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			MedGen

  Source:		MedGen UID: 5846


     		Interferon gamma product

			Definition
			Interferon gamma (166 aa, ~19 kDa) is encoded
			by the human IFNG gene. This protein is
			involved in antiviral activity, macrophage
			activation, antiproliferative activity and
			immunopotentiation.

			Related Concepts
			Interleukin-12
			Poly IC
			Poly ICLC
			latent tuberculosis
			granulomatous lymphadenitis
			blood
			inflammation
			enzyme
			nitric oxide
			inhibition
			antibody
			tuberculosis
			infiltration
			peripheral
			active tuberculosis
			tuberculosis screening
			immunomodulator
			interferon
			polysaccharide

			PubMed
			32346613 Analysis of Lung Adenocarcinoma
			Subtypes Based on Immune Signatures Identifies
			Clinical Implications for Cancer Therapy.

			32337262 Construction of a CXC Chemokine-Based
			Prediction Model for the Prognosis of
			Colon Cancer.

			32318029 A Novel wx2 Gene of Toxoplasma
			gondii Inhibits the Parasitic Invasion and
			Proliferation in vitro and Attenuates Virulence
			in vivo via Immune Response Modulation.

			32307013 Peritoneal tuberculosis mimicking
			carcinomatous ascites in a child living in a low
			prevalence country: a case report.

			32306920 GRP78 expression in peripheral
			blood mononuclear cells is a new predictive
			marker for the benefit of taxanes in breast cancer
			neoadjuvant treatment.

			32294698 Acute effect of passive cycle-ergometry
			and functional electrical stimulation on
			nitrosative stress and inflammatory cytokines
			in mechanically ventilated critically ill patients:
			a randomized controlled trial.

			32292895 Interferon-Gamma Stimulated
			Murine Macrophages In Vitro: Impact of Ionic
			Composition and Osmolarity and Therapeutic
			Implications.

			32266098 KRAS signaling enriched
			triple negative breast cancer is associated with
			favorable tumor immune microenvironment
			and better survival.

			32265897 NGS Evaluation of Colorectal Cancer
			Reveals Interferon Gamma Dependent
			Expression of Immune Checkpoint Genes and
			Identification of Novel IFNγ Induced Genes.

			32265833 Evidence for a More Disrupted
			Immune-Endocrine Relation and Cortisol
			Immunologic Influences in the Context of
			Tuberculosis and Type 2 Diabetes Comorbidity.

			32258853 Conversion and Reversion Rates
			of Tuberculosis Screening Assays in Patients
			With Rheumatic Diseases and Negative Baseline
			Screening Under Long-Term Biologic Treatment.

			32256565 Diagnostic Value of Interferon-Gamma
			Release Assays Combined with Multiple
			Indicators for Tuberculous Peritonitis.

			32256470 A First Plasmodium vivax Natural
			Infection Induces Increased Activity of the
			Interferon Gamma-Driven Tryptophan Catabolism
			Pathway.

			32256272 The small chain fatty acid butyrate
			antagonizes the TCR-stimulation-induced
			metabolic shift in murine epidermal gamma
			delta T cells.

			32256194 I-alowCD11bhigh DC Regulates
			the Immune Response in the Eyes of
			Experimental Autoimmune Uveitis.

			32256028 The association between intravitreal
			ranibizumab therapy and serum cytokine
			concentrations in patients with diabetic macular edema.

			32246039 Peripheral proinflammatory Th1/Th17
			immune cell shift is linked to disease severity
			in amyotrophic lateral sclerosis.

			32244969 Anti-Inflammatory Effects of Alnus
			Sibirica Extract on In Vitro and In Vivo Models.

			32244926 A Cross-Sectional Study Evaluating
			the Effects of Resistance Exercise on
			Inflammation and Neurotrophic Factors in
			Elderly Women with Obesity.

			32210257 Visualization of cell-type dependent
			effects of anti-E2 antibody and
			interferon-gamma treatments on localization
			and expression of Broccoli aptamer-tagged
			alphavirus RNAs.

			32194559 Defective Interferon Gamma
			Production by Tumor-Specific CD8+ T Cells Is
			Associated With 5'Methylcytosine-Guanine
			Hypermethylation of Interferon Gamma
			Promoter.

			32194558 CCL3/Macrophage Inflammatory
			Protein-1α Is Dually Involved in Parasite
			Persistence and Induction of a TNF- and
			IFNγ-Enriched Inflammatory Milieu in
			Trypanosoma cruzi-Induced Chronic
			Cardiomyopathy.

			32188404 Triple infection with Cryptococcus,
			varicella-zoster virus, and Mycobacterium
			abscessus in a patient with
			anti-interferon-gamma autoantibodies: a case
			report.

			32185294 Multicenter Cross-sectional Study of
			Patients with Rheumatoid Arthritis in Greece:
			Results from a cohort of 2.491 patients.

			32185190 Chronic Inflammatory Lameness
			Increases Cytokine Concentration in the Spinal
			Cord of Dairy Cows.

			32181327 Inhibition of Cholesterol Esterification
			Enzyme Enhances the Potency of Human
			Chimeric Antigen Receptor T Cells against
			Pancreatic Carcinoma.

			32181106 Schinus terebinthifolia leaf lectin
			(SteLL) is an immunomodulatory agent by
			altering cytokine release by mice splenocytes.

			32176735 Clinical implications of APOBEC3A
			and 3B expression in patients with
			breast cancer.

			32174990 A cardiac rehabilitation exercise
			program potentially inhibits
			progressive inflammation in patients with severe
			Chagas cardiomyopathy: A pilot single-arm
			clinical trial.

