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			MedGen

  Source:		MedGen UID: 262817


     		Severe acute respiratory syndrome

			Definition
			A viral disorder characterized by high FEVER,
			dry COUGH, shortness of breath (DYSPNEA) or
			breathing difficulties, and ATYPICAL PNEUMONIA.
			A virus in the genus CORONAVIRUS is the
			suspected agent.

			Related Concepts
			Antiserum product
			Middle East respiratory syndrome
			SARS Coronavirus Protease Pathway
			Susceptibility to coronavirus 229e
			Viral Breakthrough
			Viral Disease
			Viral Fusion Protein Inhibitors
			Viral Load
			Viral Lower Respiratory Infection
			Viral Pathogenesis
			Viral Pneumonia
			Viral Respiratory Tract Infection
			Viral Upper Respiratory Tract Infection
			Viral Vaccine
			Viral Vector
			Viremia

			BioProject
			PRJNA244298 Cytokine stimulation systems
			approach demonstrates differences in innate
			and pro-inflammatory host responses between
			genetically distinct MERS-CoV isolates.

			PRJNA118845 Dynamic Innate Immune
			Responses of Human Bronchial Epithelial Cells
			against SARS-CoV and DOHV infection

			PRJNA97445 Gene expression profiling of
			patients with severe acute respiratory
			syndrome (SARS)

			PRJNA90357 SARS

			PubMed
			32130047 Déjà Vu or Jamais Vu? How the Severe
			Acute Respiratory Syndrome Experience
			Influenced a Singapore Radiology Department's
			Response to the Coronavirus Disease
			(COVID-19) Epidemic.

			32130038 Coronavirus Disease 2019
			(COVID-19): Role of Chest CT in Diagnosis and
			Management.

			32128276 Long-term bone and lung
			consequences associated with
			hospital-acquired severe acute
			respiratory syndrome: a 15-year
			follow-up from a prospective cohort study.

			32125362 Epidemiologic Features and
			Clinical Course of Patients Infected With
			SARS-CoV-2 in Singapore.

			32124990 Analyzing the Epidemiological
			Outbreak of COVID-19: A Visual Exploratory
			Data Analysis (EDA) Approach.

			32117225 Novel Insights Into Immune Systems
			of Bats.

			32116147 Coronavirus disinfection in
			histopathology.

			32115733 Coronavirus disease (COVID-19) and
			neonate: What neonatologist need to know.

			32115732 The Wuhan SARS-CoV-2 -
			What's Next for China.

			32112977 World Health Organization declares
			Global Emergency: A review of the 2019 Novel
			Coronavirus (COVID-19).

			32111449 2019 novel coronavirus disease
			(COVID-19) in Taiwan: Reports of two cases
			from Wuhan, China.

			32111262 A mathematical model for simulating
			the phase-based transmissibility of a novel
			coronavirus.

			32110875 Potential Rapid Diagnostics, Vaccine
			and Therapeutics for 2019 Novel Coronavirus
			(2019-nCoV): A Systematic Review.

			32109254 A Bayesian approach for detecting a
			disease that is not being modeled.

			32108862 Genome Detective Coronavirus
			Typing Tool for rapid identification and
			characterization of novel coronavirus genomes.

			32108495 Radiology Perspective of
			Coronavirus Disease 2019 (COVID-19):
			Lessons From
			Severe Acute Respiratory Syndrome and
			Middle East Respiratory Syndrome.

			32108351 Clinical characteristics of 50466
			hospitalized patients with 2019-nCoV infection.

			32107119 Coronavirus Disease 2019:
			Coronaviruses and Blood Safety.

			32106567 Preliminary Identification of Potential
			Vaccine Targets for the COVID-19 Coronavirus
			(SARS-CoV-2) Based on SARS-CoV
			Immunological Studies.

			32105680 Coronavirus Disease 2019
			(COVID-19) and Pregnancy: What obstetricians
			need to know.

			32105637 Radiological findings from 81
			patients with COVID-19 pneumonia in Wuhan,
			China: a descriptive study.

			32104915 The neuroinvasive potential of
			SARS-CoV2 may be at least partially
			responsible for the respiratory failure of
			COVID-19 patients.

			32098422 Systematic Comparison of Two
			Animal-to-Human Transmitted Human
			Coronaviruses: SARS-CoV-2 and SARS-CoV.

			32096611 2019 novel coronavirus infection and
			gastrointestinal tract.

			32094225 The antiviral compound remdesivir
			potently inhibits RNA-dependent RNA
			polymerase from
			Middle East respiratory syndrome coronavirus.

