Download: https://www.ncbi.nlm.nih.gov/projects/genome/assembly/grc/index.shtml⇩ The Human Genome Project, currently maintained
by the Genome Reference Consortium (GRC)
Genome Reference Consortium (Owner) [website]
International Human Genome Sequencing Consortium
(IHGSC) (Participant) [website]The human reference assembly defines a standard
upon which other whole genome studies are
based. Providing the best representation of the
human genome is essential for facilitating
continued progress in understanding and
improving human health. The Human Genome
Project (HGP) was an international research
collaboration coordinated by the U.S. Department
of Energy (DOE) and National Institutes
of Health (NIH) whose goals were to determine
the sequence of the human chromosomes and
identify and map all human genes. The project
began in 1988 when Congress funded both
the NIH and the DOE and was completed in
April of 2003. The HGP used a clone-oriented
approach to produce map data, clone reagents,
and the assembled human genome sequence.
The International Human Genome Sequencing
Consortium published the first draft of
the human genome, with the sequence 90%
complete, in the journal Nature in February
2001. The full sequence was completed in
April 2003. The HGP resulted in significant
technology, tool, and resource development
that continues to have a significant impact
on medicine and other life sciences. The
Genome Reference Consortium (GRC) was formed
in 2008 to maintain the reference assembly
for the human genome. The goals of this
group are to correct regions that are
misrepresented, to close remaining gaps,
and to produce alternative assemblies of
structurally variant loci. The consortium
does experimental work to address gaps or
sub-optimal sequence regions and has developed
the infrastructure to review and curate
assembly joins. The GRC consists of: The
Wellcome Trust Sanger Institute, The Genome
Center at Washington University, The European
Bioinformatics Institute and The National
Center for Biotechnology Information. The
public can see regions under review and
report genome problems at the GRC website,
The human genome assembly submitted by the GRC
is available in GenBank under accession
ranges GL000001-GL000258 (the scaffolds),
and CM000663-CM000686 (the chromosomes).
11237011 Initial sequencing and analysis of the
15496913 Finishing the euchromatic sequence
of the human genome.
15372022 The DNA sequence and
comparative analysis of human chromosome 5.
12853948 The DNA sequence of human
12508121 The DNA sequence and analysis of
human chromosome 14.
11780052 The DNA sequence and
comparative analysis of human chromosome
10830953 The DNA sequence of human
10591208 The DNA sequence of human
12815422 The male-specific region of the
human Y chromosome is a mosaic of discrete
15164054 The DNA sequence and
comparative analysis of human chromosome
15164053 DNA sequence and analysis of
human chromosome 9.
15057823 The DNA sequence and analysis of
human chromosome 13.
14574404 The DNA sequence and analysis of
human chromosome 6.
15057824 The DNA sequence and biology of
human chromosome 19.
15616553 The sequence and analysis of
duplication-rich human chromosome 16.
16554811 Human chromosome 11 DNA
sequence and analysis including novel gene
16541075 The finished DNA sequence of
human chromosome 12.
16177791 DNA sequence and analysis of
human chromosome 18.
15815621 Generation and annotation of the
DNA sequences of human chromosomes 2 and
15772651 The DNA sequence of the human X
16710414 The DNA sequence and biological
annotation of human chromosome 1.
16641997 The DNA sequence, annotation and
analysis of human chromosome 3.
16421571 DNA sequence and analysis of
human chromosome 8.
16572171 Analysis of the DNA sequence and
duplication history of human chromosome 15.
16625196 DNA sequence of human
chromosome 17 and analysis of rearrangement
in the human lineage.
18477386 Finishing the finished human
chromosome 22 sequence.
11687796 The AZFc region of the Y
chromosome features massive palindromes
and uniform recurrent deletions in infertile men.
15653831 Interchromosomal segmental
duplications of the pericentromeric region on
the human Y chromosome.
17573966 Detailed analysis of 15q11-q14
sequence corrects errors and gaps in the public
access sequence to fully reveal large segmental
duplications at breakpoints for Prader-Willi,
Angelman, and inv dup(15) syndromes.
18193213 Variation analysis and gene
annotation of eight MHC haplotypes: the MHC
18760392 Adaptive evolution of UGT2B17
19165922 Evolutionary toggling of the MAPT
17q21.31 inversion region.
19490611 Closing gaps in the human genome
using sequencing by synthesis.
20534489 High-resolution human genome
structure by single-molecule analysis.
21206914 Different patterns of evolution in the
centromeric and telomeric regions of group A
and B haplotypes of the human killer cell Ig-like
22482802 Resolving the breakpoints of the
17q21.31 microdeletion syndrome with
23042453 DNA template strand sequencing of
single-cells maps genomic rearrangements at
23435088 Using population admixture to help
complete maps of the human genome.
23541343 Complete haplotype sequence of
the human immunoglobulin heavy-chain
variable, diversity, and joining genes and
characterization of allelic and copy-number
23872635 Independent specialization of the
human and mouse X chromosomes for the
male germ line.
23932108 Mapping the human reference
genome's missing sequence by three-way
admixture in Latino genomes.
25326701 Palindromic GOLGA8 core duplicons
promote chromosome 15q13.3 microdeletion
and evolutionary instability.
14618296 Cytochrome P450 2D6: overview
and update on pharmacology, genetics,
20183526 Genetic polymorphism in
cytochrome P450 2D6 (CYP2D6): Population
distribution of CYP2D6 activity.
12355084 Facioscapulohumeral muscular
dystrophy is uniquely associated with one of the
two variants of the 4q subtelomere.
17924332 Specific sequence variations within
the 4q35 region are associated with
facioscapulohumeral muscular dystrophy.
20206332 Worldwide population analysis of the
4q and 10q subtelomeres identifies only four
discrete interchromosomal sequence transfers
in human evolution.
20724583 A unifying genetic model for
facioscapulohumeral muscular dystrophy.
7219534 Sequence and organization of the
human mitochondrial genome.
10508508 Reanalysis and revision of the
Cambridge reference sequence for human
18674749 Extensive copy-number variation of
the human olfactory receptor gene family.
20729854 A large and complex structural
polymorphism at 16p12.1 underlies
microdeletion disease risk.
12173 Post-proline cleaving enzyme.
Purification of this endopeptidase by affinity
72068 Carbohydrate moiety of HLA antigens.
Antigenic properties and amino acid sequences
around the site of glycosylation.
116880 Effect of delta 9-tetrahydrocannabinol
(THC) on female reproductive function.
146197 Chemical evidence that proteolytic
cleavage causes the heterogeneity present in
human ceruloplasmin preparations.
195962 Effects of altered thyroid function on
galactosyl diacylglycerol metabolism in
myelinating rat brain.
221492 Sequence of two phosphorylated sites
in the catalytic subunit of bovine cardiac muscle
278975 Specific phosphorylation at serine-283
of alpha tropomyosin from frog skeletal and
rabbit skeletal and cardiac muscle.
325004 Limited pepsin digestion of human
407930 Primary structure of human J chain:
alignment of peptides from chemical and
479158 Carbohydrate of the human
plasminogen variants. III. Structure of the
O-glycosidically linked oligosaccharide unit.
518865 Complete amino acid sequence of a
papain-solubilized human histocompatibility
antigen, HLA-B7. 2. Sequence determination
and search for homologies.
600212 [Viscosimetry in clinical practice].
602896 Cystitis emphysematosa.
838735 Complete covalent structure of
statherin, a tyrosine-rich acidic peptide which
inhibits calcium phosphate precipitation from
human parotid saliva.
890569 Human pituitary thyrotropin. The
primary structure of the alpha and beta
1056466 Antibiotic treatment of oral anaerobic
1088347 [Study of the heterogenetic antigens
in vaccinal preparations of V. cholerae].
1127890 Symptoms of stress in four societies.
1181841 Proceedings: Aneurysmal bone cysts
of the spine.
1309762 Mechanism of desensitization of the
epidermal growth factor receptor
1311327 Proteolytic inactivation of alpha
1-proteinase inhibitor and alpha
1-antichymotrypsin by oxidatively activated
human neutrophil metalloproteinases.
1314426 Calcium-regulated phosphorylation
within the leucine zipper of C/EBP beta.
1319925 Heterogeneous expression of four
MAP kinase isoforms in human tissues.
1321150 Identification of the cAMP-dependent
protein kinase and protein kinase C
phosphorylation sites within the major
intracellular domains of the beta 1, gamma 2S,
and gamma 2L subunits of the
gamma-aminobutyric acid type A receptor.
1322130 The two forms of bovine heart
result from alternative splicing.
1322891 Specific phosphorylation of a
COOH-terminal site on the full-length form of
the alpha 1 subunit of the skeletal muscle
calcium channel by cAMP-dependent protein
1330687 p42 MAP kinase phosphorylation
sites in microtubule-associated protein tau are
dephosphorylated by protein phosphatase 2A1.
Implications for Alzheimer's disease [corrected].
1332886 Identification of MAPKAP kinase 2 as
a major enzyme responsible for the
phosphorylation of the small mammalian heat
1334087 Unique autolytic cleavage of human
myeloperoxidase. Implications for the
involvement of active site MET409.
1334482 Function of the alpha 1 beta 2
gamma 2S gamma-aminobutyric acid type A
receptor is modulated by protein kinase C via
multiple phosphorylation sites.
1335366 FGF inactivates myogenic
helix-loop-helix proteins through
phosphorylation of a conserved protein kinase
C site in their DNA-binding domains.
1347949 ERK1 and ERK2, two
microtubule-associated protein 2 kinases,
mediate the phosphorylation of tyrosine
hydroxylase at serine-31 in situ.
1350383 Heteromeric NMDA receptors:
molecular and functional distinction of
1370477 Patterns of prohormone processing.
Order revealed by a new
1373652 Sequential dephosphorylation of a
multiply phosphorylated insulin receptor peptide
by protein tyrosine phosphatases.
1374067 PKC epsilon-related kinase
associates with and phosphorylates cytokeratin
8 and 18.
1375933 Nitric oxide synthase regulatory sites.
Phosphorylation by cyclic AMP-dependent
protein kinase, protein kinase C, and
calcium/calmodulin protein kinase; identification
of flavin and calmodulin binding sites.
1377674 Phosphorylation of the cystic fibrosis
transmembrane conductance regulator.
1378617 Identification of Tyr-185 as the site of
tyrosine autophosphorylation of recombinant
mitogen-activated protein kinase p42mapk.
1380064 Cytokine RANTES released by
thrombin-stimulated platelets is a potent
attractant for human eosinophils.
1381905 Post-translational processing of
membrane-associated recombinant human
stem cell factor expressed in Chinese hamster
1382070 Identification of the two major
epidermal growth factor-induced tyrosine
phosphorylation sites in the microvillar core
1387511 Generation of the
neutrophil-activating peptide-2 by cathepsin G
and cathepsin G-treated human platelets.
1400319 Post-translational modifications of
1400350 Casein kinase II phosphorylates
p34cdc2 kinase in G1 phase of the HeLa cell
1402651 Myristyl acylation of the tumor
necrosis factor alpha precursor on specific
the localization of rab4 during the cell cycle.
1425701 Specific phosphorylation of the acidic
central region of the N-myc protein by casein
1426245 Prothymosin alpha is phosphorylated
by casein kinase-2.
1451807 Natural human tumor necrosis factor
beta (lymphotoxin). Variable O-glycosylation at
Thr7, proteolytic processing, and allelic
1454855 Characterization of the tumor
suppressor protein p53 as a protein kinase C
substrate and a S100b-binding protein.
1476071 [Topical timolol and blood-aqueous
barrier permeability to protein in human eyes].
1498334 Role of individual
gamma-carboxyglutamic acid residues of
activated human protein C in defining its in vitro
1505778 The site of nonenzymic glycation of
human extracellular-superoxide dismutase in
1512232 Localization of O-GlcNAc modification
on the serum response transcription factor.
1516134 Casein kinase II is a negative
regulator of c-Jun DNA binding and AP-1
1518044 Sequences of 20 subunits of
NADH:ubiquinone oxidoreductase from bovine
heart mitochondria. Application of a novel
strategy for sequencing proteins using the
polymerase chain reaction.
1525182 Site-specific glycation of lens
crystallins by ascorbic acid.
1527025 Identification of the
autophosphorylation sites in rhodopsin kinase.
1530946 A strategy for isolation of cDNAs
encoding proteins affecting human intestinal
epithelial cell growth and differentiation:
characterization of a novel gut-specific
1533159 Recombinant human complement
subcomponent C1s lacking
beta-hydroxyasparagine, sialic acid, and one of
its two carbohydrate chains still reassembles
with C1q and C1r to form a functional C1
1533624 GAP-43, a protein associated with
axon growth, is phosphorylated at three sites in
cultured neurons and rat brain.
1545828 Alteration of a cyclic AMP-dependent
protein kinase phosphorylation site in the c-Fos
protein augments its transforming potential.
1551416 Effective activation of the proenzyme
form of the urokinase-type plasminogen
activator (pro-uPA) by the cysteine protease
1553557 An amino acid mutation in a
potassium channel that prevents inhibition by
protein kinase C.
1556125 Cell-associated episialin is a complex
containing two proteins derived from a
1556128 Structure of heparin-binding EGF-like
growth factor. Multiple forms, primary structure,
and glycosylation of the mature protein.
1558967 The effect of leukocyte elastase on
tissue factor pathway inhibitor.
1587862 Sequencing, cloning, and expression
of human red cell-type acid phosphatase, a
cytoplasmic phosphotyrosyl protein
1597471 Proprotein conversion is determined
by a multiplicity of factors including convertase
processing, substrate specificity, and
intracellular environment. Cell type-specific
processing of human prorenin by the
1601129 Phosphorylation sequences in
h-caldesmon from phorbol ester-stimulated
1610348 Phosphorylation of interleukin-6 at
serine54: an early event in the secretory
pathway in human fibroblasts.
1618861 Identification of palmitoylation sites on
CD4, the human immunodeficiency virus
1627603 Human red cell acid phosphatase
(ACP1): the primary structure of the two pairs
of isozymes encoded by the ACP1*A and
1629222 Activation of human furin precursor
processing endoprotease occurs by an
intramolecular autoproteolytic cleavage.
1647028 Phosphorylation of protein 4.1 on
tyrosine-418 modulates its function in vitro.
1648089 In vitro phosphorylation of the
adipocyte lipid-binding protein (p15) by the
insulin receptor. Effects of fatty acid on
receptor kinase and substrate phosphorylation.
1654338 Connective tissue growth factor: a
cysteine-rich mitogen secreted by human
vascular endothelial cells is related to the
SRC-induced immediate early gene product
1677563 A synthetic peptide substrate for
initiation factor-2 kinases.
1689310 Tyrosine residues in bovine
phospholipase C-gamma phosphorylated by
the epidermal growth factor receptor in vitro.
1692828 Structural characterization of natural
and recombinant human granulocyte
1694784 Location and characterization of the
three carbohydrate prosthetic groups of human
1706595 Endogenous cleavage of the
Arg-379-Ala-380 bond in vitronectin results in a
distinct conformational change which 'buries'
Ser-378, its site of phosphorylation by protein
1706616 Identification of autophosphorylation
sites of HER2/neu.
1712480 Microtubule-associated protein 2
kinases, ERK1 and ERK2, undergo
autophosphorylation on both tyrosine and
threonine residues: implications for their
mechanism of activation.
1713455 Novel serine phosphorylation occurs
in the fibroblast form of pp60c-src from Y79
1722201 CSK: a protein-tyrosine kinase
involved in regulation of src family kinases.
1730617 Vertebrate lens alpha-crystallins are
modified by O-linked N-acetylglucosamine.
1730718 Functional and structural analysis of
VLA-4 integrin alpha 4 subunit cleavage.
1733926 The predominant form of secreted
colony stimulating factor-1 is a proteoglycan.
1740119 Casein kinase II phosphorylation
increases the rate of serum response
factor-binding site exchange.
1740409 The cytoplasmic domain of tissue
factor is phosphorylated by a protein kinase
1748630 A phosphorylation site located in the
NH2-terminal domain of c-Myc increases
transactivation of gene expression.
1756735 The retinoblastoma protein is
phosphorylated on multiple sites by human
1778989 Identification of full-sized forms of
salivary (S-type) cystatins (cystatin SN, cystatin
SA, cystatin S, and two phosphorylated forms
of cystatin S) in human whole saliva and
determination of phosphorylation sites of
1820200 Site-specific N-glycosylation of
human chorionic gonadotrophin--structural
analysis of glycopeptides by one- and
two-dimensional 1H NMR spectroscopy.
1824699 Glycophospholipid membrane anchor
attachment. Molecular analysis of the
1825608 Protein-induced inactivation and
phosphorylation of rabbit muscle
1827443 Protein kinase C phosphorylates the
carboxyl terminus of the plasma membrane
Ca(2+)-ATPase from human erythrocytes.
1828073 Phosphorylation of neuromodulin
(GAP-43) by casein kinase II. Identification of
phosphorylation sites and regulation by
1833648 Myc rescue of a mutant CSF-1
receptor impaired in mitogenic signalling.
1845981 Phosphorylation of the 48-kDa
subunit of the glycine receptor by protein kinase
phosphorylation of the beta 2-adrenergic
receptor decreases its coupling to Gs.
1850098 The epidermal growth factor receptor
phosphorylates GTPase-activating protein
(GAP) at Tyr-460, adjacent to the GAP SH2
1851158 Nucleoside diphosphate kinase from
human erythrocytes. Structural characterization
of the two polypeptide chains responsible for
heterogeneity of the hexameric enzyme.
1861080 Proteolysis of C3 on U937 cell
plasma membranes. Purification of cathepsin
1900431 Tissue plasminogen activator has an
O-linked fucose attached to threonine-61 in the
epidermal growth factor domain.
1900515 Cathepsin B efficiently activates the
soluble and the tumor cell receptor-bound form
of the proenzyme urokinase-type plasminogen
1919001 IL-1-converting enzyme requires
aspartic acid residues for processing of the IL-1
beta precursor at two distinct sites and does
not cleave 31-kDa IL-1 alpha.
1924301 Endocytosis by the asialoglycoprotein
receptor is independent of cytoplasmic serine
1939057 Phosphorylation by cdc2 kinase
modulates DNA binding activity of high mobility
group I nonhistone chromatin protein.
1939080 Thyroglobulin processing by thyroidal
proteases. Major sites of cleavage by
cathepsins B, D, and L.
1939094 Phosphorylation of the beta subunit of
casein kinase II in human A431 cells.
Identification of the autophosphorylation site
and a site phosphorylated by p34cdc2.
1939112 Human red cell acid phosphatase
(ACP1). The amino acid sequence of the two
isozymes Bf and Bs encoded by the ACP1*B
1956339 Protein kinase phosphorylation site
sequences and consensus specificity motifs:
1959628 Proteolytic activity and cleavage
specificity of cathepsin E at the physiological
pH as examined towards the B chain of
1973163 Phosphorylation of tyrosine
hydroxylase in situ at serine 8, 19, 31, and 40.
1985196 Structural elements that regulate
pp59c-fyn catalytic activity, transforming
potential, and ability to associate with
polyomavirus middle-T antigen.
1985906 Multisite phosphorylation of a
synthetic peptide derived from the carboxyl
terminus of the ribosomal protein S6.
1985907 Phosphorylation of cardiac and
skeletal muscle calsequestrin isoforms by
casein kinase II. Demonstration of a cluster of
unique rapidly phosphorylated sites in cardiac
1991173 Molecular characterization of
erythrocyte glycophorin C variants.
1993068 Mapping of carbohydrate sites on the
human insulin receptor.
1993171 Disulfide assignments in recombinant
mouse and human interleukin 4.
1995645 Phosphorylation and subcellular
distribution of calpastatin in human
hematopoietic system cells.
1998697 Phosphorylation sites in human
erythrocyte band 3 protein.
2005884 Biosynthesis of human fibroblast
2006911 The principal site of glycation of
human complement factor B.
2013294 Primary structure of a new
actin-binding protein from human seminal
2013314 Inactivation of human cystatin C and
kininogen by human cathepsin D.
2019585 Identification of phosphorylated sites
in the mouse glucocorticoid receptor.
2033065 Glycosylation of human protein C
affects its secretion, processing, functional
activities, and activation by thrombin.
2040274 Nuclear transition protein 1 from ram
elongating spermatids. Mass spectrometric
characterization, primary structure and
phosphorylation sites of two variants.
2040602 Inactivation of DNA polymerase beta
by in vitro phosphorylation with protein kinase
2040636 Cooperative activation of human
factor IX by the human extrinsic pathway of
2046671 Mutation of serum response factor
phosphorylation sites and the mechanism by
which its DNA-binding activity is increased by
casein kinase II.
2061332 Identification of renal cathepsin B as a
human prorenin-processing enzyme.
2065054 Structures of the
assembled on recombinant human
plasminogen expressed in a Mamestra
brassicae cell line (IZD-MBO503).
2065070 Three regions of erythrocyte band 3
protein are phosphorylated on tyrosines:
characterization of the phosphorylation sites by
solid phase sequencing combined with capillary
2109157 Closely related glycosylation patterns
of recombinant human IL-2 expressed in a
CHO cell line and natural IL-2.
2112085 Proteolytic processing of the 600 kd
low density lipoprotein receptor-related protein
(LRP) occurs in a trans-Golgi compartment.
2114109 Ca2(+)-calmodulin-dependent protein
kinase II phosphorylates various types of
non-epithelial intermediate filament proteins.
2116318 Two phosphorylation sites on eIF-2
2117608 Phosphate groups as substrate
determinants for casein kinase I action.
2123345 Posttranslationally processed
structure of the human platelet protein smg
p21B: evidence for geranylgeranylation and
carboxyl methylation of the C-terminal cysteine.
2129526 Primary structure of human placental
5'-nucleotidase and identification of the
glycolipid anchor in the mature form.
2136742 The amino terminus of muscle
tropomyosin is a major determinant for
2140056 Identification of the protein kinase C
phosphorylation site in neuromodulin.
2153964 G-protein alpha-subunit expression,
myristoylation, and membrane association in
2155236 Phosphorylation sites linked to glial
filament disassembly in vitro locate in a
non-alpha-helical head domain.
2160950 Phosphorylation of smooth myosin
light chain kinase by smooth muscle
2168396 Substrate- and kinase-directed
regulation of phosphorylation of a
cGMP-binding phosphodiesterase by cGMP.
2168407 Identification of membrane anchoring
site of human renal dipeptidase and
construction and expression of a cDNA for its
2176601 Amino acid sequence of in vivo
phosphorylation sites in the main intrinsic
protein (MIP) of lens membranes.
2183353 Differential phosphorylation of c-Abl in
cell cycle determined by cdc2 kinase and
2186807 Substrate specificity of recombinant
human renal renin: effect of histidine in the P2
subsite on pH dependence.
2203348 The purification and characterization
of recombinant human renin expressed in the
human kidney cell line 293.
2209608 Primary structure of the bovine
analogues to human apolipoproteins CII and
CIII. Studies on isoforms and evidence for
2211721 Differential expression and distinct
structure of 69- and 100-kDa forms of 2-5A
synthetase in human cells treated with
2212658 Rapid nonlysosomal degradation of
assembled HLA class II glycoproteins
incorporating a mutant DR alpha-chain.
2217184 Identification and preliminary
characterization of protein-cysteine
2243102 The polylactosaminoglycans of
human lysosomal membrane glycoproteins
lamp-1 and lamp-2. Localization on the peptide
2249995 Site-directed mutagenesis of the m2
muscarinic acetylcholine receptor. Analysis of
the role of N-glycosylation in receptor
expression and function.
2269661 cDNA cloning reveals the molecular
structure of a sperm surface protein, PH-20,
involved in sperm-egg adhesion and the wide
distribution of its gene among mammals.
2275556 Comparison of cathepsin L
synthesized by normal and transformed cells at
the gene, message, protein, and
2318846 Kinetic determination of the effects of
ADP-ribosylation on the interaction of
eukaryotic elongation factor 2 with ribosomes.
2318847 Interaction of heparin cofactor II with
neutrophil elastase and cathepsin G.
2335219 Fatty acid acylation of lens fiber
plasma membrane proteins. MP26 and
alpha-crystallin are palmitoylated.
2344612 Mutations of phosphorylation sites in
lamin A that prevent nuclear lamina
disassembly in mitosis.
2361960 Structure of recombinant human
interleukin 5 produced by Chinese hamster
2365696 Purification and characterization of
catalytic fragments of phosphorylase kinase
gamma subunit missing a calmodulin-binding
2369897 Regulation of HMG-CoA reductase:
identification of the site phosphorylated by the
AMP-activated protein kinase in vitro and in
intact rat liver.
2394722 Cloning and sequencing of a human
pancreatic tumor mucin cDNA.
2394752 Protein kinase A phosphorylates
retinal phosducin on serine 73 in situ.
2406364 Generation of the
neutrophil-activating peptide NAP-2 from
platelet basic protein or connective
tissue-activating peptide III through monocyte
2413024 Studies on the phosphorylation of
myelin basic protein by protein kinase C and
2423119 Characterization of human platelet
basic protein, a precursor form of low-affinity
platelet factor 4 and beta-thromboglobulin.
2434496 Sulfation of a tyrosine residue in the
plasmin-binding domain of alpha 2-antiplasmin.
2434500 Tyrosine kinase catalyzed
phosphorylation and inactivation of the inhibitor
protein of the cAMP-dependent protein kinase.
2437112 The reactive site of human alpha
2440681 Amino-acid sequence of human alpha
2449425 Phosphorylation sites of bovine brain
myelin basic protein phosphorylated with
Ca2+-calmodulin-dependent protein kinase
from rat brain.
2456953 A discontinuous epitope on p36, the
major substrate of src tyrosine-protein-kinase,
brings the phosphorylation site into the
neighbourhood of a consensus sequence for
2457390 Location of sites in human lipocortin I
that are phosphorylated by protein tyrosine
kinases and protein kinases A and C.
2478889 Ionomycin-regulated phosphorylation
of the myeloid calcium-binding protein p14.
2493268 N-terminal sequence extension in the
glycosylated forms of human pancreatic stone
protein. The 5-oxoproline N-terminal chain is
O-glycosylated on the 5th amino acid residue.
2496749 The single-chain form of tissue-type
plasminogen activator has catalytic activity:
studies with a mutant enzyme that lacks the
2498325 Glycosylation of human apolipoprotein
E. The carbohydrate attachment site is
2500966 Domain- and sequence-specific
phosphorylation of vimentin induces
disassembly of the filament structure.
2504723 Platelet glycoprotein Ib beta is
phosphorylated on serine 166 by cyclic
AMP-dependent protein kinase.
2507633 The invariant chain is a
phosphorylated subunit of class II molecules.
2511201 Identification of a disaccharide
(Xyl-Glc) and a trisaccharide (Xyl2-Glc)
O-glycosidically linked to a serine residue in the
first epidermal growth factor-like domain of
human factors VII and IX and protein Z and
bovine protein Z.
2513186 Carbohydrate structure of
recombinant human uterine tissue plasminogen
activator expressed in mouse epithelial cells.
2531377 Endopeptidase-24.11 in human
plasma degrades atrial natriuretic factor (ANF)
2540197 Palmitoylation of the human beta
2-adrenergic receptor. Mutation of Cys341 in
the carboxyl tail leads to an uncoupled
nonpalmitoylated form of the receptor.
2543683 Mechanism of phosphorylation of the
epidermal growth factor receptor at threonine
2546149 Human placenta
protein-tyrosine-phosphatase: amino acid
sequence and relationship to a family of
2548572 Primary structure of the
cAMP-dependent phosphorylation site of the
plasma membrane calcium pump.
2557337 Phosphorylation of DARPP-32, a
dopamine- and cAMP-regulated
phosphoprotein, by casein kinase II.
2584229 Structure of human lysosomal
membrane glycoprotein 1. Assignment of
disulfide bonds and visualization of its domain
2584239 Identification of sites phosphorylated
in bovine cardiac troponin I and troponin T by
protein kinase C and comparative substrate
activity of synthetic peptides containing the
2663470 Myc oncoproteins are phosphorylated
by casein kinase II.
2722853 Phosphorylation modulates the
activity of glycine N-methyltransferase, a folate
binding protein. In vitro phosphorylation is
inhibited by the natural folate ligand.
2736261 Degradation of human gastrin and
CCK by endopeptidase 24.11: differential
behaviour of the sulphated and unsulphated
2753907 Molecular cloning and sequencing of
the cDNA for human membrane-bound
carboxypeptidase M. Comparison with
carboxypeptidases A, B, H, and N.
2762314 Molecular cloning and expression of
cDNA encoding a lumenal calcium binding
glycoprotein from sarcoplasmic reticulum.
2806554 Identification of sites on chromosomal
protein HMG-I phosphorylated by casein kinase
2808373 Normal rat kidney cells secrete both
phosphorylated and nonphosphorylated forms
of osteopontin showing different physiological
2842767 Ca2+/calmodulin-dependent protein
kinase II: identification of threonine-286 as the
autophosphorylation site in the alpha subunit
associated with the generation of
2844809 cAMP-dependent protein kinase
rapidly phosphorylates serine- 687 of the
skeletal muscle receptor for calcium channel
2867902 Transglutaminase-sensitive glutamine
residues of human plasma fibronectin revealed
by studying its proteolytic fragments.
2874131 Clathrin-coated vesicles contain two
protein kinase activities. Phosphorylation of
clathrin beta-light chain by casein kinase II.
2880847 Lecithin:cholesterol acyltransferase.
Functional regions and a structural model of the
2900138 Identification by amino acid
sequencing of three major regulatory
phosphorylation sites on rat acetyl-CoA
2900140 Analysis of sites phosphorylated on
acetyl-CoA carboxylase in response to insulin in
isolated adipocytes. Comparison with sites
phosphorylated by casein kinase-2 and the
calmodulin-dependent multiprotein kinase.
2941417 Identification of lymphocyte integral
membrane proteins as substrates for protein
kinase C. Phosphorylation of the interleukin-2
receptor, class I HLA antigens, and T200
2946940 The protein-tyrosine kinase substrate
p36 is also a substrate for protein kinase C in
vitro and in vivo.
2962191 Structure and formation of
2972276 Hydrolysis of alpha-human atrial
natriuretic peptide in vitro by human kidney
membranes and purified endopeptidase-24.11.
Evidence for a novel cleavage site.
2984676 Tumor-promoting phorbol diesters
cause the phosphorylation of epidermal growth
factor receptors in normal human fibroblasts at
2987962 Platelet-derived growth factor mimics
phorbol diester action on epidermal growth
factor receptor phosphorylation at
2991859 The structure and evolution of a 461
amino acid human protein C precursor and its
messenger RNA, based upon the DNA
sequence of cloned human liver cDNAs.
2991887 The nucleotide sequence of the gene
for human protein C.
2996780 Protein kinase C phosphorylates
pp60src at a novel site.
3026468 A new acylphosphatase isoenzyme
from human erythrocytes: purification,
characterization, and primary structure.
3053705 An islet amyloid peptide is derived
from an 89-amino acid precursor by proteolytic
3066525 Characterization of N-linked
oligosaccharides attached to human renin
expressed in COS cells.
3103680 Functional role of proteolytic cleavage
at arginine-275 of human tissue plasminogen
activator as assessed by site-directed
3112145 Phosphorylation site of eukaryotic
initiation factor 4E.
3118371 Amino acid sequences surrounding
the cAMP-dependent and
sites in rat and bovine synapsin I.
3123586 Molecular cloning of a human apoC-III
variant: Thr 74----Ala 74 mutation prevents
3126184 The precursor of interleukin-1 alpha is
phosphorylated at residue serine 90.
3126346 Relationships between structure and
function of tissue-type plasminogen activator.
3128543 Identification of the phosphorylation
sites of clathrin light chain LCb.
3166978 Human tissue factor contains
thioester-linked palmitate and stearate on the
3198605 Cloning of cDNAs encoding human
lysosomal membrane glycoproteins, h-lamp-1
and h-lamp-2. Comparison of their deduced
amino acid sequences.
3212432 [Root resorption. The maintenance for
many years of an incisor almost devoid of root].
3288503 Role of N-linked oligosaccharides
attached to human renin expressed in COS
3335520 Botulinum C2 toxin ADP-ribosylates
cytoplasmic beta/gamma-actin in arginine 177.
3350146 Two adjacent cysteine residues in the
C-terminal cytoplasmic fragment of bovine
rhodopsin are palmitylated.
3417668 Ca2+/calmodulin-dependent protein
kinase II. Identification of a regulatory
autophosphorylation site adjacent to the
inhibitory and calmodulin-binding domains.
3458201 Amino acid sequence of human
plasma alpha 1B-glycoprotein: homology to the
immunoglobulin supergene family.
3480538 Cloning, sequence analysis, and
expression of the large subunit of the human
lymphocyte activation antigen 4F2.
3493529 Human CSF-1: molecular cloning and
expression of 4-kb cDNA encoding the human
3521732 Human plasma prekallikrein, a
zymogen to a serine protease that contains
four tandem repeats.
3525527 Human preproapolipoprotein C-II.
Analysis of major plasma isoforms.
3542989 Complete amino acid sequence of
human serum cholinesterase.
3542996 Characterization of pure human renal
renin. Evidence for a subunit structure.
3667593 Structure of the carbohydrate moiety
of human interferon-beta secreted by a
recombinant Chinese hamster ovary cell line.
3680284 Glycation and inactivation of human
Cu-Zn-superoxide dismutase. Identification of
the in vitro glycated sites.
3756141 Human C1 inhibitor: primary
structure, cDNA cloning, and chromosomal
3759968 Sequence analysis of
phospholamban. Identification of
phosphorylation sites and two major structural
3759977 Nonenzymatic glycosylation of
albumin in vivo. Identification of multiple
3782093 Identification of two sites of sulfation
of human heparin cofactor II.
3866610 Ia-associated invariant chain is fatty
acylated before addition of sialic acid.
3917576 Amino terminal myristylation of the
protein kinase p60src, a retroviral transforming
3927292 Cloning and sequence analysis of
cDNA for human cathepsin D.
3944102 Distribution of
gamma-carboxyglutamic acid residues in
partially carboxylated human prothrombins.
3944109 Identification of the site of sulfation of
the fourth component of human complement.
3944116 Amino acid sequence of protein B23
4055725 The primary structure of human tissue
amyloid P component from a patient with
primary idiopathic amyloidosis.
4092695 Phosphorylation and activation of
hamster carbamyl phosphate synthetase II by
cAMP-dependent protein kinase. A novel
mechanism for regulation of pyrimidine
4226004 The peptide chains of human plasmin.
Mechanism of activation of human plasminogen
4369265 The amino acid sequences of the
phosphorylated sites in troponin-I from rabbit
4711474 Structure of 1 -acid glycoprotein. The
complete amino acid sequence, multiple amino
acid substitutions, and homology with the
4924231 Specific enzymic methylation of an
arginine in the experimental allergic
encephalomyelitis protein from human myelin.
5554303 Human fetal hemoglobin F 1.
6150037 Phosphorylation of tyrosine
hydroxylase by calmodulin-dependent
6172423 The complete amino acid sequence
of the rabbit P2 protein.
6196363 Phosphorylation of human
choriogonadotropin. Stoichiometry and sites of
6262777 Complete amino acid sequence of
the catalytic subunit of bovine cardiac muscle
cyclic AMP-dependent protein kinase.
6287816 Phosphorylation of cAMP-dependent
protein kinase subunits.
6293815 Phosphorylation of the type-II
regulatory subunit of cyclic-AMP-dependent
protein kinase by glycogen synthase kinase 3
and glycogen synthase kinase 5.
6304688 HLA-A2 and HLA-B7 antigens are
phosphorylated in vitro by rous sarcoma virus
kinase (pp60v-src) at a tyrosine residue
encoded in a highly conserved exon of the
6324166 cDNA clone for the human invariant
gamma chain of class II histocompatibility
antigens and its implications for the protein
6330071 Amino acid sequence of the
phosphorylation site of rat liver
6333425 HLA-A2 antigen phosphorylation in
vitro by cyclic AMP-dependent protein kinase.
Sites of phosphorylation and segmentation in
class i major histocompatibility complex gene
6351842 Action of human liver cathepsin B on
the oxidized insulin B chain.
6371807 Structure of human hemopexin:
O-glycosyl and N-glycosyl sites and unusual
clustering of tryptophan residues.
6427007 Acetyl-blocked N-terminal structures
of sorbitol and aldehyde dehydrogenases.
6427223 Natural human interferon-gamma.
Complete amino acid sequence and
determination of sites of glycosylation.
6430898 Human and murine class I MHC
antigens share conserved serine 335, the site
of HLA phosphorylation in vivo.
6433976 Tissue plasminogen activator: peptide
analyses confirm an indirectly derived amino
acid sequence, identify the active site serine
residue, establish glycosylation sites, and
localize variant differences.
6438100 The enzyme that cleaves
apolipoprotein A-II upon in vitro incubation of
human plasma high-density lipoprotein-3 with
blood polymorphonuclear cells is an elastase.
6510521 Amino acid sequence of the
N-terminal region of human hemopexin.
6572368 Structural and biological
characteristics of connective tissue activating
peptide (CTAP-III), a major human
platelet-derived growth factor.
6572939 beta-Hydroxyaspartic acid in vitamin
K-dependent protein C.
6582496 Single-chain structure of human
ceruloplasmin: the complete amino acid
sequence of the whole molecule.
6719396 The location of a second in vivo
phosphorylation site in the A alpha-chain of
6725286 A vascular smooth muscle
alpha-isoactin biosynthetic intermediate in
BC3H1 cells. Identification of acetylcysteine at
the NH2 terminus.
6772446 Glycogen synthase from rabbit
skeletal muscle. Amino acid sequence at the
sites phosphorylated by glycogen synthase
kinase-3, and extension of the N-terminal
sequence containing the site phosphorylated by
6812963 Alpha chain of HLA-DR
transplantation antigens is a member of the
same protein superfamily as the
6838832 Amino acid sequence analysis of the
asparagine-288 region of the carbohydrate
variants of human plasminogen.
6864486 Kinetics of the rapid modification of
human serum albumin with
trinitrobenzenesulfonate and localization of its
7238875 The site in human antithrombin for
functional proteolytic cleavage by human
7340337 Action of rat liver cathepsin L on
7358733 Sites of nonenzymatic glycosylation of
human hemoglobin A.
7477119 Brief report: impaired processing of
prohormones associated with abnormalities of
glucose homeostasis and adrenal function.
7477354 Phosphorylation of Raf by
ceramide-activated protein kinase.
7479834 Mxi2, a mitogen-activated protein
kinase that recognizes and phosphorylates Max
7479855 Point mutation of the
autophosphorylation site or in the nuclear
location signal causes protein kinase A RII beta
regulatory subunit to lose its ability to revert
7479976 Signal-induced degradation of I kappa
B alpha requires site-specific ubiquitination.
7492318 Evaluation of the extent of the binding
site in human tissue kallikrein by synthetic
substrates with sequences of human kininogen
7493986 Primary structure of a gamma subunit
of G protein, gamma 12, and its
phosphorylation by protein kinase C.
7493990 Structural and functional
consequences of mutations in
6-pyruvoyltetrahydropterin synthase causing
hyperphenylalaninemia in humans.
Phosphorylation is a requirement for in vivo
7499230 Characterization of the mitotic
specific phosphorylation site of histone H1.
Absence of a consensus sequence for the
p34cdc2/cyclin B kinase.
7499244 Differential sensitivity of interleukin-1
alpha and -beta precursor proteins to cleavage
by calpain, a calcium-dependent protease.
