Source:		MedGen UID: 61674

     		Coronavirus infection

			An interactive web-based dashboard to track COVID-19 in real time.
https://nlm.life/JHUdb ⇗ https://arcg.is/0fHmTX ⇗ Definition Virus diseases caused by the Coronavirus genus.
The novel coronavirus causes the illness COVID-19, a viral respiratory tract infection. Viral pathogenesis and course of illness vary. Most infections are mild and may cause symptoms such as cough, congestion, fever or chills. Mild weakness, fatigue and joint pain (arthralgia) may also occur. Life threatening respiratory distress as in Severe Acute Respiratory Syndrome (SARS) is rare for individuals under 65 years of age with no other conditions. Patients with pre-existing conditions, significant comorbidity or respiratory problems are at increased risk of serious adverse events. Reports from Italy indicate that patients currently being treated for hypertension may be at greater risk of mortality, raising concern that prescription of Angiotensin-converting enzyme inhibitor is a significant risk factor. Efforts to reduce disease transmission emphasize avoiding non-essential interaction with others. Contaminated surfaces are known mediators of contact transmission. Droplet transmission may occur if the viral vector is directly inhaled. Cell entry of coronaviruses depends on binding of the viral PROS1 spike proteins to the ACE2 cellular receptor, and processing by the TMPRSS2 serine protease or CTSB/CTSL cysteine proteases. The SARS Coronavirus Protease Pathway can be blocked with the serine protease inhibitor Camostat and the endosomal cysteine protease inhibitor Aloxistatin, see ncbi.life/SARSCOV2DPZ The National Institute of Allergy and Infectious Diseases (NIAID) is currently conducting clinical trials to identify effective therapeutic treatments and protective vaccines.
Notice of Special Interest (NOSI) regarding the Availability of Urgent Competitive Revisions for Research on the 2019 Novel Coronavirus (2019-nCoV) https://grants.nih.gov/grants/guide/notice-files/NOT-AI-20-030.html Related Concepts Acute respiratory distress syndrome Aloxistatin Ampligen (Rintatolimod) Antiserum product APN01 Camostat Camrelizumab Chloroquine (Resochin) Danoprevir Favipiravir Kaletra (Lopinavir and ritonavir product) Oseltamivir product Pirfenidone (Esbriet) Rapivab (Peramivir) Remdesivir (GS-5734) Ritonavir product Soliris (Eculizumab) Tocilizumab Amprenavir product Asunaprevir Atazanavir Atazanavir response Atazanavir sulfate Boceprevir Boceprevir response Brincidofovir Cidofovir Anhydrous Cidofovir product Crixivan Cyclopropavir Darunavir ethanolate Darunavir product Feline Infectious Peritonitides Fosamprenavir Fosamprenavir calcium Grazoprevir Indinavir Anhydrous Indinavir product Indinavir sulfate Interferon beta JNJ-53718678 Letermovir Lopinavir and ritonavir product Lopinavir product Maribavir Middle East respiratory syndrome Nelfinavir Nelfinavir mesylate Nitazoxanide Norvir Oseltamivir carboxylate Oseltamivir phosphate Paritaprevir Peginterferon alfa-2a response Peginterferon alfa-2b response Presatovir (GS-5806) Ribavarin Ribavirin response Resochin SARS Coronavirus Protease Pathway Saquinavir mesylate Saquinavir product Severe acute respiratory syndrome Simeprevir Simeprevir response Sofosbuvir Sofosbuvir response Susceptibility to coronavirus 229e Taribavirin Taribavirin Hydrochloride Telaprevir Telaprevir response Tipranavir Tipranavir Disodium Viracept Viral Breakthrough Viral Disease Viral Fusion Protein Inhibitors Viral Load Viral Lower Respiratory Infection Viral Pathogenesis Viral Pneumonia Viral Respiratory Tract Infection Viral Upper Respiratory Tract Infection Viral Vaccine Viral Vector Viremia Zanamivir product GenBank MN994467 Wuhan seafood market pneumonia virus isolate 2019-nCoV/USA-CA1/2020, complete genome MN988668 Wuhan seafood market pneumonia virus isolate 2019-nCoV WHU01, complete genome MN985325 Wuhan seafood market pneumonia virus isolate 2019-nCoV/USA-WA1/2020, complete genome MN938384 Wuhan seafood market pneumonia virus isolate 2019-nCoV_HKU-SZ-002a_2020, complete genome MN908947 Wuhan seafood market pneumonia virus isolate 2019-nCoV Wuhan-Hu-1, complete genome BioProject PRJEB36487 2019_nCoV data generated by BGI PRJNA603194 Wuhan seafood market pneumonia virus PRJNA601736 Wuhan seafood market pneumonia virus PRJNA601630 Wuhan seafood market pneumonia virus PRJNA350589 HCoV-229E infection of the human HuH7 cell line [Experiment B] PRJNA350588 Time-course of HCoV-229E infection of A549 cells PRJNA350587 HCoV-229E infection in A549 cells: gene regulation in cells adjacent and distant to infected cells PRJNA350586 HCoV-229E infection of the human HuH7 cell line [Experiment A] PRJNA118845 Dynamic Innate Immune Responses of Human Bronchial Epithelial Cells against SARS-CoV and DOHV infection 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coronavirus pneumonia. 