445 Biased G protein-coupled receptor
			agonism mediates Neu1 sialidase and matrix
			metalloproteinase-9 crosstalk to induce
			transactivation of insulin receptor signaling.

			Clinical Trials
			3947411 Evaluate the Safety and Efficacy of
			Xiyanping in Pediatric Participants With Severe
			Influenza-Like Symptoms

			2662426 Lingdancao Granules in the
			Treatment of Seasonal Influenza

			2572583 A Clinical Study of Treating Influenza
			With Liugan Shuangjie Heji

			1690637 Panama and El Salvador Children's
			Oseltamivir Study

			1443806 Characterisation of the Human
			Carboxylesterase 1 (CES1) Mutations in
			Thailand

			1179919 Pharmacokinetics of Oseltamivir
			Carboxylate In Morbidly Obese Subjects

			1130636 Observational Study on the
			Pharmacokinetics of Oseltamivir in the
			Treatment of Influenza During Lactation

			803595 A Multinational Phase III Study of
			CS-8958 (MARVEL)

			453999 Evaluation of Efficacy and Safety of
			Peramivir in Adults With Acute Serious or
			Potentially Life-threatening Influenza

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