			32093211 Characteristics of and Public Health
			Responses to the Coronavirus Disease 2019
			Outbreak in China.

			32092911 Rigidity of the Outer Shell Predicted
			by a Protein Intrinsic Disorder Model Sheds
			Light on the COVID-19 (Wuhan-2019-nCoV)
			Infectivity.

			32091134 Facing the COVID-19 outbreak:
			What should we know and what could we do?

			32086938 The SARS, MERS and novel
			coronavirus (COVID-19) epidemics, the newest
			and biggest global health threats: what lessons
			have we learned?

			32083985 Coronavirus Disease 2019
			(COVID-19): A Perspective from China.

			32083638 Processing of the SARS-CoV
			pp1a/ab nsp7-10 region.

			32081636 Severe acute respiratory syndrome
			coronavirus 2 (SARS-CoV-2) and coronavirus
			disease-2019 (COVID-19): The epidemic and
			the challenges.

			32080991 Viral Load Kinetics of SARS-CoV-2
			Infection in First Two Patients in Korea.

			32077115 Clinical characteristics of 140
			patients infected with SARS-CoV-2 in Wuhan,
			China.

			32073161 The course of clinical diagnosis and
			treatment of a case infected with
			coronavirus disease 2019.

			32070465 First cases of coronavirus disease
			2019 (COVID-19) in France: surveillance,
			investigations and control measures, January
			2020.

			32065348 Can Chinese Medicine Be Used for
			Prevention of Corona Virus Disease 2019
			(COVID-19)? A Review of Historical Classics,
			Research Evidence and Current Prevention
			Programs.

			32062645 Challenges to the system of reserve
			medical supplies for public health emergencies:
			reflections on the outbreak of the
			severe acute respiratory syndrome coronavirus
			2 (SARS-CoV-2) epidemic in China.

			32056249 Overlapping and discrete aspects of
			the pathology and pathogenesis of the
			emerging human pathogenic coronaviruses
			SARS-CoV, MERS-CoV, and 2019-nCoV.

			32056235 Does SARS-CoV-2 has a longer
			incubation period than SARS and MERS?

			32054787 Prophylactic and therapeutic
			remdesivir (GS-5734) treatment in the rhesus
			macaque model of MERS-CoV infection.

			32052918 The 2019 Coronavirus: Learning
			Curves, Lessons, and the Weakest Link.

			32052373 Practical recommendations for
			critical care and anesthesiology teams caring
			for novel coronavirus (2019-nCoV) patients.

			32050635 Potential Maternal and Infant
			Outcomes from (Wuhan) Coronavirus
			2019-nCoV Infecting Pregnant Women:
			Lessons from SARS, MERS, and Other Human
			Coronavirus Infections.

			32048815 Preliminary prediction of the basic
			reproduction number of the Wuhan novel
			coronavirus 2019-nCoV.

			32040667 Critical care management of adults
			with community-acquired severe respiratory
			viral infection.

			32040506 Host factor prioritization for pan-viral
			genetic perturbation screens using random
			intercept models and network propagation.

			32037447 Griffithsin Inhibits Nipah Virus Entry
			and Fusion and Can Protect Syrian Golden
			Hamsters From Lethal Nipah Virus Challenge.

			32036774 Emerging novel Coronavirus
			(2019-nCoV) - Current scenario, evolutionary
			perspective based on genome analysis and
			recent developments.

			32035997 Persistence of coronaviruses on
			inanimate surfaces and their inactivation with
			biocidal agents.

			32035028 Genome Composition and
			Divergence of the Novel Coronavirus
			(2019-nCoV) Originating in China.

			32031668 An integrative review of the limited
			evidence on international travel bans as an
			emerging infectious disease disaster control
			measure.

			32027036 Genomic variance of the 2019-nCoV
			coronavirus.

			32024089 Estimating the Unreported Number
			of Novel Coronavirus (2019-nCoV) Cases in
			China in the First Half of January 2020: A
			Data-Driven Modelling Analysis of the Early
			Outbreak.

			32019669 Pattern of early human-to-human
			transmission of Wuhan 2019 novel coronavirus
			(2019-nCoV), December 2019 to January
			2020.

			32007145 Genomic characterisation and
			epidemiology of 2019 novel coronavirus:
			implications for virus origins and
			receptor binding.

			32006468 Recent discovery and development
			of inhibitors targeting coronaviruses.

			31244113 Design, Synthesis, and Anti-RNA
			Virus Activity of 6'-Fluorinated-Aristeromycin
			Analogues.

			31231549 SARS-Coronavirus Open Reading
			Frame-8b triggers intracellular stress pathways
			and activates NLRP3 inflammasomes.

