Source:		MedGen UID: 172701


			An inhibitor of cysteine protease with blood
			platelet aggregation inhibiting activity.
			Aloxistatin is an irreversible,
			membrane-permeable inhibitor of lysosomal
			and cytosolic cysteine proteases with the ability
			to inhibit calpain activity in intact platelets.
			Aloxistatin is also known as E64d.


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			E64d inhibitor
			SARS Coronavirus Protease Pathway

			32142651 SARS-CoV-2 Cell Entry Depends
			on ACE2 and TMPRSS2 and Is Blocked by
			a Clinically Proven Protease Inhibitor.

			32123827 Calpain-mediated cleavage of p53 in
			human cytomegalovirus-infected lung

			31231548 Curcumin induced oxidative stress
			causes autophagy and apoptosis in bovine
			leucocytes transformed by Theileria annulata.

			30974805 Ethanol-Mediated Stress Promotes
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			30755067 A novel transgenic zebrafish line
			allows for in vivo quantification of autophagic
			activity in neurons.

			30652348 Menadione-induced apoptosis in
			U937 cells involves Bid cleavage and stefin B

			30602534 Identifying
			purine nucleoside phosphorylase
			as the target of quinine using cellular thermal
			shift assay.

			30417443 The absence of Rab27a absence
			the degradation of Melanophilin.

			30406036 The Correlation Between Hepatitis B
			Virus Precore/Core Mutations and the
			Progression of Severe Liver Disease.

			30311874 Induction of selective autophagy in
			cells replicating hepatitis C virus genome.

			29805718 Potential Alzheimer's Disease
			Therapeutics Among Weak Cysteine Protease
			Inhibitors Exhibit Mechanistic Differences
			Regarding Extent of Cathepsin B Up-Regulation
			and Ability to Block Calpain.

			29588492 SFTS phlebovirus promotes LC3-II
			accumulation and nonstructural protein of SFTS
			phlebovirus co-localizes with autophagy proteins.

			29515581 Autophagy Mediates Interleukin-1β
			Secretion in Human Neutrophils.

			29501728 Targeting of cathepsin C induces
			autophagic dysregulation that directs ER stress
			mediated cellular cytotoxicity in colorectal cancer

			29434757 miR-221 inhibits autophagy and
			targets TP53INP1 in colorectal cancer cells.

			29386384 DJ-1 deficiency impairs synaptic
			vesicle endocytosis and reavailability at
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			28965934 The activation of autophagy protects
			neurons and astrocytes against
			bilirubin-induced cytotoxicity.

			28854341 The protease inhibitor E64d
			improves ox-LDL-induced endothelial
			dysfunction in human aortic endothelial cells.

			28502922 Design, Synthesis, and
			Structure-Activity Relationship Study of
			Epoxysuccinyl-Peptide Derivatives as
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			28212430 A calmodulin-like protein suppresses
			RNA silencing and promotes geminivirus
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			pathway in Nicotiana benthamiana.

			27030368 Kinetic, Mutational, and Structural
			Studies of the Venezuelan Equine Encephalitis
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			26388830 Cathepsin B is a New Drug Target
			for Traumatic Brain Injury Therapeutics:
			Evidence for E64d as a Promising Lead Drug

			25925704 Autophagy inhibitors reduce
			avian-reovirus-mediated apoptosis in cultured
			cells and in chicken embryos.

			25625842 Cathepsin inhibition-induced lysosomal
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			21613740 The cysteine protease inhibitor,
			E64d, reduces brain amyloid-β and improves
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			models by inhibiting cathepsin B, but not
			BACE1, β-secretase activity.

			16802320 Neurovascular and neuronal
			protection by E64d after focal cerebral
			ischemia in rats.

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