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  Source:		MedGen UID: 5921


     		Ivermectin

			Definition
			Discovered in the late-1970s, Ivermectin is a
			dihydro derivative of avermectin, produced by
			the microorganism Streptomyces avermitilis.
			Ivermectin is an FDA approved antiparasitic
			medication on the World Health Organization's
			List of Essential Medicines [58] and was recently
			shown to reduce SARS-CoV-2 novel coronavirus
			viral load substantially in vitro within 48 hours.
			It can be taken orally or applied to the skin to
			treat external parasitic infections caused by
			skin infestation. Common side effects include
			eye redness, eye irritation, skin irritation, and
			burning sensation of skin. A macrocyclic lactone
			derived from Streptomyces avermitilis, Ivermectin
			exerts its anthelmintic effect via activating
			glutamate-gated chloride channels expressed on
			nematode neurons and pharyngeal muscle cells.
			Distinct from the channel opening induced by
			endogenous glutamate transmitter,
			ivermectin-activated channels open very slowly
			but essentially irreversibly. As a result, neurons
			or muscle cells remain at either hyperpolarisation
			or depolarization state, thereby resulting in
			paralysis and death of the parasites. Ivermectin
			does not readily pass the mammal blood-brain
			barrier to the central nervous system where
			glutamate-gated chloride channels locate,
			hence the hosts are relatively resistant to the
			effects of this agent.

			Related Concepts
			doramectin
			eprinomectin
			albendazole
			onchocerciasis
			lymphatic filariasis
			moxidectin
			volvulus
			Rosacea
			serious adverse events
			antiviral
			antiparasitic
			strongyloidiasis
			infestation

			sciencedirect.com The FDA-approved Drug
			Ivermectin inhibits the replication of SARS-CoV-2
			in vitro

			Related Genes
			karyopherin subunit alpha 1 (KPNA1)
			karyopherin subunit beta 1 (KPNB1)

			BioProject
			PRJNA380271 AmpliSeq analysis of human
			iPSC-derived cardiomyocytes

			PRJNA347986 Long-lasting WNT-TCF
			response blocking and epigenetic modifying
			activities of withanolide F in human cancer
			cells

			PRJNA279909 Selective inhibition of SIN3
			corepressor with avermectins as a novel
			therapeutic strategy in
			triple negative breast cancer

			PRJNA91755 Filaria induced monocyte
			dysfunction and its reversal following
			treatment

			PubMed
			32336928 Determinants of community-led
			ivermectin treatment adherence for onchocerciasis
			control in Western Ethiopia: a case-control
			study.

			32299374 Mapping lymphatic filariasis in Loa
			loa endemic health districts naïve for ivermectin
			mass administration and situated in the forested
			zone of Cameroon.

			32282840 Low transmission of Wuchereria
			bancrofti in cross-border districts of Côte d'Ivoire:
			A great step towards lymphatic filariasis
			elimination in West Africa.

			32269438 Post-Renal Transplant Miliary Mottling:
			Not Always Tuberculosis.

			32251768 The FDA-approved drug ivermectin
			inhibits the replication of SARS-CoV-2 in vitro.

			32186510 Oral migration of Dirofilaria repens
			after creeping dermatitis.

			32206773 Serological Evaluation of
			Onchocerciasis and Lymphatic Filariasis
			Elimination in the Bakoye and Falémé foci, Mali.

			32201246 Inhibition of TMEM16A
			Ca2+-activated Cl- channels by avermectins is
			essential for their anticancer effects.

			32189533 Value of reflectance confocal
			microscopy for the monitoring of rosacea
			during treatment with topical ivermectin.

			32186510 Oral migration of Dirofilaria repens
			after creeping dermatitis.

			32183205 Ivermectin Inhibits Bovine
			Herpesvirus 1 DNA Polymerase Nuclear Import
			and Interferes with Viral Replication.

			32181912 Implications of Endectocide
			Residues on the Survival of Aphodiine Dung
			Beetles: A Meta-Analysis.

			32179135 Multiple anthelmintic resistance in
			gastrointestinal nematodes of small ruminants
			in Bangladesh.

			32178241 Strongyloides Hyperinfection
			Associated with Enterococcus faecalis
			Bacteremia, Meningitis, Ventriculitis and
			Gas-Forming Spondylodiscitis: A Case Report.

			32176703 The safety of combined triple
			drug therapy with ivermectin,
			diethylcarbamazine and albendazole in the
			neglected tropical diseases co-endemic setting
			of Fiji: A cluster randomised trial.

