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			MedGen

  Source:		MedGen UID: 5171


     		Interferon beta

			Definition
			A class of interferon elaborated by fibroblasts.

			Related Concepts
			Bone Remodeling Pathway
			Fiblaferon
			Interferon Type I
			Recombinant Adenovirus-hIFN-beta
			Recombinant Interferon Beta
			VSV-hIFNbeta-NIS
			multiple sclerosis
			glatiramer acetate
			talizumab
			human immunodeficiency virus
			attack
			inflammatory response
			signaling pathway
			accumulation
			antiviral

			BioProject
			PRJNA112731 Analysis of wild-type and C
			mutant human HPIV1 and interferon beta
			treatment in human respiratory epithelial A549
			cells

			PRJNA470689 Cell type specific gene
			expression patterns associated with
			posttraumatic stress disorder in World Trade
			Center responders

			PRJNA274307 Constitutively-active MAVS
			inhibits HIV-1 replication via type I interferon
			secretion and induction of HIV-1 restriction
			factors

			PRJNA121751 Dynamic responses of primary
			human bronchial epithelial cells to influenza
			virus, viral RNA and interferon-beta

			PRJNA401684 Expression data from HeLa
			cells upon interferon-gamma or interferon-beta
			treatment

			PRJNA117153 Expression data from
			relapsing-remitting MS samples

			PRJNA449725 Expression data from whole
			blood of RRMS patients initiating treatment with
			intramuscular IFN-β1a (Avonex®) obtained exactly
			12 hours after treatment.

			PRJNA449724 Expression data from whole
			blood of RRMS patients initiating treatment with
			intramuscular IFN-β1a (Avonex®) obtained
			immediately prior to treatment.

			PRJNA198641 Expression data of multiple
			sclerosis patients receiving Interferon-beta
			therapy [HG-U133_Plus_2]

			PRJNA198640 Expression data of multiple
			sclerosis patients receiving Interferon-beta
			therapy [miRNA-2_0]

			PRJNA198639 Expression data of multiple
			sclerosis patients receiving Interferon-beta
			therapy [TaqMan(r) Array Human MicroRNA A
			Cards v2.0]

			PRJNA198638 Expression data of multiple
			sclerosis patients receiving Interferon-beta
			therapy [TaqMan(r) Array Human MicroRNA B
			Cards v2.0]

			PRJNA95431 Gene expression in PBMC from
			Multiple Sclerosis patients undergoing interferon
			beta therapy.

			PRJNA291682 Gene expression profiling of
			healthy controls upon Interferon-beta
			stimulation

			PRJNA251683 Gene expression profiling of the
			response to interferon beta in EBV-transformed
			and primary B cells of patients with multiple
			sclerosis

			PRJNA418007 Genome-wide analysis of gene
			expression by IFNβ in Transformed HMEC
			(Epithelial/non-CSC, Mesenchymal/CSC)

			PRJNA151275 Genome-wide analysis of
			monocytes and T cells' response to interferon
			beta

			PRJNA79723 Highly Recurrent MYD88
			Mutations That Promote Human Lymphoma
			Cell Survival

			PRJNA371407 Identification of transcriptome
			signatures and biomarkers specific for potential
			developmental toxicants inhibiting human neural
			crest cell migration

			PRJNA152523 Influence of Interferon-beta on
			expression profile of memory T-cells

			PRJNA379183 Interferon receptor signaling
			pathways regulating PD-L1 and PD-L2
			expression

			PRJNA515908 Interferon-beta-inducible genes
			in human monocyte-derived macrophages
			(MDMs)

			PRJNA433884 Leo1 occupancy in presence of
			dengue virus NS5

			PRJNA261038 Modified Stat1 Confers
			Enhanced Interferon Responsiveness and
			Improved Baseline Antiviral Host Defense

			PRJNA127653 Monocyte vs Macrophage
			Study

			PRJNA381100 Multiplexing droplet-based
			single cell RNA-sequencing using genetic
			barcodes

			PRJNA177120 Mutant p53 attenuates the
			anti-tumorigenic activity of fibroblasts secreted
			interferon (IFN) beta

			PRJNA96963 Profiling of interferon beta
			immediate transcriptional effects in humans

			PRJNA221224 The effect of MEK inhibition,
			Interferon beta, and their combination on
			transcription in melanoma

			PubMed
			32210609 Interferon-Beta-Induced Headache
			in Patients with Multiple Sclerosis: Frequency
			and Characterization.

			31252545 BK Virus Replication in the
			Glomerular Vascular Unit: Implications for BK
			Virus Associated Nephropathy.

			31252170 A Systematic Review of therapeutic
			agents for the treatment of the Middle East
			Respiratory Syndrome Coronavirus
			(MERS-CoV).

			31233973 Relapse numbers and earlier
			intervention by disease modifying drugs are
			related with progression of less brain atrophy in
			patients with multiple sclerosis.

			31233762 Intranasal interferon beta improves
			memory and modulates inflammatory
			responses in a mutant APP-overexpressing rat
			model of Alzheimer's disease.

