Source:		MedGen UID: 5921


			Discovered in the late-1970s, Ivermectin is a
			dihydro derivative of avermectin, produced by
			the microorganism Streptomyces avermitilis.
			Ivermectin is an FDA approved antiparasitic
			medication on the World Health Organization's
			List of Essential Medicines [58] and was recently
			shown to reduce SARS-CoV-2 novel coronavirus
			viral load substantially in vitro within 48 hours.
			It can be taken orally or applied to the skin to
			treat external parasitic infections caused by
			skin infestation. Common side effects include
			eye redness, eye irritation, skin irritation, and
			burning sensation of skin. A macrocyclic lactone
			derived from Streptomyces avermitilis, Ivermectin
			exerts its anthelmintic effect via activating
			glutamate-gated chloride channels expressed on
			nematode neurons and pharyngeal muscle cells.
			Distinct from the channel opening induced by
			endogenous glutamate transmitter,
			ivermectin-activated channels open very slowly
			but essentially irreversibly. As a result, neurons
			or muscle cells remain at either hyperpolarisation
			or depolarization state, thereby resulting in
			paralysis and death of the parasites. Ivermectin
			does not readily pass the mammal blood-brain
			barrier to the central nervous system where
			glutamate-gated chloride channels locate,
			hence the hosts are relatively resistant to the
			effects of this agent.

			Related Concepts
			lymphatic filariasis
			serious adverse events

			sciencedirect.com The FDA-approved Drug
			Ivermectin inhibits the replication of SARS-CoV-2
			in vitro

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			therapeutic strategy in
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			PRJNA91755 Filaria induced monocyte
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			32336928 Determinants of community-led
			ivermectin treatment adherence for onchocerciasis
			control in Western Ethiopia: a case-control

			32299374 Mapping lymphatic filariasis in Loa
			loa endemic health districts naïve for ivermectin
			mass administration and situated in the forested
			zone of Cameroon.

			32282840 Low transmission of Wuchereria
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			32269438 Post-Renal Transplant Miliary Mottling:
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			32251768 The FDA-approved drug ivermectin
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			32186510 Oral migration of Dirofilaria repens
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			32206773 Serological Evaluation of
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			32201246 Inhibition of TMEM16A
			Ca2+-activated Cl- channels by avermectins is
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			32189533 Value of reflectance confocal
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			during treatment with topical ivermectin.

			32186510 Oral migration of Dirofilaria repens
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			32183205 Ivermectin Inhibits Bovine
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			32181912 Implications of Endectocide
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			32176703 The safety of combined triple
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			32173745 Structural Uncertainty in
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			32164367 Single versus Multiple Dose
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			32135219 The broad spectrum antiviral
			ivermectin targets the host nuclear transport
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			21321478 Ivermectin, 'wonder drug' from
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			Clinical Trials
			4332068 Ivermectin Safety in Small Children

			4311671 Safety of a Single Dose of Moxidectin
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			4275999 Rosacea and Ivermectin

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			475 FTM Inflatable Penile Implant in the
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			4049851 Clinical Trial Evaluating the Safety and
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			4041453 Albendazole Plus High Dose
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			3967054 Repeat Ivermectin Mass Drug
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			3876262 Safety and Efficacy of Annual or
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			3852303 Ivermectin Treatment of Persons With
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			3717558 Bioavailability Pilot Study of Versus
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			3690453 Effect of Ivermectin Metabolites on
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			3676140 Safety of Co-administration of IDA
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			3664063 PK PD Study of IDA and Azithromycin
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			3653975 Clinical Features and Potential
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			3605758 Treatment of Strongyloides Infection

			3598842 Tuberculosis - Learning the Impact of

			3578679 Treatment of Pediculosis (Head Lice)
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			3576313 Mass Drug Administration of
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			3570814 Cluster RCT of Co-administration
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			3553615 Open-label Pilot Clinical Trial of Oral
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			3527732 Efficacy and Safety of IVM/ALB

			3517462 Ocular Changes After Ivermectin -
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			3459794 Ivermectin and Human Immunity

			3432442 Pharmacokinetics and
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			3352206 Prevalence Studies After Triple
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			3337490 A Clinical Endpoint Bioequivalence
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			Ivermectin 0.5% Lotion in the Treatment of
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			3301649 Clinical Endpoint Study of Ivermectin
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			3286101 Efficacy and Safety of Topical 0.5%
			Ivermectin Lotion for the Treatment of Head
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			3257943 A Bioequivalence Study, Comparing
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			3238131 IVM Alone vs ALB + IVM Against

			3236168 Impact of Community Scabies
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			3177993 Fiji Integrated Therapy (FIT) - Triple
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			3173742 Bioavailability and Safety of Two Oral
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			(REVECTINA®, Abbott Laboratórios do Brasil
			Ltda, Brazil)

			3131401 Prevalence of LF Infection in Districts
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			3075891 Oracea Soolantra Association in
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			3074435 Insecticide Resistance Management in
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			3052998 Ivermectin Treatment in Patients With
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			3036059 Twice Yearly Treatment for the
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			3014167 Field Studies on the Feasibility of
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			2974049 Lymphatic Filariasis (LF) in Ivory Coast

