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			MedGen

  Source:		MedGen UID: 904053


     		GS-5734

			Related Concepts
			Remdesivir
			Middle East respiratory syndrome
			inflammatory response
			stress

			PubMed
			32258351 Current knowledge about the antivirals
			remdesivir (GS-5734) and GS-441524 as
			therapeutic options for coronaviruses.

			31233808 Broad spectrum antiviral remdesivir
			inhibits human endemic and zoonotic
			deltacoronaviruses with a highly divergent RNA
			dependent RNA polymerase.

			31142680 Remdesivir (GS-5734) protects
			African green monkeys from Nipah virus
			challenge.

			30987343 Mechanism of Inhibition of Ebola
			Virus RNA-Dependent RNA Polymerase by
			Remdesivir.

			29511076 Coronavirus Susceptibility to the
			Antiviral Remdesivir (GS-5734) Is Mediated by
			the Viral Polymerase and the Proofreading
			Exoribonuclease.

			29425244 Initiation, extension, and termination
			of RNA synthesis by a paramyxovirus
			polymerase.

			28659436 Broad-spectrum antiviral GS-5734
			inhibits both epidemic and zoonotic
			coronaviruses.

			Clinical Trials
			2818582 GS-5734 to Assess the Antiviral
			Activity, Longer-Term Clearance of Ebola Virus,
			and Safety in Male Ebola Survivors With
			Evidence of Ebola Virus Persistence in Semen

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