			31174334 Isolation and
			Immunocharacterization of Lactobacillus
			salivarius from the Intestine of Wakame-Fed
			Pigs to Develop Novel "Immunosynbiotics".

			31153744 Bone marrow mesenchymal stem
			cells from patients with SLE maintain an
			interferon signature during in vitro culture.

			31152860 Interferon beta ameliorates cognitive
			dysfunction in a rat model of Alzheimer's
			disease: Modulation of hippocampal
			neurogenesis and apoptosis as underlying
			mechanism.

			31100209 Repurposing multiple sclerosis
			drugs: a review of studies in other neurological
			and psychiatric conditions.

			31097999 Discovery of GSK8612, a Highly
			Selective and Potent TBK1 Inhibitor.

			31083335 Histone Deacetylase Inhibitors
			Enhance Cell Killing and Block Interferon-Beta
			Synthesis Elicited by Infection with an Oncolytic
			Parainfluenza Virus.

			31064978 DNA methylation signatures of
			monozygotic twins clinically discordant for
			multiple sclerosis.

			31046913 Morphea secondary to interferon
			beta1b injection: a case and review of the
			literature.

			31045320 Identification of lncRNA-155
			encoded by MIR155HG as a novel regulator of
			innate immunity against influenza A virus
			infection.

			31036052 The opposing effects of
			interferon-beta and oncostatin-M as regulators
			of cancer stem cell plasticity in triple-negative
			breast cancer.

			30919591 Interferon-regulated suprabasin is
			essential for stress-induced stem-like cell
			conversion and therapy resistance of human
			malignancies.

			30897575 Interferon-Beta Treatment
			Differentially Alters TLR2 and TLR4-Dependent
			Cytokine Production in Multiple Sclerosis
			Patients.

			30886680 Induction or aggravation of other
			immune-mediated disorders by
			disease-modifying therapy in treatment of
			multiple sclerosis.

			30863357 Pharmacogenomics of Multiple
			Sclerosis: A Systematic Review.

			30848986 Different Interferon Beta
			Preparations Induce the Same Qualitative
			Immune Response in Human Skin.

			30841910 Radiotherapy enhances responses
			of lung cancer to CTLA-4 blockade.

			Clinical Trials
			3888924 Bacille Calmette-Guérin (BCG) Vaccine
			In Radiologically Isolated Syndrome (RIS)

			3865212 Modified Virus VSV-IFNbetaTYRP1 in
			Treating Patients With Stage III-IV Melanoma

			3784547 Real-world Data of Ocrelizumab in
			Multiple Sclerosis in LATAM

			3570359 A Study to Test a Potential New
			Treatment for COPD Patients Suffering From
			the Common Cold or Influenza

			3424733 Evaluating the Use of Prednisone to
			Decrease Pegylated Interferon Beta-1a Side
			Effects

			3399981 Tysabri Observational Cohort Study -
			Multiple Sclerosis (MS) Registries

			3347370 A Post-Authorization Safety Study of
			Interferon Beta Therapy in Participants With
			Multiple Sclerosis

			3120624 VSV-hIFNbeta-NIS in Treating
			Patients With Stage IV or Recurrent
			Endometrial Cancer

			3017820 VSV-hIFNbeta-NIS in Treating
			Patients With Relapsed or Refractory Multiple
			Myeloma, Acute Myeloid Leukemia, or T-cell
			Lymphoma

			2937285 National Multicenter, Controlled,
			Single-blind Study With Two Parallel Groups
			Evaluating the Safety and Efficacy of Sequential
			Treatment With Mitoxantrone and Interferon
			Versus Interferon Alone in Patients With Strong
			Risk of Progression in the Initial Phase of
			Multiple Sclerosis

			2530047 Mesenchymal Stem Cells (MSC) for
			Ovarian Cancer

			2401165 Quantification of GADD34 Expression
			in RA

			2364986 Immune- and miRNA-response to
			Recombinant Interferon Beta in Healthy
			Volunteers and Patients With Relapsing
			Remitting Multiple Sclerosis

			2280876 Efficacy Study of Andrographis
			Paniculata Purified Standardized Extract (ApE)
			in Patients With Multiple Sclerosis (MS)

			2236624 Aerobic Exercise and Flu-like
			Symptoms Following Interferon Beta 1a
			Injections in Patients With Multiple Sclerosis?

			2234869 Transition to Peginterferon Beta-1a
			(BIIB017) From Subcutaneous Interferon
			Therapy

			1994018 Correlation Between Relapses in
			Multiple Sclerosis (MS) and Vitamin D Intake

			1939002 Characterize Flu-like Symptoms in
			Relapsing Multiple Sclerosis Patients
			Transitioning From Non-Pegylated Interferon
			Beta (IFN-β) Therapies to Peginterferon Beta-1a
			(BIIB017)

			1929382 Determining the Effect of Actimmune
			(Interferon Gamma 1b)Dose Titration on
			Flu-Like Symptoms in Healthy Volunteers

			1834586 Anesthetic Topical Adhesive (Synera™)
			to Reduce Injection Pain With Subcutaneous
			Multiple Sclerosis Medications

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