7499337 Cell cycle phase-specific
phosphorylation of human topoisomerase II
alpha. Evidence of a role for protein kinase C.
7505568 Identification of the glycosylated
sequons of human myelin-associated
7507481 Membrane topology of aquaporin
CHIP. Analysis of functional epitope-scanning
mutants by vectorial proteolysis.
7509446 Autophosphorylation of the focal
adhesion kinase, pp125FAK, directs
SH2-dependent binding of pp60src.
7509796 Tyrosine residue 719 of the c-kit
receptor is essential for binding of the P85
subunit of phosphatidylinositol (PI) 3-kinase and
for c-kit-associated PI 3-kinase activity in
7512951 Identification of covalently bound
amino-terminal myristic acid in endothelial nitric
7512963 Insulin stimulates the phosphorylation
of Tyr538 and the catalytic activity of PTP1C, a
protein tyrosine phosphatase with Src
7513258 A multifunctional docking site
mediates signaling and transformation by the
hepatocyte growth factor/scatter factor
7514605 Biogenesis and transmembrane
topology of the CHIP28 water channel at the
7515063 Regulation of c-Fgr protein kinase by
c-Src kinase (CSK) and by polycationic
7516330 Internalization of fibroblast growth
factor receptor is inhibited by a point mutation
at tyrosine 766.
7518772 Phosphorylation of receptor
protein-tyrosine phosphatase alpha on Tyr789,
a binding site for the SH3-SH2-SH3 adaptor
protein GRB-2 in vivo.
7522165 Interleukin-7 induces the association
of phosphatidylinositol 3-kinase with the alpha
chain of the interleukin-7 receptor.
7522656 Adhesive properties of osteopontin:
regulation by a naturally occurring
thrombin-cleavage in close proximity to the
GRGDS cell-binding domain.
7523122 A unique autophosphorylation site in
the platelet-derived growth factor alpha
receptor from a heterodimeric receptor
7523391 Matrix metalloproteinases degrade
insulin-like growth factor-binding protein-3 in
dermal fibroblast cultures.
7523394 Hydrolytic inactivation of a breast
carcinoma cell-derived serpin by human
7523419 Identification of the major physiologic
phosphorylation site of human keratin 18:
potential kinases and a role in filament
7524678 Expression of rat alpha-fetoprotein
cDNA and its mutants in cultured mouse
fibroblasts and identification of glycosylation
sites related to electrophoretic variants.
7525550 Identification of tyrosine 620 as the
major phosphorylation site of myelin-associated
glycoprotein and its implication in interacting
with signaling molecules.
7525582 Phosphorylation of the desmoplakin
COOH terminus negatively regulates its
interaction with keratin intermediate filament
7525583 Regulation of p68 RNA helicase by
calmodulin and protein kinase C.
7527558 Amino-terminal basic residues of Src
mediate membrane binding through
electrostatic interaction with acidic
7529874 Tyrosine phosphorylation of BCR by
FPS/FES protein-tyrosine kinases induces
association of BCR with GRB-2/SOS.
7529876 Tyrosine phosphorylation of focal
adhesion kinase at sites in the catalytic domain
regulates kinase activity: a role for Src family
7532004 Purification and structure-function
analysis of native, PNGase F-treated, and
7535770 Pro-inflammatory cytokines and
environmental stress cause p38
mitogen-activated protein kinase activation by
dual phosphorylation on tyrosine and threonine.
7535778 Demonstration of functionally different
interactions between phospholipase C-gamma
and the two types of platelet-derived growth
7538124 Identification and mutational analysis
of the glycosylation sites of human keratin 18.
7538844 Biochemical analysis of prostate
specific antigen-proteolyzed insulin-like growth
factor binding protein-3.
7539106 Phosphorylation of the human
estrogen receptor on tyrosine 537 in vivo and
by src family tyrosine kinases in vitro.
7539415 Secretory leucocyte protease inhibitor
in the male genital tract: PSA-induced
proteolytic processing in human semen and
7539802 Identification of the major
phosphorylation sites for protein kinase C in
kit/stem cell factor receptor in vitro and in intact
7543024 Maximal activation of transcription by
Stat1 and Stat3 requires both tyrosine and
7544284 Site-specific and complete enzymic
deglycosylation of the native human chorionic
7545675 Identification of a putative Syp
substrate, the PDGF beta receptor.
7547927 Binding of prenylated and polybasic
peptides to membranes: affinities and
7556643 A novel tau-tubulin kinase from bovine
7559455 Phosphorylation of Gz alpha by
protein kinase C blocks interaction with the
beta gamma complex.
7559469 Role of N-linked glycosylation in
human osteonectin. Effect of carbohydrate
removal by N-glycanase and site-directed
mutagenesis on structure and binding of type V
7566346 Hyperphosphorylation of tau in PHF.
7575560 Development of a rapid approach to
identification of tyrosine phosphorylation sites:
application to PKC delta phosphorylated upon
activation of the high affinity receptor for IgE in
rat basophilic leukemia cells.
7578066 Preferred sites of
glycosylphosphatidylinositol modification in
folate receptors and constraints in the primary
structure of the hydrophobic portion of the
7578077 Isolation and structural
characterization of different isoforms of the
hypusine-containing protein eIF-5A from HeLa
7578274 The protein kinase from mitotic
human cells that phosphorylates Ser-209 on
the casein kinase II beta-subunit is p34cdc2.
7592613 Structural analysis of the
oligosaccharides derived from glycodelin, a
human glycoprotein with potent
immunosuppressive and contraceptive
7592773 Phosphorylation of casein kinase II by
p34cdc2. Identification of phosphorylation sites
using phosphorylation site mutants in vitro.
7592818 Calpain cleavage of the cytoplasmic
domain of the integrin beta 3 subunit.
7592967 Repetitive Ser-Gly sequences
enhance heparan sulfate assembly in
7592979 Constitutive activation of
mitogen-activated protein kinase-activated
protein kinase 2 by mutation of phosphorylation
sites and an A-helix motif.
7595479 Modulation of a recombinant glycine
transporter (GLYT1b) by activation of protein
7598724 Phorbol ester stimulates rapid
intracellular phosphorylation of glia maturation
7599134 Partial glycosylation of antithrombin III
asparagine-135 is caused by the serine in the
third position of its N-glycosylation consensus
sequence and is responsible for production of
the beta-antithrombin III isoform with enhanced
7613477 Site-specific detection and structural
characterization of the glycosylation of human
plasma proteins lecithin:cholesterol
acyltransferase and apolipoprotein D using
HPLC/electrospray mass spectrometry and
sequential glycosidase digestion.
7613486 Glycosylation sites encoded by exon
2 of the human insulin receptor gene are not
required for the oligomerization, ligand binding,
or kinase activity of the insulin receptor.
7615564 Reactivation of phosphorylated actin
depolymerizing factor and identification of the
7615569 Phosphorylation and activation of
Ca(2+)-calmodulin-dependent protein kinase IV
by Ca(2+)-calmodulin-dependent protein kinase
Ia kinase. Phosphorylation of threonine 196 is
essential for activation.
7625839 Carbonic anhydrase IV: role of
removal of C-terminal domain in
glycosylphosphatidylinositol anchoring and
realization of enzyme activity.
7635160 Human topoisomerase II alpha is
phosphorylated in a cell-cycle
phase-dependent manner by a proline-directed
7641687 Human calcium-calmodulin
dependent protein kinase I: cDNA cloning,
domain structure and activation by
phosphorylation at threonine-177 by
calcium-calmodulin dependent protein kinase I
7642555 c-Myc is glycosylated at threonine 58,
a known phosphorylation site and a mutational
hot spot in lymphomas.
7642584 Identification of the major
phosphorylation sites in human C5a
anaphylatoxin receptor in vivo.
7642585 Truncated forms of the human prion
protein in normal brain and in prion diseases.
7646439 Mechanisms of platelet activation by
a stimulatory antibody: cross-linking of a novel
platelet receptor for monoclonal antibody F11
with the Fc gamma RII receptor.
7657660 Phosphorylation and activation of the
DNA binding activity of purified Stat1 by the
Janus protein-tyrosine kinases and the
epidermal growth factor receptor.
7657720 Role of glycosylation in the expression
of human procathepsin D.
7664271 Association of the DF3/MUC1 breast
cancer antigen with Grb2 and the Sos/Ras
7665596 Isolation of cDNA clones encoding
eight different human G protein gamma
subunits, including three novel forms
designated the gamma 4, gamma 10, and
gamma 11 subunits.
7673335 Ubiquitin-activating enzyme, E1, is
phosphorylated in mammalian cells by the
protein kinase Cdc2.
7675451 Mutation at tyrosine residue 1337
abrogates ligand-dependent transforming
capacity of the FLT4 receptor.
7678037 Insulin regulates serine/threonine
phosphorylation in activated human B
7678248 Identification of the sites of
phosphorylation in insulin-like growth factor
binding protein-1. Regulation of its affinity by
phosphorylation of serine 101.
7678701 Phosphorylation of Src mutants at Tyr
527 in fibroblasts does not correlate with in
vitro phosphorylation by CSK.
7682059 In vitro tyrosine phosphorylation of
PLC-gamma 1 and PLC-gamma 2 by
src-family protein tyrosine kinases.
7683678 Isolation and primary structure of
NGAL, a novel protein associated with human
7687743 Molecular cloning, expression, and
characterization of the human
mitogen-activated protein kinase p44erk1.
7688466 The 64-kDa protein that associates
with the platelet-derived growth factor receptor
beta subunit via Tyr-1009 is the SH2-containing
phosphotyrosine phosphatase Syp.
7690989 A single phosphotyrosine residue of
Stat91 required for gene activation by
7691597 Receptor protein tyrosine
phosphatase alpha activates pp60c-src and is
involved in neuronal differentiation.
7691811 Activation of the SH2-containing
phosphotyrosine phosphatase SH-PTP2 by its
binding site, phosphotyrosine 1009, on the
human platelet-derived growth factor receptor.
7691977 Fatty acid-binding protein from rat
heart is phosphorylated on Tyr19 in response to
7694569 Matrix metalloproteinases cleave at
two distinct sites on human cartilage link
protein/microtubule affinity-regulating kinase
(p110mark). A novel protein kinase that
regulates tau-microtubule interactions and
dynamic instability by phosphorylation at the
Alzheimer-specific site serine 262.
7708691 Mutation of juxtamembrane tyrosine
residue 1001 suppresses loss-of-function
mutations of the met receptor in epithelial cells.
7713879 CAAX geranylgeranyl transferase
transfers farnesyl as efficiently as
geranylgeranyl to RhoB.
7721861 Expression, refolding, and
autocatalytic proteolytic processing of the
interleukin-1 beta-converting enzyme precursor.
7721869 The role of N-glycosylation in the
targeting and activity of the GLYT1 glycine
7724583 Phosphorylation of ubiquitin-activating
enzyme in cultured cells.
7727388 The disulfide linkages and
glycosylation sites of the human natriuretic
peptide receptor-C homodimer.
7731718 The motogenic and mitogenic
responses to HGF are amplified by the Shc
7731720 B-Raf protein isoforms interact with
and phosphorylate Mek-1 on serine residues
218 and 222.
7737129 ATF-2 contains a
7743995 Regulation of the human WEE1Hu
CDK tyrosine 15-kinase during the cell cycle.
7750576 Activation of the MAP kinase
homologue RK requires the phosphorylation of
Thr-180 and Tyr-182 and both residues are
phosphorylated in chemically stressed KB cells.
7759517 Components of a new human protein
kinase signal transduction pathway.
7775468 Structural basis for species-specific
differences in the phosphorylation of
Na,K-ATPase by protein kinase C.
7777512 Phosphorylation of the human
leukemia inhibitory factor (LIF) receptor by
mitogen-activated protein kinase and the
regulation of LIF receptor function by
heterologous receptor activation.
7782287 Mutagenesis studies of the
phosphorylation sites of recombinant human
pyruvate dehydrogenase. Site-specific
7790363 The human E48 antigen, highly
homologous to the murine Ly-6 antigen ThB, is
a GPI-anchored molecule apparently involved in
keratinocyte cell-cell adhesion.
7797510 Identification and characterization of
ICH-2, a novel member of the interleukin-1
beta-converting enzyme family of cysteine
7799959 Modulation of cellular
thermoresistance and actin filament stability
changes in the oligomeric structure of heat
shock protein 27.
7806540 A mutant insulin receptor induces
formation of a Shc-growth factor receptor
bound protein 2 (Grb2) complex and
p21ras-GTP without detectable interaction of
insulin receptor substrate 1 (IRS1) with Grb2.
Evidence for IRS1-independent p21ras-GTP
7814421 Hepsin, a putative
membrane-associated serine protease,
activates human factor VII and initiates a
pathway of blood coagulation on the cell
surface leading to thrombin formation.
7816602 Phosphorylation of the c-Fos and
c-Jun HOB1 motif stimulates its activation
7822264 Identification of phosphorylation sites
on glial fibrillary acidic protein for cdc2 kinase
and Ca(2+)-calmodulin-dependent protein
7827091 In vivo glycation of aldehyde
reductase, a major 3-deoxyglucosone reducing
enzyme: identification of glycation sites.
7836371 Phosphorylation of the N-formyl
peptide receptor carboxyl terminus by the G
protein-coupled receptor kinase, GRK2.
7836436 Contribution of aromatic moieties of
tyrosine 133 and of the anionic subsite
tryptophan 86 to catalytic efficiency and
allosteric modulation of acetylcholinesterase.
7836437 Characterization of a mitochondrial
metallopeptidase reveals neurolysin as a
homologue of thimet oligopeptidase.
hyperphosphorylation of specific
phosphorylated sites in the mouse
7876250 Post-translational processing of
membrane-associated neu differentiation factor
proisoforms expressed in mammalian cells.
7876254 Characterization of Rad, a new
member of Ras/GTPase superfamily, and its
regulation by a unique GTPase-activating
protein (GAP)-like activity.
7889566 Specific recruitment of SH-PTP1 to
the erythropoietin receptor causes inactivation
of JAK2 and termination of proliferative signals.
7890696 14-3-3 alpha and delta are the
phosphorylated forms of raf-activating 14-3-3
beta and zeta. In vivo stoichiometric
phosphorylation in brain at a Ser-Pro-Glu-Lys
7890742 Primary structure of CD52.
7890750 Protein kinase C delta-specific
phosphorylation of the elongation factor
eEF-alpha and an eEF-1 alpha peptide at
7890771 Limited and defined truncation at the
C terminus enhances receptor binding and
degranulation activity of the
neutrophil-activating peptide 2 (NAP-2).
Comparison of native and recombinant NAP-2
7896811 Matrix metalloproteinase 7 (matrilysin)
from human rectal carcinoma cells. Activation
of the precursor, interaction with other matrix
metalloproteinases and enzymic properties.
7901013 Phosphorylation and activation of
human tyrosine hydroxylase in vitro by
mitogen-activated protein (MAP) kinase and
MAP-kinase-activated kinases 1 and 2.
7907095 Isolation and characterization of a
novel acetyl-CoA carboxylase kinase from rat
7909431 Phosphorylation by protein kinase C
and cyclic AMP-dependent protein kinase of
synthetic peptides derived from the linker region
of human P-glycoprotein.
7915280 Critical phosphorylation sites for
acetyl-CoA carboxylase activity.
7925280 Prolactin induces phosphorylation of
Tyr694 of Stat5 (MGF), a prerequisite for DNA
binding and induction of transcription.
7925482 Functional analysis of phosphorylation
sites in human lamin A controlling lamin
disassembly, nuclear transport and assembly.
7926007 Identification of serines-1035/1037 in
the kinase domain of the insulin receptor as
protein kinase C alpha mediated
7929343 Phorbol ester stimulates
phosphorylation on serine 1327 of the human
7929371 Identification of Ser38 as the site in
cardiac sarcoplasmic reticulum Ca(2+)-ATPase
that is phosphorylated by
Ca2+/calmodulin-dependent protein kinase.
7931292 Protein kinase FA/glycogen synthase
kinase-3 alpha after heparin potentiation
phosphorylates tau on sites abnormally
phosphorylated in Alzheimer's disease brain.
7935360 Preparation and functional
characterization of a catalytically active
fragment of phosphorylase kinase.
7935386 Role of SH-PTP2, a protein-tyrosine
phosphatase with Src homology 2 domains, in
insulin-stimulated Ras activation.
7935391 Tyr-716 in the platelet-derived growth
factor beta-receptor kinase insert is involved in
GRB2 binding and Ras activation.
7944411 Identification, assay, and purification
of a Cdc2-activating threonine-161 protein
kinase from human cells.
7961692 Requirement for negative charge on
"activation loop" of protein kinase C.
7961702 Palmitoylation of G protein-coupled
receptor kinase, GRK6. Lipid modification
diversity in the GRK family.
7961936 Identification by electrospray
ionization mass spectrometry of the sites of
tyrosine phosphorylation induced in activated
Jurkat T cells on the protein tyrosine kinase
7961967 Serine 1524 is a major site of
phosphorylation on human topoisomerase II
alpha protein in vivo and is a substrate for
casein kinase II in vitro.
7961992 Tyrosine 1356 in the
carboxyl-terminal tail of the HGF/SF receptor is
essential for the transduction of signals for cell
motility and morphogenesis.
7980522 Matrilysin is much more efficient than
other matrix metalloproteinases in the
proteolytic inactivation of alpha 1-antitrypsin.
7983041 Identification of phosphorylation sites
unique to the B form of human progesterone
receptor. In vitro phosphorylation by casein
7983050 Visualization and function of vimentin
phosphorylation by cdc2 kinase during mitosis.
7989361 The mechanism of inactivation of
human factor V and human factor Va by
activated protein C.
7991565 Rab geranylgeranyl transferase
catalyzes the geranylgeranylation of adjacent
cysteines in the small GTPases Rab1A, Rab3A,
7997267 Integrin-mediated signal transduction
linked to Ras pathway by GRB2 binding to focal
7999001 Protein kinase C and cyclic
AMP-dependent protein kinase phosphorylate
phospholemman, an insulin and
phosphoprotein, at specific sites in the carboxy
8002936 Molecular characterization of human
stathmin expressed in Escherichia coli:
site-directed mutagenesis of two
phosphorylatable serines (Ser-25 and Ser-63).
8006040 Molecular structure of pulmonary
surfactant protein D (SP-D).
8019440 The amino acid sequence and
phosphorylation sites of a boar transition
8024572 Identification of novel phosphorylation
sites in the beta-subunit of translation initiation
8027066 The functions of the human insulin
receptor are affected in different ways by
mutation of each of the four N-glycosylation
sites in the beta subunit.
8027075 Activation of human interstitial
procollagenase through direct cleavage of the
Leu83-Thr84 bond by mast cell chymase.
8034666 Identification of nuclear beta II protein
kinase C as a mitotic lamin kinase.
8034726 Phosphorylation of Thr642 is an early
event in the processing of newly synthesized
protein kinase C beta 1 and is essential for its
SHPTP2 couples platelet-derived growth factor
receptor beta to Ras.
8058322 In vitro phosphorylation of
caveolin-rich membrane domains: identification
of an associated serine kinase activity as a
casein kinase II-like enzyme.
8058338 Protein kinase A phosphorylates
cyclin D1 at three distinct sites within the cyclin
box and at the C-terminus.
8061611 Conserved phosphorylation of serines
in the Ser-X-Glu/Ser(P) sequences of the
vitamin K-dependent matrix Gla protein from
shark, lamb, rat, cow, and human.
8076689 Identification and hypotensive activity
of proadrenomedullin N-terminal 20 peptide
8077654 Activation and serine phosphorylation
of the p56lck protein tyrosine kinase in
response to antigen receptor cross-linking in B
8080473 Characterization of a 7.5-kDa protein
kinase C substrate (RC3 protein, neurogranin)
from rat brain.
8083223 Phosphorylation of PHAS-I by
mitogen-activated protein (MAP) kinase.
Identification of a site phosphorylated by MAP
kinase in vitro and in response to insulin in rat
8084605 p56/p53lyn tyrosine kinase activation
in mammalian cells treated with mitomycin C.
8087847 Phosphorylation of E2F-1 modulates
its interaction with the retinoblastoma gene
product and the adenoviral E4 19 kDa protein.
8094892 Phosphorylation and modulation of
recombinant GluR6 glutamate receptors by
cAMP-dependent protein kinase.
8097117 Site-directed mutagenesis of
alpha-tubulin. Reductive methylation studies of
the Lys 394 region.
8099443 Mammalian eukaryotic initiation factor
2 alpha kinases functionally substitute for
GCN2 protein kinase in the GCN4 translational
control mechanism of yeast.
8114715 Lck-dependent tyrosyl
phosphorylation of the phosphotyrosine
phosphatase SH-PTP1 in murine T cells.
8119945 Activation of p34cdc2 protein kinase
by microinjection of human cdc25C into
mammalian cells. Requirement for prior
phosphorylation of cdc25C by p34cdc2 on
sites phosphorylated at mitosis.
8119947 Molecular cloning of the human
mucosal lymphocyte integrin alpha E subunit.
Unusual structure and restricted RNA
8121489 The X-ray crystal structure of the
membrane protein prostaglandin H2
8125092 Cell-cycle-regulated phosphorylation
of oncoprotein 18 on Ser16, Ser25 and Ser38.
8137421 JNK1: a protein kinase stimulated by
UV light and Ha-Ras that binds and
phosphorylates the c-Jun activation domain.
8139570 Regulation of cyclin D-dependent
kinase 4 (cdk4) by cdk4-activating kinase.
autophosphorylation activates the G
protein-coupled receptor kinase GRK5.
8152805 Products of the TAL2 oncogene in
leukemic T cells: bHLH phosphoproteins with
8156998 Ligand-induced IFN gamma receptor
tyrosine phosphorylation couples the receptor
to its signal transduction system (p91).
8157000 Identification of the sites in MAP
kinase kinase-1 phosphorylated by p74raf-1.
8163463 Transmembrane topology of the
glutamate receptor subunit GluR6.
8163498 Identification of the phosphorylation
site in vitro for cAMP-dependent protein kinase
on the rat adipocyte cGMP-inhibited cAMP
8163535 Core protein structure and sequence
determine the site and presence of heparan
sulfate and chondroitin sulfate on syndecan-1.
8175798 Determination of structural
requirements for the interaction of Rab6 with
RabGDI and Rab geranylgeranyltransferase.
8179825 Cloning and expression of the gene
for the melanoma-associated ME20 antigen.
8180202 Glycosylation of human
corticosteroid-binding globulin. Differential
processing and significance of carbohydrate
chains at individual sites.
8180207 Fluorescence studies of the location
and membrane accessibility of the
palmitoylation sites of rhodopsin.
8182057 cAMP- and cGMP-dependent protein
kinase phosphorylation sites of the focal
phosphoprotein (VASP) in vitro and in intact
8188697 A transmembrane model for an
ionotropic glutamate receptor predicted on the
basis of the location of asparagine-linked
8194526 c-Abl kinase regulates the protein
binding activity of c-Crk.
8195113 Dephosphorylation of osteopontin
and bone sialoprotein by osteoclastic
tartrate-resistant acid phosphatase. Modulation
of osteoclast adhesion in vitro.
8195171 Direct interaction between Shc and
the platelet-derived growth factor
8195709 Isolation, cDNA cloning, and
overexpression of a 33-kD cell surface
glycoprotein that binds to the globular "heads"
8206937 The catalytic subunit of protein
phosphatase 2A is carboxyl-methylated in vivo.
8206977 Phosphorylation of the erythroid
transcription factor GATA-1.
8221888 MKP-1 (3CH134), an immediate early
gene product, is a dual specificity phosphatase
that dephosphorylates MAP kinase in vivo.
8224842 Identification of an oncoprotein- and
UV-responsive protein kinase that binds and
potentiates the c-Jun activation domain.
8226803 Activation of the zymogen of
hepatocyte growth factor activator by thrombin.
8226933 Properties of MEKs, the kinases that
phosphorylate and activate the extracellular
8227042 The phosphorylation and DNA binding
of the DNA-binding domain of the orphan
nuclear receptor NGFI-B.
8227063 Palmitoylation is required for signaling
functions and membrane attachment of Gq
alpha and Gs alpha.
8240296 Post-translational processing of
progastrin: inhibition of cleavage,
phosphorylation and sulphation by brefeldin A.
8243461 Identification of O-linked
oligosaccharide chains in the activation
peptides of blood coagulation factor X. The role
of the carbohydrate moieties in the activation of
8245015 A serine phosphorylation of Nm23,
and not its nucleoside diphosphate kinase
activity, correlates with suppression of tumor
8247524 Phosphorylation sites mapping in the
N-terminal domain of c-myc modulate its
8247525 Identification of casein kinase II
phosphorylation sites in Max: effects on
DNA-binding kinetics of Max homo- and
8248197 Phosphorylation of the c-Fos
transrepression domain by mitogen-activated
protein kinase and 90-kDa ribosomal S6 kinase.
8253769 Proteolytic release of human
angiotensin-converting enzyme. Localization of
the cleavage site.
8253806 L-29, a soluble lactose-binding lectin,
is phosphorylated on serine 6 and serine 12 in
vivo and by casein kinase I.
8257432 The 50 kDa protein subunit of
assembly polypeptide (AP) AP-2 adaptor from
clathrin-coated vesicles is phosphorylated on
threonine-156 by AP-1 and a soluble AP50
kinase which co-purifies with the assembly
8258691 Fc gamma RIIIA-mediated signaling
involves src-family lck in human natural killer
8262977 Iron-responsive element-binding
protein. Phosphorylation by protein kinase C.
8272872 Association of transcription factor
APRF and protein kinase Jak1 with the
interleukin-6 signal transducer gp130.
8276756 Determination of carboxyl-terminal
residue and disulfide bonds of MACIF (CD59), a
8276855 Autocatalytic maturation of the
prohormone convertase PC2.
8280063 N-glycosylation of human
acetylcholinesterase: effects on activity, stability
8288564 Enzymatic methylation of
recombinant heterogeneous nuclear RNP
protein A1. Dual substrate specificity for
8288610 Dominant inhibitory mutants of ARF1
block endoplasmic reticulum to Golgi transport
and trigger disassembly of the Golgi apparatus.
8288648 Molecular mechanism of the
synergistic phosphorylation of phosphatase
inhibitor-2. Cloning, expression, and
site-directed mutagenesis of inhibitor-2.
8294430 Phosphorylation of serine 985
negatively regulates the hepatocyte growth
factor receptor kinase.
8294455 In vitro analysis of microtubule
assembly of isotypically pure tubulin dimers.
Intrinsic differences in the assembly properties
of alpha beta II, alpha beta III, and alpha beta IV
tubulin dimers in the absence of
8302603 Tyrosines1234-1235 are critical for
activation of the tyrosine kinase encoded by the
MET proto-oncogene (HGF receptor).
8308015 Phosphorylation of the human
estrogen receptor. Identification of
hormone-regulated sites and examination of
their influence on transcriptional activity.
8313897 PI 3-kinase is a dual specificity
enzyme: autoregulation by an intrinsic
protein-serine kinase activity.
8316301 Regulation of NMDA receptor
phosphorylation by alternative splicing of the
8321321 Protein kinase C alpha activates
RAF-1 by direct phosphorylation.
8323280 N-linked sugar chain structure of
recombinant human lymphotoxin produced by
CHO cells: the functional role of carbohydrate
as to its lectin-like character and clearance
8323299 Assignment of O-glycan attachment
sites to the hinge-like regions of human
lysosomal membrane glycoproteins lamp-1 and
8325847 Characterization of rabbit skeletal
muscle glycogenin. Tyrosine 194 is essential for
8325880 Serine 25 of oncoprotein 18 is a
major cytosolic target for the mitogen-activated
8327493 Characterization of site-specific
mutants altered at protein kinase C beta 1
isozyme autophosphorylation sites.
8336134 Purification and chemical
characterization of beta-trace protein from
human cerebrospinal fluid: its identification as
prostaglandin D synthase.
8344946 Glycosylation of mammalian
neurofilaments. Localization of multiple O-linked
N-acetylglucosamine moieties on neurofilament
polypeptides L and M.
8346912 Isolation and biochemical
characterization of procathepsin E from human
8347587 Specific glycosylation site mutations
of the insulin receptor alpha subunit impair
8348977 Determination of the disulphide bridge
arrangement of bovine histidine-rich
8349614 Identification of the major
phosphorylation sites of the Raf-1 kinase.
8349691 Phosphorylation of the insulin
receptor substrate IRS-1 by casein kinase II.
8349699 N-glycosylation of prostaglandin
endoperoxide synthases-1 and -2 and their
orientations in the endoplasmic reticulum.
8360179 Myristoylation of hippocalcin is linked
to its calcium-dependent membrane
8366859 Efficient complement-mediated lysis
of cells containing the CAMPATH-1 (CDw52)
8373790 Identification of the phosphorylation
site on human erythrocyte band 7 integral
membrane protein: implications for a
monotopic protein structure.
8375503 Isoprenylation of Rab proteins
possessing a C-terminal CaaX motif.
8376365 Multiple phosphorylation of stathmin.
Identification of four sites phosphorylated in
intact cells and in vitro by cyclic
AMP-dependent protein kinase and p34cdc2.
8380342 Phosphorylation of serine 2843 in
ryanodine receptor-calcium release channel of
skeletal muscle by cAMP-, cGMP- and
CaM-dependent protein kinase.
8382613 Modulation of the glycogen synthase
kinase-3 family by tyrosine phosphorylation.
8384217 Activating transcription factor-1 can
mediate Ca(2+)- and cAMP-inducible
8384717 Phosphorylation at threonine-235 by
a ras-dependent mitogen-activated protein
kinase cascade is essential for transcription
8385099 The alpha-type 85-kDa subunit of
phosphatidylinositol 3-kinase is phosphorylated
at tyrosines 368, 580, and 607 by the insulin
8386634 Regulation of elongation factor-2 by
8389479 The growth factor-inducible
immediate-early gene 3CH134 encodes a
8390988 Phosphorylation of connexin-32 by
protein kinase C prevents its proteolysis by
mu-calpain and m-calpain.
8393577 Crystal structures of native and
inhibited forms of human cathepsin D:
implications for lysosomal targeting and drug
8394352 Activation of mitogen-activated
protein kinase/extracellular signal-regulated
kinase kinase by G protein and tyrosine kinase
8395513 Identification of phosphorylation sites
in the recombinant catalytic subunit of
cAMP-dependent protein kinase.
8404858 Multiple and cooperative
phosphorylation events regulate the CREM
8405050 Association of the p56lck protein
tyrosine kinase with the Fc gamma RIIIA/CD16
complex in human natural killer cells.
8407908 Cloning and characterization of the
gene encoding the human platelet glycoprotein
V. A member of the leucine-rich glycoprotein
family cleaved during thrombin-induced platelet
8407951 The carboxyl-terminal transactivation
domain of human serum response factor
contains DNA-activated protein kinase
8413226 A growth factor-induced kinase
phosphorylates the serum response factor at a
site that regulates its DNA-binding activity.
8423803 Phosphorylation of the TAL1
oncoprotein by the
extracellular-signal-regulated protein kinase
8428596 Human Wee1 kinase inhibits cell
division by phosphorylating p34cdc2 exclusively
8429024 Analysis of Gz alpha by site-directed
mutagenesis. Sites and specificity of protein
kinase C-dependent phosphorylation.
8440392 Dephosphorylation of human
p34cdc2 kinase on both Thr-14 and Tyr-15 by
human cdc25B phosphatase.
8440735 Identification of 40 S ribosomal
protein S6 phosphorylation sites in Swiss
mouse 3T3 fibroblasts stimulated with serum.
8463287 Interaction of the human insulin
receptor tyrosine kinase from the baculovirus
expression system with protein kinase C in a
8463311 The adipocyte lipid-binding protein at
1.6-A resolution. Crystal structures of the
apoprotein and with bound saturated and
unsaturated fatty acids.
8464713 c-Jun is phosphorylated by the
DNA-dependent protein kinase in vitro;
definition of the minimal kinase recognition
8475115 Lipid modifications of G proteins:
alpha subunits are palmitoylated.
8477740 Identification of novel phosphorylation
sites in murine A-type lamins.
8491187 Multi-site phosphorylation of the
protein tyrosine phosphatase, PTP1B:
identification of cell cycle regulated and phorbol
ester stimulated sites of phosphorylation.
8494607 Glycosylation of active human renin is
necessary for secretion: effect of targeted
modifications of Asn-5 and Asn-75.
8496180 Insulin stimulates serine and tyrosine
phosphorylation in the juxtamembrane region of
the insulin receptor.
8499451 Expression of glycosylated and
nonglycosylated human transferrin in
mammalian cells. Characterization of the
recombinant proteins with comparison to three
commercially available transferrins.
8504096 Insulin receptor autophosphorylation.
II. Determination of autophosphorylation sites
by chemical sequence analysis and
identification of the juxtamembrane sites.
8506364 Phosphorylation of Ser-42 and
Ser-59 in the N-terminal region of the tyrosine
8513978 Glycosylation of Asn397 or Asn418 is
required for normal insulin receptor biosynthesis
8524413 Inhibition of glycogen synthase
kinase-3 by insulin mediated by protein kinase
8530377 Substrate specificities of the insulin
and insulin-like growth factor 1 receptor
tyrosine kinase catalytic domains.
8530385 N-glycans modulate in vivo and in
vitro thyroid hormone synthesis. Study at the
N-terminal domain of thyroglobulin.
8530412 Phosphorylation of the cytosolic
domain of peptidylglycine alpha-amidating
8542290 Cell signalling. Receptor orphans find
8546712 The low-density-lipoprotein
receptor-related protein (LRP) is processed by
furin in vivo and in vitro.
8547318 Expression of recombinant elongation
factor 1 beta from rabbit in Escherichia coli.
Phosphorylation by casein kinase II.
8548803 Phosphorylation by p34cdc2
regulates spindle association of human Eg5, a
kinesin-related motor essential for bipolar
spindle formation in vivo.
8550552 Effect of tyrosine mutations on the
kinase activity and transforming potential of an
oncogenic human insulin-like growth factor I
8557106 Processing of pro-islet amyloid
polypeptide (proIAPP) by the prohormone
8557631 The beta-adrenergic receptor is a
substrate for the insulin receptor tyrosine
8576110 Association of a 85-kDa serine kinase
with activated fibroblast growth factor
8576253 Identification of important regions in
the cytoplasmic juxtamembrane domain of type
I receptor that separate signaling pathways of
transforming growth factor-beta.
8592152 Casein kinase II phosphorylates the
neural cell adhesion molecule L1.
8597870 Phosphorylation of the 26 kDa TNF
precursor in monocytic cells and in transfected
8601309 Site-specific phosphorylation of
IkappaBalpha by a novel
ubiquitination-dependent protein kinase activity.
8609233 Cloning, expression, and type II
collagenolytic activity of matrix
metalloproteinase-13 from human osteoarthritic
8612628 A comparative study of the
phosphotyrosyl phosphatase specificity of
protein phosphatase type 2A and
phosphotyrosyl phosphatase type 1B using
phosphopeptides and the phosphoproteins
p50/HS1, c-Fgr and Lyn.
8612821 A potential site of functional
modulation by protein kinase A in the cardiac
Ca2+ channel alpha 1C subunit.
8615697 Glycosylation in human thyroglobulin:
location of the N-linked oligosaccharide units
and comparison with bovine thyroglobulin.
8615762 PC8 [corrected], a new member of
the convertase family.
8617237 Interleukin-2 activation of STAT5
requires the convergent action of tyrosine
kinases and a serine/threonine kinase pathway
distinct from the Raf1/ERK2 MAP kinase
8617742 Syk, activated by cross-linking the
B-cell antigen receptor, localizes to the cytosol
where it interacts with and phosphorylates
alpha-tubulin on tyrosine.
8617789 Structural determinants in the
platelet-derived growth factor alpha-receptor
implicated in modulation of chemotaxis.
8617805 Structural and enzymatic aspects of
8618850 Palmitoylation of the GluR6 kainate
8618896 Phosphotyrosine-independent binding
of a 62-kDa protein to the src homology 2
(SH2) domain of p56lck and its regulation by
phosphorylation of Ser-59 in the lck unique
8619990 Phosphorylation of beta III-tubulin.
8619999 Phosphorylation of C8 and C9
subunits of the multicatalytic proteinase by
casein kinase II and identification of the C8
phosphorylation sites by direct mutagenesis.
8621380 Oncogenic RET receptors display
different autophosphorylation sites and
substrate binding specificities.
8621423 Requirements for calcium and
calmodulin in the calmodulin kinase activation
8621539 ERK3 is a constitutively nuclear
8621594 Phosphorylation of the ATP-sensitive,
inwardly rectifying K+ channel, ROMK, by cyclic
AMP-dependent protein kinase.
8621729 Selective activation of MEK1 but not
MEK2 by A-Raf from epidermal growth
factor-stimulated Hela cells.
8622669 MKK3- and MKK6-regulated gene
expression is mediated by the p38
mitogen-activated protein kinase signal
8622692 Casein kinase II phosphorylates I
kappa B alpha at S-283, S-289, S-293, and
T-291 and is required for its degradation.
8622701 Identification of six novel
autophosphorylation sites on fibroblast growth
factor receptor 1 and elucidation of their
importance in receptor activation and signal
8622703 Inhibition of Bcr serine kinase by
8622893 A juxtamembrane
autophosphorylation site in the Eph family
receptor tyrosine kinase, Sek, mediates high
affinity interaction with p59fyn.
8622969 Human vitamin D receptor
phosphorylation by casein kinase II at Ser-208
potentiates transcriptional activation.
8624803 Growth and gene expression are
predominantly controlled by distinct regions of
the human IL-4 receptor.
8626374 Dominant negative stat3 mutant
inhibits interleukin-6-induced Jak-STAT signal
8626492 Protein kinase A-dependent
phosphorylation of GLUT2 in pancreatic beta
8626512 Identification of plectin as a substrate
of p34cdc2 kinase and mapping of a single
8626527 Differential regulation of
retinoblastoma protein function by specific Cdk
8626580 A novel Ca2+-binding protein, p22, is
required for constitutive membrane traffic.
8626610 Regulated cleavage of sterol
regulatory element binding proteins requires
sequences on both sides of the endoplasmic
8626671 Phosphorylation of insulin receptor
substrate-1 on multiple serine residues, 612,
632, 662, and 731, modulates insulin action.
8626720 Identification of the site in the
phosphorylated in adipocytes in response to
insulin and isoproterenol.
8626767 Characterization of ERK1 activation
site mutants and the effect on recognition by
MEK1 and MEK2.
8626774 The sequence of human
betaB1-crystallin cDNA allows mass
spectrometric detection of betaB1 protein
missing portions of its N-terminal extension.
8629002 Activation of BTK by a
phosphorylation mechanism initiated by SRC
8630736 Regulation of Btk function by a major
autophosphorylation site within the SH3
8631738 Phosphorylation of
Munc-18/n-Sec1/rbSec1 by protein kinase C:
its implication in regulating the interaction of
Munc-18/n-Sec1/rbSec1 with syntaxin.
8631817 Identification of a consensus
cyclin-dependent kinase phosphorylation site
unique to the nuclear form of human
deoxyuridine triphosphate nucleotidohydrolase.
8631895 Processing and activation of CMH-1
by granzyme B.
8631898 Phosphorylation of
microtubule-associated proteins MAP2 and
MAP4 by the protein kinase p110mark.
Phosphorylation sites and regulation of
8631994 Characterization of the
mitogen-activated protein kinase
phosphorylation sites on the connexin-43 gap
8632005 Phosphorylation of caveolin by src
tyrosine kinases. The alpha-isoform of caveolin
is selectively phosphorylated by v-Src in vivo.