32063887 Comprehensive Genomic Characterization Analysis of lncRNAs in Cells With Porcine Delta Coronavirus Infection. 32062875 [Retracted: Clinical and epidemiological characteristics of 34 children with 2019 novel coronavirus infection in Shenzhen]. 32061200 [Analysis of CT features of 15 Children with 2019 novel coronavirus infection]. 32057210 [The prevention and control of a new coronavirus infection in department of stomatology]. 32052466 Potential Interventions for Novel Coronavirus in China: A Systematic Review. 32050635 Potential Maternal and Infant Outcomes from (Wuhan) Coronavirus 2019-nCoV Infecting Pregnant Women: Lessons from SARS, MERS, and Other Human Coronavirus Infections. 32047128 Distinct Roles for Sialoside and Protein Receptors in Coronavirus Infection. 32043842 [2019-novel coronavirus infection in a three-month-old baby]. 32036011 Coronavirus infections reported by ProMED, February 2000-January 2020. 32035428 [Suggestions for disinfection of ophthalmic examination equipment and protection of ophthalmologist against 2019 novel coronavirus infection]. 32034659 Diagnosis, treatment, and prevention of 2019 novel coronavirus infection in children: experts' consensus statement. 32025807 miRNA repertoire and host immune factor regulation upon avian coronavirus infection in eggs. 32023680 [Suggestions for prevention of 2019 novel coronavirus infection in otolaryngology head and neck surgery medical staff]. 32023679 [First case of 2019 novel coronavirus infection in children in Shanghai]. 32023678 [Facing the pandemic of 2019 novel coronavirus infections: the pediatric perspectives]. 32013309 Mast cells contribute to coronavirus-induced inflammation: new anti-inflammatory strategy. 32009759 Isolation and characterization of avian coronavirus from healthy Eclectus parrots (Eclectus roratus) from Indonesia. 32004427 First Case of 2019 Novel Coronavirus in the United States. 31999307 The Novel Coronavirus Originating in Wuhan, China: Challenges for Global Health Governance. 31987001 Genomic characterization of the 2019 novel human-pathogenic coronavirus isolated from a patient with atypical pneumonia after visiting Wuhan. 31781765 A review of asymptomatic and sub-clinical Middle East Respiratory Syndrome Coronavirus Infections. 31769524 Typical epidemiology of respiratory virus infections in a Brazilian slum. 31694960 Murine coronavirus infection activates AhR in an IDO1-independent manner contributing to cytokine modulation and pro-viral TiPARP expression. 31694947 Three Amino Acid Changes In Avian Coronavirus Spike Protein Allows Binding To Kidney Tissue. 31692019 Gold nanoparticle-adjuvanted S protein induces a strong antigen-specific IgG response against severe acute respiratory syndrome-related coronavirus infection, but fails to induce protective antibodies and limit eosinophilic infiltration in lungs. 31578288 Small molecule antiviral β-D-N 4-hydroxycytidine inhibits a proofreading-intact coronavirus with a high genetic barrier to resistance. 31234434 Susceptibility of Chickens to Porcine Deltacoronavirus Infection. 31223425 Improved Wound Healing of Airway Epithelial Cells Is Mediated by Cold Atmospheric Plasma: A Time Course-Related Proteome Analysis. 31139937 Epidemiology of respiratory viruses in Saudi Arabia: toward a complete picture. 31125806 Nucleoside analogues for the treatment of coronavirus infections. 31113572 Clinical presentation, diagnostic findings, and outcome of adult horses with equine coronavirus infection at a veterinary teaching hospital: 33 cases (2012-2018). 31094626 Effect of cat litters on feline coronavirus infection of cell culture and cats. 31082732 The ER stress sensor IRE1 and MAP kinase ERK modulate autophagy induction in cells infected with coronavirus infectious bronchitis virus. 31048107 Differential recognition of peptides within feline coronavirus polyprotein 1 ab by sera from healthy cats and cats with feline infectious peritonitis. 30984127 Recent Aspects on the Pathogenesis Mechanism, Animal Models and Novel Therapeutic Interventions for Middle East Respiratory Syndrome Coronavirus Infections. 30971240 Analysis of long non-coding RNAs in neonatal piglets at different stages of porcine deltacoronavirus infection. 30964454 Epidemiological study of Middle East respiratory syndrome coronavirus infection in dromedary camels in Saudi Arabia, April-May 2015. 30918074 High-throughput Screening and Identification of Potent Broad-spectrum Inhibitors of Coronaviruses. 