			31226023 Human Coronavirus: Host-Pathogen
			Interaction.

			31199522 Severe acute respiratory syndrome
			coronavirus spike protein counteracts
			BST2-mediated restriction of virus-like particle
			release.

			31191192 History and Future of Nucleic Acid
			Amplification Technology Blood Donor Testing.

			31133031 Coronavirus envelope protein:
			current knowledge.

			31131400 Delicate structural coordination of
			the Severe Acute Respiratory Syndrome
			coronavirus Nsp13 upon ATP hydrolysis.

			31076983 Complete genome analysis of a
			SARS-like bat coronavirus identified in the
			Republic of Korea.

			31054790 Emerging respiratory infections: The
			infectious disease pathology of SARS, MERS,
			pandemic influenza, and Legionella.

			31034780 Severe acute respiratory syndrome
			coronavirus ORF3a protein activates the
			NLRP3 inflammasome by promoting
			TRAF3-dependent ubiquitination of ASC.

			31013648 Factors Influencing the Response to
			Infectious Diseases: Focusing on the Case of
			SARS and MERS in South Korea.

			31007619 An overview of the National
			Microbiology Laboratory emergency
			management program.

			31007618 Fifteen years post-SARS: Key
			milestones in Canada's public health
			emergency response.

			30993689 Vaccines for emerging pathogens:
			from research to the clinic.

			30985968 Emerging respiratory infections
			threatening public health in the Asia-Pacific
			region: A position paper of the Asian Pacific
			Society of Respirology.

			30984169 Infectious Disease Threats in the
			Twenty-First Century: Strengthening the Global
			Response.

			30943371 SARS coronavirus protein nsp1
			disrupts localization of Nup93 from the nuclear
			pore complex.

			30925168 Bayesian inference of transmission
			chains using timing of symptoms, pathogen
			genomes and contact data.

			30918074 High-throughput Screening and
			Identification of Potent Broad-spectrum
			Inhibitors of Coronaviruses.

			30891557 The battle against SARS and MERS
			coronaviruses: Reservoirs and Animal Models.

			28659436 Broad-spectrum antiviral GS-5734
			inhibits both epidemic and zoonotic
			coronaviruses.

			21325420 Evidence that TMPRSS2 activates the
			severe acute respiratory syndrome coronavirus
			spike protein for membrane fusion and reduces
			viral control by the humoral immune response.

			16912115 Severe acute respiratory syndrome
			coronavirus nsp1 protein suppresses host gene
			expression by promoting host mRNA degradation.

			15655079 Expression profile of immune response
			genes in patients with Severe Acute Respiratory
			Syndrome.

			Clinical Trials
			3443102 Long-term Assessment of Organ
			Functions Among Survivors of Severe Acute
			Respiratory Syndrome

			3274544 Clinical Trial of Chinese Herbal
			Medicine for Idiopathic Pulmonary Fibrosis (IPF)

			2738645 A Clinical Cohort Study of Pneumonia
			in Respiratory Intensive Care Unit

			2670187 Phase I, Open Label Dose Ranging
			Safety Study of GLS-5300 in Healthy
			Volunteers

			2338986 Collection of Plasma From People
			Who Recovered From or Were Vaccinated to
			Emerging Infectious Diseases

			1979705 Detect Novel Pathogens and
			Characterize Emerging Infections

			1376765 Phase I Dose Escalation SARS-CoV
			Recombinant S Protein, With and Without
			Adjuvant, Vaccine Study

			1302418 Collection and Testing of Respiratory
			Samples

			1200953 Admission and Management of
			Occupational or Other Exposures to
			Biodefense/Bioterrorism Agents or to
			Epidemic/Emerging Infectious Diseases

			578825 A Multi-centre, Double-blinded,
			Randomized, Placebo-controlled Trial on the
			Efficacy and Safety of Lopinavir / Ritonavir Plus
			Ribavirin in the Treatment of Severe Acute
			Respiratory Syndrome

			533741 SARS Coronavirus Vaccine
			(SARS-CoV)

			523276 SARS Survivor Evaluations

			342524 Collection of Convalescent SARS
			Plasma by Apheresis

			215826 Study of Alferon® LDO (Low Dose Oral)
			in Normal Volunteers

			173576 Clinical Study of SARS in Children

			173563 Induction of Cytokines in Human
			Monocytes by SARS-CoV in Adults and
			Children

			173459 Dynamic Profiles of
			Cytokine/Chemokine in Severe Acute
			Respiratory Syndrome

			173017 The Physiological Impact of N95
			Masks on Medical Staff

			172263 The Interaction Between Severe Acute
			Respiratory Distress Syndrome Viral Proteins
			and Monocytes

			150475 Contamination During Removal of Two
			Different Personal Protective Systems

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