8632909 Differential phosphorylations of Spi-B
and Spi-1 transcription factors.
8633035 The phosphatase activity of carbonic
anhydrase III is reversibly regulated by
8635221 Removal of Arg141 from the alpha
chain of human hemoglobin by
carboxypeptidases N and M.
8635594 Identification of a cryptic protein
kinase CK2 phosphorylation site in human
complement protease Clr, and its use to probe
8636128 Identification of phosphorylation sites
of human 85-kDa cytosolic phospholipase A2
expressed in insect cells and present in human
8636146 Metalloproteinase activity secreted by
fibrogenic cells in the processing of prolysyl
oxidase. Potential role of procollagen
8636209 Role of CD3 gamma in T cell receptor
8639509 Dynamic O-GlcNAcylation of the small
heat shock protein alpha B-crystallin.
8639568 Identification of insulin-stimulated
phosphorylation sites on calmodulin.
8639592 Amino acid sequence and
carbohydrate structure of a recombinant
human tissue factor pathway inhibitor
expressed in Chinese hamster ovary cells: one
N-and two O-linked carbohydrate chains are
located between Kunitz domains 2 and 3 and
one N-linked carbohydrate chain is in Kunitz
8639654 Mutagenesis of N-glycosylation sites
in the human vasoactive intestinal peptide 1
receptor. Evidence that asparagine 58 or 69 is
crucial for correct delivery of the receptor to
8647260 Site-directed mutagenesis but not
gamma-carboxylation of Glu-35 in factor VIIa
affects the association with tissue factor.
8647855 Modulation of the SH2 binding
specificity and kinase activity of Src by tyrosine
phosphorylation within its SH2 domain.
8647860 Proteolytic activity of human
osteoclast cathepsin K. Expression,
purification, activation, and substrate
8647875 Phosphorylation of human fascin
inhibits its actin binding and bundling activities.
8650547 Stress-induced phosphorylation and
activation of the transcription factor CHOP
(GADD153) by p38 MAP Kinase.
8654373 Selective interaction of JNK protein
kinase isoforms with transcription factors.
8657102 Mapping of the inducible IkappaB
phosphorylation sites that signal its
ubiquitination and degradation.
8657103 Phospholipase C-gamma1 interacts
with conserved phosphotyrosyl residues in the
linker region of Syk and is a substrate for Syk.
8662663 Phosphorylation of eIF-4E on serine
209 by protein kinase C is inhibited by the
translational repressors, 4E-binding proteins.
8662759 Casein kinase II associates with Egr-1
and acts as a negative modulator of its DNA
binding and transcription activities in NIH 3T3
8662852 Identification of the G protein-coupled
receptor kinase phosphorylation sites in the
human beta2-adrenergic receptor.
8663227 Phosphorylation and activation of a
cAMP-specific phosphodiesterase by the
cAMP-dependent protein kinase. Involvement
of serine 54 in the enzyme activation.
8663255 Cellular mechanisms for human
procollagenase-3 (MMP-13) activation.
Evidence that MT1-MMP (MMP-14) and
gelatinase a (MMP-2) are able to generate
8663267 Phosphorylation of purified bovine
bone sialoprotein and osteopontin by protein
8663297 Degradation of interleukin 1beta by
8663317 Calmodulin-dependent protein kinase
II potentiates transcriptional activation through
activating transcription factor 1 but not cAMP
response element-binding protein.
8663332 The soluble catalytic domain of
membrane type 1 matrix metalloproteinase
cleaves the propeptide of progelatinase A and
initiates autoproteolytic activation. Regulation
by TIMP-2 and TIMP-3.
8663403 Phosphorylation of the MADS-Box
transcription factor MEF2C enhances its DNA
8663427 Autophosphorylation of the Fes
tyrosine kinase. Evidence for an intermolecular
mechanism involving two kinase domain
8663450 An activated epidermal growth factor
receptor/Lck chimera restores early T cell
receptor-mediated calcium response in a
CD45-deficient T cell line.
8663493 Involvement of p90rsk in neurite
outgrowth mediated by the cell adhesion
8664319 Cyclic AMP-dependent protein kinase
phosphorylates residues in the C-terminal
domain of the cardiac L-type calcium channel
8668151 Identification of a binding site in
c-Ab1 tyrosine kinase for the C-terminal
repeated domain of RNA polymerase II.
8670172 Structural composition and functional
characterization of soluble CD59: heterogeneity
of the oligosaccharide and
glycophosphoinositol (GPI) anchor revealed by
laser-desorption mass spectrometric analysis.
8672508 Cell cycle-dependent phosphorylation
of nucleoporins and nuclear pore membrane
8674111 Tertiary structure of destrin and
structural similarity between two
actin-regulating protein families.
8674818 The post-translational processing and
intracellular sorting of carboxypeptidase H in
the islets of Langerhans.
8683601 Crystal structure of human trypsin 1:
unexpected phosphorylation of Tyr151.
8683730 Prostate specific antigen cleaves
parathyroid hormone-related protein in the
PTH-like domain: inactivation of
PTHrP-stimulated cAMP accumulation in
8687431 Proadrenomedullin N-terminal 20
peptide is rapidly cleaved by neutral
8688081 Coupling of the RAS-MAPK pathway
to gene activation by RSK2, a growth
factor-regulated CREB kinase.
8692868 A human axillary odorant is carried by
8692915 The stress response to ionizing
radiation involoves c-Abl-dependent
phosphorylation of SHPTP1.
8692946 Matrix metalloproteinase 2 releases
active soluble ectodomain of fibroblast growth
factor receptor 1.
8694767 Phosphorylation of GAP-43
(growth-associated protein of 43 kDa) by
conventional, novel and atypical isotypes of the
protein kinase C gene family: differences
between oligopeptide and polypeptide
8700888 Different interleukin 2 receptor
beta-chain tyrosines couple to at least two
signaling pathways and synergistically mediate
interleukin 2-induced proliferation.
8702477 Identification of the major
autophosphorylation sites of Nyk/Mer, an
NCAM-related receptor tyrosine kinase.
8702538 A single N-linked glycosylation site is
implicated in the regulation of ligand recognition
by the I-type lectins CD22 and CD33.
8702662 Phosphorylation of SLP-76 by the
ZAP-70 protein-tyrosine kinase is required for
T-cell receptor function.
8702728 Functional importance of
amino-terminal domain of Shc for interaction
with insulin and epidermal growth factor
receptors in phosphorylation-independent
8702840 Cytoplasmic O-GlcNAc modification
of the head domain and the KSP repeat motif
of the neurofilament protein neurofilament-H.
8702879 Site-specific phosphorylation of
synapsin I by mitogen-activated protein kinase
and Cdk5 and its effects on physiological
8707854 Identification of stromal cell products
that interact with pre-B cells.
8749392 Protein kinase C is regulated in vivo
by three functionally distinct phosphorylations.
8753751 Alteration of the hormonal bioactivity
of parathyroid hormone-related protein (PTHrP)
as a result of limited proteolysis by
8755496 In vitro activation of CPP32 and Mch3
by Mch4, a novel human apoptotic cysteine
protease containing two FADD-like domains.
8756628 A single tyrosine of the interleukin-9
(IL-9) receptor is required for STAT activation,
antiapoptotic activity, and growth regulation by
8756631 In vivo and in vitro specificity of
protein tyrosine kinases for immunoglobulin G
receptor (FcgammaRII) phosphorylation.
8764598 In vitro phosphorylation of the
cytoplasmic domain of the amyloid precursor
protein by glycogen synthase kinase-3beta.
8774846 A comparison of the substrate
specificity of MAPKAP kinase-2 and MAPKAP
kinase-3 and their activation by cytokines and
8783018 Mass spectrometric characterization
of glycosylated interferon-gamma variants
separated by gel electrophoresis.
8797825 Tyrosine phosphorylation of I kappa
B-alpha activates NF-kappa B without
proteolytic degradation of I kappa B-alpha.
8798390 CD36 is palmitoylated on both N- and
C-terminal cytoplasmic tails.
8798570 Ligand activation of ELK receptor
tyrosine kinase promotes its association with
Grb10 and Grb2 in vascular endothelial cells.
8798614 Elimination of potential sites of
glycosylation fails to abrogate complement
regulatory function of cell surface CD59.
8798667 Phosphorylation and inhibition of type
III adenylyl cyclase by calmodulin-dependent
protein kinase II in vivo.
8798697 Stimulation of tumor cell motility
linked to phosphodiesterase catalytic site of
8798764 Regulation of the Lck SH2 domain by
8804068 The in vivo metabolism of
cholecystokinin (CCK-8) is essentially ensured
by aminopeptidase A.
8804412 CPP32/Yama/apopain cleaves the
catalytic component of DNA-dependent protein
kinase in the holoenzyme.
8810265 Site-directed mutagenesis of
nm23-H1. Mutation of proline 96 or serine 120
abrogates its motility inhibitory activity upon
transfection into human breast carcinoma cells.
8810272 Adducin regulation. Definition of the
calmodulin-binding domain and sites of
phosphorylation by protein kinases A and C.
8816475 Evidence for in vivo phosphorylation
of the Grb2 SH2-domain binding site on focal
adhesion kinase by Src-family protein-tyrosine
8816480 Identification of the mitogen-activated
protein kinase phosphorylation sites on human
Sos1 that regulate interaction with Grb2.
8824278 Dephosphorylation of serine 3
regulates nuclear translocation of cofilin.
(GM2 synthase) is released from Golgi
membranes as a neuraminidase-sensitive,
disulfide-bonded dimer by a cathepsin D-like
8843739 IGFBP-3 proteolysis by plasmin,
thrombin, serum: heparin binding, IGF binding,
and structure of fragments.
8845374 In vitro phosphorylation of the
epidermal growth factor receptor
autophosphorylation domain by c-src:
identification of phosphorylation sites and c-src
SH2 domain binding sites.
8846784 Identification of novel phosphorylation
sites required for activation of MAPKAP
8848293 Antibody specific for phosphorylated
AMPA-type glutamate receptors at GluR2
8855939 Disulfide structure and
N-glycosylation sites of an extracellular domain
of granulocyte-colony stimulating factor
8856079 Replacement of Ser657 of protein
kinase C-alpha by alanine leads to premature
down regulation after phorbol-ester-induced
translocation to the membrane.
8861947 Activation of cyclin E/CDK2 is
coupled to site-specific autophosphorylation
and ubiquitin-dependent degradation of cyclin
8864963 Functional and metabolic differences
between elastase-generated fragments of
human lipoprotein[a] and apolipoprotein[a].
8869556 Purification and characterization of
human endopeptidase 188.8.131.52. Comparison
with the porcine counterpart indicates a unique
cleavage site on neurotensin.
8870657 Heterogeneity in utilization of
N-glycosylation sites Asn624 and Asn138 in
human lactoferrin: a study with
8875975 Proline-rich sequences mediate the
interaction of the Arg protein tyrosine kinase
8876196 The cytokine-activated tyrosine
kinase JAK2 activates Raf-1 in a
8885240 Characterization and determination of
the biological activities of noncleavable high
molecular weight forms of inhibin A and activin
8885868 Protein kinase C mu (PKC mu)
associates with the B cell antigen receptor
complex and regulates lymphocyte signaling.
8886014 Ser-27, Tyr-10 and Tyr-7 in the
alpha-chain of pig stomach H+,K(+)-ATPase as
Ca(2+)-dependent phosphorylatable sites by
intrinsic and extrinsic protein kinases.
8887554 FGF and stress regulate CREB and
ATF-1 via a pathway involving p38 MAP kinase
and MAPKAP kinase-2.
8887659 Autophosphorylation sites participate
in the activation of the
double-stranded-RNA-activated protein kinase
8898866 Mapping of a regulatory important site
for protein kinase C phosphorylation in the
N-terminal domain of annexin II.
8900201 The Ced-3/interleukin 1beta
converting enzyme-like homolog Mch6 and the
lamin-cleaving enzyme Mch2alpha are
substrates for the apoptotic mediator CPP32.
8910387 Characterization of the
AMP-activated protein kinase kinase from rat
liver and identification of threonine 172 as the
major site at which it phosphorylates
AMP-activated protein kinase.
8910476 Osteopontin N-terminal domain
contains a cryptic adhesive sequence
recognized by alpha9beta1 integrin.
8910478 Cysteines 153 and 154 of
transmembrane transforming growth
factor-alpha are palmitoylated and mediate
cytoplasmic protein association.
8910482 Antibacterial activity of glycosylated
and phosphorylated chromogranin A-derived
peptide 173-194 from bovine adrenal medullary
8917518 Independent regulation of JNK/p38
mitogen-activated protein kinases by metabolic
oxidative stress in the liver.
8939955 Threonine 1342 in human
topoisomerase IIalpha is phosphorylated
throughout the cell cycle.
8940068 Sequential phosphorylation by
mitogen-activated protein kinase and glycogen
synthase kinase 3 represses transcriptional
activation by heat shock factor-1.
8940081 Grb7 is a downstream signaling
component of platelet-derived growth factor
alpha- and beta-receptors.
8940173 Src phosphorylates the insulin-like
growth factor type I receptor on the
autophosphorylation sites. Requirement for
transformation by src.
8941336 Focal adhesion kinase tyrosine-861 is
a major site of phosphorylation by Src.
8942648 Peptide, disulfide, and glycosylation
mapping of recombinant human thrombopoietin
from ser1 to Arg246.
8943232 Processing of beta-amyloid precursor
protein by cathepsin D.
8943344 A novel membrane glycoprotein,
SHPS-1, that binds the SH2-domain-containing
protein tyrosine phosphatase SHP-2 in
response to mitogens and cell adhesion.
8943348 Phosphorylation of tyrosine 720 in the
platelet-derived growth factor alpha receptor is
required for binding of Grb2 and SHP-2 but not
for activation of Ras or cell proliferation.
8943850 CD10/neutral endopeptidase 24.11 is
phosphorylated by casein kinase II and
coassociates with other phosphoproteins
including the lyn src-related kinase.
8945479 Structural basis for activation of
human lymphocyte kinase Lck upon tyrosine
8947046 Phosphorylation of Ser165 in
TGF-beta type I receptor modulates
TGF-beta1-induced cellular responses.
8950790 Thrombin-activated human platelets
release two NAP-2 variants that stimulate
8954982 Casein kinase 2 phosphorylates
recombinant human spermidine/spermine
N1-acetyltransferase on both serine and
8955135 Co-expression with BCR induces
activation of the FES tyrosine kinase and
phosphorylation of specific N-terminal BCR
8959326 Multiple in vivo phosphorylated
tyrosine phosphatase SHP-2 engages binding
to Grb2 via tyrosine 584.
8960373 Functional analysis of phosphorylation
at serine 532 of human c-Myb by MAP kinase.
8962078 Molecular ordering of the
Fas-apoptotic pathway: the Fas/APO-1
protease Mch5 is a CrmA-inhibitable protease
that activates multiple Ced-3/ICE-like cysteine
8971927 Identification of the site of glycation of
8973632 Biosynthesis and N-glycosylation of
human interferon-gamma. Asn25 and Asn97
differ markedly in how efficiently they are
glycosylated and in their oligosaccharide
8978814 Lamin proteolysis facilitates nuclear
events during apoptosis.
8978818 A role for N-myristoylation in protein
targeting: NADH-cytochrome b5 reductase
requires myristic acid for association with outer
mitochondrial but not ER membranes.
8980254 Lineage- and differentiation
stage-specific expression of LSM-1 (LPAP), a
possible substrate for CD45, in human
8992971 Analysis of CD28 cytoplasmic tail
tyrosine residues as regulators and substrates
for the protein tyrosine kinases, EMT and LCK.
8995217 LSP1 is the major substrate for
mitogen-activated protein kinase-activated
protein kinase 2 in human neutrophils.
8999860 The regulatory Ser262 of
microtubule-associated protein tau is
phosphorylated by phosphorylase kinase.
8999969 Identification of an actin binding
region and a protein kinase C phosphorylation
site on human fascin.
9001210 The human Myt1 kinase preferentially
phosphorylates Cdc2 on threonine 14 and
localizes to the endoplasmic reticulum and
9003781 The consensus motif for
phosphorylation by cyclin D1-Cdk4 is different
from that for phosphorylation by cyclin
9006104 Structural characterization by mass
spectrometry of hemoglobin adducts formed
after in vivo exposure to methyl bromide.
9012831 BAP-135, a target for Bruton's
tyrosine kinase in response to B cell receptor
9013710 Inhibition of protein dephosphorylation
results in the accumulation of splicing snRNPs
and coiled bodies within the nucleolus.
9016641 Phosphorylation of ATF-1 enhances
its DNA binding and transcription of the
Na,K-ATPase alpha 1 subunit gene promoter.
9016807 Phosphorylation of growth factor
receptor binding protein-2 by pp60c-src
9020112 Interactions of mast cell tryptase with
thrombin receptors and PAR-2.
9020188 Stat2 is a transcriptional activator that
requires sequence-specific contacts provided
by stat1 and p48 for stable interaction with
9023104 tRNAscan-SE: a program for
improved detection of transfer RNA genes in
9029153 Cdk2-dependent phosphorylation of
Id2 modulates activity of E2A-related
9030579 Transcriptional activation by
peroxisome proliferator-activated receptor
gamma is inhibited by phosphorylation at a
consensus mitogen-activated protein kinase
9030583 Characterization of protein kinase A
and protein kinase C phosphorylation of the
N-methyl-D-aspartate receptor NR1 subunit
using phosphorylation site-specific antibodies.
9030585 Targeting of SCG10 to the area of the
Golgi complex is mediated by its NH2-terminal
9030586 Protein kinase A (PKA)- and protein
kinase C-phosphorylated glia maturation factor
promotes the catalytic activity of PKA.
9030603 In vitro assay and characterization of
the farnesylation-dependent prelamin A
9030777 Phosphorylation of vitronectin on
Ser362 by protein kinase C attenuates its
cleavage by plasmin.
9032240 Expression of constitutively active
alpha-PAK reveals effects of the kinase on actin
and focal complexes.
9038134 Regulation of the low molecular
weight phosphotyrosine phosphatase by
phosphorylation at tyrosines 131 and 132.
9038175 Sequence-specific DNA binding and
transcription factor phosphorylation by Ku
Autoantigen/DNA-dependent protein kinase.
Phosphorylation of Ser-527 of the rat
9038210 Direct association of Csk homologous
kinase (CHK) with the diphosphorylated site
Tyr568/570 of the activated c-KIT in
9045708 Phosphorylation of a vesicular
monoamine transporter by casein kinase II.
9047237 Regulation of Vav-SLP-76 binding by
ZAP-70 and its relevance to TCR zeta/CD3
induction of interleukin-2.
9053848 Tyrosine 207 in CRKL is the
BCR/ABL phosphorylation site.
9054419 The glycosylation of the complement
regulatory protein, human erythrocyte CD59.
9054441 Evidence for a novel O-linked
sialylated trisaccharide on Ser-248 of human
9054461 Phosphorylation of human keratin 8 in
vivo at conserved head domain serine 23 and
at epidermal growth factor-stimulated tail
domain serine 431.
9060467 Rapid plasma membrane anchoring
of newly synthesized p59fyn: selective
requirement for NH2-terminal myristoylation
and palmitoylation at cysteine-3.
9069290 Activation of the transcription factor
MEF2C by the MAP kinase p38 in inflammation.
9072970 Nuclear export of NF-ATc enhanced
by glycogen synthase kinase-3.
9074495 The putative cell cycle gene,
enhancer of rudimentary, encodes a highly
conserved protein found in plants and animals.
9076588 Identification of peptide fragments
generated by digestion of bovine and human
osteocalcin with the lysosomal proteinases
cathepsin B, D, L, H, and S.
9079638 Ligand-induced desensitization of the
human CXC chemokine receptor-2 is
modulated by multiple serine residues in the
carboxyl-terminal domain of the receptor.
9091312 Identification of Raf-1 Ser621 kinase
activity from NIH 3T3 cells as AMP-activated
9092573 Identification of phosphorylation sites
in the translational regulator, PHAS-I, that are
controlled by insulin and rapamycin in rat
9092810 Characterization of prostate-specific
antigen proteolytic activity on its major
physiological substrate, the sperm motility
inhibitor precursor/semenogelin I.
9092949 Retargeting of cytosolic proteins to
the plasma membrane by the Lck protein
tyrosine kinase dual acylation motif.
9096689 Antisense src expression inhibits
tyrosine phosphorylation of Shc and its
association with Grb2 and Sos which leads to
MAP kinase activation in U937 human leukemia
9099667 Phosphorylation of glial fibrillary acidic
protein at the same sites by cleavage furrow
kinase and Rho-associated kinase.
9099669 Identification of protein kinase C
phosphorylation sites on bovine rhodopsin.
9099694 A 180-kDa protein kinase seems to
be responsible for the phosphorylation of
prothymosin alpha observed in proliferating
9099755 Autophosphorylation of activation
loop tyrosines regulates signaling by the TRK
nerve growth factor receptor.
9108473 DFF, a heterodimeric protein that
functions downstream of caspase-3 to trigger
DNA fragmentation during apoptosis.
9109541 The neuronal calcium-sensor protein
VILIP modulates cyclic AMP accumulation in
stably transfected C6 glioma cells:
amino-terminal myristoylation determines
9109552 Phosphorylation and activation of
brain tryptophan hydroxylase: identification of
serine-58 as a substrate site for protein kinase
9109675 Phosphorylation of Alzheimer
beta-amyloid precursor-like proteins.
9111002 Polymorphonuclear cells isolated from
human peripheral blood cleave lipoprotein(a)
and apolipoprotein(a) at multiple interkringle
sites via the enzyme elastase. Generation of
mini-Lp(a) particles and apo(a) fragments.
9111020 Regulation by cAMP of
post-translational processing and subcellular
targeting of endothelial nitric-oxide synthase
(type 3) in cardiac myocytes.
9111058 Target-dependent effect of
phosphorylation on the DNA binding activity of
the TAL1/SCL oncoprotein.
9111318 Activation of Jak2 catalytic activity
requires phosphorylation of Y1007 in the kinase
9113412 T cell signalling through CD73.
9115255 Phosphorylation and O-glycosylation
sites of bovine chromogranin A from adrenal
medullary chromaffin granules and their
relationship with biological activities.
9115440 The crystal structure of an intact
human Max-DNA complex: new insights into
mechanisms of transcriptional control.
9121430 Tyrosine phosphorylation sites at
amino acids 239 and 240 of Shc are involved in
epidermal growth factor-induced mitogenic
signaling that is distinct from
Ras/mitogen-activated protein kinase
9121492 Identification of growth hormone
receptor (GHR) tyrosine residues required for
GHR phosphorylation and JAK2 and STAT5
9122198 Dissecting the thrombopoietin
receptor: functional elements of the Mpl
9126608 Purification, characterization, and in
vitro phosphorylation of the neuron-specific
membrane-associated protein SCG10.
9128250 Regulated membrane localization of
Tiam1, mediated by the NH2-terminal pleckstrin
homology domain, is required for
Rac-dependent membrane ruffling and C-Jun
NH2-terminal kinase activation.
9136927 The TGF-beta family mediator Smad1
is phosphorylated directly and activated
functionally by the BMP receptor kinase.
9139732 Differential phosphorylation of the
retinoblastoma protein by G1/S
9141461 Cdc25 protein phosphatases in cell
9146608 Prostate specific antigen in benign
prostatic hyperplasia: purification and
9148753 Degradation of decorin by matrix
metalloproteinases: identification of the
cleavage sites, kinetic analyses and
transforming growth factor-beta1 release.
9148770 Identification of csk tyrosine
phosphorylation sites and a tyrosine residue
important for kinase domain structure.
9148944 Contraction-induced changes in
acetyl-CoA carboxylase and 5'-AMP-activated
kinase in skeletal muscle.
9153193 Casein kinase II-mediated
phosphorylation of the C terminus of Sp1
decreases its DNA binding activity.
9155017 Mitogen-activated protein kinases
activate the serine/threonine kinases Mnk1 and
9155018 MNK1, a new MAP kinase-activated
protein kinase, isolated by a novel expression
screening method for identifying protein kinase
9155020 D-myo-inositol 1,4,5-trisphosphate
3-kinase A is activated by receptor activation
through a calcium:calmodulin-dependent
protein kinase II phosphorylation mechanism.
9155023 Positive and negative regulation of
type II TGF-beta receptor signal transduction
by autophosphorylation on multiple serine
9158146 alpha-Mannosidosis: functional
cloning of the lysosomal alpha-mannosidase
cDNA and identification of a mutation in two
9162089 SHP1 and SHP2 protein-tyrosine
phosphatases associate with betac after
interleukin-3-induced receptor tyrosine
phosphorylation. Identification of potential
binding sites and substrates.
9162092 Characterization of the
mitogen-activated protein kinase kinase 4
(MKK4)/c-Jun NH2-terminal kinase 1 and
MKK3/p38 pathways regulated by MEK kinases
2 and 3. MEK kinase 3 activates MKK3 but
does not cause activation of p38 kinase in vivo.
9166747 Functional role of amino-terminal
serine16 and serine27 of G alphaZ in receptor
and effector coupling.
9168116 Ataxia telangiectasia mutant protein
activates c-Abl tyrosine kinase in response to
9169414 Characterization of Lnk. An adaptor
protein expressed in lymphocytes.
9169442 Rhodopsin phosphorylation sites and
their role in arrestin binding.
9169454 The type II transforming growth
factor-beta receptor autophosphorylates not
only on serine and threonine but also on
9171348 Translocation of the Csk homologous
kinase (Chk/Hyl) controls activity of
CD36-anchored Lyn tyrosine kinase in
9173929 Presenilin proteins undergo
heterogeneous endoproteolysis between
Thr291 and Ala299 and occur as stable N- and
C-terminal fragments in normal and Alzheimer
9174053 ALK, the chromosome 2 gene locus
altered by the t(2;5) in non-Hodgkin's
lymphoma, encodes a novel neural receptor
tyrosine kinase that is highly related to
leukocyte tyrosine kinase (LTK)
9174342 Structure and assembly of the
catalytic region of human complement protease
C1r: a three-dimensional model based on
chemical cross-linking and homology modeling.
9175863 Interaction of the G-protein G11alpha
with receptors and phosphoinositidase C: the
contribution of G-protein palmitoylation and
9178760 Intracellular signaling of the Ufo/Axl
receptor tyrosine kinase is mediated mainly by
a multi-substrate docking-site.
9178913 Bcr phosphorylated on tyrosine 177
9182531 Regulation of platelet plasma
membrane Ca2+-ATPase by cAMP-dependent
and tyrosine phosphorylation.
9182757 A lipid-anchored Grb2-binding protein
that links FGF-receptor activation to the
Ras/MAPK signaling pathway.
9183006 The in vitro phosphorylation of p53 by
calcium-dependent protein kinase
C--characterization of a
protein-kinase-C-binding site on p53.
9190208 Cyclin D1/Cdk4 regulates
retinoblastoma protein-mediated cell cycle
arrest by site-specific phosphorylation.
9191055 Recognition of activated CSF-1
receptor in breast carcinomas by a tyrosine
723 phosphospecific antibody.
9192730 HSDJ, a human homolog of DnaJ, is
farnesylated and is involved in protein import
9192873 Cyclin E-CDK2 is a regulator of
9195912 Alternative splicing of the high affinity
cAMP-specific phosphodiesterase (PDE7A)
mRNA in human skeletal muscle and heart.
9195949 Tyr624 and Tyr628 in insulin receptor
substrate-2 mediate its association with the
9199329 Mitogen-activated and
cyclin-dependent protein kinases selectively
and differentially modulate transcriptional
enhancement by the glucocorticoid receptor.
9199504 Phosphorylation of
microtubule-associated protein tau by
stress-activated protein kinases.
9201958 Serine-578 is a major phosphorylation
locus in human plasma plasminogen.
9208935 Sequence specificity of C-terminal
Src kinase (CSK)--a comparison with
Src-related kinases c-Fgr and Lyn.
9211903 Stress, apoptosis, and mitosis induce
phosphorylation of human keratin 8 at Ser-73 in
tissues and cultured cells.
9214631 IkappaB alpha is a target for the
mitogen-activated 90 kDa ribosomal S6 kinase.
9218798 Activation of the novel
stress-activated protein kinase SAPK4 by
cytokines and cellular stresses is mediated by
SKK3 (MKK6); comparison of its substrate
specificity with that of other SAP kinases.
9221902 Molecular characterization and
pharmacological properties of the human P2X3
9224808 Palmitoylation of the V2 vasopressin
9232196 Comparison of the hydrolysis of the
three types of natriuretic peptides by human
kidney neutral endopeptidase 24.11.
9233763 Involvement of caspase-4(-like)
protease in Fas-mediated apoptotic pathway.
9233798 Juxtamembrane tyrosine residues
couple the Eph family receptor EphB2/Nuk to
specific SH2 domain proteins in neuronal cells.
9234708 Phosphorylation of Raf-1 serine
338-serine 339 is an essential regulatory event
for Ras-dependent activation and biological
9235942 Phosphorylation by p34cdc2 protein
kinase regulates binding of the kinesin-related
motor HsEg5 to the dynactin subunit p150.
9238677 Cell-to-cell transfer of
membrane proteins during sperm maturation.
9242537 Human neutrophil elastase activates
human factor V but inactivates
thrombin-activated human factor V.
9242710 Phosphorylation and calmodulin
binding of the metabotropic glutamate receptor
subtype 5 (mGluR5) are antagonistic in vitro.
9244383 Serine phosphorylation of syndecan-2
proteoglycan cytoplasmic domain.
9244386 Glycosylation of bile-salt-stimulated
lipase from human milk: comparison of native
and recombinant forms.
9247274 cAMP-dependent regulation of
cardiac L-type Ca2+ channels requires
membrane targeting of PKA and
phosphorylation of channel subunits.
9252332 Caspase-3-mediated cleavage of
protein kinase C theta in induction of apoptosis.
9252406 Association of the multisubstrate
docking protein Gab1 with the hepatocyte
growth factor receptor requires a functional
Grb2 binding site involving tyrosine 1356.
9254654 Src homology 2 protein tyrosine
phosphatase (SHPTP2)/Src homology 2
phosphatase 2 (SHP2) tyrosine phosphatase is
a positive regulator of the interleukin 5 receptor
signal transduction pathways leading to the
prolongation of eosinophil survival.
9257712 Multiple tyrosine residues in the
intracellular domain of the common beta
subunit of the interleukin 5 receptor are involved
in activation of STAT5.
9257865 Selective conversion of big
endothelins to tracheal smooth
muscle-constricting 31-amino acid-length
endothelins by chymase from human mast
9261102 Activation of caspase-2 in apoptosis.
9261109 Activation of type IV procollagenases
by human tumor-associated trypsin-2.
9261115 Src kinase activity is regulated by the
SHP-1 protein-tyrosine phosphatase.
9266968 Ligand-independent activation of
fibroblast growth factor receptor-2 by carboxyl
9268380 Human Myt1 is a cell cycle-regulated
kinase that inhibits Cdc2 but not Cdk2 activity.
9271440 Dual requirement for a newly identified
phosphorylation site in p70s6k.
9271576 A critical role for tapasin in the
assembly and function of multimeric MHC class
9275067 Proteolysis of insulin-like growth
factors (IGF) and IGF binding proteins by
9275097 Cholecystokinin (CCK) levels are
greatly reduced in the brains but not the
duodenums of Cpe(fat)/Cpe(fat) mice: a
regional difference in the involvement of
carboxypeptidase E (Cpe) in pro-CCK
9276160 Characterization of kininogenase
activity of an acidic proteinase isolated from
9278383 Phosphorylation of the PEST domain
of IkappaBbeta regulates the function of
9278461 Proteolytic cleavage of the mdm2
oncoprotein during apoptosis.
9278511 Conservation of the Chk1 checkpoint
pathway in mammals: linkage of DNA damage
to Cdk regulation through Cdc25.
9278512 Mitotic and G2 checkpoint control:
regulation of 14-3-3 protein binding by
phosphorylation of Cdc25C on serine-216.
9287346 Identification of the membrane
receptor binding domain of thyroglobulin.
Insights into quality control of thyroglobulin
9288740 Activation of p53 sequence-specific
DNA binding by acetylation of the p53
9295285 Substrate specificities of three
members of the human
GalNAc-T1, -T2, and -T3.
9295302 Membrane topology of the multidrug
resistance protein (MRP). A study of
glycosylation-site mutants reveals an
extracytosolic NH2 terminus.
9295322 Phosphorylation of four amino acid
residues in the carboxyl terminus of the rat
somatostatin receptor subtype 3 is crucial for
its desensitization and internalization.
9295339 Sites of UV-induced phosphorylation
of the p34 subunit of replication protein A from
9298992 Caspase cleavage of keratin 18 and
reorganization of intermediate filaments during
epithelial cell apoptosis.
9305909 Posttranslational modifications of the
5'-AMP-activated protein kinase beta1 subunit.
9305920 Identification of serine 643 of protein
kinase C-delta as an important
autophosphorylation site for its enzymatic
9310187 The BASP1 family of myristoylated
proteins abundant in axonal termini. Primary
structure analysis and physico-chemical
9312058 Induced N- and C-terminal cleavage
of p53: a core fragment of p53, generated by
interaction with damaged DNA, promotes
cleavage of the N-terminus of full-length p53,
whereas ssDNA induces C-terminal cleavage of
9312100 Agonist-induced desensitization of
the mu opioid receptor is determined by
threonine 394 preceded by acidic amino acids
in the COOH-terminal tail.
9312162 Lck phosphorylates the activation
loop tyrosine of the Itk kinase domain and
activates Itk kinase activity.
9315091 Phosphorylation of the Src substrate
Sam68 by Cdc2 during mitosis.
9315635 Dual mechanisms for the inhibition of
E2F binding to RB by cyclin-dependent
kinase-mediated RB phosphorylation.
9323209 Caspase-3-generated fragment of
gelsolin: effector of morphological change in
9334240 Involvement of caspase-1 and
caspase-3 in the production and processing of
mature human interleukin 18 in monocytic
9335504 Opposing BMP and EGF signalling
pathways converge on the TGF-beta family
9337875 Characterization of iduronate
sulphatase mutants affecting N-glycosylation
sites and the cysteine-84 residue.
9337997 Proteolytic fragments of insulin-like
growth factor binding protein-3: N-terminal
sequences and relationships between structure
and biological activity.
9341152 Biosynthesis, distinct
post-translational modifications, and functional
characterization of lymphoma proprotein
9341188 The prooncoprotein EWS binds
calmodulin and is phosphorylated by protein
kinase C through an IQ domain.
9343410 O glycosylation of an Sp1-derived
peptide blocks known Sp1 protein interactions.
9343414 STAT3 serine phosphorylation by
ERK-dependent and -independent pathways
negatively modulates its tyrosine
9344465 Interaction of matrix
metalloproteinases-2 and -9 with pregnancy
zone protein and alpha2-macroglobulin.
9346908 TbetaRI phosphorylation of Smad2 on
Ser465 and Ser467 is required for
Smad2-Smad4 complex formation and
9349507 p53 is phosphorylated in vitro and in
vivo by the delta and epsilon isoforms of casein
kinase 1 and enhances the level of casein
kinase 1 delta in response to
9349529 Characterization of the palmitoylation
domain of SNAP-25.
9351815 Regulation of stability and function of
the epithelial Na+ channel (ENaC) by
9351817 The large subunit of replication factor
C is a substrate for caspase-3 in vitro and is
cleaved by a caspase-3-like protease during
9351825 Cross-cascade activation of ERKs
and ternary complex factors by Rho family
9353289 Phosphorylation by neuronal cdc2-like
protein kinase promotes dimerization of Tau
protein in vitro.
9353319 Characterization of NEDD8, a
developmentally down-regulated ubiquitin-like
9353340 Characterization of the
phosphorylation sites involved in G
protein-coupled receptor kinase- and protein
kinase C-mediated desensitization of the
9355737 Stat1 associates with c-kit and is
activated in response to stem cell factor.
9355745 Protein tyrosine phosphatase 1B
interacts with and is tyrosine phosphorylated by
the epidermal growth factor receptor.
9360944 Angiostatin-converting enzyme
activities of human matrilysin (MMP-7) and
gelatinase B/type IV collagenase (MMP-9).
9360956 14-3-3 is phosphorylated by casein
kinase I on residue 233. Phosphorylation at this
site in vivo regulates Raf/14-3-3 interaction.
9360968 Butylated hydroxyanisole and its
metabolite tert-butylhydroquinone differentially
regulate mitogen-activated protein kinases. The
role of oxidative stress in the activation of
mitogen-activated protein kinases by phenolic
9360983 Tyrosine phosphorylation of
Crk-associated substrates by focal adhesion
kinase. A putative mechanism for the
integrin-mediated tyrosine phosphorylation of
9361003 Dentatorubral pallidoluysian atrophy
(DRPLA) protein is cleaved by caspase-3 during
9363897 Tyrosine phosphorylation of the EGF
receptor by the kinase Jak2 is induced by
9365923 The unusual amino acid triplet
Asn-Ile-Cys is a glycosylation consensus site in
9366517 Inhibition of the DNA-binding and
transcriptional repression activity of the Wilms'
tumor gene product, WT1, by
cAMP-dependent protein kinase-mediated
phosphorylation of Ser-365 and Ser-393 in the
zinc finger domain.
9368003 Specific proteolysis of the kinase
protein kinase C-related kinase 2 by caspase-3
during apoptosis. Identification by a novel, small
pool expression cloning strategy.
9368023 Serpin-derived peptide substrates for
investigating the substrate specificity of human
tissue kallikreins hK1 and hK2.
protein kinase-1 (PDK1): structural and
functional homology with the Drosophila
9369230 Disturbed progastrin processing in
carboxypeptidase E-deficient fat mice.
9371782 The phosphorylation state of the
FIGQY tyrosine of neurofascin determines
ankyrin-binding activity and patterns of cell
9374467 Nuclear accumulation of NFAT4
opposed by the JNK signal transduction
9374536 Expression, purification, and
regulation of two isoforms of the inositol
9374542 Mitogenic activation, phosphorylation,
and nuclear translocation of protein kinase
9380693 Transforming growth factor
beta-induced phosphorylation of Smad3 is
required for growth inhibition and transcriptional
induction in epithelial cells.
9381178 Interleukin-3-induced phosphorylation
of BAD through the protein kinase Akt.
9384584 BMK1/ERK5 regulates
serum-induced early gene expression through
transcription factor MEF2C.
9388255 Clathrin-mediated endocytosis of the
beta-adrenergic receptor is regulated by
9388490 Tyrosine residues 239 and 240 of Shc
sites by c-Src.
9389649 Mediation of NGF signaling by
post-translational inhibition of HES-1, a basic
helix-loop-helix repressor of neuronal
9391116 Distinct tyrosine phosphorylation sites
in JAK3 kinase domain positively and negatively
regulate its enzymatic activity.
9395403 Conversion of Bcl-2 to a Bax-like
death effector by caspases.
9395448 Characterization of substrate
phosphorylation and use of calmodulin mutants
to address implications from the enzyme crystal
structure of calmodulin-dependent protein
9395533 Regulation of leukotriene A4
hydrolase activity in endothelial cells by
9398320 MAP4 is the in vivo substrate for
CDC2 kinase in HeLa cells: identification of an
M-phase specific and a cell cycle-independent
phosphorylation site in MAP4.
9405425 Separate domains of the human fas
ligand dictate self-association and receptor
9405468 The mammalian target of rapamycin
phosphorylates sites having a (Ser/Thr)-Pro
motif and is activated by antibodies to a region
near its COOH terminus.