30914508 Antagonism of dsRNA-Induced Innate Immune Pathways by NS4a and NS4b Accessory Proteins during MERS Coronavirus Infection. 30882305 Middle East Respiratory Syndrome Coronavirus Infection Dynamics and Antibody Responses among Clinically Diverse Patients, Saudi Arabia. 30866764 Middle East respiratory syndrome coronavirus infection in non-camelid domestic mammals. 30849247 Broad-spectrum coronavirus antiviral drug discovery. 30775355 Absence of neutralizing activity in serum 1 year after successful treatment with antivirals and recovery from MERS in South Korea. 30658691 Antiviral activity of itraconazole against type I feline coronavirus infection. 30654597 Characterization of the Lipidomic Profile of Human Coronavirus-Infected Cells: Implications for Lipid Metabolism Remodeling upon Coronavirus Replication. 30626688 TMPRSS2 contributes to virus spread and immunopathology in the airways of murine models after coronavirus infection. 30550651 SARS, MERS and coronavirus infections. 28659436 Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses. 25720466 Coronaviruses: an overview of their replication and pathogenesis. 21994708 Coronavirus genomics and bioinformatics analysis. 21325420 Evidence that TMPRSS2 activates the severe acute respiratory syndrome coronavirus spike protein for membrane fusion and reduces viral control by the humoral immune response. 16912115 Severe acute respiratory syndrome coronavirus nsp1 protein suppresses host gene expression by promoting host mRNA degradation. 17534355 Lack of support for an association between CLEC4M homozygosity and protection against SARS coronavirus infection. 17534354 Lack of support for an association between CLEC4M homozygosity and protection against SARS coronavirus infection. 16369534 Homozygous L-SIGN (CLEC4M) plays a protective role in SARS coronavirus infection. 15809906 Detection of airborne severe acute respiratory syndrome (SARS) coronavirus and environmental contamination in SARS outbreak units. 15638943 Dynamic changes of serum SARS-coronavirus IgG, pulmonary function and radiography in patients recovering from SARS after hospital discharge. 12746549 Coronavirus main proteinase (3CLpro) structure: basis for design of anti-SARS drugs. 12690092 A novel coronavirus associated with severe acute respiratory syndrome. Clinical Trials 4283461 Safety and Immunogenicity Study of 2019-nCov Vaccine (mRNA-1273) to Treat Novel Coronavirus (Recruiting) 4280705 Adaptive COVID-19 Treatment Trial (Recruiting) 3615911 Safety, Tolerability and Immunogenicity of Vaccine Candidate MVA-MERS-S (Completed) 3233516 Trial of Respiratory Infections in Children for Enhanced Diagnostics (Recruiting) 3277170 Pragmatic RCT of High-dose Oral Montelukast for Moderate and Severe Pediatric Acute Asthma Exacerbations (Not yet recruiting) 2670187 Phase I, Open Label Dose Ranging Safety Study of GLS-5300 in Healthy Volunteers (Completed) 2644135 A Pilot Study of the Safety, Tolerability, and Effectiveness of Halo (Completed) 2627378 Saudi Outcomes of ECMO-treated MERS-CoV Patients (Completed) 2203110 The Impact of Simultaneous Presence of Viral and Bacterial Pathogens on Therapy and Course of Severe Pneumonia (Unknown status) 2190799 Anti-MERS-CoV Convalescent Plasma Therapy (Withdrawn) 2003651 Echinacea and Acute Respiratory Illness (Completed) 1979705 Detect Novel Pathogens and Characterize Emerging Infections (Recruiting) 1546935 Oseltamivir for Influenza Lower Respiratory Tract Infection in Children Under One (Withdrawn) 1486160 Respiratory Viral Infection in Nursing Home Slovenia (Completed) 1056354 Respiratory Virus Outpatient Study (FLU 002 Plus) (Completed) 1056185 Respiratory Virus Hospitalization Study (FLU 003 Plus) (Recruiting) 533741 SARS Coronavirus Vaccine (SARS-CoV) (Withdrawn) 523276 SARS Survivor Evaluations (Withdrawn) 494624 Efficacy of Systemic Glucocorticoid in the Treatment of Wheezing in Children (Unknown status) 342524 Collection of Convalescent SARS Plasma by Apheresis (Completed) 215826 Study of Alferon® LDO (Low Dose Oral) in Normal Volunteers (Completed) 202239 [Occurrence of rota- and coronavirus as a cause of neonatal calf diarrhea in the Federal Republic of Germany]. 173576 Clinical Study of SARS in Children (Completed) 173563 Induction of Cytokines in Human Monocytes by SARS-CoV in Adults and Children (Unknown status) 172263 The Interaction Between Severe Acute Respiratory Distress Syndrome Viral Proteins and Monocytes (Withdrawn) 99463 Phase I Study of a Vaccine for Severe Acute Respiratory Syndrome (SARS) (Completed) 66209 Investigating Severe Acute Respiratory Syndrome (SARS) (Completed) Embed Tweet Print