			32173745 Structural Uncertainty in
			Onchocerciasis Transmission Models Influences
			the Estimation of Elimination Thresholds and
			Selection of Age Groups for Seromonitoring.

			32164367 Single versus Multiple Dose
			Ivermectin Regimen in Onchocerciasis-Infected
			Persons with Epilepsy Treated with
			Phenobarbital: A Randomized Clinical Trial in
			the Democratic Republic of Congo.

			32141785 Pulsed dye laser alone versus its
			combination with topical ivermectin 1% in
			treatment of Rosacea: a randomized
			comparative study.

			32135219 The broad spectrum antiviral
			ivermectin targets the host nuclear transport
			importin α/β1 heterodimer.

			21321478 Ivermectin, 'wonder drug' from
			Japan: the human use perspective.

			Clinical Trials
			4332068 Ivermectin Safety in Small Children

			4311671 Safety of a Single Dose of Moxidectin
			Compared With Ivermectin in Individuals Living
			in Onchocerciasis Endemic Areas

			4275999 Rosacea and Ivermectin

			4188301 Safety and Efficacy of IDA for
			Onchocerciasis

			4186546 Zephyr Valve Registry (ZEVR)

			4174469 Ivermectin Neurotoxicity and ABCB1
			Gene Mutations

			4161235 Post-Market Clinical Evaluation of the
			Zephyr Valve 5.5-LP EBV

			4124250 East New Britain Province Monitoring
			& Evaluation

			4108897 Analysis of the Microbiome in
			Rosacea

			4106726 Bioequivalence Study of Ivermectin
			Cream 1% in Treatment of Moderate to Severe
			Facial Rosacea

			4064671 ZEPHYR: A Study Evaluating Surgical
			Outcome After Implantation of the Zephyr ZSI
			475 FTM Inflatable Penile Implant in the
			Neophallus After Female-to-male Sex
			Reassignment Surgery

			4056325 Efficacy, Safety, and PK of Ascending
			Dosages of Moxidectin Versus Ivermectin
			Against Strongyloidiasis Stercoralis

			4049851 Clinical Trial Evaluating the Safety and
			Efficacy of Moxidectin 2 mg
			Ivermectin-controlled in Loa Loa Microfilaremic
			Patients

			4041453 Albendazole Plus High Dose
			Ivermectin for Trichuriasis in Pediatric Patients

			3967054 Repeat Ivermectin Mass Drug
			Administrations for MALaria Control II

			3876262 Safety and Efficacy of Annual or
			Biannual Doses of Moxidectin or Ivermectin for
			Onchocerciasis

			3852303 Ivermectin Treatment of Persons With
			Onchocerciasis-associated Epilepsy

			3717558 Bioavailability Pilot Study of Versus
			W0035 Versus Stromectol

			3690453 Effect of Ivermectin Metabolites on
			Mosquito Survival

			3676140 Safety of Co-administration of IDA
			and Azithromycin for NTDs ( ComboNTDs )

			3664063 PK PD Study of IDA and Azithromycin
			for NTDs ( ComboNTDs )

			3653975 Clinical Features and Potential
			Etiology of Epilepsy and Nodding Syndrome in
			the Mahenge Area, Ulanga District

			3605758 Treatment of Strongyloides Infection

			3598842 Tuberculosis - Learning the Impact of
			Nutrition

			3578679 Treatment of Pediculosis (Head Lice)
			in Senegal

			3576313 Mass Drug Administration of
			Ivermectin and Dihydroartemisinin-piperaquine
			as an Additional Intervention for Malaria
			Elimination

			3570814 Cluster RCT of Co-administration
			Azithromycin, Albendazole & Ivermectin

			3553615 Open-label Pilot Clinical Trial of Oral
			Ivermectin to Treat Atopic Dermatitis

			3527732 Efficacy and Safety of IVM/ALB
			Co-administration

			3517462 Ocular Changes After Ivermectin -
			(DOLF IVM/Oncho)

			3459794 Ivermectin and Human Immunity

			3432442 Pharmacokinetics and
			Pharmacodynamics of Ivermectin in Pediatric
			Dengue Patients

			3352206 Prevalence Studies After Triple
			Drug Therapy for Lymphatic Filariasis

			3337490 A Clinical Endpoint Bioequivalence
			Study to Assess Efficacy and Safety of
			Ivermectin 0.5% Lotion in the Treatment of
			Head Lice

			3301649 Clinical Endpoint Study of Ivermectin
			0.5% Lotion

			3286101 Efficacy and Safety of Topical 0.5%
			Ivermectin Lotion for the Treatment of Head
			Lice Infestation in Filipinos