9405642 Phosphorylation of the
immunosuppressant FK506-binding protein
FKBP52 by casein kinase II: regulation of
HSP90-binding activity of FKBP52.
9407077 Properties and phosphorylation sites
of baculovirus-expressed nuclear inhibitor of
protein phosphatase-1 (NIPP-1).
9407116 The Src family kinase Hck interacts
with Bcr-Abl by a kinase-independent
mechanism and phosphorylates the
Grb2-binding site of Bcr.
9417067 Identification of novel phosphorylation
sites in hormone-sensitive lipase that are
phosphorylated in response to isoproterenol
and govern activation properties in vitro.
9418861 Myotonic dystrophy kinase-related
Cdc42-binding kinase acts as a Cdc42 effector
in promoting cytoskeletal reorganization.
9418908 Pex19p, a farnesylated protein
essential for peroxisome biogenesis.
9422780 Processing and activation of
pro-interleukin-16 by caspase-3.
9425062 Posttranslational modifications of
human inter-alpha-inhibitor: identification of
glycans and disulfide bridges in heavy chains 1
9425276 PDGF-induced phosphorylation of
Tyr28 in the N-terminus of Fyn affects Fyn
protein kinase 1 (PDK1) phosphorylates and
activates the p70 S6 kinase in vivo and in vitro.
9428684 Human amyloid precursor-like protein
1--cDNA cloning, ectopic expression in COS-7
cells and identification of soluble forms in the
9430688 Identification of regulatory
phosphorylation sites in mitogen-activated
protein kinase (MAPK)-activated protein
kinase-1a/p90rsk that are inducible by MAPK.
9433921 The role of N-terminal glycosylation in
the human oxytocin receptor.
9435230 Modulation of cell death by Bcl-XL
through caspase interaction.
9444958 Gab1 coupling to the HGF/Met
receptor multifunctional docking site requires
binding of Grb2 and correlates with the
9446569 Activation of P2Y2 receptors by UTP
and ATP stimulates mitogen-activated kinase
activity through a pathway that involves related
adhesion focal tyrosine kinase and protein
9446654 The p85 and p110 subunits of
phosphatidylinositol 3-kinase-alpha are
substrates, in vitro, for a constitutively
associated protein tyrosine kinase in platelets.
9450956 Recognition signal for
C-mannosylation of Trp-7 in RNase 2 consists
of sequence Trp-x-x-Trp.
9452388 Autophosphorylation at Thr286 of the
alpha calcium-calmodulin kinase II in LTP and
9453548 Peripherin is tyrosine-phosphorylated
at its carboxyl-terminal tyrosine.
9456324 Rho-kinase phosphorylates
COOH-terminal threonines of
ezrin/radixin/moesin (ERM) proteins and
regulates their head-to-tail association.
9461559 Regulation of Rad51 function by c-Abl
in response to DNA damage.
9461588 Modification of phosphatidylinositol
3-kinase SH2 domain binding properties by
Abl- or Lck-mediated tyrosine phosphorylation
9463386 Direct triggering of the type I
interferon system by virus infection: activation
of a transcription factor complex containing
IRF-3 and CBP/p300.
9465032 RAFT1 phosphorylation of the
translational regulators p70 S6 kinase and
9465305 Sequence characterization of a newly
identified human alpha-tubulin gene (TUBA2).
9467953 Requirement of two specific tyrosine
residues for the catalytic activity of Bcr
9468292 Regulation of eukaryotic initiation
factor eIF2B: glycogen synthase kinase-3
phosphorylates a conserved serine which
undergoes dephosphorylation in response to
9468497 Identification of the phosphorylation
sites of cytosolic phospholipase A2 in
agonist-stimulated human platelets and HeLa
9468501 Autocatalytic processing of
recombinant human procathepsin L.
Contribution of both intermolecular and
unimolecular events in the processing of
procathepsin L in vitro.
9468536 Transgenic approaches to define the
functional role of dual site phospholamban
9473672 cDNA cloning of a novel trypsin
inhibitor with similarity to pathogenesis-related
proteins, and its frequent expression in human
brain cancer cells.
9480911 Interaction in vitro of the product of
the c-Crk-II proto-oncogene with the insulin-like
growth factor I receptor.
9484232 Peroxynitrite-mediated inactivation of
manganese superoxide dismutase involves
nitration and oxidation of critical tyrosine
9485375 Human mast cell tryptase
fibrinogenolysis: kinetics, anticoagulation
mechanism, and cell adhesion disruption.
9485474 Galpha12 requires acylation for its
9488723 DNA double-stranded breaks induce
histone H2AX phosphorylation on serine 139.
9490415 Immunoreceptor DAP12 bearing a
tyrosine-based activation motif is involved in
activating NK cells.
9491897 Orexins and orexin receptors: a family
of hypothalamic neuropeptides and G
protein-coupled receptors that regulate feeding
9507031 p125Fak focal adhesion kinase is a
substrate for the insulin and insulin-like growth
factor-I tyrosine kinase receptors.
9512493 Activation of protein kinase B beta
and gamma isoforms by insulin in vivo and by
3-phosphoinositide-dependent protein kinase-1
in vitro: comparison with protein kinase B alpha.
9516414 Amino-terminal truncation of
chemokines by CD26/dipeptidyl-peptidase IV.
Conversion of RANTES into a potent inhibitor of
monocyte chemotaxis and HIV-1-infection.
9516463 Protein kinase C-theta
phosphorylation of moesin in the actin-binding
9516479 Analysis of Grb7 recruitment by
heregulin-activated erbB receptors reveals a
novel target selectivity for erbB3.
9520446 NF-kappaB-inducing kinase activates
IKK-alpha by phosphorylation of Ser-176.
9520483 Mechanism of nicotinic acetylcholine
receptor cluster formation by rapsyn.
9524113 Phosphorylation of human keratin 18
serine 33 regulates binding to 14-3-3 proteins.
9525956 Identification of in vitro
phosphorylation sites in the growth cone
protein SCG10. Effect Of phosphorylation site
mutants on microtubule-destabilizing activity.
9525959 Identification and partial
characterization of factor Va heavy chain kinase
from human platelets.
9528769 pp90rsk1 regulates estrogen
receptor-mediated transcription through
phosphorylation of Ser-167.
9528781 SHP-1 binds and negatively
modulates the c-Kit receptor by interaction with
tyrosine 569 in the c-Kit juxtamembrane
9528799 Autophosphorylation in the activation
loop is required for full kinase activity in vivo of
human and yeast eukaryotic initiation factor
2alpha kinases PKR and GCN2.
9528953 Insulin-like growth factor-binding
protein-5 is cleaved by physiological
concentrations of thrombin.
9531288 Asymmetrical phosphorylation and
function of immunoreceptor tyrosine-based
activation motif tyrosines in B cell antigen
receptor signal transduction.
9535738 Mutations which abolish
phosphorylation of the TRAF-binding domain of
TNF receptor 2 enhance receptor-mediated
NF-kappa B activation.
9535845 Physical and functional interactions
between receptor-like protein-tyrosine
phosphatase alpha and p59fyn.
9535905 Identification of a domain on the
beta-subunit of the rod cGMP-gated cation
channel that mediates inhibition by
9535906 Caspase cleavage of gene products
associated with triplet expansion disorders
generates truncated fragments containing the
9535909 Regulation of connexin-43 gap
junctional intercellular communication by
mitogen-activated protein kinase.
9538022 Structure/function analyses of
recombinant variants of human factor Xa: factor
Xa incorporation into prothrombinase on the
thrombin-activated platelet surface is not
mimicked by synthetic phospholipid vesicles.
9543386 C-TAK1 protein kinase
phosphorylates human Cdc25C on serine 216
and promotes 14-3-3 protein binding.
9544990 N-glycosylation of the prolactin
receptor is not required for activation of gene
transcription but is crucial for its cell surface
9545236 Caspase-mediated activation and
induction of apoptosis by the mammalian
Ste20-like kinase Mst1.
9545332 A role for the insulin-interleukin (IL)-4
receptor motif of the IL-4 receptor alpha-chain
in regulating activation of the insulin receptor
substrate 2 and signal transducer and activator
of transcription 6 pathways. Analysis by
9546424 Identification of Tyr-762 in the
platelet-derived growth factor alpha-receptor
as the binding site for Crk proteins.
9546672 Sequential phosphorylation of Tau by
glycogen synthase kinase-3beta and protein
kinase A at Thr212 and Ser214 generates the
Alzheimer-specific epitope of antibody AT100
and requires a paired-helical-filament-like
9548733 Generation of an angiostatin-like
fragment from plasminogen by stromelysin-1
9548757 Cross-class inhibition of the cysteine
proteinases cathepsins K, L, and S by the
serpin squamous cell carcinoma antigen 1: a
9556568 Regulation of syndecan-4
phosphorylation in vivo.
9558113 Posttranslational modifications affect
the activity of the human monocyte
chemotactic proteins MCP-1 and MCP-2:
identification of MCP-2(6-76) as a natural
9560226 Activation of protein tyrosine kinase
PYK2 by the m1 muscarinic acetylcholine
9565595 Phosphorylation of vimentin by
Rho-associated kinase at a unique
amino-terminal site that is specifically
phosphorylated during cytokinesis.
9565682 Characterization of tau
phosphorylation in glycogen synthase
kinase-3beta and cyclin dependent kinase-5
activator (p23) transfected cells.
9566874 Stat3 activation by Src induces
specific gene regulation and is required for cell
9566916 Protein tyrosine phosphatase 1B
antagonizes signalling by oncoprotein tyrosine
kinase p210 bcr-abl in vivo.
9566918 Virus-dependent phosphorylation of
the IRF-3 transcription factor regulates nuclear
translocation, transactivation potential, and
9571186 Regulation of the p53 protein by
protein kinase C alpha and protein kinase C
9572267 Palmitoylation of neurofascin at a site
in the membrane-spanning domain highly
conserved among the L1 family of cell adhesion
9572875 Identification of O-glycosylation sites
and partial characterization of carbohydrate
structure and disulfide linkages of human
insulin-like growth factor binding protein 6.
9576847 Molecular cloning, expression and
catalytic activity of a human AKR7 member of
the aldo-keto reductase superfamily: evidence
that the major 2-carboxybenzaldehyde
reductase from human liver is a homologue of
rat aflatoxin B1-aldehyde reductase.
9576926 Plasma membrane localization is
required for RGS4 function in Saccharomyces
9578462 Activation of the precursor of human
stromelysin 2 and its interactions with other
9578468 Delayed production of biologically
active O-glycosylated forms of human eotaxin
9580567 Hyaluronan-dependent cell migration
can be blocked by a CD44 cytoplasmic domain
peptide containing a phosphoserine at position
9584194 Cell cycle-regulated processing of
HEF1 to multiple protein forms differentially
targeted to multiple subcellular compartments.
9585407 Nuclear localization of cyclin B1
controls mitotic entry after DNA damage.
9586635 Granzyme B directly and efficiently
cleaves several downstream caspase
substrates: implications for CTL-induced
9592082 Mitogen-activated protein kinases
(Erk1,2) phosphorylate Lys-Ser-Pro (KSP)
repeats in neurofilament proteins NF-H and
9593687 Caspase-mediated cleavage of the
ubiquitin-protein ligase Nedd4 during apoptosis.
9600099 Multiple phosphorylation of chicken
protein tyrosine phosphatase 1 and human
protein tyrosine phosphatase 1B by casein
kinase II and p60c-src in vitro.
9607320 Proteolytic cleavage of HsRad51
9614189 The endogenous and cell
cycle-dependent phosphorylation of tau protein
in living cells: implications for Alzheimer's
9618465 Cloning and characterization of
human protease-activated receptor 4.
9620884 Human alpha-galactosidase A:
glycosylation site 3 is essential for enzyme
9624142 Identification and characterization of
the major phosphorylation sites of the B-type
natriuretic peptide receptor.
9626554 Prolactin (PRL) and its receptor:
actions, signal transduction pathways and
phenotypes observed in PRL receptor knockout
9628863 Mapping the interaction between
GRASP65 and GM130, components of a
protein complex involved in the stacking of
9628874 PRAK, a novel protein kinase
regulated by the p38 MAP kinase.
9630228 Intramolecular masking of nuclear
import signal on NF-AT4 by casein kinase I and
9632142 Complex formation between EphB2
and Src requires phosphorylation of tyrosine
611 in the EphB2 juxtamembrane region.
9632781 Binding of Shp2 tyrosine phosphatase
to FRS2 is essential for fibroblast growth
factor-induced PC12 cell differentiation.
9632797 Tyrosine 1101 of Tie2 is the major
site of association of p85 and is required for
activation of phosphatidylinositol 3-kinase and
9637505 HLA-G isoforms produced by
placental cytotrophoblasts and found in
amniotic fluid are due to unusual glycosylation.
9642263 Human ADAM 12 (meltrin alpha) is an
9642276 Caspases cleave focal adhesion
kinase during apoptosis to generate a
9642287 Phosphorylation of CrkII adaptor
protein at tyrosine 221 by epidermal growth
9642293 Conserved in vivo phosphorylation of
calnexin at casein kinase II sites as well as a
protein kinase C/proline-directed kinase site.
9651578 Autoactivation of procaspase-9 by
9651683 The kit receptor promotes cell survival
via activation of PI 3-kinase and subsequent
Akt-mediated phosphorylation of Bad on
9655255 Formation of a stable src-AFAP-110
complex through either an amino-terminal or a
carboxy-terminal SH2-binding motif.
9655398 Cofilin phosphorylation by LIM-kinase
1 and its role in Rac-mediated actin
9658162 Tyrosine phosphorylation of selected
secretory carrier membrane proteins, SCAMP1
and SCAMP3, and association with the EGF
9659899 The discoidin domain receptor
tyrosine kinases are activated by collagen.
9659901 Differential roles of p300 and PCAF
acetyltransferases in muscle differentiation.
9660939 Cleavage of p21Cip1/Waf1 and
p27Kip1 mediates apoptosis in endothelial cells
through activation of Cdk2: role of a caspase
9660947 Selective inhibition of NFAT activation
by a peptide spanning the calcineurin targeting
site of NFAT.
9670964 Regulation of apoptosis by
tyrosine-containing domains of IL-4R alpha:
Y497 and Y713, but not the STAT6-docking
tyrosines, signal protection from apoptosis.
9671712 A cloning method for caspase
substrates that uses the yeast two-hybrid
system: cloning of the antiapoptotic gene
9674711 Tyrosine-614, the major
autophosphorylation site of the receptor
tyrosine kinase HEK2, functions as
multi-docking site for SH2-domain mediated
9677202 Fidelity of T cell activation through
multistep T cell receptor zeta phosphorylation.
9677319 Effects of phosphorylation on function
of the Rad GTPase.
9677337 Glycosylation pattern of human
inter-alpha-inhibitor heavy chains.
9677359 Cytoplasmic domains of the human
factor (GM-CSF) receptor beta chain (hbetac)
responsible for human GM-CSF-induced
myeloid cell differentiation.
9677371 Identification of amino acid residues
critical for the Src-homology 2
domain-dependent docking of Stat2 to the
interferon alpha receptor.
9679146 Adducin is an in vivo substrate for
protein kinase C: phosphorylation in the
MARCKS-related domain inhibits activity in
promoting spectrin-actin complexes and
occurs in many cells, including dendritic spines
9685404 Tyrosine 474 of ZAP-70 is required
for association with the Shc adaptor and for
T-cell antigen receptor-dependent gene
9685505 Casein kinase II interacts with the
bZIP domains of several transcription factors.
9687510 Mitogen- and stress-activated protein
kinase-1 (MSK1) is directly activated by MAPK
and SAPK2/p38, and may mediate activation of
9689060 Autoregulation of the Raf-1
9689078 MEKK1 activates both IkappaB
kinase alpha and IkappaB kinase beta.
9694850 Mutation of a Shc binding site
tyrosine residue in ErbB3/HER3 blocks
heregulin-dependent activation of
mitogen-activated protein kinase.
9694881 Role of N-glycosylation in human
9694885 Cytotoxic T lymphocyte-assisted
suicide. Caspase 3 activation is primarily the
result of the direct action of granzyme B.
9694886 Protein kinase C phosphorylation of
threonine at position 888 in Ca2+o-sensing
receptor (CaR) inhibits coupling to Ca2+ store
9697832 FRIP, a hematopoietic cell-specific
rasGAP-interacting protein phosphorylated in
response to cytokine stimulation.
9705209 Caspase-mediated fragmentation of
calpain inhibitor protein calpastatin during
9705322 A novel sphingosine-dependent
protein kinase (SDK1) specifically
phosphorylates certain isoforms of 14-3-3
9705354 Tyrosine phosphorylation of c-ErbB-2
is regulated by the cellular form of prostatic
acid phosphatase in human prostate cancer
9710204 Roles of Lck, Syk and ZAP-70
tyrosine kinases in TCR-mediated
phosphorylation of the adapter protein Shc.
9710583 Phosphorylation of nuclear MyoD is
required for its rapid degradation.
9710607 14-3-3 proteins are required for
maintenance of Raf-1 phosphorylation and
9716136 Protein kinase C regulates the nuclear
localization of diacylglycerol kinase-zeta.
9719562 Rab11a is modified in vivo by
9721103 Direct phosphorylation of IkappaB by
IKKalpha and IKKbeta: discrimination between
free and NF-kappaB-bound substrate.
9721757 Endothelin induces a
calcium-dependent phosphorylation of PEA-15
in intact astrocytes: identification of Ser104 and
Ser116 phosphorylated, respectively, by protein
kinase C and calcium/calmodulin kinase II in
9722526 Regulation of erythroid Krüppel-like
factor (EKLF) transcriptional activity by
phosphorylation of a protein kinase casein
kinase II site within its interaction domain.
9722557 Phosphorylation of the prostacyclin
receptor during homologous desensitization. A
critical role for protein kinase c.
9727491 Bid, a Bcl2 interacting protein,
mediates cytochrome c release from
mitochondria in response to activation of cell
surface death receptors.
9729044 LAT palmitoylation: its essential role in
membrane microdomain targeting and tyrosine
phosphorylation during T cell activation.
9733650 A model of Cdc25 phosphatase
catalytic domain and Cdk-interaction surface
based on the presence of a rhodanese
9733784 Phosphorylation of vitronectin by
casein kinase II. Identification of the sites and
their promotion of cell adhesion and spreading.
9733788 Phosphotyrosine 1173 mediates
binding of the protein-tyrosine phosphatase
SHP-1 to the epidermal growth factor receptor
and attenuation of receptor signaling.
9734360 SUMO-1 modification of
IkappaBalpha inhibits NF-kappaB activation.
9735171 Phosphorylation of tau at both Thr
231 and Ser 262 is required for maximal
inhibition of its binding to microtubules.
kinase-dependent regulation of glycogen
synthase kinase 3 and protein kinase B/AKT by
the integrin-linked kinase.
9738012 A functional role for mitochondrial
protein kinase Calpha in Bcl2 phosphorylation
and suppression of apoptosis.
9738469 Biosynthetic processing and
quaternary interactions of proprotein
convertase SPC4 (PACE4).
9741627 A requirement for caveolin-1 and
associated kinase Fyn in integrin signaling and
anchorage-dependent cell growth.
9742107 Molecular determinants of
NF-kappaB-inducing kinase action.
9742969 Tyrosine phosphorylation of the
Wiskott-Aldrich syndrome protein by Lyn and
Btk is regulated by CDC42.
9744860 DNA damage activates p53 through a
9744883 Active MAP kinase in mitosis:
localization at kinetochores and association
with the motor protein CENP-E.
9748166 Protein kinase C isotypes controlled
by phosphoinositide 3-kinase through the
protein kinase PDK1.
9748228 Specific activation of Smad1 signaling
pathways by the BMP7 type I receptor, ALK2.
9748248 The role of tyrosine phosphorylation
of cortactin in the locomotion of endothelial
9748270 Two forms of collagen XVII in
keratinocytes. A full-length transmembrane
protein and a soluble ectodomain.
9751498 A protease-resistant form of
insulin-like growth factor (IGF) binding protein 4
inhibits IGF-1 actions.
9751706 Proteolytic activation of PKN by
caspase-3 or related protease during
9756909 Identification of three major
sentrinization sites in PML.
9756938 The COOH-terminal tyrosine
phosphorylation sites on IRS-1 bind SHP-2 and
negatively regulate insulin signaling.
9757569 Effects of glycosylation of the residue
at position 14 in ovine angiotensinogen on the
human renin reaction.
9764820 The Tek/Tie2 receptor signals through
a novel Dok-related docking protein, Dok-R.
9765199 The complexity of p53 modulation:
emerging patterns from divergent signals.
9766811 Native thrombopoietin: structure and
9768757 The structure of HLA-DM, the peptide
exchange catalyst that loads antigen onto class
II MHC molecules during antigen presentation.
9768837 Phosphorylation and inhibition of
olfactory adenylyl cyclase by CaM kinase II in
Neurons: a mechanism for attenuation of
9771888 Tau is phosphorylated by GSK-3 at
several sites found in Alzheimer disease and its
biological activity markedly inhibited only after it
is prephosphorylated by A-kinase.
9774477 Association of GAP-43 with
detergent-resistant membranes requires two
palmitoylated cysteine residues.
9774483 Differential and cooperative
polysialylation of the neural cell adhesion
molecule by two polysialyltransferases, PST
9784398 Gustin from human parotid saliva is
carbonic anhydrase VI.
9786864 Human leptin receptor. Determination
of disulfide structure and N-glycosylation sites
of the extracellular domain.
9786869 Cleavage and activation of
p21-activated protein kinase gamma-PAK by
CPP32 (caspase 3). Effects of
autophosphorylation on activity.
9789013 Identification of two distinct human
SMC protein complexes involved in mitotic
9790917 The Src-like tyrosine kinase Hck is
activated by granulocyte colony-stimulating
factor (G-CSF) and docks to the activated
9792637 Purification and cloning of PZR, a
binding protein and putative physiological
substrate of tyrosine phosphatase SHP-2.
9792645 Tumor necrosis factor-alpha
activation of nuclear transcription
factor-kappaB in marrow macrophages is
mediated by c-Src tyrosine phosphorylation of
9794236 Autophosphorylation of Src and Yes
blocks their inactivation by Csk
9797370 Modulation of the cleavage of the
gastrin precursor by prohormone
9798950 Brain beta-spectrin phosphorylation:
phosphate analysis and identification of
threonine-347 as a heparin-sensitive protein
kinase phosphorylation site.
9798985 Platelet glycoprotein Ia* is the
processed form of multimerin--isolation and
determination of N-terminal sequences of
stored and released forms.
9799125 Caspase 3 specifically cleaves
p21WAF1/CIP1 in the earlier stage of apoptosis
in SK-HEP-1 human hepatoma cells.
9799234 Kit signaling through PI 3-kinase and
Src kinase pathways: an essential role for Rac1
and JNK activation in mast cell proliferation.
9804419 Structural basis for activation of the
titin kinase domain during myofibrillogenesis.
9804763 p40(phox) is phosphorylated on
threonine 154 and serine 315 during activation
of the phagocyte NADPH oxidase. Implication
of a protein kinase c-type kinase in the
9804779 Differential control of the
phosphorylation state of proline-juxtaposed
serine residues Ser725 of Stat5a and Ser730 of
Stat5b in prolactin-sensitive cells.
9804834 Casein kinase II catalyzes a mitotic
phosphorylation on threonine 1342 of human
DNA topoisomerase IIalpha, which is
recognized by the 3F3/2 phosphoepitope
9806882 Insulin-stimulated kinase from rat fat
cells that phosphorylates initiation factor
4E-binding protein 1 on the
rapamycin-insensitive site (serine-111).
9812896 Regulation of cell death protease
caspase-9 by phosphorylation.
9813138 Resting lymphocyte kinase (Rlk/Txk)
phosphorylates the YVKM motif and regulates
PI 3-kinase binding to T-cell antigen CTLA-4.
protein kinase II controls integrin
alpha5beta1-mediated cell adhesion through
the integrin cytoplasmic domain associated
9819383 Nucleophosmin-anaplastic lymphoma
kinase of large-cell anaplastic lymphoma is a
constitutively active tyrosine kinase that utilizes
phospholipase C-gamma to mediate its
9819408 Interaction of glycogen synthase
kinase 3beta with the DF3/MUC1
carcinoma-associated antigen and
9819420 Coordinate regulation of IkappaB
kinases by mitogen-activated protein kinase
kinase kinase 1 and NF-kappaB-inducing
9819435 Identification and characterization of
pancreatic eukaryotic initiation factor 2
alpha-subunit kinase, PEK, involved in
9820500 Syk- and Lyn-dependent
phosphorylation of Syk on multiple tyrosines
following B cell activation includes a site that
negatively regulates signaling.
9820826 Human carbon catabolite repressor
protein (CCR4)-associative factor 1: cloning,
expression and characterization of its
interaction with the B-cell translocation protein
9822657 Components of a
calmodulin-dependent protein kinase cascade.
Molecular cloning, functional characterization
and cellular localization of
Ca2+/calmodulin-dependent protein kinase
9823899 The protein kinase Pak3 positively
regulates Raf-1 activity through phosphorylation
of serine 338.
9827566 NADH:ubiquinone oxidoreductase
from bovine heart mitochondria: sequence of a
novel 17.2-kDa subunit.
9829964 CREB is a regulatory target for the
protein kinase Akt/PKB.
9832145 New phosphorylation sites identified
in hyperphosphorylated tau (paired helical
filament-tau) from Alzheimer's disease brain
using nanoelectrospray mass spectrometry.
9832503 Glycogen synthase kinase-3beta
regulates cyclin D1 proteolysis and subcellular
9832630 Human erythrocyte
bisphosphoglycerate mutase: inactivation by
glycation in vivo and in vitro.
9837919 Role of asparagine-linked
oligosaccharides in protein folding, membrane
targeting, and thyrotropin and autoantibody
binding of the human thyrotropin receptor.
9837922 Regulation of TFII-I activity by
9840932 The cell-cycle regulated transcription
factor B-Myb is phosphorylated by cyclin
A/Cdk2 at sites that enhance its transactivation
9840943 Cyclin E2, a novel human G1 cyclin
and activating partner of CDK2 and CDK3, is
induced by viral oncoproteins.
9843217 ATM associates with and
phosphorylates p53: mapping the region of
9852066 Phosphorylation and O-glycosylation
sites of human chromogranin A (CGA79-439)
from urine of patients with carcinoid tumors.
9852126 Identification of the sites of N-linked
glycosylation on the human calcium receptor
and assessment of their role in cell surface
expression and signal transduction.
9853757 Functional interaction between InsP3
receptors and store-operated Htrp3 channels.
9856983 Phosphorylation of moesin by
rho-associated kinase (Rho-kinase) plays a
crucial role in the formation of microvilli-like
9857012 Characterization of human
glycogenin-2, a self-glucosylating initiator of
liver glycogen metabolism.
9857068 Cbl-mediated negative regulation of
the Syk tyrosine kinase. A critical role for Cbl
phosphotyrosine-binding domain binding to Syk
9858547 Identification of constitutive and
ras-inducible phosphorylation sites of KSR:
implications for 14-3-3 binding,
mitogen-activated protein kinase binding, and
9858576 Identification of the in vivo casein
kinase II phosphorylation site within the
homeodomain of the cardiac tisue-specifying
homeobox gene product Csx/Nkx2.5.
9867809 Effect of phosphorylation on activities
of Rap1A to interact with Raf-1 and to
suppress Ras-dependent Raf-1 activation.
9867848 The carboxyl-terminal region of biliary
glycoprotein controls its tyrosine
phosphorylation and association with
protein-tyrosine phosphatases SHP-1 and
SHP-2 in epithelial cells.
9872331 Repression of Stat3 activity by
activation of mitogen-activated protein kinase
9878069 Human eukaryotic translation initiation
factor 4G (eIF4G) recruits mnk1 to
9880482 Src-mediated tyrosine
phosphorylation of dynamin is required for
beta2-adrenergic receptor internalization and
mitogen-activated protein kinase signaling.
9883900 Isolation and characterization of
circulating 13-kDa C-terminal fragments of
human insulin-like growth factor binding
9884403 Glycosylation sites and site-specific
glycosylation in human Tamm-Horsfall
9885575 PRC1: a human mitotic
spindle-associated CDK substrate protein
required for cytokinesis.
9886053 Molecular cloning and regional
distribution of a human proton receptor subunit
with biphasic functional properties.
9889196 Phosphorylation of mammalian CDC6
by cyclin A/CDK2 regulates its subcellular
9889198 Regulation of IL-4 expression by the
transcription factor JunB during T helper cell
9890970 Fyn associates with Cbl and
phosphorylates tyrosine 731 in Cbl, a binding
site for phosphatidylinositol 3-kinase.
9891054 p53 sites acetylated in vitro by PCAF
and p300 are acetylated in vivo in response to
9891755 Recent advances in protein
methylation: enzymatic methylation of nucleic
acid binding proteins.
9892009 Roles of pathway-specific and
inhibitory Smads in activin receptor signaling.
9920899 Metalloprotease-disintegrin MDC9:
intracellular maturation and catalytic activity.
9928950 Prorenin processing by cathepsin B in
vitro and in transfected cells.
9930733 Differential phosphorylation of
syntaxin and synaptosome-associated protein
of 25 kDa (SNAP-25) isoforms.
9933589 Truncation of macrophage-derived
chemokine by CD26/ dipeptidyl-peptidase IV
beyond its predicted cleavage site affects
chemotactic activity and CC chemokine
receptor 4 interaction.
9933635 Caspase-mediated cleavage of DNA
topoisomerase I at unconventional sites during
9973379 Regulation of cytotoxic T
lymphocyte-associated molecule-4 by Src
9973453 Cutting edge: the CD45 tyrosine
phosphatase is an inhibitor of Lck activity in
9988270 Activating SRC mutation in a subset
of advanced human colon cancers.
9990022 Mammalian subtilisin/kexin isozyme
SKI-1: A widely expressed proprotein
convertase with a unique cleavage specificity
and cellular localization.
9990288 Ribonucleotide reductase R2 protein
is phosphorylated at serine-20 by P34cdc2
10022118 Caspase-mediated cleavage of
p21Waf1/Cip1 converts cancer cells from
growth arrest to undergoing apoptosis.
10022904 Activation of IkappaB kinase beta by
protein kinase C isoforms.
10023679 Phosphorylation of the DNA repair
protein APE/REF-1 by CKII affects redox
regulation of AP-1.
10026263 Factor VIIa/tissue factor generates a
form of factor V with unchanged specific
activity, resistance to activation by thrombin,
and increased sensitivity to activated protein C.
10029531 Human cathepsin V functional
expression, tissue distribution, electrostatic
surface potential, enzymatic characterization,
and chromosomal localization.
10037717 Tyrosine 319, a newly identified
phosphorylation site of ZAP-70, plays a critical
role in T cell antigen receptor signaling.
10037747 Cellular localization and role of
prohormone convertases in the processing of
pro-melanin concentrating hormone in
10037773 Intracellular proteolytic processing of
the heavy chain of rat pre-alpha-inhibitor. The
COOH-terminal propeptide is required for
coupling to bikunin.
10049997 The glutamate receptor ion
10066732 Nitric oxide inhibits caspase-3 by
S-nitrosation in vivo.
10066782 Disulfide bond structure and
N-glycosylation sites of the extracellular domain
of the human interleukin-6 receptor.
10067969 Modifications to rat lens major
intrinsic protein in selenite-induced cataract.
10068651 Gab-family adapter proteins act
downstream of cytokine and growth factor
receptors and T- and B-cell antigen receptors.
10068673 Involvement of wiskott-aldrich
syndrome protein in B-cell cytoplasmic tyrosine
10069390 Identification of caspases that
cleave presenilin-1 and presenilin-2. Five
presenilin-1 (PS1) mutations do not alter the
sensitivity of PS1 to caspases.
10069512 Muscarinic cholinergic signaling in
cardiac myocytes: dynamic targeting of
M2AChR to sarcolemmal caveolae and eNOS
10069803 The multisubstrate docking site of
the MET receptor is dispensable for
MET-mediated RAS signaling and cell
10072438 Two novel genes in the center of the
11p15 imprinted domain escape genomic
10072540 Mutations of the type A domain of
complement factor B that promote high-affinity
10075701 Multisite autophosphorylation of
p21-activated protein kinase gamma-PAK as a
function of activation.
10075741 c-Src-mediated phosphorylation of
the epidermal growth factor receptor on Tyr845
and Tyr1101 is associated with modulation of
10076184 Characterisation of recombinant
glycosylation variants of insulin-like growth
factor binding protein-3.
10080942 Structural requirements of a human
deoxyribonuclease II for the development of the
active enzyme form, revealed by site-directed
10082566 Role for caspase-mediated cleavage
of Rad51 in induction of apoptosis by DNA
10085087 Correlations in palmitoylation and
multiple phosphorylation of rat bradykinin B2
receptor in Chinese hamster ovary cells.
10085121 MEKK-1, a component of the stress
(stress-activated protein kinase/c-Jun
N-terminal kinase) pathway, can selectively
activate Smad2-mediated transcriptional
activation in endothelial cells.
10085131 Differential effects of CC
chemokines on CC chemokine receptor 5
(CCR5) phosphorylation and identification of
phosphorylation sites on the CCR5 carboxyl
10085140 ATF-2 is a common nuclear target
of Smad and TAK1 pathways in transforming
growth factor-beta signaling.
10087256 A conserved biogenesis pathway for
nucleoporins: proteolytic processing of a
186-kilodalton precursor generates Nup98 and
the novel nucleoporin, Nup96.
10089882 Tyrosine sulfation of the amino
terminus of CCR5 facilitates HIV-1 entry.
10090741 Phosphorylation that detaches tau
protein from microtubules (Ser262, Ser214)
also protects it against aggregation into
Alzheimer paired helical filaments.
10092231 Inhibition of myosin light chain kinase
by p21-activated kinase.
10092517 Identification of NEDD8-conjugation
site in human cullin-2.
10092522 The proto-oncogene p120(Cbl) is a
downstream substrate of the Hck
10095772 Identification of cyclin A/Cdk2
phosphorylation sites in B-Myb.
10095777 Isolation of the CXC chemokines
ENA-78, GRO alpha and GRO gamma from
tumor cells and leukocytes reveals
NH2-terminal heterogeneity. Functional
comparison of different natural isoforms.
10096020 Tip60 acetylates six lysines of a
specific class in core histones in vitro.
10102268 Slit proteins bind Robo receptors
and have an evolutionarily conserved role in
repulsive axon guidance.
10102273 Akt promotes cell survival by
phosphorylating and inhibiting a Forkhead
10102815 Two distinct cytokines released from
a human aminoacyl-tRNA synthetase.
10103059 Cleavage of transcription factor SP1
by caspases during anti-IgM-induced B-cell
10187779 Macrophage metalloelastase,
MMP-12, cleaves human apolipoprotein(a) in
the linker region between kringles IV-4 and
IV-5. Potential relevance to lipoprotein(a)
10187789 Inhibition of the
Ca2+/calmodulin-dependent protein kinase I
cascade by cAMP-dependent protein kinase.
10187842 Regulation of the transcriptional
activity of the peroxisome proliferator-activated
receptor alpha by phosphorylation of a
ligand-independent trans-activating domain.
10191262 Activation of serum- and
glucocorticoid-regulated protein kinase by
agonists that activate phosphatidylinositide
3-kinase is mediated by
3-phosphoinositide-dependent protein kinase-1
(PDK1) and PDK2.
10195142 Tyrosine kinase potentiates NMDA
receptor currents by reducing tonic zinc
10195894 Positive and negative regulation of
IkappaB kinase activity through IKKbeta subunit
10195903 Ca2+-induced apoptosis through
calcineurin dephosphorylation of BAD.
10197530 Synaptic targeting of the
postsynaptic density protein PSD-95 mediated
by lipid and protein motifs.
10197981 A mechanism of repression of
TGFbeta/ Smad signaling by oncogenic Ras.
10200531 Proteolytic cleavage of ras
GTPase-activating protein during apoptosis.
10201980 Phosphorylation of CD19 Y484 and
Y515, and linked activation of
phosphatidylinositol 3-kinase, are required for B
cell antigen receptor-mediated activation of
Bruton's tyrosine kinase.
10202152 Phosphorylation by G1-specific
cdk-cyclin complexes activates the nucleolar
transcription factor UBF.
10204117 The connective tissue growth
overexpressed (CCN) family.
10205168 Serine and tyrosine phosphorylations
cooperate in Raf-1, but not B-Raf activation.
10206955 The myeloid-specific sialic
acid-binding receptor, CD33, associates with
the protein-tyrosine phosphatases, SHP-1 and
10206975 Suppression of Kir2.3 activity by
protein kinase C phosphorylation of the channel
protein at threonine 53.
10206983 Inhibition of T cell signaling by
mitogen-activated protein kinase-targeted
hematopoietic tyrosine phosphatase (HePTP).
10207045 Dual specificity protein kinase
activity of testis-specific protein kinase 1 and its
regulation by autophosphorylation of serine-215
within the activation loop.
10207050 Cumulative effect of phosphorylation
of pRB on regulation of E2F activity.
10207070 Specific acetylation of chromosomal
protein HMG-17 by PCAF alters its interaction
10209029 Phosphorylation of adducin by
Rho-kinase plays a crucial role in cell motility.
10209036 SHP2-interacting transmembrane
adaptor protein (SIT), a novel disulfide-linked
dimer regulating human T cell activation.
10209959 Prostatic human kallikrein 2
inactivates and complexes with plasminogen
10210201 Identification of Tyr438 as the major
in vitro c-Src phosphorylation site in human
gelsolin: a mass spectrometric approach.
10212242 Stress-activated protein kinase-3
interacts with the PDZ domain of
alpha1-syntrophin. A mechanism for specific
10212258 Radiation-induced assembly of
Rad51 and Rad52 recombination complex
requires ATM and c-Abl.
10212274 Characterization of the major
physiologic phosphorylation site of human
keratin 19 and its role in filament organization.
10214954 Biochemical analysis of interleukin-2
receptor beta chain phosphorylation by
10217147 Direct control of the Forkhead
transcription factor AFX by protein kinase B.
10218588 The cleavage site specificity of
human prostate specific antigen for insulin-like
growth factor binding protein-3.
10224060 Akt protein kinase enhances human
telomerase activity through phosphorylation of
telomerase reverse transcriptase subunit.
10224081 Unusual sites of arginine methylation
in Poly(A)-binding protein II and in vitro
methylation by protein arginine
methyltransferases PRMT1 and PRMT3.
10224087 Extracellular regulated kinases (ERK)
1 and ERK2 are authentic substrates for the
dual-specificity protein-tyrosine phosphatase
VHR. A novel role in down-regulating the ERK
10224464 Novel autocrine and paracrine loops
of the stem cell factor/chymase network.
10226025 PDK1 acquires PDK2 activity in the
presence of a synthetic peptide derived from
the carboxyl terminus of PRK2.
10229237 Enhanced inhibition of hepatitis B
virus production by asialoglycoprotein
10229683 Complex formation between
deoxyhypusine synthase and its protein
substrate, the eukaryotic translation initiation
factor 5A (eIF5A) precursor.
10230405 Phosphorylation of the nuclear
receptor SF-1 modulates cofactor recruitment:
integration of hormone signaling in reproduction
10318803 The tumor suppressor EXT-like gene
EXTL2 encodes an alpha1,
transfers N-acetylgalactosamine and
N-acetylglucosamine to the common
glycosaminoglycan-protein linkage region. The
key enzyme for the chain initiation of heparan
10318843 Tyrosine 319 in the interdomain B of
ZAP-70 is a binding site for the Src homology 2
domain of Lck.