			2963324 Physiologically-based
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			2961894 Revolution™ Peripheral Atherectomy
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			2899936 Death to Onchocerciasis and
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			2845713 Pharmacokinetics &
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			2841215 Efficacy Study Between Two Different
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			2840461 Clinical Endpoint Study of Ivermectin
			1% Cream

			2806414 Evaluation of the Inhibitory Effects of
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			2795117 Comparative Safety and Efficacy of
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			2784743 Impact of Albendazole -Ivermectin on
			Wuchereria Bancrofti in Mali

			2775617 Azithromycin - Ivermectin Mass Drug
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			2616250 MirvasO Soolantra Association In the
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			2568098 Pharmacokinetic and Mosquito-Lethal
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			2511353 Efficacy and Safety of High-dose
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			2509481 Repeat Ivermectin Mass Drug
			Administrations for Control of Malaria: a Pilot
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			2407782 Oral Ivermectin Versus Topical
			Permethrin to Treat Scabies in Children

			2366884 Clinical Evaluation of a New Form of
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			2236403 Treatment of Demodex Blepharitis
			With Ivermectin Gel 0.1% Plus Metronidazole

			2078024 Efficacy of Ivermectin and
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			2046200 Development of Ivermectin for
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			2045069 Efficacy and Safety of Ivermectin
			Against Dengue Infection

			2036229 Topical 0.5% Ivermectin Cream for
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			2032043 Optimization of Mass Drug
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			Ivory Coast (DOLF-Ivory Coast)

			1975441 Eval 3-Drug Therapy
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			That Could Accelerate LF Elimination Outside of

			1905436 Mass Drug Administration for
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			1903057 Safety Study of Combined
			Azithromycin, Ivermectin and Albendazole for
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			1780792 Examining the Effects of Video-game
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			1730313 Treatment of Nodding Syndrome -
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			1603251 Trial of Artemether-Lumefantrine Alone
			and in Combination With Ivermectin to Reduce
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			1593722 Post-treatment Effects of Ivermectin
			(IVM) or Diethylcarbamazine (DEC) in Loiasis

			1586169 Safety of the Co-administration of
			Three Drugs for Trachoma and
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			1570504 Multiple Versus Single Dose of
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			1493947 CD5024 1% [Ivermectin 1%] Cream
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			1308268 Management of Soil-transmitted
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			1287663 Effectiveness of Permethrin
			Impregnated Underwear in Preventing Louse
			Proliferation in Infected Homeless

			1213576 Efficacy of Higher Albendazole and
			Ivermectin Doses on Wuchereria Bancrofti
			Microfilarial Clearance in Malawi

			1080989 The Sero-Prevalence and Genetic
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			Metabolic Syndrome in Solomon Islands

			1068158 A Study Comparing the Safety and
			Efficacy of 0.5% Ivermectin Cream to Placebo
			in Lice Infested Subjects

			1066585 A Safety and Efficacy Study
			Comparing 0.5% Ivermectin Cream to a Vehicle
			Control in Subjects With Head Lice Infestation

			1050517 Safety and Efficacy of
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			1050452 Safety and Efficacy of
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			994422 Study Comparing the Safety and
			Efficacy of 0.5% Ivermectin Cream to Placebo
			in Lice Infested Subjects

			988533 A Pharmacokinetics (PK) Study in Lice
			Infested Children 6 Months to 3 Years of Age

			921674 Ivermectin Solution Bioequivalence
			Study - With Food

			921219 Ivermectin Solution Bioequivalence
			Study - With Food (Repeat)

			921154 Ivermectin Solution Bioequivalence
			Study - Fasted

			857948 Dose Ranging Study of Ivermectin
			Treatment Conditioner in Subjects With Head
			Lice Infestation

			819520 Ivermectin in the Treatment of Head

			817713 Can Presumptive Anthelminthic
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			790998 Study Comparing Moxidectin And
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			Volvulus Infection

			765024 Ivermectin Versus Albendazole for
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			604084 Veron Scabies Education and
			Eradication Program

			342576 Host Response to Infection and
			Treatment in Lymphatic Filarial Disease in India

			340691 Doxycycline to Treat Mansonella
			Perstans Infection in Patients With and Without
			Lymphatic Filariasis

			339417 Effect of Albendazole Dose on
			Clearance of Filarial Worms

			300768 Study Evaluating Orally Administered
			Moxidectin In Subjects With Onchocerca
			Volvulus Infection

			262418 Comparison of the Efficacy and Safety
			of Ivermectin to Permethrin

			215280 Epidemiology and Control of
			Mansonella Perstans Infection in Uganda

			207753 Effectiveness of Combined
			Albendazole and Ivermectin Treatment for
			Intestinal Worm Infections

			1245 Study of Patients With Strongyloides
			Stercoralis Infection

			1230 Host Response to Infection and
			Treatment in Filarial Diseases

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