			3257943 A Bioequivalence Study, Comparing
			Two Formulations of Ivermectin Lotion, 0.5%

			3238131 IVM Alone vs ALB + IVM Against
			Onchocerciasis

			3236168 Impact of Community Scabies
			Treatment on Head Lice Prevalence in the
			Solomon Islands

			3177993 Fiji Integrated Therapy (FIT) - Triple
			Therapy for Lymphatic Filariasis, Scabies and
			Soil Transmitted Helminths in Fiji

			3173742 Bioavailability and Safety of Two Oral
			Fixed Dose Preparations Containing 18 mg
			Ivermectin (IVM 18 MG TABLETS, LICONSA
			S.A., Spain) Versus Reference Dosing (Weight
			Based) Containing 6 mg Ivermectin
			(REVECTINA®, Abbott Laboratórios do Brasil
			Ltda, Brazil)

			3131401 Prevalence of LF Infection in Districts
			Not Included in LF Control Activities

			3075891 Oracea Soolantra Association in
			Patients With Severe Rosacea

			3074435 Insecticide Resistance Management in
			Burkina Faso and Côte d'Ivoire

			3052998 Ivermectin Treatment in Patients With
			Onchocerciasis-associated Epilepsy

			3036059 Twice Yearly Treatment for the
			Control of LF

			3014167 Field Studies on the Feasibility of
			Interrupting the Transmission of
			Soil-transmitted Helminths (STH)

			2974049 Lymphatic Filariasis (LF) in Ivory Coast

			2963324 Physiologically-based
			Pharmacokinetic Modeling of Ivermectin in
			Healthy Human Volunteers

			2961894 Revolution™ Peripheral Atherectomy
			System for Lower Extremity Peripheral Arterial
			Revascularization

			2899936 Death to Onchocerciasis and
			Lymphatic Filariasis (DOLF) Triple Drug Therapy
			for Lymphatic Filariasis

			2875756 Effect of the Number of Needle
			Revolutions Inside the Node on the Diagnostic
			Yield of EBUS-TBNA in Sarcoidosis

			2845713 Pharmacokinetics &
			Pharmacodynamics of Diethylcarbamazine
			(DEC)+ Albendazole (ALB) + Ivermectin (IVE)

			2841215 Efficacy Study Between Two Different
			Dosages of an Antiparasitic in Patients With
			Crusted Scabies

			2840461 Clinical Endpoint Study of Ivermectin
			1% Cream

			2806414 Evaluation of the Inhibitory Effects of
			Topical Ivermectin on Markers of Rosacea
			Specific Inflammation.

			2795117 Comparative Safety and Efficacy of
			Two Treatments in the Treatment of
			Inflammatory Lesions of Rosacea

			2784743 Impact of Albendazole -Ivermectin on
			Wuchereria Bancrofti in Mali

			2775617 Azithromycin - Ivermectin Mass Drug
			Administration for Skin Disease

			2616250 MirvasO Soolantra Association In the
			Treatment of Moderate to Severe rosaCea.

			2568098 Pharmacokinetic and Mosquito-Lethal
			Effects of Ivermectin (IVM), Primaquine (PQ),
			Dihydroartemisinin-Piperaquine (DHA-PQP) and
			Albendazole (ABZ) in Healthy Subjects

			2511353 Efficacy and Safety of High-dose
			Ivermectin for Reducing Malaria Transmission:
			A Dose Finding Study

			2509481 Repeat Ivermectin Mass Drug
			Administrations for Control of Malaria: a Pilot
			Safety and Efficacy Study

			2407782 Oral Ivermectin Versus Topical
			Permethrin to Treat Scabies in Children

			2366884 Clinical Evaluation of a New Form of
			Cancer Therapy Based on the Principles of
			Atavistic Metamorphosis (Atavistic
			Chemotherapy).