10318861 Activation of C3G guanine
nucleotide exchange factor for Rap1 by
phosphorylation of tyrosine 504.
10318869 MAPKAP kinase 2 phosphorylates
serum response factor in vitro and in vivo.
10318905 From HER2/Neu signal cascade to
androgen receptor and its coactivators: a novel
pathway by induction of androgen target genes
through MAP kinase in prostate cancer cells.
10327653 Phylogenetically conserved CK-II
phosphorylation site of the murine
homeodomain protein Hoxb-6.
10329716 Regulated interaction of protein
kinase Cdelta with the heterogeneous nuclear
ribonucleoprotein K protein.
10330160 Expression of the p56(Lck) Y505F
mutation in CD45-deficient mice rescues
10333484 Structural elements within the
methylation loop (residues 112-117) and EF
hands III and IV of calmodulin are required for
10334944 Overexpression of wild-type and
catalytically inactive forms of GRK2 and GRK6
fails to alter the agonist-induced
phosphorylation of the C5a receptor (CD88):
evidence that GRK6 is autophosphorylated in
10338112 Cysteine 29 is the major
palmitoylation site on stomatin.
phosphorylation of PKC on a carboxy-terminal
site by an atypical PKC complex.
10339564 Multistep regulation of DNA
replication by Cdk phosphorylation of HsCdc6.
10347142 Feedback regulation of
beta-arrestin1 function by extracellular
10347170 Ca2+/calmodulin-dependent kinase
II phosphorylates the epidermal growth factor
receptor on multiple sites in the cytoplasmic tail
and serine 744 within the kinase domain to
regulate signal generation.
10348343 The double-stranded RNA activated
protein kinase PKR physically associates with
the tumor suppressor p53 protein and
phosphorylates human p53 on serine 392 in
10350471 Proteolysis of blood coagulation
factor VIII by the factor VIIa-tissue factor
complex: generation of an inactive factor VIII
10350489 Regulation of PTP1B via
glutathionylation of the active site cysteine 215.
10357815 Serum and glucocorticoid-inducible
kinase (SGK) is a target of the PI
3-kinase-stimulated signaling pathway.
10358014 Negative regulation of the forkhead
transcription factor FKHR by Akt.
10358049 Crystal structure of human gastric
lipase and model of lysosomal acid lipase, two
lipolytic enzymes of medical interest.
10359578 BAFF, a novel ligand of the tumor
necrosis factor family, stimulates B cell growth.
10362354 Regulation and function of protein
kinase B and MAP kinase activation by the
10364159 Regulation of 4E-BP1
phosphorylation: a novel two-step mechanism.
10364201 Calnexin interaction with
N-glycosylation mutants of a polytopic
membrane glycoprotein, the human erythrocyte
anion exchanger 1 (band 3).
10364220 Structure and function of human
10364224 Identification of the cell cycle
regulator VCP (p97/CDC48) as a substrate of
the band 4.1-related protein-tyrosine
10364453 Identification and characterization of
a myristylated and palmitylated serine/threonine
10368301 Crystal structure of the kinase
domain of human vascular endothelial growth
factor receptor 2: a key enzyme in
10372802 Intensification of growth factor
receptor signalling by phorbol treatment of
ligand-primed cells implies a dimer-stabilizing
effect of protein kinase C-dependent
juxtamembrane domain phosphorylation.
10373416 CAST, a novel CD3epsilon-binding
protein transducing activation signal for
interleukin-2 production in T cells.
10373465 Phosphorylation at the
cyclin-dependent kinases site (Thr85) of
parathyroid hormone-related protein negatively
regulates its nuclear localization.
10373500 ADAMTS-1 is an active
metalloproteinase associated with the
10373531 Tyrosine phosphorylation of the
proto-oncoprotein Raf-1 is regulated by Raf-1
itself and the phosphatase Cdc25A.
10373534 BRCA1 is phosphorylated at serine
1497 in vivo at a cyclin-dependent kinase 2
10376603 Activation of nitric oxide synthase in
endothelial cells by Akt-dependent
10377264 Identification of Tyr-703 and Tyr-936
as the primary association sites for Grb2 and
Grb7 in the c-Kit/stem cell factor receptor.
10386950 Molecular cloning of testican-2:
defining a novel calcium-binding proteoglycan
family expressed in brain.
10386995 Glycosylation sites flank
phosphorylation sites on synapsin I: O-linked
N-acetylglucosamine residues are localized
within domains mediating synapsin I
10391251 p73 is regulated by tyrosine kinase
c-Abl in the apoptotic response to DNA
10391677 SHP-2 binds to Tyr763 and Tyr1009
in the PDGF beta-receptor and mediates
PDGF-induced activation of the Ras/MAP
kinase pathway and chemotaxis.
10398585 Serine 32 and serine 36 of
IkappaBalpha are directly phosphorylated by
protein kinase CKII in vitro.
10400690 Regulation of neuronal nitric-oxide
synthase by calmodulin kinases.
10400703 PTEN interactions with focal
adhesion kinase and suppression of the
phosphatidylinositol 3-kinase/Akt cell survival
10403367 The small GTPases Rab5a, Rab5b
and Rab5c are differentially phosphorylated in
10403822 Casein kinase 2 binds to and
10405182 Mutational analysis of sites in the
translational regulator, PHAS-I, that are
selectively phosphorylated by mTOR.
10409727 Mol Cell Biol. 1999
10409742 Kinase suppressor of Ras forms a
multiprotein signaling complex and modulates
10411623 Site-directed removal of
N-glycosylation sites in human gastric lipase.
10411640 Enzymatic action of human glandular
kallikrein 2 (hK2). Substrate specificity and
regulation by Zn2+ and extracellular protease
10411906 Suppression of apoptosis
signal-regulating kinase 1-induced cell death by
10412982 Endomembrane trafficking of ras:
the CAAX motif targets proteins to the ER and
10415030 CD45 negatively regulates lyn
activity by dephosphorylating both positive and
negative regulatory tyrosine residues in
immature B cells.
10421793 IKK-i, a novel
lipopolysaccharide-inducible kinase that is
related to IkappaB kinases.
10428479 Cathepsin L is capable of truncating
cystatin C of 11 N-terminal amino acids.
10428862 Independent SH2-binding sites
mediate interaction of Dok-related protein with
RasGTPase-activating protein and Nck.
10428966 Residues phosphorylated by TFIIH
are required for E2F-1 degradation during
10432301 Caspase-mediated cleavage of
eukaryotic translation initiation factor subunit
10435619 Cleavage and relocation of the
tyrosine kinase P59FYN during Fas-mediated
apoptosis in T lymphocytes.
10436156 Requirement of Rsk-2 for epidermal
growth factor-activated phosphorylation of
10438520 Caspase-6 role in apoptosis of
human neurons, amyloidogenesis, and
10438732 Proteolytic processing of big
endothelin-3 by the kell blood group protein.
10439036 Evidence for an important role of
serine 16 and its phosphorylation in the
stabilization of c-Mos.
10441128 Phosphorylation and activation of
phospholipase D1 by protein kinase C in vivo:
determination of multiple phosphorylation sites.
10441130 Identification of the sites
phosphorylated by cyclic AMP-dependent
protein kinase on the beta 2 subunit of L-type
voltage-dependent calcium channels.
10441371 Distinct but dispensable
N-glycosylation of human CD69 proteins.
10445857 Biological and biochemical
properties of Ret with kinase domain mutations
identified in multiple endocrine neoplasia type
2B and familial medullary thyroid carcinoma.
10446129 The prostacyclin receptor is
isoprenylated. Isoprenylation is required for
efficient receptor-effector coupling.
10446210 G protein-coupled receptor kinase
6A phosphorylates the Na(+)/H(+) exchanger
regulatory factor via a PDZ domain-mediated
10446219 Protein kinase C delta associates
with and phosphorylates Stat3 in an
10448092 The DNA-binding and transcriptional
activities of MAZ, a myc-associated zinc finger
protein, are regulated by casein kinase II.
10449420 Phosphorylation of splicing factor
SF1 on Ser20 by cGMP-dependent protein
kinase regulates spliceosome assembly.
10449753 Leptin receptor activation of SH2
domain containing protein tyrosine
phosphatase 2 modulates Ob receptor signal
10454575 Insulin-induced phosphorylation and
activation of cyclic nucleotide
phosphodiesterase 3B by the serine-threonine
10455013 Phosphorylation of Ser-241 is
essential for the activity of
kinase-1: identification of five sites of
phosphorylation in vivo.
10455026 Palmitoylation of the recombinant
human A1 adenosine receptor: enhanced
proteolysis of palmitoylation-deficient mutant
10467162 Mutational analysis of the regulatory
mechanism of PKN: the regulatory region of
PKN contains an arachidonic acid-sensitive
10469173 Changes in nuclear morphology
during apoptosis correlate with vimentin
cleavage by different caspases located either
upstream or downstream of Bcl-2 action.
10469655 NF-kappaB p105 is a target of
IkappaB kinases and controls signal induction
of Bcl-3-p50 complexes.
10469656 The nucleosomal response
associated with immediate-early gene induction
is mediated via alternative MAP kinase
cascades: MSK1 as a potential histone
10473631 Insulin-induced stimulation of
Na+,K(+)-ATPase activity in kidney proximal
tubule cells depends on phosphorylation of the
alpha-subunit at Tyr-10.
10477722 Identification of a 14-3-3 binding
sequence in the common beta chain of the
factor (GM-CSF), interleukin-3 (IL-3), and IL-5
receptors that is serine-phosphorylated by
10479448 Mammalian BMP-1/Tolloid-related
metalloproteinases, including novel family
member mammalian Tolloid-like 2, have
differential enzymatic activities and distributions
of expression relevant to patterning and
10479680 Neuronal interleukin-16 (NIL-16): a
dual function PDZ domain protein.
10480872 The CLK family kinases, CLK1 and
CLK2, phosphorylate and activate the tyrosine
10480873 Protein phosphatase 2C inactivates
F-actin binding of human platelet moesin.
10480933 90-kDa ribosomal S6 kinase is
phosphorylated and activated by
10482988 SHC and SHIP phosphorylation and
interaction in response to activation of the FLT3
10485710 NF-kappaB activation by tumour
necrosis factor requires the Akt
10488096 SHP-1 regulates Lck-induced
phosphatidylinositol 3-kinase phosphorylation
10490026 Acinus is a caspase-3-activated
protein required for apoptotic chromatin
10490839 The transmembranal and
cytoplasmic forms of protein tyrosine
phosphatase epsilon physically associate with
the adaptor molecule Grb2.
10498895 Phosphorylation at Tyr-838 in the
kinase domain of EphA8 modulates Fyn binding
to the Tyr-615 site by enhancing tyrosine
10500146 Regulation of cyclin-dependent
kinase 5 catalytic activity by phosphorylation.
10501226 Phosphorylation of serine-880 in
GluR2 by protein kinase C prevents its C
terminus from binding with glutamate
10504264 Transient palmitoylation supports
H-Ras membrane binding but only partial
10508159 Cathepsin D targeted by acid
10508618 Recruitment of Dok-R to the EGF
receptor through its PTB domain is required for
attenuation of Erk MAP kinase activation.
10512690 Inflammation-related neutrophil
proteases, cathepsin G and elastase, function
as insulin-like growth factor binding protein
10518318 Arginine methylation of a glycine and
arginine rich peptide derived from sequences of
human FMRP and fibrillarin.
10521265 Partial glycosylation of Asn2181 in
human factor V as a cause of molecular and
functional heterogeneity. Modulation of
glycosylation efficiency by mutagenesis of the
consensus sequence for N-linked glycosylation.
10521396 Cleavage of the death domain
kinase RIP by caspase-8 prompts TNF-induced
10521483 Identification of Tek/Tie2 binding
partners. Binding to a multifunctional docking
site mediates cell survival and migration.
10521505 Serine phosphorylation and negative
regulation of Stat3 by JNK.
10521512 Regulation of bad phosphorylation
and association with Bcl-x(L) by the MAPK/Erk
10523317 The replication factory targeting
sequence/PCNA-binding site is required in G(1)
to control the phosphorylation status of DNA
10523642 JSAP1, a novel jun N-terminal
protein kinase (JNK)-binding protein that
functions as a Scaffold factor in the JNK
10531036 Regulation of ARNO nucleotide
exchange by a PH domain electrostatic switch.
10531052 Beta-secretase cleavage of
Alzheimer's amyloid precursor protein by the
transmembrane aspartic protease BACE.
10531334 Serine 19 of human
6-pyruvoyltetrahydropterin synthase is
phosphorylated by cGMP protein kinase II.
10533983 The TrkB receptor tyrosine kinase
regulates cellular proliferation via signal
transduction pathways involving SHC,
PLCgamma, and CBL.
10537138 Role of N-linked glycosylation on the
function and expression of the human secretin
10537323 Signaling pathways and structural
domains required for phosphorylation of
10541800 Cloning of a new lectin-like receptor
expressed on human NK cells.
10542228 The role of DOC-2/DAB2 protein
phosphorylation in the inhibition of AP-1 activity.
An underlying mechanism of its
tumor-suppressive function in prostate cancer.
10542239 Identification of inhibitory
autophosphorylation sites in casein kinase I
10542248 Biosynthesis of vascular endothelial
growth factor-D involves proteolytic processing
which generates non-covalent homodimers.
10542257 The interferon-induced
double-stranded RNA-activated protein kinase
PKR will phosphorylate serine, threonine, or
tyrosine at residue 51 in eukaryotic initiation
10542266 Heregulin induces phosphorylation
of BRCA1 through phosphatidylinositol
3-Kinase/AKT in breast cancer cells.
10544291 Neuron-specific Cdk5 kinase is
responsible for mitosis-independent
phosphorylation of c-Src at Ser75 in human
Y79 retinoblastoma cells.
10548550 Characterization of the structure and
regulation of two novel isoforms of serum- and
glucocorticoid-induced protein kinase.
10550055 Requirement of ATM-dependent
phosphorylation of brca1 in the DNA damage
response to double-strand breaks.
10551811 Regulation of c-Myc through
phosphorylation at Ser-62 and Ser-71 by c-Jun
10551839 The four terminal components of the
complement system are C-mannosylated on
multiple tryptophan residues.
10556562 Carbohydrate moieties in human
10556651 Process of carboxylation of glutamic
acid residues in the gla domain of human
10557092 The physical association and
phosphorylation of Cdc25C protein
phosphatase by Prk.
10559204 Human JIK, a novel member of the
STE20 kinase family that inhibits JNK and is
negatively regulated by epidermal growth
10559254 The kinesin-like motor protein KIF1C
occurs in intact cells as a dimer and associates
with proteins of the 14-3-3 family.
10559936 Activation of LIM-kinase by Pak1
couples Rac/Cdc42 GTPase signalling to actin
10559944 Crosstalk between
cAMP-dependent kinase and MAP kinase
through a protein tyrosine phosphatase.
10564259 Mechanisms of G2 arrest in
response to overexpression of p53.
10564664 Caspase-3 and caspase-7 but not
caspase-6 cleave Gas2 in vitro: implications for
microfilament reorganization during apoptosis.
10567342 Functional regulation of L-type
calcium channels via protein kinase A-mediated
phosphorylation of the beta(2) subunit.
10567568 Glycogen synthase kinase 3 is an
insulin-regulated C/EBPalpha kinase.
10567572 BCL-2 is phosphorylated and
inactivated by an ASK1/Jun N-terminal protein
kinase pathway normally activated at G(2)/M.
10567720 Kinetic mechanism and ATP-binding
site reactivity of p38gamma MAP kinase.
10570155 An Eph receptor regulates integrin
activity through R-Ras.
10570256 Cutting edge: SLP-76 cooperativity
with FYB/FYN-T in the Up-regulation of
TCR-driven IL-2 transcription requires SLP-76
binding to FYB at Tyr595 and Tyr651.
10571231 A phospho-switch controls the
dynamic association of synapsins with synaptic
10572014 Multiple in vivo tyrosine
phosphorylation sites in EphB receptors.
10574913 Feedback inhibition of G
protein-coupled receptor kinase 2 (GRK2)
activity by extracellular signal-regulated kinases.
10574929 The novel kinase peptidylglycine
alpha-amidating monooxygenase cytosolic
interactor protein 2 interacts with the cytosolic
routing determinants of the peptide processing
enzyme peptidylglycine alpha-amidating
10574931 Functional interaction between
SHPTP1 and the Lyn tyrosine kinase in the
apoptotic response to DNA damage.
10574968 Balance between activities of Rho
kinase and type 1 protein phosphatase
modulates turnover of phosphorylation and
dynamics of desmin/vimentin filaments.
10576742 Phosphorylation and regulation of
Raf by Akt (protein kinase B).
10579917 Signaling via vascular endothelial
growth factor receptors.
10581160 A GSK3beta phosphorylation site in
axin modulates interaction with beta-catenin
and Tcf-mediated gene expression.
10582246 Control of NF-kappa B
transcriptional activation by signal induced
proteolysis of I kappa B alpha.
10587587 Ser298 of MITF, a mutation site in
Waardenburg syndrome type 2, is a
phosphorylation site with functional
10593981 Phosphorylation of B-Myb regulates
its transactivation potential and DNA binding.
10601309 Inhibitory phosphorylation site for
Rho-associated kinase on smooth muscle
10601311 Evidence that
3-phosphoinositide-dependent protein kinase-1
mediates phosphorylation of p70 S6 kinase in
vivo at Thr-412 as well as Thr-252.
10602493 Caspase-mediated cleavage and
functional changes of hematopoietic progenitor
kinase 1 (HPK1).
10604470 Ghrelin is a
growth-hormone-releasing acylated peptide
10604473 Phosphorylation of DARPP-32 by
Cdk5 modulates dopamine signalling in
10604721 Generation of angiostatin-like
fragments from plasminogen by
10605825 In vitro processing of amyloid
precursor protein by cathepsin D.
10606744 Protein kinase CK1 is a
p53-threonine 18 kinase which requires prior
phosphorylation of serine 15.
10608806 Substrate specificities and
identification of putative substrates of ATM
kinase family members.
10608812 Human rabaptin-5 is selectively
cleaved by caspase-3 during apoptosis.
10608901 Palmitoylation of a conserved
cysteine in the regulator of G protein signaling
(RGS) domain modulates the
GTPase-activating activity of RGS4 and
10617468 Reduced MAP kinase
phosphatase-1 degradation after
10617630 Constitutive phosphorylation of the
Parkinson's disease associated
10617634 Akt protein kinase inhibits Rac1-GTP
binding through phosphorylation at serine 71 of
10617656 Cytosolic tyrosine dephosphorylation
of STAT5. Potential role of SHP-2 in STAT5
10618483 Palmitoylation occurs at cysteine
347 and cysteine 351 of the dopamine D(1)
10618498 Phosphorylation of the Spi-B
transcription factor reduces its intrinsic stability.
10619020 Acetylation of MyoD directed by
PCAF is necessary for the execution of the
10620507 14-3-3 isotypes facilitate coupling of
protein kinase C-zeta to Raf-1: negative
regulation by 14-3-3 phosphorylation.
10625670 Five members of a novel
Ca(2+)-binding protein (CABP) subfamily with
similarity to calmodulin.
10629060 Interaction of a mitogen-activated
protein kinase signaling module with the
neuronal protein JIP3.
10635327 Ubiquitin ligase activity and tyrosine
phosphorylation underlie suppression of growth
factor signaling by c-Cbl/Sli-1.
10635333 Phosphorylation of rat serine 105 or
mouse threonine 217 in C/EBP beta is required
for hepatocyte proliferation induced by TGF
10636877 Architecture of high mobility group
protein I-C.DNA complex and its perturbation
upon phosphorylation by Cdc2 kinase.
10637231 A nuclear tyrosine phosphorylation
circuit: c-Jun as an activator and substrate of
c-Abl and JNK.
10640736 Phosphorylation of FADD/ MORT1
at serine 194 and association with a 70-kDa
cell cycle-regulated protein kinase.
10642499 The regulation of AMP-activated
protein kinase by phosphorylation.
10642527 LKB1, a novel serine/threonine
protein kinase and potential tumour suppressor,
is phosphorylated by cAMP-dependent protein
kinase (PKA) and prenylated in vivo.
10644439 Identification of FLRT1, FLRT2, and
FLRT3: a novel family of transmembrane
leucine-rich repeat proteins.
10644685 Biosynthesis and enzymatic
characterization of human SKI-1/S1P and the
processing of its inhibitory prosegment.
10644693 The human Cdc14 phosphatases
interact with and dephosphorylate the tumor
suppressor protein p53.
10644707 Identification of a human
brain-specific isoform of mammalian STE20-like
kinase 3 that is regulated by cAMP-dependent
10646852 A novel form of prostate-specific
antigen transcript produced by alternative
10648599 Extracellular signal-regulated kinase
binds to TFII-I and regulates its activation of the
10648825 Phosphorylation of the skeletal
muscle glycogen-targetting subunit of protein
phosphatase 1 in response to adrenaline in
10650937 The effect of phosphorylation by
casein kinase 2 on the activity of insulin-like
growth factor-binding protein-3.
10652353 Rho-associated kinase ROCK
activates LIM-kinase 1 by phosphorylation at
threonine 508 within the activation loop.
10652356 Regulation of protein kinase Ctheta
function during T cell activation by
Lck-mediated tyrosine phosphorylation.
10653665 Phosphorylation of recombinant
human ATP:citrate lyase by cAMP-dependent
protein kinase abolishes homotropic allosteric
regulation of the enzyme by citrate and
increases the enzyme activity. Allosteric
activation of ATP:citrate lyase by
10656688 Cell cycle regulated expression and
phosphorylation of hpttg proto-oncogene
10656693 c-Myb acetylation at the
carboxyl-terminal conserved domain by
transcriptional co-activator p300.
10660534 Resting lymphocyte kinase (Rlk/Txk)
targets lymphoid adaptor SLP-76 in the
cooperative activation of interleukin-2
transcription in T-cells.
10660621 Phosphorylation of steroid receptor
coactivator-1. Identification of the
phosphorylation sites and phosphorylation
through the mitogen-activated protein kinase
autopolysialylation is not requisite for
polysialylation of neural cell adhesion molecule.
10669731 Nck-interacting Ste20 kinase
couples Eph receptors to c-Jun N-terminal
kinase and integrin activation.
10669745 Tyrosine phosphorylation mediates
both activation and downmodulation of the
biological activity of Vav.
10669763 Posttranslational modification of
Bcl-2 facilitates its proteasome-dependent
degradation: molecular characterization of the
involved signaling pathway.
10671526 Binding and phosphorylation of a
novel male germ cell-specific cGMP-dependent
protein kinase-anchoring protein by
cGMP-dependent protein kinase Ialpha.
10671544 Apoptotic cleavage of scaffold
attachment factor A (SAF-A) by caspase-3
occurs at a noncanonical cleavage site.
10671552 Casein kinase II phosphorylation of
E-cadherin increases E-cadherin/beta-catenin
interaction and strengthens cell-cell adhesion.
10671558 Direct cleavage by the
calcium-activated protease calpain can lead to
inactivation of caspases.
10672017 Changes in integrity and association
of eukaryotic protein synthesis initiation factors
10673501 The human homologs of checkpoint
kinases Chk1 and Cds1 (Chk2) phosphorylate
p53 at multiple DNA damage-inducible sites.
10675528 Prothymosin alpha fragmentation in
10677483 Human aspartic protease memapsin
2 cleaves the beta-secretase site of
beta-amyloid precursor protein.
10679026 Palmitoylation of apolipoprotein B is
required for proper intracellular sorting and
transport of cholesteroyl esters and
10679189 Evidence for the carboxyl
methylation of nuclear lamin-B in the pancreatic
10681522 Dissecting the interaction of SHP-2
with PZR, an immunoglobulin family protein
containing immunoreceptor tyrosine-based
10681529 Cysteine-rich protein 2, a novel
substrate for cGMP kinase I in enteric neurons
and intestinal smooth muscle.
10681541 The Chk1 protein kinase and the
Cdc25C regulatory pathways are targets of the
anticancer agent UCN-01.
10683417 The neuronal EF-hand
calcium-binding protein visinin-like protein-3 is
expressed in cerebellar Purkinje cells and
shows a calcium-dependent membrane
10688651 Etk, a Btk family tyrosine kinase,
mediates cellular transformation by linking Src
to STAT3 activation.
10694430 Regulation of
microphthalmia-associated transcription factor
MITF protein levels by association with the
ubiquitin-conjugating enzyme hUBC9.
10698938 A phosphotyrosine displacement
mechanism for activation of Src by PTPalpha.
10699974 Intestinal cell kinase (ICK) localizes
to the crypt region and requires a dual
phosphorylation site found in map kinases.
10702256 SPACRCAN, a novel human
interphotoreceptor matrix hyaluronan-binding
proteoglycan synthesized by photoreceptors
protein (FRAP) autophosphorylates at serine
2481 under translationally repressive
10702794 The MAP-kinase ERK2 is a specific
substrate of the protein tyrosine phosphatase
10706702 Systematic analysis of the role of
CD19 cytoplasmic tyrosines in enhancement of
activation in Daudi human B cells: clustering of
phospholipase C and Vav and of Grb2 and Sos
with different CD19 tyrosines.
10708851 S-nitrosylated human
10710543 Prostaglandin E(2) interaction with
AVP: effects on AQP2 phosphorylation and
10712510 Caspase-mediated cleavage of
p130cas in etoposide-induced apoptotic Rat-1
10715123 Detailed analysis of the
phosphorylation of the human La (SS-B)
autoantigen. (De)phosphorylation does not
affect its subcellular distribution.
10715136 Activation of JNK3 alpha 1 requires
both MKK4 and MKK7: kinetic characterization
of in vitro phosphorylated JNK3 alpha 1.
10715549 Additional N-glycosylation at Asn(13)
rescues the human LHbeta-subunit from
10716671 The human two domain trefoil
protein, TFF2, is glycosylated in vivo in the
10722662 The roles of carbohydrate chains of
the beta-subunit on the functional expression of
10722755 The c-Jun NH(2)-terminal kinase
promotes insulin resistance during association
with insulin receptor substrate-1 and
phosphorylation of Ser(307).
10723127 Activation of NF-kappa B by the
dsRNA-dependent protein kinase, PKR involves
the I kappa B kinase complex.
10724175 hCds1-mediated phosphorylation of
BRCA1 regulates the DNA damage response.
10727525 Agonist-dependent modulation of G
protein-coupled receptor kinase 2 by
mitogen-activated protein kinases.
10727951 Structural characterization of the
oligosaccharide chains of human
alpha1-microglobulin from urine and amniotic
10728420 Human connexin40 gap junction
channels are modulated by cAMP.
10734073 Identification of caspase 3-mediated
cleavage and functional alteration of eukaryotic
initiation factor 2alpha in apoptosis.
10734227 Distinct versus redundant properties
among members of the INK4 family of
cyclin-dependent kinase inhibitors.
10734310 Sustained recruitment of
phospholipase C-gamma to Gab1 is required
for HGF-induced branching tubulogenesis.
10737616 Phosphorylation sites on tau
identified by nanoelectrospray mass
spectrometry: differences in vitro between the
mitogen-activated protein kinases ERK2, c-Jun
N-terminal kinase and P38, and glycogen
10739259 Phosphorylation and subcellular
redistribution of high mobility group proteins 14
and 17, analyzed by mass spectrometry.
10744722 Caffeine abolishes the mammalian
G(2)/M DNA damage checkpoint by inhibiting
ataxia-telangiectasia-mutated kinase activity.
10744726 Tumor necrosis
factor-alpha-converting enzyme is required for
cleavage of erbB4/HER4.
10747894 The C-terminal RG dipeptide repeats
of the spliceosomal Sm proteins D1 and D3
contain symmetrical dimethylarginines, which
form a major B-cell epitope for anti-Sm
10747897 Stress-induced activation of protein
kinase CK2 by direct interaction with p38
mitogen-activated protein kinase.
10747909 Galpha 13 requires palmitoylation for
plasma membrane localization, Rho-dependent
signaling, and promotion of p115-RhoGEF
10747914 Prenylation-dependent association
of protein-tyrosine phosphatases PRL-1, -2,
and -3 with the plasma membrane and the
10747973 c-Jun NH2-terminal kinase targeting
and phosphorylation of heat shock factor-1
suppress its transcriptional activity.
10748018 Phosphorylation of myosin light
chain kinase by p21-activated kinase PAK2.
10749680 The Shc-related adaptor protein,
Sck, forms a complex with the
KDR in transfected cells.
10753652 Skeletal muscle CaMKII enriches in
nuclei and phosphorylates myogenic factor SRF
at multiple sites.
10753910 Rho GTPase control of protein
kinase C-related protein kinase activation by
3-phosphoinositide-dependent protein kinase.
10753971 Acetylation of novel sites in the
nucleosomal binding domain of chromosomal
protein HMG-14 by p300 alters its interaction
10756055 N-linked glycosylation of CXCR4
masks coreceptor function for
CCR5-dependent human immunodeficiency
virus type 1 isolates.
10760275 Membrane-associated GAIP is a
phosphoprotein and can be phosphorylated by
10764745 Regulation of complex formation of
POB1/epsin/adaptor protein complex 2 by
10764799 Selective attenuation of metabolic
branch of insulin receptor down-signaling by
high glucose in a hepatoma cell line, HepG2
10766777 Phosphorylation of dynamin I on
Ser-795 by protein kinase C blocks its
association with phospholipids.
10769174 Shedding of somatic
angiotensin-converting enzyme (ACE) is
inefficient compared with testis ACE despite
cleavage at identical stalk sites.
10770929 Inhibiting caspase cleavage of
huntingtin reduces toxicity and aggregate
formation in neuronal and nonneuronal cells.
10770950 Regulation of phospholipid
scramblase activity during apoptosis and cell
activation by protein kinase Cdelta.
10772824 The RGG domain in hnRNP A2
affects subcellular localization.
10772927 Phosphorylation of the 105-kDa
heat shock proteins, HSP105alpha and
HSP105beta, by casein kinase II.
10777477 Histone deacetylases specifically
down-regulate p53-dependent gene activation.
10779345 Multiple mechanisms control
phosphorylation of PHAS-I in five (S/T)P sites
that govern translational repression.
10779355 IkappaB kinase alpha (IKKalpha)
regulation of IKKbeta kinase activity.
10779504 p300 and p300/cAMP-response
element-binding protein-associated factor
acetylate the androgen receptor at sites
governing hormone-dependent transactivation.
10779545 5-lipoxygenase is phosphorylated by
p38 kinase-dependent MAPKAP kinases.
10783893 NAK is an IkappaB kinase-activating
10787408 Identification of p130cas as an in
vivo substrate of receptor protein-tyrosine
10791974 Caspase-2 is localized at the Golgi
complex and cleaves golgin-160 during
10792047 Phosphorylation of protein kinase N
by phosphoinositide-dependent protein
kinase-1 mediates insulin signals to the actin
10799478 Membrane type 4 matrix
metalloproteinase (MMP17) has tumor necrosis
factor-alpha convertase activity but does not
10799545 Evidence that Llck-mediated
phosphorylation of p56dok and p62dok may
play a role in CD2 signaling.
10799548 Hck enhances the adherence of
lipopolysaccharide-stimulated macrophages via
Cbl and phosphatidylinositol 3-kinase.
10801418 Acetylation of importin-alpha nuclear
import factors by CBP/p300.
10805734 Interaction between PAK and nck: a
template for Nck targets and role of PAK
10805738 p38 and extracellular
signal-regulated kinases regulate the myogenic
program at multiple steps.
10805756 Phosphorylation of SOX9 by cyclic
AMP-dependent protein kinase A enhances
SOX9's ability to transactivate a Col2a1
10805801 Molecular basis for a link between
complement and the vascular complications of
10806207 Control sites of ribosomal S6 kinase
B and persistent activation through tumor
10809756 Interactions between the exocytic
and endocytic pathways in polarized
Madin-Darby canine kidney cells.
10811661 Phosphorylation of human gp130 at
Ser-782 adjacent to the Di-leucine
internalization motif. Effects on expression and
10816433 The m3 muscarinic acetylcholine
receptor is coupled to mitogen-activated
protein kinase via protein kinase C and
epidermal growth factor receptor kinase.
10816555 Deletion of the serotonin 5-HT2C
receptor PDZ recognition motif prevents
receptor phosphorylation and delays
resensitization of receptor responses.
10816571 Interaction between endothelial
differentiation-related factor-1 and calmodulin in
vitro and in vivo.
10818093 Phosphorylation of collapsin
response mediator protein-2 by Rho-kinase.
Evidence for two separate signaling pathways
for growth cone collapse.
10821277 ATF-2 has intrinsic histone
acetyltransferase activity which is modulated by
10821673 Effects of the N-linked glycans on
the 3D structure of the free alpha-subunit of
human chorionic gonadotropin.
10821867 Site-selective dephosphorylation of
the platelet-derived growth factor beta-receptor
by the receptor-like protein-tyrosine
10823823 Cleavage of the actin-capping
protein alpha -adducin at
Asp-Asp-Ser-Asp633-Ala by caspase-3 is
preceded by its phosphorylation on serine 726
in cisplatin-induced apoptosis of renal epithelial
10828960 Monoclonal antibody light chain with
10830164 PKA phosphorylation dissociates
FKBP12.6 from the calcium release channel
(ryanodine receptor): defective regulation in
10830966 Neurotoxicity induces cleavage of
p35 to p25 by calpain.
10831592 Localization of disulfide bonds in the
cystine knot domain of human von Willebrand
10833263 Studies on the phosphorylation of
protein kinase B by
Ca(2+)/calmodulin-dependent protein kinases.
10837138 Platelet-derived growth
factor-mediated signaling through the Shb
adaptor protein: effects on cytoskeletal
10837251 Cyclic AMP regulates the HERG K(+)
channel by dual pathways.
10837486 BAD Ser-155 phosphorylation
regulates BAD/Bcl-XL interaction and cell
activation of TAK1 mitogen-activated protein
kinase kinase kinase by TAB1.
10839544 Functional link between
ataxia-telangiectasia and Nijmegen breakage
syndrome gene products.
10839545 ATM phosphorylation of Nijmegen
breakage syndrome protein is required in a
DNA damage response.
10842184 Negative regulation of growth
hormone receptor/JAK2 signaling by signal
regulatory protein alpha.
10842319 Janus kinase 2 is associated with a
box 1-like motif and phosphorylates a critical
tyrosine residue in the cytoplasmic region of
cytotoxic T lymphocyte associated molecule-4.
10844023 Phosphorylated syntaxin 1 is
localized to discrete domains along a subset of
10846177 Human Cdc7-related kinase
complex. In vitro phosphorylation of MCM by
concerted actions of Cdks and Cdc7 and that
of a criticial threonine residue of Cdc7 bY Cdks.
10846184 Src-mediated tyrosine
phosphorylation of NR2 subunits of
N-methyl-D-aspartate receptors protects from
calpain-mediated truncation of their C-terminal
10849446 Big mitogen-activated kinase
regulates multiple members of the MEF2
10851017 Relationship between contact
inhibition and intranuclear S100C of normal
10851066 Interaction between protein tyrosine
phosphatase and protein tyrosine kinase is
involved in androgen-promoted growth of
human prostate cancer cells.
10851246 Regulation of human endothelial cell
focal adhesion sites and migration by
cGMP-dependent protein kinase I.
10852915 Farnesyl transferase inhibitors block
the farnesylation of CENP-E and CENP-F and
alter the association of CENP-E with the
10852916 Synucleins are a novel class of
substrates for G protein-coupled receptor
10852918 Activation of
Ca2+/calmodulin-dependent protein kinase II
within post-synaptic dendritic spines of cultured
10859319 Matrix metalloproteinases cleave
tissue factor pathway inhibitor. Effects on
10864201 ATM protein and p53-serine 15
phosphorylation in ataxia-telangiectasia (AT)
patients and at heterozygotes.
10866324 Role for ATM in DNA
damage-induced phosphorylation of BRCA1.
10866658 Phosphorylation of the PTEN tail
regulates protein stability and function.
10866685 The B56alpha regulatory subunit of
protein phosphatase 2A is a target for
regulation by double-stranded RNA-dependent
protein kinase PKR.
10866806 Mutational analysis of arginine 177 in
the nucleotide binding site of beta-actin.
10867018 Regulation of protein kinase D by
multisite phosphorylation. Identification of
phosphorylation sites by mass spectrometry
and characterization by site-directed
10869359 Negative regulation of the
serine/threonine kinase B-Raf by Akt.
10871288 Phosphorylation of connexin43 on
serine368 by protein kinase C regulates gap
10871631 Torsin A and its torsion
dystonia-associated mutant forms are lumenal
glycoproteins that exhibit distinct subcellular
10871840 Identification of Grb10 as a direct
substrate for members of the Src tyrosine
10874031 Inhibition of neuronal nitric-oxide
synthase by calcium/ calmodulin-dependent
protein kinase IIalpha through Ser847
phosphorylation in NG108-15 neuronal cells.
10877842 Thrombocidins, microbicidal proteins
from human blood platelets, are C-terminal
deletion products of CXC chemokines.
10878002 Properdin, the positive regulator of
complement, is highly C-mannosylated.
10880354 Regulation of BAD by
cAMP-dependent protein kinase is mediated via
phosphorylation of a novel site, Ser155.
10880513 SHP2 mediates the protective effect
of interleukin-6 against
dexamethasone-induced apoptosis in multiple
10884347 The C-terminal regulatory domain of
p53 contains a functional docking site for cyclin
10887202 Characterization of Alzheimer's beta
-secretase protein BACE. A pepsin family
member with unusual properties.
10889209 Glycosylation of GIRK1 at Asn119
and ROMK1 at Asn117 has different
consequences in potassium channel function.
10891503 Identification of the cytolinker plectin
as a major early in vivo substrate for caspase 8
during CD95- and tumor necrosis factor
10893227 The low pH in trans-Golgi triggers
autocatalytic cleavage of pre-alpha -inhibitor
heavy chain precursor.
10893432 Molecular analysis of the
sodium/iodide symporter: impact on thyroid
and extrathyroid pathophysiology.
10896159 Cables links Cdk5 and c-Abl and
facilitates Cdk5 tyrosine phosphorylation,
kinase upregulation, and neurite outgrowth.
10896916 Alpha(2) adrenoceptors regulate
proliferation of human intestinal epithelial cells.
10896934 Threonine phosphorylation of the
beta 3 integrin cytoplasmic tail, at a site
recognized by PDK1 and Akt/PKB in vitro,
regulates Shc binding.
10898738 VACM-1, a cullin gene family
member, regulates cellular signaling.
10899625 Angiotensin II generation by mast
cell alpha- and beta-chymases.
10903717 FDF03, a novel inhibitory receptor of
the immunoglobulin superfamily, is expressed
by human dendritic and myeloid cells.
10910062 A direct linkage between the
phosphoinositide 3-kinase-AKT signaling
pathway and the mammalian target of
rapamycin in mitogen-stimulated and
10910078 Mirk protein kinase is a
mitogen-activated protein kinase substrate that
mediates survival of colon cancer cells.
10910365 Functional link of BRCA1 and ataxia
telangiectasia gene product in DNA damage
10910956 A potential mechanism for fumonisin
B(1)-mediated hepatocarcinogenesis: cyclin D1
stabilization associated with activation of Akt
and inhibition of GSK-3beta activity.
10911985 Synergistic coupling of histone H3
phosphorylation and acetylation in response to
epidermal growth factor stimulation.
10911986 Phosphorylation of serine 10 in
histone H3 is functionally linked in vitro and in
vivo to Gcn5-mediated acetylation at lysine 14.
