Source: MedGen UID: 172701⇩ Aloxistatin
An inhibitor of cysteine protease with blood
platelet aggregation inhibiting activity.
Aloxistatin is an irreversible,
membrane-permeable inhibitor of lysosomal
and cytosolic cysteine proteases with the ability
to inhibit calpain activity in intact platelets.
Aloxistatin is also known as E64d.
E64d inhibitorCamostatSARS Coronavirus Protease Pathway
32142651SARS-CoV-2 Cell Entry Depends
on ACE2 and TMPRSS2 and Is Blocked by
a Clinically Proven Protease Inhibitor.
32123827 Calpain-mediated cleavage of p53 in
human cytomegalovirus-infected lung
31231548 Curcumin induced oxidative stress
causes autophagy and apoptosis in bovine
leucocytes transformed by Theileria annulata.
30974805 Ethanol-Mediated Stress Promotes
Autophagic Survival and Aggressiveness of
Colon Cancer Cells via Activation of Nrf2/HO-1
30755067 A novel transgenic zebrafish line
allows for in vivo quantification of autophagic
activity in neurons.
30652348 Menadione-induced apoptosis in
U937 cells involves Bid cleavage and stefin B
purine nucleoside phosphorylase
as the target of quinine using cellular thermal
30417443 The absence of Rab27a absence
the degradation of Melanophilin.
30406036 The Correlation Between Hepatitis B
Virus Precore/Core Mutations and the
Progression of Severe Liver Disease.
30311874 Induction of selective autophagy in
cells replicating hepatitis C virus genome.
29805718 Potential Alzheimer's Disease
Therapeutics Among Weak Cysteine Protease
Inhibitors Exhibit Mechanistic Differences
Regarding Extent of Cathepsin B Up-Regulation
and Ability to Block Calpain.
29588492 SFTS phlebovirus promotes LC3-II
accumulation and nonstructural protein of SFTS
phlebovirus co-localizes with autophagy proteins.
29515581 Autophagy Mediates Interleukin-1β
Secretion in Human Neutrophils.
29501728 Targeting of cathepsin C induces
autophagic dysregulation that directs ER stress
mediated cellular cytotoxicity in colorectal cancer
29434757 miR-221 inhibits autophagy and
targets TP53INP1 in colorectal cancer cells.
29386384 DJ-1 deficiency impairs synaptic
vesicle endocytosis and reavailability at
28965934 The activation of autophagy protects
neurons and astrocytes against
28854341 The protease inhibitor E64d
improves ox-LDL-induced endothelial
dysfunction in human aortic endothelial cells.
28502922 Design, Synthesis, and
Structure-Activity Relationship Study of
Epoxysuccinyl-Peptide Derivatives as
Cathepsin B Inhibitors.
28212430 A calmodulin-like protein suppresses
RNA silencing and promotes geminivirus
infection by degrading SGS3 via the autophagy
pathway in Nicotiana benthamiana.
27030368 Kinetic, Mutational, and Structural
Studies of the Venezuelan Equine Encephalitis
Virus Nonstructural Protein 2 Cysteine
26388830Cathepsin B is a New Drug Target
for Traumatic Brain Injury Therapeutics:
Evidence for E64d as a Promising Lead Drug
25925704 Autophagy inhibitors reduce
avian-reovirus-mediated apoptosis in cultured
cells and in chicken embryos.
25625842 Cathepsin inhibition-induced lysosomal
dysfunction enhances pancreatic beta-cell apoptosis
in high glucose.
21613740 The cysteine protease inhibitor,
E64d, reduces brain amyloid-β and improves
memory deficits in Alzheimer's disease animal
models by inhibiting cathepsin B, but not
BACE1, β-secretase activity.
16802320 Neurovascular and neuronal
protection by E64d after focal cerebral
ischemia in rats.