			32158775 Oral Cytokine Levels Are More
			Linked to Levels of Plasma and Oral HIV-1 RNA
			Than to CD4+ T-Cell Counts in People With
			HIV.

			32158626 Deep neural network classification
			based on somatic mutations potentially
			predicts clinical benefit of immune checkpoint
			blockade in lung adenocarcinoma.

			32156805 In Vitro Characterization of Protein
			Effector Export in the Bradyzoite Stage of
			Toxoplasma gondii.

			32153557 Reduced miR-146a Promotes
			REG3A Expression and Macrophage Migration
			in Polymyositis and Dermatomyositis.

			32133208 Screening for latent tuberculosis
			infection by an Aboriginal Community
			Controlled Health Service, New South Wales,
			Australia, 2015.

			32133069 Immunization against Leishmania
			major infection in BALB/c mice using a
			subunit-based DNA vaccine derived from TSA,
			LmSTI1, KMP11, and LACK predominant
			antigens.

			31252187 Hepcidin exerts a negative
			immunological effect in pulmonary tuberculosis
			without HIV co-infection, prolonging the time to
			culture negative.

			31132974 Mitogen-Induced Interferon Gamma
			Production in Human Whole Blood: The Effect
			of Heat and Cations.

			31123562 Persistence of dysfunctional natural
			killer cells in adults with high-functioning autism
			spectrum disorders: stigma/consequence of
			unresolved early infectious events?

			31061151 Treatment with Bumped kinase
			inhibitor BKI-1294 is safe and leads to
			significant protection against abortion and
			vertical transmission in sheep experimentally
			infected with Toxoplasma gondii during
			pregnancy.

			30878088 Neospora GRA6 possesses
			immune-stimulating activity and confers
			efficient protection against Neospora caninum
			infection in mice.

			30825273 Tonsil-derived mesenchymal stem
			cells exert immunosuppressive effects on T
			cells.

			30661002 IFNG-AS1 Enhances Interferon
			Gamma Production in Human Natural Killer
			Cells.

			30660401 Critical role of TLR2 in triggering
			protective immunity with cyclophilin entrapped
			in oligomannose-coated liposomes against
			Neospora caninum infection in mice.

			30558534 Gene co-expression networks from
			RNA sequencing of dairy cattle identifies genes
			and pathways affecting feed efficiency.

			30550623 Interferon-gamma production in
			Lyme arthritis synovial tissue promotes
			differentiation of fibroblast-like synoviocytes into
			immune effector cells.

			30457360 Synergistic Antitumor Effect on
			Bladder Cancer by Rational Combination of
			Programmed Cell Death 1 Blockade and
			CRISPR-Cas9-Mediated Long Non-Coding
			RNA Urothelial Carcinoma Associated 1
			Knockout.

			30453935 Microscopic polyangiitis secondary
			to Mycobacterium abscessus in a patient with
			bronchiectasis: a case report.

			30258008 Comparison of the immunogenicity
			and cross-lineage efficacy of live attenuated
			peste des petits ruminants virus vaccines
			PPRV/Nigeria/75/1 and PPRV/Sungri/96.

			30228201 Comparison of total-mixed-ration
			and feed-to-yield strategies on blood profiles
			and dairy cow health.

			30086091 Clinical Correlation of
			Cytomegalovirus Infection with CMV-Specific
			CD8+ T Cell Immune Competence Score and
			Lymphocyte Subsets in Solid Organ Transplant
			Recipients.

			30083167 Glucocorticoid-Induced Leucine
			Zipper Inhibits Interferon-Gamma Production in
			B Cells and Suppresses Colitis in Mice.

			29936407 T-Track-CMV and
			QuantiFERON-CMV assays for prediction of
			protection from CMV reactivation in kidney
			transplant recipients.

			29904012 Tuberculosis Specific
			Interferon-Gamma Production in a Current
			Refugee Cohort in Western Europe.

			29773597 Hematopoietic stem cell loss and
			hematopoietic failure in severe aplastic anemia
			is driven by macrophages and aberrant
			podoplanin expression.

			29688129 Genetic and substrate-level
			modulation of Bacillus subtilis physiology for
			enhanced extracellular human interferon
			gamma production.

			Clinical Trials
			3572842 Functional Non Specific Immunity
			Monitoring After Kidney Transplantation Using
			an Interferon Gamma Test

			3493932 Cytokine Microdialysis for Real-Time
			Immune Monitoring in Glioblastoma Patients
			Undergoing Checkpoint Blockade

			2653404 IGRA and Mantoux Response in
			Children With Suspected Latent or Active TB
			Infection

			2590068 Effects of Chronic Viral Infection on
			Immune Response to Zoster Vaccination

			957866 Prospective Anti-Hepatitis C Virus
			(Anti-HCV) Trial of Peg-Interferon and Ribavirin
			in Subjects of First Nations, Metis and
			Caucasian Ethnicity

			281229 T Lymphocyte Cells in Individuals
			Experiencing an Acute Exacerbation of Chronic
			Obstructive Pulmonary Disease

			52377 Interleukin-12 and Interleukin-2 in
			Treating Patients With Mycosis Fungoides

			52195 Investigational Vaccine for the
			Prevention of Disseminated Tuberculosis in HIV
			Infected People

			3568 Vaccine Therapy With High-Dose
			Interleukin-2 in Treating Patients With
			Metastatic Melanoma

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