10915800 MAP kinases Erk1/2 phosphorylate
sterol regulatory element-binding protein
(SREBP)-1a at serine 117 in vitro.
10918587 Transformation and Stat activation
by derivatives of FGFR1, FGFR3, and FGFR4.
10921917 Cell volume-dependent
phosphorylation of proteins of the cortical
cytoskeleton and cell-cell contact sites. The
role of Fyn and FER kinases.
10921922 Intracellular signaling mechanisms
leading to synergistic effects of endothelin-1
and stem cell factor on proliferation of cultured
human melanocytes. Cross-talk via
trans-activation of the tyrosine kinase c-kit
10922374 KT5823 inhibits cGMP-dependent
protein kinase activity in vitro but not in intact
human platelets and rat mesangial cells.
10922491 Acylation of Galpha(13) is important
for its interaction with thrombin receptor,
transforming activity and actin stress fiber
10930399 Matrix metalloproteinases
collagenase-2, macrophage elastase,
collagenase-3, and membrane type 1-matrix
metalloproteinase impair clotting by
degradation of fibrinogen and factor XII.
10931181 Processing of synthetic pro-islet
amyloid polypeptide (proIAPP) 'amylin' by
recombinant prohormone convertase enzymes,
PC2 and PC3, in vitro.
10931940 BACE2, a beta -secretase homolog,
cleaves at the beta site and within the
amyloid-beta region of the amyloid-beta
10933394 CD19 regulates Src family protein
tyrosine kinase activation in B lymphocytes
through processive amplification.
10934191 Modulation of the catalytic activity of
the Src family tyrosine kinase Hck by
autophosphorylation at a novel site in the
10934208 Dephosphorylation of human
cyclin-dependent kinases by protein
phosphatase type 2C alpha and beta 2
10936190 Neuron-specific phosphorylation of
Alzheimer's beta-amyloid precursor protein by
cyclin-dependent kinase 5.
10940639 Structure-function and biological role
10942405 Sequential phosphorylation of
protein band 3 by Syk and Lyn tyrosine kinases
in intact human erythrocytes: identification of
primary and secondary phosphorylation sites.
10942766 Mitotic phosphorylation of DNA
topoisomerase II alpha by protein kinase CK2
creates the MPM-2 phosphoepitope on
10942774 Mammalian target of
rapamycin-dependent phosphorylation of
PHAS-I in four (S/T)P sites detected by
10944113 Mechanism of regulation of the
hypoxia-inducible factor-1 alpha by the von
Hippel-Lindau tumor suppressor protein.
10944526 CREB-binding protein/p300
activates MyoD by acetylation.
10945988 Association of immature
hypophosphorylated protein kinase cepsilon
with an anchoring protein CG-NAP.
10945993 Phosphorylation of protein kinase
Cdelta on distinct tyrosine residues regulates
specific cellular functions.
10945997 cAMP-dependent protein kinase
phosphorylation of EVL, a Mena/VASP relative,
regulates its interaction with actin and SH3
10947801 Localization and targeting of SCG10
to the trans-Golgi apparatus and growth cone
10947989 Inflammation dampened by
gelatinase A cleavage of monocyte
10949026 14-3-3 proteins and survival kinases
cooperate to inactivate BAD by BH3 domain
10949034 Activation of estrogen receptor
alpha by S118 phosphorylation involves a
ligand-dependent interaction with TFIIH and
participation of CDK7.
10951572 The human vaccinia-related kinase 1
(VRK1) phosphorylates threonine-18 within the
mdm-2 binding site of the p53 tumour
10953014 Tyrosine phosphorylation of Eps15 is
required for ligand-regulated, but not
10954418 Membrane localization and biological
activity of SNAP-25 cysteine mutants in
10954746 Relative role of heme nitrosylation
and beta-cysteine 93 nitrosation in the
transport and metabolism of nitric oxide by
hemoglobin in the human circulation.
10958788 Cross-linking of wild-type and
mutant alpha 2-antiplasmins to fibrin by
activated factor XIII and by a tissue
10959835 Dab1 tyrosine phosphorylation sites
relay positional signals during mouse brain
10961862 Cleavage by CD26/dipeptidyl
peptidase IV converts the chemokine LD78beta
into a most efficient monocyte attractant and
10961885 Importance of the MKK6/p38
pathway for interleukin-12-induced STAT4
serine phosphorylation and transcriptional
10961987 Phosphorylation of the
beta-galactoside-binding protein galectin-3
modulates binding to its ligands.
10962009 Activation of hepatocyte growth
factor and urokinase/plasminogen activator by
matriptase, an epithelial membrane serine
10963790 alpha(2)-plasmin inhibitor is a
substrate for tissue transglutaminase: an in
10966857 Translational regulation of proinsulin
biosynthesis and proinsulin conversion in the
10967118 Inactivation of plasminogen activator
inhibitor-1 by specific proteolysis with
10969042 A novel angiotensin-converting
enzyme-related carboxypeptidase (ACE2)
converts angiotensin I to angiotensin 1-9.
10969067 The neuropeptide processing
enzyme EC 184.108.40.206 is modulated by protein
kinase A phosphorylation.
10970850 Ezrin function is required for
ROCK-mediated fibroblast transformation by
the Net and Dbl oncogenes.
10973490 Ataxia telangiectasia-mutated
phosphorylates Chk2 in vivo and in vitro.
10975838 Serine 6 of Lck tyrosine kinase: a
critical site for Lck myristoylation, membrane
localization, and function in T lymphocytes.
10978165 Posttranslationally processed forms
of the human chemokine HCC-1.
10978167 Proteolysis of the exodomain of
recombinant protease-activated receptors:
prediction of receptor activation or inactivation
by MALDI mass spectrometry.
10978177 Identification of major tyrosine
phosphorylation sites in the human insulin
receptor substrate Gab-1 by insulin receptor
kinase in vitro.
10978317 Serine 727 phosphorylation and
activation of cytosolic phospholipase A2 by
MNK1-related protein kinases.
10980603 SPAK, a STE20/SPS1-related
kinase that activates the p38 pathway.
10982389 Exposure at the cell surface is
required for gas3/PMP22 To regulate both cell
death and cell spreading: implication for the
Charcot-Marie-Tooth type 1A and
10982844 Regulation of STAT1 nuclear export
10986281 Brevican is degraded by matrix
metalloproteinases and aggrecanase-1
(ADAMTS4) at different sites.
10993082 TFIIH is negatively regulated by
cdk8-containing mediator complexes.
10993892 Erk1/2-dependent phosphorylation
of Galpha-interacting protein stimulates its
GTPase accelerating activity and autophagy in
human colon cancer cells.
10993906 Identification of a novel
immunoreceptor tyrosine-based activation
motif-containing molecule, STAM2, by mass
spectrometry and its involvement in growth
factor and cytokine receptor signaling
10995762 p21-activated kinase (PAK1) is
phosphorylated and activated by
10998058 Caspase-3 mediated cleavage of
HsRad51 at an unconventional site.
10998246 N-terminal sequences direct the
autophosphorylation states of the FER tyrosine
kinases in vivo.
10998417 Identification and cloning of
Kidins220, a novel neuronal substrate of protein
11004509 Functional cloning and mutational
analysis of the human cDNA for
identification of the amino acid residues
essential for the catalysis.
factor/neuroleukin/maturation factor is a
11007774 Identification of protein-tyrosine
phosphatase 1B as the major tyrosine
phosphatase activity capable of
dephosphorylating and activating c-Src in
several human breast cancer cell lines.
11007883 Phosphorylation of the AMPA
receptor subunit GluR2 differentially regulates
its interaction with PDZ domain-containing
11016947 Activation of atypical protein kinase
C zeta by caspase processing and degradation
by the ubiquitin-proteasome system.
11017939 Production and characterization of
novel anti-prostate-specific antigen (PSA)
monoclonal antibodies that do not detect
internally cleaved Lys145-Lys146 inactive PSA.
11018042 Specific activation of LIM kinase 2
via phosphorylation of threonine 505 by ROCK,
a Rho-dependent protein kinase.
11018520 MSK1 is required for CREB
phosphorylation in response to mitogens in
mouse embryonic stem cells.
11020388 Phosphorylation of p300 at serine
89 by protein kinase C.
11023497 Neutrophil gelatinase B potentiates
interleukin-8 tenfold by aminoterminal
processing, whereas it degrades CTAP-III,
PF-4, and GRO-alpha and leaves RANTES and
11024037 Regulation of Cbl molecular
interactions by the co-receptor molecule CD43
in human T cells.
11024467 Crystal structure of S-glutathiolated
carbonic anhydrase III.
11027273 ets-2 is a target for an akt (Protein
kinase B)/jun N-terminal kinase signaling
pathway in macrophages of motheaten-viable
11027280 Inactivation of smad-transforming
growth factor beta signaling by
Ca(2+)-calmodulin-dependent protein kinase II.
11027412 Enzymatic action of
prostate-specific antigen (PSA or hK3):
substrate specificity and regulation by Zn(2+), a
localization of microtubule-associated protein
MAP2c to the actin cytoskeleton.
11030334 Concerted dephosphorylation of the
transcription factor NFAT1 induces a
conformational switch that regulates
11032419 Regulation of DNA binding activity of
the ligand-activated aryl hydrocarbon receptor
by tyrosine phosphorylation.
11032800 Post-translational hydroxylation at
the N-terminus of the prion protein reveals
presence of PPII structure in vivo.
11032810 Activation of B-Raf kinase requires
phosphorylation of the conserved residues
Thr598 and Ser601.
11034606 FIST/HIPK3: a Fas/FADD-interacting
serine/threonine kinase that induces FADD
phosphorylation and inhibits fas-mediated Jun
NH(2)-terminal kinase activation.
11035810 Phosphorylation and inactivation of
glycogen synthase kinase 3 by protein kinase
11039908 The mitotic serine/threonine kinase
Aurora2/AIK is regulated by phosphorylation
11040053 Identification of G protein-coupled
receptor kinase 2 phosphorylation sites
responsible for agonist-stimulated delta-opioid
11042170 Domain-dependent function of the
rasGAP-binding protein p62Dok in cell
11042191 Phosphorylation of GRK2 by protein
kinase C abolishes its inhibition by calmodulin.
11042209 The SH2 domain containing tyrosine
phosphatase-1 down-regulates activation of
Lyn and Lyn-induced tyrosine phosphorylation
of the CD19 receptor in B cells.
11042212 Regulation of apoptosis by
phosphatidylinositol 4,5-bisphosphate inhibition
of caspases, and caspase inactivation of
phosphatidylinositol phosphate 5-kinases.
11042679 Neuroblastoma specific effects of
DR-nm23 and its mutant forms on
differentiation and apoptosis.
11042683 The effector loop and prenylation
site of R-Ras are involved in the regulation of
11042694 The ternary complex factor Net
contains two distinct elements that mediate
different responses to MAP kinase signalling
11046142 Multiple C-terminal lysine residues
target p53 for ubiquitin-proteasome-mediated
11050185 Phosphorylation near nuclear
localization signal regulates nuclear import of
adenomatous polyposis coli protein.
11052978 AMPK signaling in contracting
human skeletal muscle: acetyl-CoA carboxylase
and NO synthase phosphorylation.
11053038 Molecular and functional properties
of two-pore-domain potassium channels.
11053353 Mutagenesis analysis of human
SM22: characterization of actin binding.
11053428 The kinase activation loop is the key
to mixed lineage kinase-3 activation via both
autophosphorylation and hematopoietic
progenitor kinase 1 phosphorylation.
11060296 Cleavage of the amino terminus of
the prion protein by reactive oxygen species.
11060299 Threonine 180 is required for
G-protein-coupled receptor kinase 3- and
beta-arrestin 2-mediated desensitization of the
mu-opioid receptor in Xenopus oocytes.
11060308 Glutathiolation of proteins by
glutathione disulfide S-oxide derived from
S-nitrosoglutathione. Modifications of rat brain
neurogranin/RC3 and neuromodulin/GAP-43.
11062054 Changes in protein kinase C epsilon
phosphorylation status and intracellular
localization as 3T3 and 3T6 fibroblasts grow to
confluency and quiescence: a role for
phosphorylation at ser-729?
11062067 Synergistic activation of
stress-activated protein kinase 1/c-Jun
N-terminal kinase (SAPK1/JNK) isoforms by
mitogen-activated protein kinase kinase 4
(MKK4) and MKK7.
11062248 Molecular cloning and
characterization of the human protein kinase
D2. A novel member of the protein kinase D
family of serine threonine kinases.
11063592 Mutations of serine 236-237 and
tyrosine 302 residues in the human lipoxin A4
receptor intracellular domains result in
11067847 Characterization of a
prostate-specific tyrosine phosphatase by
mutagenesis and expression in human prostate
11067851 C-mannosylation and O-fucosylation
of the thrombospondin type 1 module.
11069302 Regulation of apoptosis at cell
division by p34cdc2 phosphorylation of survivin.
11075717 The functional significance of Shc in
insulin signaling as a substrate of the insulin
11076522 Role of tyrosine sulfation and serine
phosphorylation in the processing of
procholecystokinin to amidated cholecystokinin
and its secretion in transfected AtT-20 cells.
11076937 Cleavage and shedding of
E-cadherin after induction of apoptosis.
11078729 Caveolin-1 binding to endoplasmic
reticulum membranes and entry into the
regulated secretory pathway are regulated by
serine phosphorylation. Protein sorting at the
level of the endoplasmic reticulum.
11080633 Structure of the Tie2 RTK domain:
self-inhibition by the nucleotide binding loop,
activation loop, and C-terminal tail.
11081517 Signal-dependent nuclear export of
a histone deacetylase regulates muscle
11085743 Initiation of apoptosis by granzyme
B requires direct cleavage of bid, but not direct
granzyme B-mediated caspase activation.
11085925 Activation of human prolegumain by
cleavage at a C-terminal asparagine residue.
11085981 Heterologous activation of protein
kinase C stimulates phosphorylation of
delta-opioid receptor at serine 344, resulting in
beta-arrestin- and clathrin-mediated receptor
11094089 Multiple lysine mutations in the
C-terminal domain of p53 interfere with
MDM2-dependent protein degradation and
11095503 Postsynaptic targeting of MAGUKs
mediated by distinct N-terminal domains.
11098060 TRAF1 is a substrate of caspases
activated during tumor necrosis factor
11098061 Determination of the disulfide
structure and N-glycosylation sites of the
extracellular domain of the human signal
11099506 Identification of the protein
C/activated protein C binding sites on the
endothelial cell protein C receptor. Implications
for a novel mode of ligand recognition by a
major histocompatibility complex class 1-type
11101516 Transmembrane transforming
growth factor-alpha tethers to the PDZ
membrane-associated protein p59/GRASP55.
11102515 Self-association of coilin reveals a
common theme in nuclear body localization.
11104670 The C-terminus of NIPP1 (nuclear
inhibitor of protein phosphatase-1) contains a
novel binding site for protein phosphatase-1
that is controlled by tyrosine phosphorylation
and RNA binding.
11104692 Dynamic palmitoylation of lymphoma
proprotein convertase prolongs its half-life, but
is not essential for trans-Golgi network
11104755 Substitution of a glycogen synthase
kinase-3beta phosphorylation site in presenilin 1
separates presenilin function from beta-catenin
11104762 Phosphorylation of tau is regulated
11104776 Protein kinase C activation
modulates alpha-calmodulin kinase II binding to
NR2A subunit of N-methyl-D-aspartate
11106428 Identification of IkappaBalpha as a
substrate of Fas-associated phosphatase-1.
11106648 Essential tyrosine residues for
interaction of the non-receptor protein-tyrosine
phosphatase PTP1B with N-cadherin.
11113134 Amphiphysin 1 binds the
cyclin-dependent kinase (cdk) 5 regulatory
subunit p35 and is phosphorylated by cdk5 and
11113184 Reciprocal activation by
cyclin-dependent kinases 2 and 7 is directed by
substrate specificity determinants outside the T
11114197 Activation of the myocyte enhancer
factor-2 transcription factor by
kinase-stimulated binding of 14-3-3 to histone
11114308 Differential regulation of the uridine
nucleotide-activated P2Y4 and P2Y6 receptors.
SER-333 and SER-334 in the carboxyl terminus
are involved in agonist-dependent
phosphorylation desensitization and
internalization of the P2Y4 receptor.
11114888 Functional interactions between
BRCA1 and the checkpoint kinase ATR during
11115400 Novel properties of the protein
kinase CK2-site-regulated nuclear- localization
sequence of the interferon-induced nuclear
factor IFI 16.
11115496 Identification of internal
autoproteolytic cleavage sites within the
prosegments of recombinant procathepsin B
and procathepsin S. Contribution of a plausible
unimolecular autoproteolytic event for the
processing of zymogens belonging to the
11116148 Insulin suppresses transactivation by
CAAT/enhancer-binding proteins beta
(C/EBPbeta). Signaling to p300/CREB-binding
protein by protein kinase B disrupts interaction
with the major activation domain of C/EBPbeta.
11118213 TAZ: a novel transcriptional
co-activator regulated by interactions with
14-3-3 and PDZ domain proteins.
11118214 P/CAF-mediated acetylation
regulates the function of the basic
helix-loop-helix transcription factor TAL1/SCL.
11120811 The c-Abl tyrosine kinase is
regulated downstream of the B cell antigen
receptor and interacts with CD19.
11121408 Differential effects of leukocyte
common antigen-related protein on
biochemical and biological activities of
RET-MEN2A and RET-MEN2B mutant proteins.
11133752 Posttranslational modifications of
recombinant myotube-synthesized human
11134009 A critical role for phosphoinositide
3-kinase upstream of Gab1 and SHP2 in the
activation of ras and mitogen-activated protein
kinases by epidermal growth factor.
11134016 J Biol Chem. 2001 Mar
30;276(13):9733-41. Epub 2000 Dec 27.
11135364 Differences in phosphorylation of
human and chicken stathmin by MAP kinase.
3-kinase/AKT-mediated activation of estrogen
receptor alpha: a new model for anti-estrogen
11146653 Participation of ATM in insulin
signalling through phosphorylation of
eIF-4E-binding protein 1.
11148205 Phosphorylation of the oncofetal
variant of the human bile salt-dependent lipase.
identification of phosphorylation site and
relation with secretion process.
11152457 The angiotensin II-dependent
nuclear translocation of Stat1 is mediated by
the Jak2 protein motif 231YRFRR.
11152665 The c-Src tyrosine kinase regulates
signaling of the human DF3/MUC1
carcinoma-associated antigen with GSK3 beta
11152678 Biosynthesis and post-translational
processing of the precursor to brain-derived
11154262 The mitogen-activated protein
kinase signal-integrating kinase Mnk2 is a
eukaryotic initiation factor 4E kinase with high
levels of basal activity in mammalian cells.
11154276 Akt phosphorylates and negatively
regulates apoptosis signal-regulating kinase 1.
11154281 Protein kinase SGK mediates
survival signals by phosphorylating the forkhead
transcription factor FKHRL1 (FOXO3a).
11154691 Stimulation of NF-E2 DNA binding
by CREB-binding protein (CBP)-mediated
11156376 HER-2/neu promotes
androgen-independent survival and growth of
prostate cancer cells through the Akt pathway.
11158290 Shared pathways of IkappaB
ubiquitination and degradation for the
NF-kappaB precursor p105 and IkappaBalpha.
11158295 SH2 domain-mediated interaction of
inhibitory protein tyrosine kinase Csk with
protein tyrosine phosphatase-HSCF.
11158305 Identification of a major cyclic
AMP-dependent protein kinase A
phosphorylation site within the cytoplasmic tail
of the low-density lipoprotein receptor-related
protein: implication for receptor-mediated
11159935 Congenital insensitivity to pain with
anhidrosis (CIPA): effect of TRKA (NTRK1)
missense mutations on autophosphorylation of
the receptor tyrosine kinase for nerve growth
11160423 Densin-180 forms a ternary complex
with the (alpha)-subunit of
Ca2+/calmodulin-dependent protein kinase II
11160818 Serine phosphorylation of focal
adhesion kinase in interphase and mitosis: a
possible role in modulating binding to
11160957 Cognitive impairment in Coffin-Lowry
syndrome correlates with reduced RSK2
11162250 Proapoptotic effects of tau cleavage
product generated by caspase-3.
11162423 Glycosylation effect on membrane
domain (GEM) involved in cell adhesion and
motility: a preliminary note on functional alpha3,
alpha5-CD82 glycosylation complex in ldlD 14
11162588 Frap-dependent serine
phosphorylation of IRS-1 inhibits IRS-1 tyrosine
11162638 Activated Fyn phosphorylates
alpha-synuclein at tyrosine residue 125.
11163076 N-linked carbohydrate on human
leukocyte antigen-C and recognition by natural
killer cell inhibitory receptors.
11163214 Cytoskeletal protein PSTPIP1
directs the PEST-type protein tyrosine
phosphatase to the c-Abl kinase to mediate Abl
11165260 Identification of the main
ubiquitination site in human erythroid
11169414 Induction, binding specificity and
function of human ICOS.
11171059 Phosphorylation of elongation
factor-2 kinase on serine 499 by
cAMP-dependent protein kinase induces
11175347 NO activation of fos promoter
elements requires nuclear translocation of
G-kinase I and CREB phosphorylation but is
independent of MAP kinase activation.
11179223 Securin degradation is mediated by
fzy and fzr, and is required for complete
chromatid separation but not for cytokinesis.
11181075 Caspase-cleaved TRAF1 negatively
regulates the antiapoptotic signals of TRAF2
during TNF-induced cell death.
11181181 Inward rectifier potassium channel
Kir2.2 is associated with synapse-associated
11181701 Activation of the COOH-terminal Src
kinase (Csk) by cAMP-dependent protein
kinase inhibits signaling through the T cell
11181841 Characterization of the in vitro
phosphorylation of human tau by tau protein
kinase II (cdk5/p20) using mass spectrometry.
11201744 CD45 is a JAK phosphatase and
negatively regulates cytokine receptor
11222751 Sp1 phosphorylation regulates
inducible expression of platelet-derived growth
factor B-chain gene via atypical protein kinase
11223155 Influence of the somatostatin
receptor sst2 on growth factor signal cascades
in human glioma cells.
11223514 Structure of fibroblast growth factor
9 shows a symmetric dimer with unique
receptor- and heparin-binding interfaces.
11226282 BLNK mediates Syk-dependent Btk
11226831 Glycosylation of the murine estrogen
11230133 Autophosphorylation restrains the
apoptotic activity of DRP-1 kinase by
controlling dimerization and calmodulin binding.
11231586 ERK phosphorylation drives
cytoplasmic accumulation of hnRNP-K and
inhibition of mRNA translation.
11232563 An hPer2 phosphorylation site
mutation in familial advanced sleep phase
11237874 'Shed' furin: mapping of the
cleavage determinants and identification of its
11238922 HIRA, the human homologue of
yeast Hir1p and Hir2p, is a novel cyclin-cdk2
substrate whose expression blocks S-phase
11239454 Interaction of the Fanconi anemia
proteins and BRCA1 in a common pathway.
11239464 RING finger mutations that abolish
c-Cbl-directed polyubiquitination and
downregulation of the EGF receptor are
insufficient for cell transformation.
11239468 NF-kappaB-inducing kinase
regulates the processing of NF-kappaB2 p100.
11241273 Rapid inactivation of stromal
cell-derived factor-1 by cathepsin G associated
11241286 Dendritic cells as a major source of
macrophage-derived chemokine/CCL22 in vitro
and in vivo.
11242082 Polo-like kinase 1 phosphorylates
cyclin B1 and targets it to the nucleus during
11246872 The prohormone convertase enzyme
2 (PC2) is essential for processing pro-islet
amyloid polypeptide at the NH2-terminal
11248093 The dependence receptor DCC
(deleted in colorectal cancer) defines an
alternative mechanism for caspase activation.
11252893 The many substrates and functions
11254654 BMK1 mediates growth
factor-induced cell proliferation through direct
cellular activation of serum and
11254678 Cutting edge: differential signaling
requirements for activation of assembled cyclin
D3-cdk4 complexes in B-1 and B-2 lymphocyte
11257227 Arginine methylation of STAT1
modulates IFNalpha/beta-induced transcription.
11257495 A new family of small, palmitoylated,
membrane-associated proteins, characterized
by the presence of a cysteine-rich hydrophobic
11258932 S100A7, S100A10, and S100A11
are transglutaminase substrates.
11259409 Identification of new JNK substrate
using ATP pocket mutant JNK and a
corresponding ATP analogue.
11259586 p38 mitogen-activated protein
kinase-dependent activation of protein
phosphatases 1 and 2A inhibits MEK1 and
MEK2 activity and collagenase 1 (MMP-1) gene
11264294 Pregnancy-associated plasma
protein-A2 (PAPP-A2), a novel insulin-like
growth factor-binding protein-5 proteinase.
11266453 A novel chromatin protein, distantly
related to histone H2A, is largely excluded from
the inactive X chromosome.
11274386 Akt phosphorylates and regulates
the orphan nuclear receptor Nur77.
11277933 Human phosphatidylinositol 4-kinase
isoform PI4K92. Expression of the recombinant
enzyme and determination of multiple
11278268 Effects of the NIK aly mutation on
NF-kappaB activation by the Epstein-Barr virus
latent infection membrane protein, lymphotoxin
beta receptor, and CD40.
11278283 MST, a physiological caspase
substrate, highly sensitizes apoptosis both
upstream and downstream of caspase
11278298 Phosphorylation and regulation of
G-protein-activated phospholipase C-beta 3 by
cGMP-dependent protein kinases.
11278340 Interaction of hematopoietic
progenitor kinase 1 and c-Abl tyrosine kinase in
response to genotoxic stress.
11278381 Sumo-1 modification regulates the
DNA binding activity of heat shock transcription
factor 2, a promyelocytic leukemia nuclear body
associated transcription factor.
11278424 Calsenilin is a substrate for
caspase-3 that preferentially interacts with the
familial Alzheimer's disease-associated
C-terminal fragment of presenilin 2.
11278446 ATM-dependent phosphorylation of
human Rad9 is required for ionizing
radiation-induced checkpoint activation.
11278469 Regulation of membrane targeting of
the G protein-coupled receptor kinase 2 by
protein kinase A and its anchoring protein
11278470 Protein kinase C alpha -mediated
negative feedback regulation is responsible for
the termination of insulin-like growth factor
I-induced activation of nuclear phospholipase C
beta1 in Swiss 3T3 cells.
11278486 The mechanism of PAK activation.
Autophosphorylation events in both regulatory
and kinase domains control activity.
11278496 Taf(II) 250 phosphorylates human
transcription factor IIA on serine residues
important for TBP binding and transcription
11278523 Phosphorylation of Ser363, Thr370,
and Ser375 residues within the carboxyl tail
differentially regulates mu-opioid receptor
11278541 Mitotic reorganization of the
intermediate filament protein nestin involves
phosphorylation by cdc2 kinase.
11278559 Versican V1 proteolysis in human
aorta in vivo occurs at the Glu441-Ala442
bond, a site that is cleaved by recombinant
ADAMTS-1 and ADAMTS-4.
11278572 Cdc42 is a substrate for caspases
and influences Fas-induced apoptosis.
11278730 A family of 16-kDa pancreatic
secretory stress proteins form highly organized
fibrillar structures upon tryptic activation.
11278782 Both phosphorylation and
caspase-mediated cleavage contribute to
regulation of the Ste20-like protein kinase Mst1
during CD95/Fas-induced apoptosis.
11278789 MAP kinases mediate UVB-induced
phosphorylation of histone H3 at serine 28.
11278797 Proteolytic activation of ETK/Bmx
tyrosine kinase by caspases.
11278835 Inhibition of insulin-induced
activation of Akt by a kinase-deficient mutant of
the epsilon isozyme of protein kinase C.
11278841 Phosphorylation regulates
intracellular trafficking of beta-secretase.
11278902 Marked differences between
metalloproteases meprin A and B in substrate
and peptide bond specificity.
11278906 Exposure on cell surface and
extensive arginine methylation of ewing
sarcoma (EWS) protein.
11278964 Ataxia telangiectasia mutated (ATM)
kinase and ATM and Rad3 related kinase
mediate phosphorylation of Brca1 at distinct
and overlapping sites. In vivo assessment using
11278991 Specific phosphorylation of
nucleophosmin on Thr(199) by
cyclin-dependent kinase 2-cyclin E and its role
in centrosome duplication.
11279024 J Biol Chem. 2001 Jun
8;276(23):20436-43. Epub 2001 Mar 13.
11279095 Unique disulfide bond structures
found in ST8Sia IV polysialyltransferase are
required for its activity.
11279131 The beta-amyloid precursor protein
APP is tyrosine-phosphorylated in cells
expressing a constitutively active form of the
11279194 Molecular cloning and
characterization of a novel (Na+,K+)/H+
exchanger localized to the trans-Golgi network.
11279195 Phosphorylation of centrin during the
cell cycle and its role in centriole separation
preceding centrosome duplication.
11279201 Identification of reelin-induced sites
of tyrosyl phosphorylation on disabled 1.
11279232 Signal transduction pathways
involved in phosphorylation and activation of
p70S6K following exposure to UVA irradiation.
11283002 Identification of amino acid residues
in bone morphogenetic protein-1 important for
procollagen C-proteinase activity.
11283254 Jun NH2-terminal kinase
phosphorylation of p53 on Thr-81 is important
for p53 stabilization and transcriptional activities
in response to stress.
11283605 Phosphorylation of Snapin by PKA
modulates its interaction with the SNARE
11284693 Posttranslational modifications of
microfibril associated glycoprotein-1 (MAGP-1).
11287604 Phosphorylation of nuclear
phospholipase C beta1 by extracellular
signal-regulated kinase mediates the mitogenic
action of insulin-like growth factor I.
11290523 Regulation of endothelial cell barrier
function by calcium/calmodulin-dependent
protein kinase II.
11290735 Tuberin phosphorylation regulates its
interaction with hamartin. Two proteins involved
in tuberous sclerosis.
11290787 Identification of novel functional
regions important for the activity of HOXB7 in
11292861 Targeting of HIF-alpha to the von
Hippel-Lindau ubiquitylation complex by
O2-regulated prolyl hydroxylation.
11292862 HIFalpha targeted for VHL-mediated
destruction by proline hydroxylation:
implications for O2 sensing.
11294838 Specific dephosphorylation of the
Lck tyrosine protein kinase at Tyr-394 by the
SHP-1 protein-tyrosine phosphatase.
11294867 Activation and functional
characterization of the mosaic receptor
11294897 Identification of tyrosine residues in
constitutively activated fibroblast growth factor
receptor 3 involved in mitogenesis, Stat
activation, and phosphatidylinositol 3-kinase
11294912 Cofilin phosphorylation by protein
kinase testicular protein kinase 1 and its role in
integrin-mediated actin reorganization and focal
11297520 Phosphorylation of the protein
kinase mutated in Peutz-Jeghers cancer
syndrome, LKB1/STK11, at Ser431 by
p90(RSK) and cAMP-dependent protein kinase,
but not its farnesylation at Cys(433), is essential
for LKB1 to suppress cell vrowth.
11298456 The ATM-Chk2-Cdc25A checkpoint
pathway guards against radioresistant DNA
11303872 Chemical synthesis of lymphotactin:
a glycosylated chemokine with a C-terminal
11307817 The amino acid sequence in fibrin
responsible for high affinity thrombin binding.
11311120 The kinase DYRK1A phosphorylates
the transcription factor FKHR at Ser329 in vitro,
a novel in vivo phosphorylation site.
11311121 The kinase DYRK phosphorylates
protein-synthesis initiation factor eIF2Bepsilon
at Ser539 and the microtubule-associated
protein tau at Thr212: potential role for DYRK
as a glycogen synthase kinase 3-priming
11313365 Regulation of protein kinase
B/Akt-serine 473 phosphorylation by
integrin-linked kinase: critical roles for kinase
activity and amino acids arginine 211 and serine
11313457 Common properties of nuclear body
protein SP100 and TIF1alpha chromatin factor:
role of SUMO modification.
11313464 JAK2 activates TFII-I and regulates
its interaction with extracellular signal-regulated
11313479 Inhibition of nuclear import by
protein kinase B (Akt) regulates the subcellular
distribution and activity of the forkhead
transcription factor AFX.
11313925 Constitutive c-Myb amino-terminal
phosphorylation and DNA binding activity
uncoupled during entry and passage through
the cell cycle.
11314030 Activation of the focal adhesion
kinase signaling pathway by structural
alterations in the carboxyl-terminal region of
11316748 The insulin-like growth factor I
receptor-induced interaction of insulin receptor
substrate-4 and Crk-II.
11316808 Prodomain processing of Asp1
(BACE2) is autocatalytic.
11319549 Beam me up, Scottie! TREK
channels swing both ways.
11320080 Neuronal Cdc2-like protein kinase
(Cdk5/p25) is associated with protein
phosphatase 1 and phosphorylates inhibitor-2.
11320094 Membrane topology of the ATP
binding cassette transporter ABCR and its
relationship to ABC1 and related ABCA
transporters: identification of N-linked
11323410 Post-translational processing of
11323411 Phosphotyrosines 627 and 659 of
Gab1 constitute a bisphosphoryl
tyrosine-based activation motif (BTAM)
conferring binding and activation of SHP2.
11325525 KN-93 inhibition of G protein
signaling is independent of the ability of
Ca2+/calmodulin-dependent protein kinase II to
phosphorylate phospholipase Cbeta3 on
11325528 Regulation of the ErbB3 binding
protein Ebp1 by protein kinase C.
11327826 Human recombinant pro-dipeptidyl
peptidase I (cathepsin C) can be activated by
cathepsins L and S but not by autocatalytic
11328818 Identification and characterization of
S2V, a novel putative siglec that contains two V
set Ig-like domains and recruits protein-tyrosine
11331285 Modulation of the G protein
regulator phosducin by
Ca2+/calmodulin-dependent protein kinase II
phosphorylation and 14-3-3 protein binding.
11331603 ATM-dependent phosphorylation of
Mdm2 on serine 395: role in p53 activation by
11331782 Granzymes A and B directly cleave
lamins and disrupt the nuclear lamina during
11331870 Regulation of the
PH-domain-containing tyrosine kinase Etk by
focal adhesion kinase through the FERM
11331881 PDGF-D is a specific,
protease-activated ligand for the PDGF
11333986 Initiation of a G2/M checkpoint after
ultraviolet radiation requires p38 kinase.
11335711 Sequential activation of Rac-1,
SEK-1/MKK-4, and protein kinase Cdelta is
required for interleukin-6-induced STAT3
Ser-727 phosphorylation and transactivation.
11336675 Crystal structure of the
complex. a role for scaffolding in enzyme
11337490 Inhibition of the catalytic activity of
cell adhesion kinase beta by protein-tyrosine
11337501 Binding of double-stranded RNA to
protein kinase PKR is required for dimerization
and promotes critical autophosphorylation
events in the activation loop.
11340065 Activation of LIM kinases by
myotonic dystrophy kinase-related
Cdc42-binding kinase alpha.
11341784 Identification of MUC1 proteolytic
cleavage sites in vivo.
11342557 HSP22, a new member of the small
heat shock protein superfamily, interacts with
mimic of phosphorylated HSP27 ((3D)HSP27).
11342590 Sulfated tyrosines contribute to the
formation of the C5a docking site of the human
C5a anaphylatoxin receptor.
11343707 Phosphorylation of murine
homeodomain protein Dlx3 by protein kinase C.
11344269 Cloning and characterization of
FGF23 as a causative factor of tumor-induced
11350938 Protein kinase PKR is required for
platelet-derived growth factor signaling of c-fos
gene expression via Erks and Stat3.
11353545 Requirements for activation and
RAFT localization of the T-lymphocyte kinase
11356849 Effect of mutation and
phosphorylation of type I keratins on their
11359875 Interaction of phosphorylated
tyrosine hydroxylase with 14-3-3 proteins:
evidence for a phosphoserine 40-dependent
11368773 Mapping the Zap-70
phosphorylation sites on LAT (linker for
activation of T cells) required for recruitment
and activation of signalling proteins in T cells.
11369760 CD44-initiated cell spreading
induces Pyk2 phosphorylation, is mediated by
Src family kinases, and is negatively regulated
11369769 The cytoskeletal/non-muscle
isoform of alpha-actinin is phosphorylated on its
actin-binding domain by the focal adhesion
11371618 Phosphorylation and microtubule
association of the Opitz syndrome protein
mid-1 is regulated by protein phosphatase 2A
via binding to the regulatory subunit alpha 4.
11373296 Identification of phosphorylation
sites for Bruton's tyrosine kinase within the
transcriptional regulator BAP/TFII-I.
11375993 Osteopontin, a novel substrate for
matrix metalloproteinase-3 (stromelysin-1) and
matrix metalloproteinase-7 (matrilysin).
11376433 Preparation and application of
antibodies to phosphoamino acid sequences.
11378439 Phosphorylation of the Fas
associated factor FAF1 by protein kinase CK2
and identification of serines 289 and 291 as the
in vitro phosphorylation sites.
11381077 Membrane-type 1 matrix
metalloproteinase cleaves CD44 and promotes
11381116 Phosphorylation sites of protein
kinase C delta in H2O2-treated cells and its
activation by tyrosine kinase in vitro.
11382764 Identification of Src phosphorylation
sites in the catenin p120ctn.
11387207 Ezrin is a downstream effector of
trafficking PKC-integrin complexes involved in
the control of cell motility.
11387210 A single autophosphorylation site on
KDR/Flk-1 is essential for VEGF-A-dependent
activation of PLC-gamma and DNA synthesis in
vascular endothelial cells.
11387340 Serum response factor cleavage by
caspases 3 and 7 linked to apoptosis in human
11389975 Glycosylation of human CRLR at
Asn123 is required for ligand binding and
11390389 c-Abl tyrosine kinase binds and
phosphorylates phospholipid scramblase 1.
11390394 Kinetic investigation of chemokine
truncation by CD26/dipeptidyl peptidase IV
reveals a striking selectivity within the
11390408 The hCds1 (Chk2)-FHA domain is
essential for a chain of phosphorylation events
on hCds1 that is induced by ionizing radiation.
11390657 Molecular cloning of ILP-2, a novel
member of the inhibitor of apoptosis protein
11395479 SET-related cell division
autoantigen-1 (CDA1) arrests cell growth.
11396978 Identification of a novel
phosphorylation site in human androgen
receptor by mass spectrometry.
11397791 Phosphorylation of Thr(495)
endothelial nitric oxide synthase activity.
11399775 Phosphorylation of a novel myosin
binding subunit of protein phosphatase 1
reveals a conserved mechanism in the
regulation of actin cytoskeleton.
11401470 Identification of Ser(1275) and
Ser(1309) as autophosphorylation sites of the
human insulin receptor in intact cells.
11404460 Akt suppresses androgen-induced
apoptosis by phosphorylating and inhibiting
11406587 Direct cleavage of the human DNA
fragmentation factor-45 by granzyme B
induces caspase-activated DNase release and
11408587 Mitotic phosphorylation of Golgi
reassembly stacking protein 55 by
mitogen-activated protein kinase ERK2.
11409876 Nuclear extracellular signal-regulated
kinase 2 phosphorylates p53 at Thr55 in
response to doxorubicin.
11410590 Serum- and glucocorticoid-inducible
kinase SGK phosphorylates and negatively
11413148 Transcription factor STAT5A is a
substrate of Bruton's tyrosine kinase in B cells.
11416124 Phosphorylation of MafA is essential
for its transcriptional and biological properties.
11416205 Mutations within a furin consensus
sequence block proteolytic release of
ectodysplasin-A and cause X-linked
hypohidrotic ectodermal dysplasia.