			2236403 Treatment of Demodex Blepharitis
			With Ivermectin Gel 0.1% Plus Metronidazole
			1%

			2078024 Efficacy of Ivermectin and
			Albendazole Against Onchocerciasis in the
			Volta Region, Ghana

			2046200 Development of Ivermectin for
			Alcohol Use Disorders

			2045069 Efficacy and Safety of Ivermectin
			Against Dengue Infection

			2036229 Topical 0.5% Ivermectin Cream for
			Treatment of Demodicidosis

			2032043 Optimization of Mass Drug
			Administration With Existing Drug Regimens for
			Lymphatic Filariasis and Onchocerciasis for
			Ivory Coast (DOLF-Ivory Coast)

			1975441 Eval 3-Drug Therapy
			Diethylcarbamize, Albendazole and Ivermectin
			That Could Accelerate LF Elimination Outside of
			Africa

			1905436 Mass Drug Administration for
			Lymphatic Filariasis and Onchocerciasis for
			Liberia

			1903057 Safety Study of Combined
			Azithromycin, Ivermectin and Albendazole for
			Trachoma and Lymphatic Filariasis

			1780792 Examining the Effects of Video-game
			Exercise on Mobility and Brain Plasticity in
			Individuals With Multiple Sclerosis

			1730313 Treatment of Nodding Syndrome -
			A Randomized Blinded Placebo-Controlled
			Crossover Trial of Oral Pyridoxine and
			Conventional Anti-Epileptic Therapy, in
			Northern Uganda — 2012

			1603251 Trial of Artemether-Lumefantrine Alone
			and in Combination With Ivermectin to Reduce
			Post-Treatment Malaria Transmission

			1593722 Post-treatment Effects of Ivermectin
			(IVM) or Diethylcarbamazine (DEC) in Loiasis

			1586169 Safety of the Co-administration of
			Three Drugs for Trachoma and
			Lymphatic Filariasis Elimination

			1570504 Multiple Versus Single Dose of
			Ivermectin for the Treatment of Strongyloidiasis

			1493947 CD5024 1% [Ivermectin 1%] Cream
			Versus Metronidazole 0.75% Cream in
			Papulopustular Rosacea (PPR) Study

			1308268 Management of Soil-transmitted
			Helminthiasis and Strongyloidiasis

			1287663 Effectiveness of Permethrin
			Impregnated Underwear in Preventing Louse
			Proliferation in Infected Homeless

			1213576 Efficacy of Higher Albendazole and
			Ivermectin Doses on Wuchereria Bancrofti
			Microfilarial Clearance in Malawi

			1080989 The Sero-Prevalence and Genetic
			Study for the Infectious Diseases and
			Metabolic Syndrome in Solomon Islands

			1068158 A Study Comparing the Safety and
			Efficacy of 0.5% Ivermectin Cream to Placebo
			in Lice Infested Subjects

			1066585 A Safety and Efficacy Study
			Comparing 0.5% Ivermectin Cream to a Vehicle
			Control in Subjects With Head Lice Infestation

			1050517 Safety and Efficacy of
			Drug Combinations Against Triple Infections

			1050452 Safety and Efficacy of
			Drug Combinations Against Trichuris Trichiura

			994422 Study Comparing the Safety and
			Efficacy of 0.5% Ivermectin Cream to Placebo
			in Lice Infested Subjects

			988533 A Pharmacokinetics (PK) Study in Lice
			Infested Children 6 Months to 3 Years of Age

			921674 Ivermectin Solution Bioequivalence
			Study - With Food

			921219 Ivermectin Solution Bioequivalence
			Study - With Food (Repeat)

			921154 Ivermectin Solution Bioequivalence
			Study - Fasted

			857948 Dose Ranging Study of Ivermectin
			Treatment Conditioner in Subjects With Head
			Lice Infestation

			819520 Ivermectin in the Treatment of Head
			Lice

			817713 Can Presumptive Anthelminthic
			Treatment Delay the Progression of HIV in
			ART-naïve Patients in Rural Africa?

			790998 Study Comparing Moxidectin And
			Ivermectin In Subjects With Onchocerca
			Volvulus Infection

			765024 Ivermectin Versus Albendazole for
			Chronic Strongyloidiasis

			604084 Veron Scabies Education and
			Eradication Program

			342576 Host Response to Infection and
			Treatment in Lymphatic Filarial Disease in India

			340691 Doxycycline to Treat Mansonella
			Perstans Infection in Patients With and Without
			Lymphatic Filariasis

			339417 Effect of Albendazole Dose on
			Clearance of Filarial Worms

			300768 Study Evaluating Orally Administered
			Moxidectin In Subjects With Onchocerca
			Volvulus Infection

			262418 Comparison of the Efficacy and Safety
			of Ivermectin to Permethrin

			215280 Epidemiology and Control of
			Mansonella Perstans Infection in Uganda

			207753 Effectiveness of Combined
			Albendazole and Ivermectin Treatment for
			Intestinal Worm Infections

			1245 Study of Patients With Strongyloides
			Stercoralis Infection

			1230 Host Response to Infection and
			Treatment in Filarial Diseases

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