11418126 Proposed lipocalin fold for
apolipoprotein M based on bioinformatics and
11418599 Cofilin phosphorylation and actin
reorganization activities of testicular protein
kinase 2 and its predominant expression in
testicular Sertoli cells.
11418864 ATR/ATM-mediated phosphorylation
of human Rad17 is required for genotoxic
11420704 Sequential two-step cleavage of the
retinoblastoma protein by caspase-3/-7 during
11422372 Proteolytic processing of a human
salivary proline-rich protein precursor by
11423543 Heterogeneous fatty acylation of Src
family kinases with polyunsaturated fatty acids
regulates raft localization and signal
11423904 Caspase cleavage of vimentin
disrupts intermediate filaments and promotes
11425860 Gas6 anti-apoptotic signaling
requires NF-kappa B activation.
11427888 Structure of GSK3beta reveals a
primed phosphorylation mechanism.
11430825 Regulation of human flap
endonuclease-1 activity by acetylation through
the transcriptional coactivator p300.
11432792 Analysis of tyrosine
interactions in TrkB-mediated intracellular
signaling using modified yeast two-hybrid
11432835 Rsk2 allosterically activates estrogen
receptor alpha by docking to the
11433379 Structural and functional dissection
of the cytoplasmic domain of the
transmembrane adaptor protein SIT
(SHP2-interacting transmembrane adaptor
11435427 Cathepsin B, L, and S cleave and
inactivate secretory leucoprotease inhibitor.
11437602 [W206R]-procaspase 3: an
inactivatable substrate for caspase 8.
11438522 Actin cytoskeletal association of
cytohesin-1 is regulated by specific
phosphorylation of its carboxyl-terminal
11438643 Transcription factor AP-2alpha is
preferentially cleaved by caspase 6 and
degraded by proteasome during tumor necrosis
factor alpha-induced apoptosis in breast
11438671 Mitotic phosphorylation prevents the
binding of HMGN proteins to chromatin.
tyrosine-phosphorylation of protein kinase CK2
alpha and alpha' subunits: implication of
11443111 Phosphorylation and nuclear
translocation of a regulator of G protein
11444831 A novel secreted tumor antigen with
structure ubiquitously expressed in human
11445557 Regulation of Akt/PKB activation by
11447113 Positive and negative regulation of
Raf kinase activity and function by
11447121 Phosphorylation of serine 230
promotes inducible transcriptional activity of
heat shock factor 1.
11447134 Complete analysis of the
glycosylation and disulfide bond pattern of
human beta-hexosaminidase B by MALDI-MS.
11447212 Interaction of farnesylated PRL-2, a
protein-tyrosine phosphatase, with the
beta-subunit of geranylgeranyltransferase II.
11448957 Characterization of sequence
determinants within the carboxyl-terminal
domain of chemokine receptor CCR5 that
regulate signaling and receptor internalization.
11451954 Polymeric chains of SUMO-2 and
SUMO-3 are conjugated to protein substrates
by SAE1/SAE2 and Ubc9.
11451957 Palmitoylation of caveolin-1 at a
single site (Cys-156) controls its coupling to the
c-Src tyrosine kinase: targeting of dually
acylated molecules (GPI-linked,
transmembrane, or cytoplasmic) to caveolae
effectively uncouples c-Src and caveolin-1
11459832 Selective induction of E2F1 in
response to DNA damage, mediated by
11459840 The role of tyrosine residues in
fibroblast growth factor receptor 1 signaling in
PC12 cells. Systematic site-directed
mutagenesis in the endodomain.
11459942 PAS kinase: an evolutionarily
conserved PAS domain-regulated
11460167 TAK1 is a ubiquitin-dependent
kinase of MKK and IKK.
11461922 Nitric oxide inhibits ornithine
decarboxylase via S-nitrosylation of cysteine
360 in the active site of the enzyme.
protein kinase mediates the phosphorylation of
CD44 required for cell migration on hyaluronan.
11463380 CREB binding protein recruitment to
the transcription complex requires growth
factor-dependent phosphorylation of its GF
11463840 SATB1 cleavage by caspase 6
disrupts PDZ domain-mediated dimerization,
causing detachment from chromatin early in
11466320 In vivo tyrosine phosphorylation sites
of activated ephrin-B1 and ephB2 from neural
11470801 Identification of a novel
kinesin-related protein, KRMP1, as a target for
mitotic peptidyl-prolyl isomerase Pin1.
11470874 Cleavage of the Bloom's syndrome
gene product during apoptosis by caspase-3
results in an impaired interaction with
11477070 DJ-1 positively regulates the
androgen receptor by impairing the binding of
PIASx alpha to the receptor.
11479297 Acetylation of steroidogenic factor 1
protein regulates its transcriptional activity and
recruits the coactivator GCN5.
11481331 Identification of tyrosine
phosphorylation sites on
3-phosphoinositide-dependent protein kinase-1
and their role in regulating kinase activity.
11483158 Glycogen synthase kinase3 beta
phosphorylates serine 33 of p53 and activates
p53's transcriptional activity.
11483516 Promoting bone morphogenetic
protein signaling through negative regulation of
11483589 The epidermal growth factor
receptor regulates interaction of the human
DF3/MUC1 carcinoma antigen with c-Src and
11485553 Regulation of pyruvate
dehydrogenase activity through phosphorylation
at multiple sites.
11485561 Polyamine analogues inhibit the
ubiquitination of spermidine/spermine
N1-acetyltransferase and prevent its targeting
to the proteasome for degradation.
11485566 Roles of the juxtamembrane and
extracellular domains of angiotensin-converting
enzyme in ectodomain shedding.
11486000 Site specificity of four pyruvate
dehydrogenase kinase isoenzymes toward the
three phosphorylation sites of human pyruvate
11487578 Axin-dependent phosphorylation of
the adenomatous polyposis coli protein
mediated by casein kinase 1epsilon.
11489887 Characterization of a novel
isopeptidase, a homologue of rat axam, which
is an axin-binding protein promoting
11498053 Multiple phosphorylation of
rhodopsin and the in vivo chemistry underlying
rod photoreceptor dark adaptation.
11498590 Coordination of a transcriptional
switch by HMGI(Y) acetylation.
11499613 Characterization of glycated
hemoglobin in diabetic patients: usefulness of
electrospray mass spectrometry in monitoring
the extent and distribution of glycation.
11500040 The N-terminal internal region of
BLM is required for the formation of
dots/rod-like structures which are associated
11500362 Eukaryotic initiation factor 2B:
identification of multiple phosphorylation sites in
the epsilon-subunit and their functions in vivo.
11500363 A novel method to identify protein
kinase substrates: eEF2 kinase is
phosphorylated and inhibited by
11500364 Regulation of elongation factor 2
kinase by p90(RSK1) and p70 S6 kinase.
11500511 The fate of desmosomal proteins in
11500516 Multiple ErbB-2/Neu
Phosphorylation Sites Mediate Transformation
through Distinct Effector Proteins.
11502179 Purification and characterization of a
soluble bioactive amino-terminal extracellular
domain of the human thyrotropin receptor.
11502742 Protein kinase C regulates the
phosphorylation and cellular localization of
11502746 Phosphorylation of Ser(19) alters the
conformation of tyrosine hydroxylase to
increase the rate of phosphorylation of Ser(40).
11502795 Characterization of human FSH
isoforms reveals a nonglycosylated
beta-subunit in addition to the conventional
11504915 A phosphatidylinositol 3-kinase/Akt
pathway promotes translocation of Mdm2 from
the cytoplasm to the nucleus.
11506178 Phosphorylation and activation of
protein tyrosine phosphatase (PTP) 1B by
11507039 Phosphatidylinositol-3-OH Kinase
(PI3K)/AKT2, activated in breast cancer,
regulates and is induced by estrogen receptor
alpha (ERalpha) via interaction between
ERalpha and PI3K.
11507089 Four tyrosine residues in
phospholipase C-gamma 2, identified as
Btk-dependent phosphorylation sites, are
required for B cell antigen receptor-coupled
11509661 Acetylation of nuclear hormone
receptor-interacting protein RIP140 regulates
binding of the transcriptional corepressor CtBP.
11510412 Phosphorylation by PKA of a site
unique to B-Raf kinase.
11513602 Mechanistic effects of
autophosphorylation on receptor tyrosine
kinase catalysis: enzymatic characterization of
Tie2 and phospho-Tie2.
11514563 Identification of a caspase-9
substrate and detection of its cleavage in
programmed cell death during mouse
11514593 v-Src phosphorylation of connexin
43 on Tyr247 and Tyr265 disrupts gap
11514608 B cell adaptor containing src
homology 2 domain (BASH) links B cell
receptor signaling to the activation of
hematopoietic progenitor kinase 1.
11516622 Membrane-targeting is critical for
the phosphorylation of Vav2 by activated EGF
11517222 Dual regulation of mammalian
myosin VI motor function.
11517230 Determination of bradykinin B2
receptor in vivo phosphorylation sites and their
role in receptor function.
11517287 Expression and function of the
HSD-3.8 gene encoding a testis-specific
11518718 Murine notch homologs (N1-4)
undergo presenilin-dependent proteolysis.
11526478 Cleavage of Fyn and Lyn in their
N-terminal unique regions during induction of
apoptosis: a new mechanism for Src kinase
11532001 The role of Thr160 phosphorylation
of Cdk2 in substrate recognition.
11533025 Phosphorylation of the integrin alpha
4 cytoplasmic domain regulates paxillin binding.
11535131 Targeting of the transcription factor
Max during apoptosis:
phosphorylation-regulated cleavage by
caspase-5 at an unusual glutamic acid residue
in position P1.
11544253 G6b, a novel immunoglobulin
superfamily member encoded in the human
major histocompatibility complex, interacts with
SHP-1 and SHP-2.
11546794 Heregulin-dependent activation of
phosphoinositide 3-kinase and Akt via the
11546811 Phosphorylation of the human
ubiquitin-conjugating enzyme, CDC34, by
casein kinase 2.
11551902 Insulin receptor-mediated p62dok
tyrosine phosphorylation at residues 362 and
398 plays distinct roles for binding
GTPase-activating protein and Nck and is
essential for inhibiting insulin-stimulated
activation of Ras and Akt.
11551919 DNA damage-dependent and
-independent phosphorylation of the hRad9
11551930 Plk3 functionally links DNA damage
to cell cycle arrest and apoptosis at least in
part via the p53 pathway.
11551945 Cell type-specific inhibition of the
ETS transcription factor ER81 by
mitogen-activated protein kinase-activated
protein kinase 2.
11551979 S-Nitrosylation of mitochondrial
11555634 Structure-function analysis of
phytanoyl-CoA 2-hydroxylase mutations
causing Refsum's disease.
11555640 Translation inhibition in apoptosis:
caspase-dependent PKR activation and
glucocorticoid receptor degradation restricts
transcriptional signaling by glucocorticoids.
11557734 Proteomic analysis of
cardiomyocytes reveals novel phosphorylation
of myosin light chain 1.
11562345 Transcription regulation by histone
methylation: interplay between different
covalent modifications of the core histone tails.
11566027 Purification and characterization of
the human PDE4A catalytic domain
(PDE4A330-723) expressed in Sf9 cells.
11571266 Biologically active APRIL is secreted
following intracellular processing in the Golgi
apparatus by furin convertase.
11571274 ATM phosphorylates histone H2AX
in response to DNA double-strand breaks.
11572860 Docking protein Gab2 is
phosphorylated by ZAP-70 and negatively
regulates T cell receptor signaling by
recruitment of inhibitory molecules.
11574070 Regulation of
Ca(2+)/calmodulin-dependent protein kinase
kinase alpha by cAMP-dependent protein
kinase: I. Biochemical analysis.
11577080 Phosphorylation of Ser2078
modulates the Notch2 function in 32D cell
11579085 The pro-apoptotic function of
death-associated protein kinase is controlled by
a unique inhibitory autophosphorylation-based
11579209 Phosphorylation of PTP1B at Ser(50)
by Akt impairs its ability to dephosphorylate the
11581251 Stimulation of lipolysis and
hormone-sensitive lipase via the extracellular
signal-regulated kinase pathway.
11583622 Phosphorylation of bid by casein
kinases I and II regulates its cleavage by
11583630 Akt-mediated phosphorylation of the
G protein-coupled receptor EDG-1 is required
for endothelial cell chemotaxis.
11584018 Phosphorylation of the CCAAT
displacement protein (CDP)/Cux transcription
factor by cyclin A-Cdk1 modulates its DNA
binding activity in G(2).
11588171 An NMDA receptor signaling
complex with protein phosphatase 2A.
11591706 Double prenylation by RabGGTase
can proceed without dissociation of the
11591726 Identification of sequences within
the gamma-carboxylase that represent a novel
contact site with vitamin K-dependent proteins
and that are required for activity.
11593427 Involvement of Jak2 tyrosine
phosphorylation in Bcr-Abl transformation.
11594778 Phosphorylation of human
N-myristoyltransferase by N-myristoylated SRC
family tyrosine kinase members.
11597569 Sequestration and phosphorylation
of the prostaglandin E2 EP4 receptor:
dependence on the C-terminal tail.
11598012 PKCbeta modulates antigen
receptor signaling via regulation of Btk
11602244 The AP-1 repressor, JDP2, is a
bona fide substrate for the c-Jun N-terminal
11602246 Signalling of GPI-anchored CD157
via focal adhesion kinase in MCA102
11602581 Histone deacetylase 1
phosphorylation promotes enzymatic activity
and complex formation.
11604394 Phosphorylation of Pak1 by the
p35/Cdk5 kinase affects neuronal morphology.
11604405 Phosphorylation of cysteine string
protein by protein kinase A. Implications for the
modulation of exocytosis.
11604491 Trophic factor withdrawal: p38
mitogen-activated protein kinase activates
NHE1, which induces intracellular alkalinization.
endoribonuclease G3Bp: selective RNA
degradation and phosphorylation-dependent
11604997 Molecular cloning and
characterization of human WNT3.
11606045 Heterogeneity in the phosphorylation
of human death receptors by p42(mapk/erk2).
11606564 Phosphorylation of Ser307 in insulin
receptor substrate-1 blocks interactions with
the insulin receptor and inhibits insulin action.
11668633 Mutation screening at the RNA level
of the STK11/LKB1 gene in Peutz-Jeghers
syndrome reveals complex splicing
abnormalities and a novel mRNA isoform
(STK11 c.597(insertion mark)598insIVS4).
11672523 hSIR2(SIRT1) functions as an
NAD-dependent p53 deacetylase.
11675505 Regulation of NMDA receptors by
11676480 Physical and functional interactions
between protein tyrosine phosphatase alpha, PI
3-kinase, and PKCdelta.
11676606 Determination of carbohydrate
structures N-linked to soluble CD154 and
characterization of the interactions of CD40
with CD154 expressed in Pichia pastoris and
Chinese hamster ovary cells.
11683421 Phosphorylation of MAP4 affects
microtubule properties and cell cycle
11684694 Phosphorylation of MEK1 by
cdk5/p35 down-regulates the
mitogen-activated protein kinase pathway.
11687586 RGC-32 increases p34CDC2 kinase
activity and entry of aortic smooth muscle cells
11687594 Tyrosine phosphorylation mapping
of the epidermal growth factor receptor
11689432 Dok-R plays a pivotal role in
angiopoietin-1-dependent cell migration
through recruitment and activation of Pak.
11689443 Negative feedback regulation of
ASK1 by protein phosphatase 5 (PP5) in
response to oxidative stress.
11689449 A specific lysine in c-Jun is required
for transcriptional repression by E1A and is
acetylated by p300.
11689711 Regulation of the Forkhead
transcription factor AFX by Ral-dependent
phosphorylation of threonines 447 and 451.
11689934 Effect of DNA damage on a BRCA1
11690653 Delineation of the minimal catalytic
domain of human Galbeta1-3GalNAc
alpha2,3-sialyltransferase (hST3Gal I).
11691836 Hierarchical phosphorylation of the
translation inhibitor 4E-BP1.
11696579 Hyperglycemia inhibits endothelial
nitric oxide synthase activity by
posttranslational modification at the Akt site.
11696592 Functional cloning of Src-like
adapter protein-2 (SLAP-2), a novel inhibitor of
antigen receptor signaling.
11698596 Stimulation of endothelin B
receptors in astrocytes induces cAMP
response element-binding protein
phosphorylation and c-fos expression via
multiple mitogen-activated protein kinase
11698641 Phosphorylation of UBF at serine
388 is required for interaction with RNA
polymerase I and activation of rDNA
11698644 Glucose and cAMP regulate the
L-type pyruvate kinase gene by
phosphorylation/dephosphorylation of the
carbohydrate response element binding protein.
11701639 Apolipoprotein E: far more than a
lipid transport protein.
11706042 MD-2 and TLR4 N-linked
glycosylations are important for a functional
11707464 Akt (protein kinase B) negatively
regulates SEK1 by means of protein
11709713 UV-radiation induces
dose-dependent regulation of p53 response
and modulates p53-HDM2 interaction in human
11711533 PSTPIP is a substrate of PTP-PEST
and serves as a scaffold guiding PTP-PEST
toward a specific dephosphorylation of WASP.
11713246 Transforming growth factor-beta 1
regulates Kir2.3 inward rectifier K+ channels via
phospholipase C and protein kinase C-delta in
reactive astrocytes from adult rat brain.
11713277 Nerve growth factor stimulates
multisite tyrosine phosphorylation and activation
of the atypical protein kinase C's via a src
11713579 FAS-associated factor 1 interacts
with protein kinase CK2 in vivo upon apoptosis
11714793 J Immunol. 2001 Dec
11714842 Role of apoA-II in lipid metabolism
and atherosclerosis: advances in the study of
an enigmatic protein.
11717309 Identification of a novel
phosphorylation site, Ser-170, as a regulator of
bad pro-apoptotic activity.
11719502 p21-activated kinase links
Rac/Cdc42 signaling to merlin.
11719549 FIGQY phosphorylation defines
discrete populations of L1 cell adhesion
molecules at sites of cell-cell contact and in
11720283 Symmetrical dimethylation of
arginine residues in spliceosomal Sm protein
B/B' and the Sm-like protein LSm4, and their
interaction with the SMN protein.
11723131 Phosphorylation of beta3 integrin
controls ligand binding strength.
11723139 Ceramide-induced inhibition of Akt is
mediated through protein kinase Czeta:
implications for growth arrest.
11726507 Nuclear export of phosphorylated
C/EBPbeta mediates the inhibition of albumin
expression by TNF-alpha.
11726515 Tyrosine phosphorylation of Grb2 by
Bcr/Abl and epidermal growth factor receptor:
a novel regulatory mechanism for tyrosine
11731474 PIASy, a nuclear matrix-associated
SUMO E3 ligase, represses LEF1 activity by
sequestration into nuclear bodies.
11733001 ik3-1/Cables is a substrate for
cyclin-dependent kinase 3 (cdk 3).
11733037 Distinct regulatory mechanism for
p70 S6 kinase beta from that for p70 S6 kinase
11733498 Interaction between active Pak1 and
Raf-1 is necessary for phosphorylation and
activation of Raf-1.
11733580 Sialylated O-glycans and sulfated
tyrosines in the NH2-terminal domain of CC
chemokine receptor 5 contribute to high affinity
binding of chemokines.
11739740 Erk5 participates in neuregulin signal
transduction and is constitutively active in
breast cancer cells overexpressing ErbB2.
11741533 Cytokine stimulation of energy
expenditure through p38 MAP kinase activation
of PPARgamma coactivator-1.
11741535 Mutation of the c-Cbl TKB domain
binding site on the Met receptor tyrosine kinase
converts it into a transforming protein.
11741541 An immediate response of ribosomal
transcription to growth factor stimulation in
mammals is mediated by ERK phosphorylation
11741879 Protein kinase C (PKC)eta-mediated
PKC mu activation modulates ERK and JNK
11741894 Different domains of the
mitogen-activated protein kinases ERK3 and
ERK2 direct subcellular localization and
upstream specificity in vivo.
11741957 A lipid-regulated docking site on
vinculin for protein kinase C.
11741999 Biosynthetic processing of the
pro-alpha 1(V)2pro-alpha 2(V) collagen
heterotrimer by bone morphogenetic protein-1
and furin-like proprotein convertases.
11742978 Polarized trafficking and surface
expression of the AQP4 water channel are
coordinated by serial and regulated interactions
with different clathrin-adaptor complexes.
11742982 Phosphorylation of Nedd4-2 by
Sgk1 regulates epithelial Na(+) channel cell
11744621 Multiple phosphorylation of
alpha-synuclein by protein tyrosine kinase Syk
prevents eosin-induced aggregation.
11744634 The polysialyltransferase ST8Sia
II/STX: posttranslational processing and role of
autopolysialylation in the polysialylation of neural
cell adhesion molecule.
11744745 Phosphorylation of Ser(982) in the
sodium bicarbonate cotransporter kNBC1
shifts the HCO(3)(-) : Na(+) stoichiometry from 3
: 1 to 2 : 1 in murine proximal tubule cells.
11747312 Release and degradation of
angiotensin I and angiotensin II from
angiotensinogen by neutrophil serine
11748222 Functional interaction between
coactivators CBP/p300, PCAF, and
transcription factor FKLF2.
11749387 Glycogen synthase kinase-3:
properties, functions, and regulation.
11751582 Methylation at arginine 17 of histone
H3 is linked to gene activation.
11751874 The prosequence of human
lactase-phlorizin hydrolase modulates the
folding of the mature enzyme.
11751923 Novel activation of STAT5b in
response to epidermal growth factor.
11751924 Cell surface glycoprotein PZR is a
major mediator of concanavalin A-induced cell
11751973 Mast cell alpha-chymase reduces
IgE recognition of birch pollen profilin by
cleaving antibody-binding epitopes.
11755217 Caspase 7 can cleave tumor
necrosis factor receptor-I (p60) at a
non-consensus motif, in vitro.
11756412 AKT/PKB phosphorylation of
p21Cip/WAF1 enhances protein stability of
p21Cip/WAF1 and promotes cell survival.
11756446 Biosynthesis and cellular trafficking
of the convertase SKI-1/S1P: ectodomain
shedding requires SKI-1 activity.
11756469 CENP-A is phosphorylated by
Aurora B kinase and plays an unexpected role
in completion of cytokinesis.
11756552 PAK5, a new brain-specific kinase,
promotes neurite outgrowth in N1E-115 cells.
11772397 Phosphorylation of the protein
kinase C-theta activation loop and hydrophobic
motif regulates its kinase activity, but only
activation loop phosphorylation is critical to in
vivo nuclear-factor-kappaB induction.
11773076 The hemopexin-like C-terminal
domain of membrane type 1 matrix
metalloproteinase regulates proteolysis of a
multifunctional protein, gC1qR.
11773080 Distinct residues in the carboxyl tail
mediate agonist-induced desensitization and
internalization of the human dopamine D1
11777913 Phosphorylation of 4E-BP1 is
mediated by the p38/MSK1 pathway in
response to UVB irradiation.
11779865 Endosomal proteolysis of
internalized insulin at the C-terminal region of
the B chain by cathepsin D.
11780126 Homeodomain-interacting protein
kinase-2 phosphorylates p53 at Ser 46 and
11781100 The Protein-tyrosine-phosphatase
SHP2 is phosphorylated on serine residues 576
and 591 by protein kinase C isoforms alpha,
beta 1, beta 2, and eta.
11781324 The intermediate filament protein
keratin 8 is a novel cytoplasmic substrate for
c-Jun N-terminal kinase.
11781820 Phosphorylation and
structure-based functional studies reveal a
positive and a negative role for the activation
loop of the c-Abl tyrosine kinase.
11782427 PKB-mediated negative feedback
tightly regulates mitogenic signalling via Gab2.
11788583 Keratin 8 phosphorylation by p38
kinase regulates cellular keratin filament
reorganization: modulation by a keratin 1-like
disease causing mutation.
11801256 Decreased intracellular degradation
of insulin-like growth factor binding protein-3 in
cathepsin L-deficient fibroblasts.
11802788 The human homologue of the yeast
polyubiquitination factor Ufd2p is cleaved by
caspase 6 and granzyme B during apoptosis.
11804956 Proteolytic processing of human
zona pellucida proteins.
11805112 Interactions of beta and gamma
ENaC with Nedd4 can be facilitated by an
11805122 Phosphorylation of stargazin by
protein kinase A regulates its interaction with
11806999 Molecular dissection of the signaling
and costimulatory functions of CD150 (SLAM):
CD150/SAP binding and CD150-mediated
11812650 Molecular interactions of SHP1 and
SHP2 in IL-3-signalling.
11812771 KEPI, a PKC-dependent protein
phosphatase 1 inhibitor regulated by morphine.
11815627 Hydrolysis of biological peptides by
human angiotensin-converting enzyme-related
11818338 An intact NEDD8 pathway is
required for Cullin-dependent ubiquitylation in
11818507 Requirement of Ca(2+) and
PKCdelta for Janus kinase 2 activation by
angiotensin II: involvement of PYK2.
11818547 Casein kinase I phosphorylates and
destabilizes the beta-catenin degradation
11823425 Cyclin-dependent kinase 5 prevents
neuronal apoptosis by negative regulation of
c-Jun N-terminal kinase 3.
11823465 Tumor necrosis factor-alpha
converting enzyme (TACE) regulates epidermal
growth factor receptor ligand availability.
11823643 Asparagine hydroxylation of the HIF
transactivation domain a hypoxic switch.
11825621 Mutational analysis of sites in
sepiapterin reductase phosphorylated by
Ca2+/calmodulin-dependent protein kinase II.
11832478 Caspase-2 induces apoptosis by
releasing proapoptotic proteins from
11834745 Peroxynitrite-induced nitration of
tyrosine hydroxylase: identification of tyrosines
423, 428, and 432 as sites of modification by
matrix-assisted laser desorption ionization
time-of-flight mass spectrometry and
11835310 Nerve growth factor-mediated
increases in protein methylation occur
predominantly at type I arginine methylation
sites and involve protein arginine
11836243 Differential use of myristoyl groups
on neuronal calcium sensor proteins as a
determinant of spatio-temporal aspects of
Ca2+ signal transduction.
11836499 BRCA1 regulates the G2/M
checkpoint by activating Chk1 kinase upon
11839738 Protein kinase C-delta (PKC-delta )
is activated by type I interferons and mediates
phosphorylation of Stat1 on serine 727.
11839743 IKK-i and TBK-1 are enzymatically
distinct from the homologous enzyme IKK-2:
comparative analysis of recombinant human
IKK-i, TBK-1, and IKK-2.
11840332 MDMX stability is regulated by
p53-induced caspase cleavage in NIH3T3
11842186 Arsenite-induced Cdc25C
degradation is through the KEN-box and
11844797 Arachidonic acid promotes
phosphorylation of 5-lipoxygenase at Ser-271
by MAPK-activated protein kinase 2 (MK2).
11846800 Tyrosine sulfation and
N-glycosylation of human heparin cofactor II
from plasma and recombinant Chinese hamster
ovary cells and their effects on heparin binding.
11847099 Tyrosine sulfation is required for
agonist recognition by glycoprotein hormone
11850402 PABP1 identified as an arginine
methyltransferase substrate using high-density
11850617 CEACAM1 regulates insulin
clearance in liver.
11853558 Identification and characterization of
four novel phosphorylation sites (Ser31,
Ser325, Thr336 and Thr366) on LKB1/STK11,
the protein kinase mutated in Peutz-Jeghers
11854294 Platelet-derived growth factor
(PDGF)-induced tyrosine phosphorylation of the
low density lipoprotein receptor-related protein
(LRP). Evidence for integrated co-receptor
function betwenn LRP and the PDGF.
11854437 Caspase-dependent cleavage of
carbamoyl phosphate synthetase II during
11855827 Phosphorylation of the N-terminal
and C-terminal CD3-epsilon-ITAM tyrosines is
differentially regulated in T cells.
11855836 Phosphorylation of Fanconi anemia
protein, FANCA, is regulated by Akt kinase.
11859414 Yeast two-hybrid screening using
constitutive-active caspase-7 as bait in the
identification of PA28gamma as an effector
11861764 Survivin exists in immunochemically
distinct subcellular pools and is involved in
spindle microtubule function.
11861906 Phosphorylation of mammalian
translation initiation factor 5 (eIF5) in vitro and in
11864601 Association of CBP/p300 acetylase
and thymine DNA glycosylase links DNA repair
11864968 Purification, cloning, and
characterization of Nek8, a novel NIMA-related
kinase, and its candidate substrate Bicd2.
11865049 Control of intracellular dynamics of
mammalian period proteins by casein kinase I
epsilon (CKIepsilon) and CKIdelta in cultured
11870081 SAMP32, a testis-specific,
isoantigenic sperm acrosomal
11870224 Ephrin-A5 induces rounding,
blebbing and de-adhesion of EphA3-expressing
293T and melanoma cells by CrkII and
11875057 ATM mediates phosphorylation at
multiple p53 sites, including Ser(46), in
response to ionizing radiation.
11875070 ERK8, a new member of the
mitogen-activated protein kinase family.
11875078 Caspase proteolysis of the cohesin
component RAD21 promotes apoptosis.
11877257 Processing of the lipocalin
alpha(1)-microglobulin by hemoglobin induces
heme-binding and heme-degradation
11877377 SMC1 is a downstream effector in
the ATM/NBS1 branch of the human S-phase
11877389 Glucocorticoids inhibit cell cycle
progression in differentiating osteoblasts via
glycogen synthase kinase-3beta.
11877440 Protein kinase C delta regulates
function of the DF3/MUC1 carcinoma antigen in
11877451 Regulation of arrestin-3
phosphorylation by casein kinase II.
11882902 Structure of the HP1 chromodomain
bound to histone H3 methylated at lysine 9.
11883897 Kinetic properties of p53
phosphorylation by the human vaccinia-related
11883936 Nuclear receptor and apoptosis
initiator NGFI-B is a substrate for kinase ERK2.
11884385 Direct phosphorylation of capsaicin
receptor VR1 by protein kinase Cepsilon and
identification of two target serine residues.
11884598 Convergence of multiple signaling
cascades at glycogen synthase kinase 3: Edg
receptor-mediated phosphorylation and
inactivation by lysophosphatidic acid through a
protein kinase C-dependent intracellular
11893489 Histone H2A variants H2AX and
11895474 Phosphorylation and reorganization
of vimentin by p21-activated kinase (PAK).
11895774 Adducin in platelets:
activation-induced phosphorylation by PKC and
proteolysis by calpain.
11897663 Plk1 promotes nuclear translocation
of human Cdc25C during prophase.
11901158 Phosphorylation of threonine 68
promotes oligomerization and
autophosphorylation of the Chk2 protein kinase
via the forkhead-associated domain.
11901164 CD46 is phosphorylated at tyrosine
354 upon infection of epithelial cells by
11903055 Protein kinase A enhances, whereas
glycogen synthase kinase-3 beta inhibits, the
activity of the exon 2-encoded transactivator
domain of heterogeneous nuclear
ribonucleoprotein D in a hierarchical fashion.
11903056 Glycosylation and epitope mapping
of the 5T4 glycoprotein oncofoetal antigen.
11904303 p59Hck isoform induces F-actin
reorganization to form protrusions of the
plasma membrane in a Cdc42- and
11904305 Identification of two Sp1
phosphorylation sites for p42/p44
mitogen-activated protein kinases: their
implication in vascular endothelial growth factor
11904443 Dominant-interfering forms of MEF2
generated by caspase cleavage contribute to
NMDA-induced neuronal apoptosis.
11906178 Revised structure of the active form
of human deoxyribonuclease IIalpha.
11907260 Palmitoylation of tetraspanin
proteins: modulation of CD151 lateral
interactions, subcellular distribution, and
integrin-dependent cell morphology.
11907583 TNF-RII and c-IAP1 mediate
ubiquitination and degradation of TRAF2.
11909529 The T cell protein tyrosine
phosphatase is a negative regulator of janus
family kinases 1 and 3.
11909853 Regulation of TRAF2 signaling by
11909961 SKAP55 coupled with CD45
positively regulates T-cell receptor-mediated
11909973 HMG2 interacts with the
nucleosome assembly protein SET and is a
target of the cytotoxic T-lymphocyte protease
11909979 MSK1 and MSK2 are required for
the mitogen- and stress-induced
phosphorylation of CREB and ATF1 in
11910029 Mass spectrometric analysis of the
kinetics of in vivo rhodopsin phosphorylation.
11911831 TL1A is a TNF-like ligand for DR3
and TR6/DcR3 and functions as a T cell
11912203 Hydroxylation and glycosylation of
the four conserved lysine residues in the
collagenous domain of adiponectin. Potential
role in the modulation of its insulin-sensitizing
11914378 Regulation of an activated S6 kinase
1 variant reveals a novel mammalian target of
rapamycin phosphorylation site.
11916978 Protein kinase C (PKC) delta
regulates PKCalpha activity in a
11920685 Activation of apoptosis
signal-regulating kinase 1 by the stress-induced
activating phosphorylation of pre-formed
11921352 Functional interaction of G
protein-coupled receptors of the
adrenomedullin peptide family with accessory
receptor-activity-modifying proteins (RAMP).
11923282 Regulation of metallothionein
transcription by the metal-responsive
transcription factor MTF-1: identification of
signal transduction cascades that control
11923305 Mitotic activation of protein-tyrosine
phosphatase alpha and regulation of its
Src-mediated transforming activity by its sites
of protein kinase C phosphorylation.
11925442 Mitosis-specific activation of LIM
motif-containing protein kinase and roles of
cofilin phosphorylation and dephosphorylation in
11927607 Src-mediated coupling of focal
adhesion kinase to integrin alpha(v)beta5 in
vascular endothelial growth factor signaling.
11928826 Apolipoprotein(a): structure-function
relationship at the lysine-binding site and
plasminogen activator cleavage site.
11931630 Integrin-linked kinase
phosphorylates the myosin phosphatase target
subunit at the inhibitory site in platelet
11931757 Human origin recognition complex
large subunit is degraded by ubiquitin-mediated
proteolysis after initiation of DNA replication.
11934902 c-Src-dependent transcriptional
activation of TFII-I.
11940572 ErbB-2 activates Stat3 alpha in a
Src- and JAK2-dependent manner.
11940573 Interactions between protein kinase
CK2 and Pin1. Evidence for
11940581 Protein kinase C-alpha and protein
kinase C-epsilon are required for
Grb2-associated binder-1 tyrosine
phosphorylation in response to platelet-derived
11944890 Phytochemical inhibition of
interleukin-4-activated Stat6 and expression of
11948414 Hepatocyte growth factor/scatter
factor activates the ETS1 transcription factor
by a RAS-RAF-MEK-ERK signaling pathway.
11948419 Motif analysis of the tumor
suppressor gene MMAC/PTEN identifies
tyrosines critical for tumor suppression and lipid
11953308 14-3-3 amplifies and prolongs
adrenergic stimulation of HERG K+ channel
11953316 Caspase-6 gene disruption reveals a
requirement for lamin A cleavage in apoptotic
11953320 Regulation of the
ubiquitin-conjugating enzyme hHR6A by
11955010 The role of MeH73 in actin
polymerization and ATP hydrolysis.
11955436 Control of beta-catenin
phosphorylation/degradation by a dual-kinase
11956190 Sphingosine 1-phosphate induces
membrane ruffling and increases motility of
human umbilical vein endothelial cells via
vascular endothelial growth factor receptor and
11956222 Identification of 14-3-3zeta as a
protein kinase B/Akt substrate.
11959144 Dephosphorylation of PKCdelta by
protein phosphatase 2Ac and its inhibition by
11959841 SETDB1: a novel KAP-1-associated
histone H3, lysine 9-specific methyltransferase
that contributes to HP1-mediated silencing of
euchromatic genes by KRAB zinc-finger
11960013 IRAK-4: a novel member of the IRAK
family with the properties of an IRAK-kinase.
11960997 SUMO-1 modification of histone
deacetylase 1 (HDAC1) modulates its biological
11969422 Identification of in vivo
phosphorylation sites of MLK3 by mass
spectrometry and phosphopeptide mapping.
11970865 Phosphorylation of CBP mediates
transcriptional activation by neural activity and
CaM kinase IV.
11971190 Mechanism of constitutive activation
of FLT3 with internal tandem duplication in the
11971877 Mutations in CD2BP1 disrupt
binding to PTP PEST and are responsible for
PAPA syndrome, an autoinflammatory disorder.
11971957 Cyclic AMP-dependent kinase
regulates Raf-1 kinase mainly by
phosphorylation of serine 259.
11971963 c-Abl tyrosine kinase regulates the
human Rad9 checkpoint protein in response to
11972023 Requirement of Ca2+ and CaMKII
for Stat1 Ser-727 phosphorylation in response
11973335 Acetylation of beta-catenin by
CREB-binding protein (CBP).
11976320 Inhibition of interleukin-1beta
-induced NF-kappa B activation by
calcium/calmodulin-dependent protein kinase
kinase occurs through Akt activation
associated with interleukin-1
receptor-associated kinase phosphorylation
and uncoupling of MyD88.
11976329 The death domain of NF-kappa B1
p105 is essential for signal-induced p105
11976341 Activation of ZAP-70 through
specific dephosphorylation at the inhibitory
Tyr-292 by the low molecular weight
phosphotyrosine phosphatase (LMPTP).
11976726 SH3-dependent stimulation of
Src-family kinase autophosphorylation without
tail release from the SH2 domain in vivo.
11980723 Two novel phosphorylation sites on
FKHR that are critical for its nuclear exclusion.
11983428 Stromal interaction molecule 1
(STIM1), a transmembrane protein with growth
suppressor activity, contains an extracellular
SAM domain modified by N-linked
11983687 Striatal enriched phosphatase 61
dephosphorylates Fyn at phosphotyrosine 420.
11983694 Src-dependent phosphorylation of
the epidermal growth factor receptor on
tyrosine 845 is required for zinc-induced Ras
11986329 Proteinases of the bone
morphogenetic protein-1 family convert
procollagen VII to mature anchoring fibril
11986331 Autophosphorylation of the
mammalian multifunctional protein that initiates
de novo pyrimidine biosynthesis.
11994045 Phosphorylation and activation of
mitogen- and stress-activated protein kinase-1
in adult rat cardiac myocytes by
G-protein-coupled receptor agonists requires
both extracellular-signal-regulated kinase and
p38 mitogen-activated protein kinase.
11994282 Inhibition of Src family kinases
blocks epidermal growth factor (EGF)-induced
activation of Akt, phosphorylation of c-Cbl, and
ubiquitination of the EGF receptor.
11994312 Tip60 and histone deacetylase 1
regulate androgen receptor activity through
changes to the acetylation status of the
11997497 APS facilitates c-Cbl tyrosine
phosphorylation and GLUT4 translocation in
response to insulin in 3T3-L1 adipocytes.
11997508 Cyclic AMP blocks cell growth
through Raf-1-dependent and
11997522 Phosphorylation of NFATc4 by p38
mitogen-activated protein kinases.
12000743 Deciphering the phosphorylation
"code" of the glucocorticoid receptor in vivo.
12000759 Ionomycin-activated calpain triggers
apoptosis. A probable role for Bcl-2 family
12000790 Axin-mediated CKI phosphorylation
of beta-catenin at Ser 45: a molecular switch
for the Wnt pathway.
12004072 Polypyrimidine tract-binding proteins
are cleaved by caspase-3 during apoptosis.
12004076 Structure of an HIF-1alpha -pVHL
complex: hydroxyproline recognition in
12006387 Role of isoprenylcysteine carboxyl
methyltransferase in tumor necrosis
factor-alpha stimulation of expression of
vascular cell adhesion molecule-1 in endothelial
12006572 Palmitoylation of KChIP splicing
variants is required for efficient cell surface
expression of Kv4.3 channels.
12006580 Distinct phosphorylation events
regulate p130- and p107-mediated repression
12006586 In vivo phosphorylation of insulin
receptor substrate 1 at serine 789 by a novel
serine kinase in insulin-resistant rodents.
12006600 Intracellular activation of human
adamalysin 19/disintegrin and
metalloproteinase 19 by furin occurs via one of
the two consecutive recognition sites.
12011079 Src-dependent tyrosine
phosphorylation regulates dynamin
self-assembly and ligand-induced endocytosis
of the epidermal growth factor receptor.
12015328 Androgen receptor phosphorylation.
Regulation and identification of the
12016211 The structure of human prokallikrein
6 reveals a novel activation mechanism for the
12021372 Fatty acid modification of the
coxsackievirus and adenovirus receptor.
12023952 The presence of a single tyrosine
residue at the carboxyl domain of vascular
endothelial growth factor receptor-2/FLK-1
regulates its autophosphorylation and activation
of signaling molecules.
12023960 Molecular basis for the substrate
specificity of NIMA-related kinase-6 (NEK6).
Evidence that NEK6 does not phosphorylate
the hydrophobic motif of ribosomal S6 protein
kinase and serum- and glucocorticoid-induced
protein kinase in vivo.
12024051 Chk2 activation and
12032545 A novel PKC-regulated mechanism
controls CD44 ezrin association and directional
12034737 The role of post-translational
modifications of the CXCR4 amino terminus in
stromal-derived factor 1 alpha association and
12034741 Molecular characterization of
hCTR1, the human copper uptake protein.
12037680 CK2-dependent phosphorylation of
the E2 ubiquitin conjugating enzyme UBC3B
induces its interaction with beta-TrCP and
enhances beta-catenin degradation.
12039864 Phosphorylation status modulates
Bcl-2 function during glucocorticoid-induced
apoptosis in T lymphocytes.
phosphatase PTP-SL regulates the ERK5
12048203 J Biol Chem. 2002 Aug
16;277(33):29973-82. Epub 2002 Jun 4.
12048211 Role of MAP kinases in the
transactivation of the rat cytochrome P450C24
(CYP24) promoter. Specific functions for
ERK1/ERK2 and ERK5.
12050114 Phosphorylation of three regulatory
serines of Tob by Erk1 and Erk2 is required for
Ras-mediated cell proliferation and
12051714 Characterisation of the
phosphorylation of beta-catenin at the GSK-3
priming site Ser45.
12052829 Serine/threonine phosphorylation of
ShcA. Regulation of protein-tyrosine
phosphatase-pest binding and involvement in
12052863 c-Src-mediated phosphorylation of
hnRNP K drives translational activation of
specifically silenced mRNAs.
12052891 Caspase processing and nuclear
export of CTP:phosphocholine
cytidylyltransferase alpha during
12054501 Human serum and
glucocorticoid-inducible kinase-like kinase
(SGKL) phosphorylates glycogen syntheses
kinase 3 beta (GSK-3beta) at serine-9 through
12056836 Cyclin-dependent kinase-5/p35
phosphorylates Presenilin 1 to regulate
carboxy-terminal fragment stability.
12058028 The stress-activated protein kinases
p38 alpha and JNK1 stabilize p21(Cip1) by
12058031 Human mannose
6-phosphate-uncovering enzyme is synthesized
as a proenzyme that is activated by the
12058066 The RNA binding activity of a
ribosome biogenesis factor,
nucleophosmin/B23, is modulated by
phosphorylation with a cell cycle-dependent
kinase and by association with its subtype.
12058067 Extracellular signal-regulated kinase
phosphorylates tumor necrosis factor
alpha-converting enzyme at threonine 735: a
potential role in regulated shedding.
12060738 Shotgun identification of protein
modifications from protein complexes and lens
12062094 The IGF-1/Akt pathway is
neuroprotective in Huntington's disease and
involves Huntingtin phosphorylation by Akt.
12062403 Primary sequence determinants
responsible for site-selective dephosphorylation
of the PDGF beta-receptor by the receptor-like
protein tyrosine phosphatase DEP-1.
12063245 Multiple domains of MCIP1
contribute to inhibition of calcineurin activity.
12063277 Role of glycosylation in cell surface
expression and stability of HERG potassium
12064478 Cdk5 phosphorylates p53 and
regulates its activity.
12069854 Early-glycation of apolipoprotein E:
effect on its binding to LDL receptor, scavenger
receptor A and heparan sulfates.
12070155 Natural truncation of the chemokine
MIP-1 beta /CCL4 affects receptor specificity
but not anti-HIV-1 activity.
12071973 Cellular stresses profoundly inhibit
protein synthesis and modulate the states of
phosphorylation of multiple translation factors.
12072434 Transcription factor AP-2 interacts
with the SUMO-conjugating enzyme UBC9 and
is sumolated in vivo.
12077128 Threonine 308 within a putative
casein kinase 2 site of the cytoplasmic tail of
leukotriene B(4) receptor (BLT1) is crucial for
receptor-specific kinase 6-mediated
12077184 Cyclin-dependent kinase 5
phosphorylates disabled 1 independently of
12077256 Negative feedback regulation of the
tumor suppressor PTEN by
12077416 Identification of signal peptide
peptidase, a presenilin-type aspartic protease.
12081135 Evidence of autophosphorylation in
Txk: Y91 is an autophosphorylation site.
12082086 cGMP-dependent protein kinase I
beta physically and functionally interacts with
the transcriptional regulator TFII-I.
12082107 The specificity of extracellular
signal-regulated kinase 2 dephosphorylation by
12084709 Pctaire1 interacts with p35 and is a
novel substrate for Cdk5/p35.
12086603 Convergence of the fanconi anemia
and ataxia telangiectasia signaling pathways.
12087059 N-glycans of sphingosine
1-phosphate receptor Edg-1 regulate
ligand-induced receptor internalization.
12089143 cAMP inhibition of Akt is mediated
by activated and phosphorylated Rap1b.
12091337 Prostaglandin-E2 enhances
EPO-mediated STAT5 transcriptional activity by
serine phosphorylation of CREB.
12091386 p38 kinase regulates nitric
oxide-induced apoptosis of articular
chondrocytes by accumulating p53 via
NFkappa B-dependent transcription and
stabilization by serine 15 phosphorylation.
12091389 Src-induced phosphorylation of
caveolin-2 on tyrosine 19. Phospho-caveolin-2
(Tyr(P)19) is localized near focal adhesions,
remains associated with lipid rafts/caveolae,
but no longer forms a high molecular mass
hetero-oligomer with caveolin-1.
12093745 Formation of an hER
alpha-COUP-TFI complex enhances hER alpha
AF-1 through Ser118 phosphorylation by
12095911 PTEN blocks insulin-mediated
ETS-2 phosphorylation through MAP kinase,
independently of the phosphoinositide 3-kinase
12096136 C-mannosylation and o-fucosylation
of thrombospondin type 1 repeats.
12096713 Activation of Pyk2/RAFTK induces
tyrosine phosphorylation of alpha-synuclein via
12097137 Inducible nitric oxide synthase
(NOS2) expressed in septic patients is nitrated
on selected tyrosine residues: implications for
12105188 Integrin (alpha 6 beta 4) regulation of
eIF-4E activity and VEGF translation: a survival
mechanism for carcinoma cells.
12107159 Caspase activation of mammalian
sterile 20-like kinase 3 (Mst3). Nuclear
translocation and induction of apoptosis.
12107172 Nuclear localization of CDC25B1
and serine 146 integrity are required for
induction of mitosis.
12107178 The germ cell-specific transcription
factor ALF. Structural properties and
stabilization of the TATA-binding protein
12110582 Chk1 is activated transiently and
targets Cdc25A for degradation at the Xenopus
12110584 Tyrosine phosphorylation of Mdm2
by c-Abl: implications for p53 regulation.
12110590 Growth factors can activate ATF2
via a two-step mechanism: phosphorylation of
Thr71 through the Ras-MEK-ERK pathway and
of Thr69 through RalGDS-Src-p38.
12111733 Checking in on Cds1 (Chk2): A
checkpoint kinase and tumor suppressor.
12112843 Identification of the phosphotyrosine
proteome from thrombin activated platelets.
12114015 Wnt signal transduction: kinase cogs
in a nano-machine?
12117418 Structural and functional
characterization of tissue factor pathway
inhibitor following degradation by matrix
12119061 A p130Cas tyrosine phosphorylated
substrate domain decoy disrupts v-crk
12119297 Peptide substrate specificities and
protein cleavage sites of human
12119401 Glutathionylation of human
thioredoxin: a possible crosstalk between the
glutathione and thioredoxin systems.
12119563 Molecular cloning and
characterization of OSR1 on human
12121988 Regulation of the nonreceptor
tyrosine kinase Brk by autophosphorylation and
12123746 Identification of two C-terminal
amino acids, Ser(355) and Thr(357), required
for short-term homologous desensitization of
12124386 The role of Asp-462 in regulating Akt
12130691 Oxidative stress decreases G
protein-coupled receptor kinase 2 in
lymphocytes via a calpain-dependent
12133000 Evidence that the dephosphorylation
of Ser(535) in the epsilon-subunit of eukaryotic
initiation factor (eIF) 2B is insufficient for the
activation of eIF2B by insulin.
12135369 The tumor necrosis factor-alpha
converting enzyme (TACE): a unique
metalloproteinase with highly defined substrate
12135390 ADP-ribosylation and functional
effects of Pseudomonas exoenzyme S on
12138165 Identification of threonine 66 as a
functionally critical residue of the interleukin-1
12138178 Identification of a nuclear Stat1
protein tyrosine phosphatase.
12138194 Regulation of estrogen receptor
nuclear export by ligand-induced and
p38-mediated receptor phosphorylation.
12138205 Akt-dependent phosphorylation
specifically regulates Cot induction of NF-kappa
12144530 Small ubiquitin-related modifier-1
(SUMO-1) modification of the glucocorticoid
12147342 Sequence determinants on the
NR2A and NR2B subunits of NMDA receptor
responsible for specificity of phosphorylation by
12147701 A-kinase anchoring protein
AKAP220 binds to glycogen synthase
kinase-3beta (GSK-3beta ) and mediates
protein kinase A-dependent inhibition of
12149126 Endogenous mono-ADP-ribosylation
of the free Gbetagamma prevents stimulation
of phosphoinositide 3-kinase-gamma and
phospholipase C-beta2 and is activated by
12149192 Matrix metalloproteinase processing
of monocyte chemoattractant proteins
generates CC chemokine receptor antagonists
with anti-inflammatory properties in vivo.
12149243 Sumoylation of topoisomerase I is
involved in its partitioning between nucleoli and
nucleoplasm and its clearing from nucleoli in
response to camptothecin.
12149249 Direct identification of tyrosine 474
as a regulatory phosphorylation site for the Akt
12149654 Caspase-3 mediated cleavage of
BRCA1 during UV-induced apoptosis.
12150915 Identification of the tuberous
sclerosis complex-2 tumor suppressor gene
product tuberin as a target of the
phosphoinositide 3-kinase/akt pathway.
12150977 Modification of Daxx by small
12151401 Tyrosine phosphorylation of Kv1.2
modulates its interaction with the actin-binding
12153558 Phosphorylation of calmodulin.
12154078 Regulation of the CDK-related
protein kinase PCTAIRE-1 and its possible role
in neurite outgrowth in Neuro-2A cells.
12162494 Induction of transcriptional activity of
the cyclic adenosine monophosphate response
element binding protein by parathyroid hormone
and epidermal growth factor in osteoblastic
12162751 Characterization of PDK2 activity
against protein kinase B gamma.
12163482 Ligand-independent activation of the
androgen receptor by interleukin-6 and the role
of steroid receptor coactivator-1 in prostate
12167161 MBLR, a new RING finger protein
resembling mammalian Polycomb gene
products, is regulated by cell cycle-dependent
12167624 Nopp140 is a mediator of the
protein kinase A signaling pathway that
activates the acute phase response
alpha1-acid glycoprotein gene.
12167714 Plk phosphorylation regulates the
microtubule-stabilizing protein TCTP.
12171600 Stress-induced regulation of
eukaryotic elongation factor 2 kinase by SB
203580-sensitive and -insensitive pathways.
12171601 Glycosylation of human
proteinase-activated receptor-2 (hPAR2): role in
cell surface expression and signalling.
12171910 Arginine methylation of STAT1
regulates its dephosphorylation by T cell protein
12171911 Structure of mitogen-activated
protein kinase-activated protein (MAPKAP)
kinase 2 suggests a bifunctional switch that
couples kinase activation with nuclear export.
12171918 Nonpalmitoylated human
asialoglycoprotein receptors recycle
constitutively but are defective in coated
pit-mediated endocytosis, dissociation, and
delivery of ligand to lysosomes.
12175333 N-glycosylation is required for full
enzymic activity of the murine
12175915 Analysis of membrane topology of
the human reduced folate carrier protein by
hemagglutinin epitope insertion and scanning
glycosylation insertion mutagenesis.
12176337 Identification of a plasma membrane
Raft-associated PKB Ser473 kinase activity
that is distinct from ILK and PDK1.
12177059 Regulation of kinase activity of
3-phosphoinositide-dependent protein kinase-1
by binding to 14-3-3.
12177195 Protective role of phosphorylation in
turnover of glial fibrillary acidic protein in mice.
12181353 The Shb adaptor protein binds to
tyrosine 766 in the FGFR-1 and regulates the
Ras/MEK/MAPK pathway via FRS2
phosphorylation in endothelial cells.
12181444 Activation of phospholipase
Cgamma2 by tyrosine phosphorylation.
12181742 Caspase cleavage of the nuclear
autoantigen LEDGF/p75 abrogates its
pro-survival function: implications for
autoimmunity in atopic disorders.
12186630 Identification of in vitro and in vivo
phosphorylation sites in the catalytic subunit of
the DNA-dependent protein kinase.
12186947 A novel chk1-dependent G1/M
checkpoint in fission yeast.
12186978 Essential myosin light chain as a
target for caspase-3 in failing myocardium.
12191471 Phosphorylation by protein kinase
CK2: a signaling switch for the
caspase-inhibiting protein ARC.
12193595 Modulation of Smad2-mediated
signaling by extracellular signal-regulated
12194871 cAMP-dependent protein kinase
regulates desensitization of the capsaicin
receptor (VR1) by direct phosphorylation.
12195704 Metalloproteases cleave the
urokinase-type plasminogen activator receptor
in the D1-D2 linker region and expose epitopes
not present in the intact soluble receptor.
12196520 Protein kinase A site-specific
phosphorylation regulates ATP-binding
cassette A1 (ABCA1)-mediated phospholipid
12198130 Phosphorylation of Nrf2 at Ser-40 by
protein kinase C regulates antioxidant response
12198159 Tyrosine 221 in Crk regulates
adhesion-dependent membrane localization of
Crk and Rac and activation of Rac signaling.
12200122 Functional analysis of
calcium-binding EF-hand motifs of visinin-like
12200128 Interaction of the developmental
regulator SALL1 with UBE2I and SUMO-1.
12200134 Processing of native caspase-14
occurs at an atypical cleavage site in normal
12207013 Phosphorylation of threonine 210
and the role of serine 137 in the regulation of
mammalian polo-like kinase.
12207903 Molecular cloning of a novel
immunoglobulin superfamily gene preferentially
expressed by brain and testis.
12208867 Coexpression of ATP-binding
cassette proteins ABCG5 and ABCG8 permits
their transport to the apical surface.
12209014 Dual localization of human DNA
topoisomerase IIIalpha to mitochondria and
12213813 Regulation of the ETS transcription
factor ER81 by the 90-kDa ribosomal S6 kinase
1 and protein kinase A.
12215447 The long form of FLIP is an activator
of caspase-8 at the Fas death-inducing
12215529 Cdc42/Rac1-mediated activation
primes PAK2 for superactivation by tyrosine
12218058 Post-translational modification of
bone morphogenetic protein-1 is required for
secretion and stability of the protein.
12220227 Reciprocal feedback regulation of
insulin receptor and insulin receptor substrate
tyrosine phosphorylation by phosphoinositide
3-kinase in primary adipocytes.
12220642 Phosphorylation of the regulatory
subunit of smooth muscle protein phosphatase
1M at Thr850 induces its dissociation from
12221079 Protein kinase C (PKC)-induced
phosphorylation of ROMK1 is essential for the
surface expression of ROMK1 channels.
12223491 SUMO-1 modification of the
C-terminal KVEKVD of Axin is required for JNK
activation but has no effect on Wnt signaling.
12223493 Mapping of MST1 kinase sites of
phosphorylation. Activation and
12223548 A new activity of doublecortin in
recognition of the phospho-FIGQY tyrosine in
the cytoplasmic domain of neurofascin.
12225289 Differential targeting of the stress
mitogen-activated protein kinases to the c-Jun
dimerization protein 2.
12226093 Truncation of CDK5 activator p35
induces intensive phosphorylation of
Ser202/Thr205 of human tau.
12226103 The extracellular N terminus of the
endothelin B (ETB) receptor is cleaved by a
metalloprotease in an agonist-dependent
12226657 RAD6-dependent DNA repair is
linked to modification of PCNA by ubiquitin and
12228252 Acyl-enzyme complexes between
tissue-type plasminogen activator and
neuroserpin are short-lived in vitro.
12231407 Calcitonin induces
dephosphorylation of Pyk2 and phosphorylation
of focal adhesion kinase in osteoclasts.
12234250 Ionizing radiation induces ataxia
telangiectasia mutated kinase (ATM)-mediated
phosphorylation of LKB1/STK11 at Thr-366.
12235133 Phosphorylation of tyrosine 291
enhances the ability of WASp to stimulate actin
polymerization and filopodium formation.
Wiskott-Aldrich Syndrome protein.
12235136 Bi-functional, substrate mimicking
RNA inhibits MSK1-mediated cAMP-response
element-binding protein phosphorylation and
reveals magnesium ion-dependent
conformational changes of the kinase.
12235182 The N-linked oligosaccharides at the
amino terminus of human apoB are important
for the assembly and secretion of VLDL.
12237126 Tyrosine phosphorylation of clathrin
heavy chain under oxidative stress.
methylation of HuR, an mRNA-stabilizing
protein, by CARM1. Coactivator-associated
12237306 Synapsin I is phosphorylated at
Ser603 by p21-activated kinases (PAKs) in vitro
and in PC12 cells stimulated with bradykinin.
12237455 The SPOT technique as a tool for
studying protein tyrosine phosphatase
12237775 Biological activity of the thyroid
TRK-T3 oncogene requires signalling through
12239280 A mass spectrometry-based
proteomic approach for identification of
serine/threonine-phosphorylated proteins by
enrichment with phospho-specific antibodies:
identification of a novel protein, Frigg, as a
protein kinase A substrate.
12241545 Substrate specificity of the
plasma protein-A (PAPP-A) assessed by
mutagenesis and analysis of synthetic peptides:
substrate residues distant from the scissile
bond are critical for proteolysis.
12242661 Mammalian Polo-like kinase 3 (Plk3)
is a multifunctional protein involved in stress
12244095 Activation of STAT3 by the Src
family kinase Hck requires a functional SH3
12244301 PKB/Akt mediates cell-cycle
progression by phosphorylation of p27(Kip1) at
threonine 157 and modulation of its cellular
12244325 Redox regulatory and anti-apoptotic
functions of thioredoxin depend on
S-nitrosylation at cysteine 69.
12270932 SHP-2 is a dual-specificity
phosphatase involved in Stat1
dephosphorylation at both tyrosine and serine
residues in nuclei.
12270943 Casein kinase 1 regulates
connexin-43 gap junction assembly.
12297295 Direct identification of PTEN
12297314 Anaphase specific auto-cleavage of
12351631 Protein kinase A negatively
modulates the nuclear accumulation of
NF-ATc1 by priming for subsequent
phosphorylation by glycogen synthase
12351658 Serine phosphorylation of insulin
receptor substrate 1 by inhibitor kappa B
12351702 Nuclear export of glucocorticoid
receptor is enhanced by c-Jun N-terminal
12354693 Induction of cancer cell migration by
epidermal growth factor is initiated by specific
phosphorylation of tyrosine 1248 of c-erbB-2
receptor via EGFR.
12354770 The aryl hydrocarbon receptor
nuclear transporter is modulated by the
SUMO-1 conjugation system.
12356731 IEX-1: a new ERK substrate involved
in both ERK survival activity and ERK activation.
12356761 Ca2+-stimulated Ca2+ oscillations
produced by the Ca2+-sensing receptor require
negative feedback by protein kinase C.
12356908 Recombinant human prion protein
mutants huPrP D178N/M129 (FFI) and
huPrP+9OR (fCJD) reveal proteinase K
12359212 M6a acts as a nerve growth
factor-gated Ca(2+) channel in neuronal
12361954 Protein kinase C delta associates
with the interleukin-6 receptor subunit
glycoprotein (gp) 130 via Stat3 and enhances
12370821 Tyr-863 phosphorylation enhances
focal adhesion kinase autophosphorylation at
12370829 The transmembrane receptor
protein tyrosine phosphatase DEP1 interacts
12372285 Fyn and Cdk5 mediate
semaphorin-3A signaling, which is involved in
regulation of dendrite orientation in cerebral
12372621 WARTS tumor suppressor is
phosphorylated by Cdc2/cyclin B at spindle
poles during mitosis.
12372819 Unusual proteolytic activation of
pro-hepatocyte growth factor by plasma
kallikrein and coagulation factor XIa.
12374744 P21-activated kinase-1
phosphorylates and transactivates estrogen
receptor-alpha and promotes hyperplasia in
12374746 Control of CBP co-activating activity
by arginine methylation.
12374802 Acetylation of interferon regulatory
factor-7 by p300/CREB-binding protein
(CBP)-associated factor (PCAF) impairs its DNA
12376572 Mapping and structural dissection of
human 20 S proteasome using proteomic
12379128 Beta 2-adrenergic receptor
stimulated, G protein-coupled receptor kinase 2
mediated, phosphorylation of ribosomal protein
12379484 Inhibition of histone
acetyltransferase function of p300 by
12379650 Regulation of ionizing
radiation-induced Rad52 nuclear foci formation
by c-Abl-mediated phosphorylation.
12381726 Definition of the nuclear encoded
protein composition of bovine heart
mitochondrial complex I. Identification of two
12386167 Phosphorylation of the mitotic
regulator protein Hec1 by Nek2 kinase is
essential for faithful chromosome segregation.
12387813 High-affinity Src-SH2 ligands which
do not activate Tyr(527)-phosphorylated Src in
an experimental in vivo system.
12387894 Involvement of aberrant
glycosylation in phosphorylation of tau by cdk5
12387897 Beta-helical catalytic domains in
glycoside hydrolase families 49, 55 and 87:
domain architecture, modelling and assignment
of catalytic residues.
12388094 Regulation of the mammalian cell
cycle: a model of the G1-to-S transition.
12392720 Phosphorylation of the
stress-activated protein kinase, MEKK3, at
12393701 Leukemia proto-oncoprotein MLL is
proteolytically processed into 2 fragments with
opposite transcriptional properties.
12393906 Sumoylation of Mdm2 by protein
inhibitor of activated STAT (PIAS) and RanBP2
12397361 The prolyl isomerase Pin1 is a
regulator of p53 in genotoxic response.
12399457 Protein kinase A-mediated
phosphorylation of the Galpha13 switch I region
alters the Galphabetagamma13-G
protein-coupled receptor complex and inhibits
12399544 Disruption of the checkpoint kinase
1/cell division cycle 25A pathway abrogates
ionizing radiation-induced S and G2
12400006 Human pEg3 kinase associates with
and phosphorylates CDC25B phosphatase: a
potential role for pEg3 in cell cycle regulation.
12403768 SHP2 and SOCS3 contribute to
Tyr-759-dependent attenuation of interleukin-6
signaling through gp130.
12408818 Control of Smad7 stability by
competition between acetylation and
12408851 Inhibitory autophosphorylation of
CaMKII controls PSD association, plasticity,
12408961 Identification and characterization of
novel members of the CREG family, putative
secreted glycoproteins expressed specifically in
12411508 Regulation of G(2)/M events by
Cdc25A through phosphorylation-dependent
modulation of its stability.
12413941 Dissociation of AMPK activity and
ACCbeta phosphorylation in human muscle
during prolonged exercise.
12414990 A developmentally regulated
ARF-like 5 protein (ARL5), localized to nuclei
and nucleoli, interacts with heterochromatin
12417300 Identification and functional analysis
of novel phosphorylation sites in Cx43 in rat
primary granulosa cells.
12417592 Phosphorylation of spinophilin
modulates its interaction with actin filaments.
12421349 Regulation of tyrosine hydroxylase
by stress-activated protein kinases.
12421832 Complex of pregnancy-associated
plasma protein-A and the proform of eosinophil
major basic protein. Disulfide structure and
12429743 Tyrosine phosphorylation of I kappa
B alpha activates NF kappa B through a
redox-regulated and c-Src-dependent
mechanism following hypoxia/reoxygenation.
12429746 Oligomerization and trafficking of the
human dopamine transporter. Mutational
analysis identifies critical domains important for
the functional expression of the transporter.
12431783 Phosphorylation of the cell cycle
inhibitor p21Cip1/WAF1 by Pim-1 kinase.
12432063 Protein kinase CKII regulates the
interaction of beta-catenin with alpha-catenin
and its protein stability.
12432067 Lasp-1 binds to non-muscle F-actin
in vitro and is localized within multiple sites of
dynamic actin assembly in vivo.
12432277 p53 Antiproliferative function is
enhanced by aspartate substitution at threonine
18 and serine 20.
12435421 Aberrant glycosylation modulates
phosphorylation of tau by protein kinase A and
dephosphorylation of tau by protein
phosphatase 2A and 5.
12436935 Molecular pharmacology and
modeling of vasopressin receptors.
12438239 14-3-3 interacts with the tumor
suppressor tuberin at Akt phosphorylation
12438317 Cell cycle-dependent regulation of
12438562 Mapping sites of O-GlcNAc
modification using affinity tags for serine and
threonine post-translational modifications.
12441002 Molecular cloning and subcellular
distribution of the novel PDE4B4 cAMP-specific
12441334 The cytokine-inducible Scr
homology domain-containing protein negatively
regulates signaling by promoting apoptosis in
erythroid progenitor cells.
12441343 Structure and activity of human
pancreasin, a novel tryptic serine peptidase
expressed primarily by the pancreas.
12442257 The spectrum of endogenous
human chromogranin A-derived peptides
identified using a modified proteomic strategy.
12445832 Phosphorylation of Bruton's tyrosine
kinase by c-Abl.
12446680 The p34cdc2-related
cyclin-dependent kinase 11 interacts with the
p47 subunit of eukaryotic initiation factor 3
12447358 Tyrosine phosphorylation of VHR
phosphatase by ZAP-70.
12447390 DNA damage-induced G2-M
checkpoint activation by histone H2AX and
12447395 Interaction of FANCD2 and NBS1 in
the DNA damage response.
12450396 Prointerleukin-16 contains a
functional CcN motif that regulates nuclear
12454019 Mechanism of epidermal growth
factor regulation of Vav2, a guanine nucleotide
exchange factor for Rac.
12456510 Felic (CIP4b), a novel binding partner
with the Src kinase Lyn and Cdc42, localizes to
the phagocytic cup.
12457462 Effect of mutation of two critical
glutamic acid residues on the activity and
stability of human carboxypeptidase M and
characterization of its signal for
12458207 Negative regulation of mixed lineage
kinase 3 by protein kinase B/AKT leads to cell
12459461 Differential phosphorylation of
SNAP-25 in vivo by protein kinase C and
protein kinase A.
12459551 The N-terminal truncated isoform of
SOCS3 translated from an alternative initiation
AUG codon under stress conditions is stable
due to the lack of a major ubiquitination site,
12459555 Sialic acid capping of CD8beta core
1-O-glycans controls thymocyte-major
histocompatibility complex class I interaction.
12463751 Glycosylation of erythropoietin
affects receptor binding kinetics: role of
12464182 Regulation and destabilization of
HIF-1alpha by ARD1-mediated acetylation.
12466020 The N-terminus of the human
copper transporter 1 (hCTR1) is localized
extracellularly, and interacts with itself.
12468530 Tip60 acetyltransferase activity is
controlled by phosphorylation.
12468540 The role of C-terminal tyrosine
phosphorylation in the regulation of SHP-1
explored via expressed protein ligation.
12468645 Expression and subcellular
distribution of the active form of c-Src tyrosine
kinase in differentiating human endometrial
12470658 Characterization of the cysteine-rich
calcium-binding S100A3 protein from human
12470661 Identification and characterization of
P15RS, a novel P15(INK4b) related gene on
12475213 S-methylated cysteines in human
lens gamma S-crystallins.
12475968 Calcium regulation of GM-CSF by
calmodulin-dependent kinase II phosphorylation
12475979 Hepatocyte growth factor receptor
tyrosine kinase met is a substrate of the
receptor protein-tyrosine phosphatase DEP-1.
12478285 Structural basis of BMP signalling
inhibition by the cystine knot protein Noggin.
12478298 Signal-dependent regulation of
splicing via phosphorylation of Sam68.
12479974 Biosynthesis and processing of pro
CCK: recent progress and future challenges.
12482870 Characterization of sorCS1, an
alternatively spliced receptor with completely
different cytoplasmic domains that mediate
different trafficking in cells.
12482972 Proteolytic cleavage of MLL
generates a complex of N- and C-terminal
fragments that confers protein stability and
12485116 Positive and negative regulation of
T-cell activation through kinases and
12488443 J Biol Chem. 2003 Feb
28;278(9):6947-58. Epub 2002 Dec 17.
12488509 Mono-ADP-ribosylation: a tool for
modulating immune response and cell signaling.
12492488 Kininogen-derived peptides for
investigating the putative vasoactive properties
of human cathepsins K and L.
12493754 Polo-like kinase 1 and Chk2 interact
and co-localize to centrosomes and the
12493777 Mechanism of Ca2+-mediated
regulation of NDR protein kinase through
autophosphorylation and phosphorylation by an
12496362 Regulation of Lck and Fyn tyrosine
kinase activities by transmembrane protein
tyrosine phosphatase leukocyte common
12498886 Nitrosopeptide mapping: a novel
methodology reveals s-nitrosylation of dexras1
on a single cysteine residue.
12501214 Site-specific dephosphorylation of
endothelial nitric oxide synthase by protein
phosphatase 2A: evidence for crosstalk
between phosphorylation sites.
12502714 Identification and characterization of
the autophosphorylation sites of
phosphoinositide 3-kinase isoforms beta and
12504004 Mechanism of recruitment of WASP
to the immunological synapse and of its
activation following TCR ligation.
12504026 CAND1 binds to unneddylated CUL1
and regulates the formation of SCF ubiquitin E3
12505983 Cathepsin A regulates
chaperone-mediated autophagy through
cleavage of the lysosomal receptor.
12507496 GATE-16 and GABARAP are
authentic modifiers mediated by Apg7 and
12509428 Nitric oxide, NOC-12, and
S-nitrosoglutathione modulate the skeletal
muscle calcium release channel/ryanodine
receptor by different mechanisms. An allosteric
function for O2 in S-nitrosylation of the channel.
12509440 Phosphoproteome analysis of
capacitated human sperm. Evidence of tyrosine
phosphorylation of a kinase-anchoring protein 3
and valosin-containing protein/p97 during
12509629 Autoantibodies to dsDNA
cross-react with the arginine-glycine-rich
domain of heterogeneous nuclear
ribonucleoprotein A2 (hnRNP A2) and promote
methylation of hnRNP A2.
12511558 A synergy control motif within the
attenuator domain of CCAAT/enhancer-binding
protein alpha inhibits transcriptional synergy
through its PIASy-enhanced modification by
SUMO-1 or SUMO-3.
12511603 A central role for Ets-2 in the
transcriptional regulation and cyclic adenosine
5'-monophosphate responsiveness of the
human chorionic gonadotropin-beta subunit
12514174 JNK1 physically interacts with WW
domain-containing oxidoreductase (WOX1) and
inhibits WOX1-mediated apoptosis.
12515807 Approaches to define antigen
receptor-induced serine kinase signal
12517957 Lipid raft distribution of CD4
depends on its palmitoylation and association
with Lck, and evidence for CD4-induced lipid
raft aggregation as an additional mechanism to
enhance CD3 signaling.
12519779 Phosphorylation of Munc18 by
protein kinase C regulates the kinetics of
12522132 Phosphorylation of tyrosine 319 of
the angiotensin II type 1 receptor mediates
angiotensin II-induced trans-activation of the
epidermal growth factor receptor.
12522270 Profiling of tyrosine phosphorylation
pathways in human cells using mass
12524442 Identification of the minimal
phosphoacceptor site required for in vivo
activation of interferon regulatory factor 3 in
response to virus and double-stranded RNA.
12524539 Cleaving the oxidative repair protein
Ape1 enhances cell death mediated by
12526767 Pathways to Parkinsonism.
12527193 Mammalian Crumbs3 is a small
transmembrane protein linked to protein
associated with Lin-7 (Pals1).
12527891 Protein kinase CK2 regulates
CDC25B phosphatase activity.
12529330 Arsenite-induced phosphorylation of
histone H3 at serine 10 is mediated by Akt1,
extracellular signal-regulated kinase 2, and p90
ribosomal S6 kinase 2 but not mitogen- and
stress-activated protein kinase 1.
12529333 Sumoylation of the progesterone
receptor and of the steroid receptor coactivator
12529443 Sam68 RNA binding protein is an in
vivo substrate for protein arginine
12534294 Phosphorylation of RGS14 by
protein kinase A potentiates its activity toward
G alpha i.
12538589 Regulation of a transient receptor
potential (TRP) channel by tyrosine
phosphorylation. SRC family kinase-dependent
tyrosine phosphorylation of TRPV4 on TYR-253
mediates its response to hypotonic stress.
12538592 Phosphorylation of the Ras-GRF1
exchange factor at Ser916/898 reveals
activation of Ras signaling in the cerebral
12538644 Multiple splice variants of the human
HIF-3 alpha locus are targets of the von
Hippel-Lindau E3 ubiquitin ligase complex.
12540842 STAP-2/BKS, an adaptor/docking
protein, modulates STAT3 activation in
acute-phase response through its YXXQ motif.
12540962 Plasma membrane Ca2+-ATPase
isoform 4b is phosphorylated on tyrosine 1176
in activated human platelets.
12546699 Regulation of eukaryotic DNA
replication at the initiation step.
12548019 Genotoxic stress-induced activation
of Plk3 is partly mediated by Chk2.
12548559 T cell recognition and therapeutic
effect of a phosphorylated synthetic peptide of
the 70K snRNP protein administered in MR/lpr
12551899 Palmitoylated peptides from the
cysteine-rich domain of SNAP-23 cause
membrane fusion depending on peptide length,
position of cysteines, and extent of
12551902 Signaling between focal adhesion
kinase and trio.
12551923 Phosphorylation of Raf-1 by
p21-activated kinase 1 and Src regulates Raf-1
12551925 Activation of Raf-1 signaling by
protein kinase C through a mechanism involving
Raf kinase inhibitory protein.
12551931 The Notch ligands, Delta1 and
Jagged2, are substrates for
12551973 Conserved protein kinases encoded
by herpesviruses and cellular protein kinase
cdc2 target the same phosphorylation site in
eukaryotic elongation factor 1delta.
12552133 The secretory proprotein convertase
neural apoptosis-regulated convertase 1
(NARC-1): liver regeneration and neuronal
12554736 Regulation of mammalian
STE20-like kinase 2 (MST2) by protein
12554790 Protein tyrosine phosphatase PTP20
induces actin cytoskeleton reorganization by
dephosphorylating p190 RhoGAP in rat ovarian
granulosa cells stimulated with
12555094 Granzyme A: the road less traveled.
12556484 Human Nudel and NudE as
regulators of cytoplasmic dynein in poleward
protein transport along the mitotic spindle.
12556497 Regulation of lymphoid enhancer
factor 1/T-cell factor by mitogen-activated
protein kinase-related Nemo-like
kinase-dependent phosphorylation in
12556884 DNA damage activates ATM through
intermolecular autophosphorylation and dimer
12558502 Protein kinase CK2 phosphorylates
Hsp105 alpha at Ser509 and modulates its
12559972 Mechanism of Janus kinase
3-catalyzed phosphorylation of a Janus kinase
1 activation loop peptide.
12560069 Estrogen regulation of Pak1 and
FKHR pathways in breast cancer cells.
12560083 Ezrin is a substrate for Lck in T cells.
12560341 Nuclear localization of the cell cycle
regulator CDH1 and its regulation by
12562768 Molecular evolution by change of
function. Alkaloid-specific homospermidine
synthase retained all properties of
deoxyhypusine synthase except binding the
eIF5A precursor protein.
12562775 Specific nitration at tyrosine 430
revealed by high resolution mass spectrometry
as basis for redox regulation of bovine
12563012 Phosphorylation of the myosin
phosphatase targeting subunit and CPI-17
during Ca2+ sensitization in rabbit smooth
12564933 Basal and hydrogen peroxide
stimulated sites of phosphorylation in
heterogeneous nuclear ribonucleoprotein
12569090 Phosphorylation of serine 1106 in
the catalytic domain of topoisomerase II alpha
regulates enzymatic activity and drug sensitivity.
12569367 Regulation of the ER81 transcription
factor and its coactivators by mitogen- and
stress-activated protein kinase 1 (MSK1).
12571245 Actin binding of human LIM and SH3
protein is regulated by cGMP- and
cAMP-dependent protein kinase
phosphorylation on serine 146.
12573241 Identification of phosphorylation
sites within the SH3 domains of Tec family
12574116 Mad2 phosphorylation regulates its
association with Mad1 and the APC/C.
12574125 STAT5-induced Id-1 transcription
involves recruitment of HDAC1 and
deacetylation of C/EBPbeta.
12576312 A predominant role for
cAMP-dependent protein kinase in the
cGMP-induced phosphorylation of
vasodilator-stimulated phosphoprotein and
platelet inhibition in humans.
12576423 Tissue microarray analysis of signal
transducers and activators of transcription 3
(Stat3) and phospho-Stat3 (Tyr705) in
node-negative breast cancer shows nuclear
localization is associated with a better
12578357 Mutational analysis of the complex
of human RNase inhibitor and human
eosinophil-derived neurotoxin (RNase 2).
12578970 cAMP-dependent protein kinase
phosphorylation of the acid-sensing ion
channel-1 regulates its binding to the protein
interacting with C-kinase-1.
12582162 The p38 and MK2 kinase cascade
phosphorylates tuberin, the tuberous sclerosis
2 gene product, and enhances its interaction
12586364 Novel insights into cadherin
processing by subtilisin-like convertases.
12586835 Mitotic regulation of ribosomal S6
kinase 1 involves Ser/Thr, Pro phosphorylation
of consensus and non-consensus sites by
12586837 Activation of pro-gelatinase B by
endometase/matrilysin-2 promotes invasion of
human prostate cancer cells.
12588975 The C terminus of initiation factor
4E-binding protein 1 contains multiple
regulatory features that influence its function
12588979 Phosphorylation of stem-loop
binding protein (SLBP) on two threonines
triggers degradation of SLBP, the sole cell
cycle-regulated factor required for regulation of
histone mRNA processing, at the end of S
12589038 Integrin-mediated tyrosine
phosphorylation of Shc in T cells is regulated by
protein kinase C-dependent phosphorylations
12589057 Nup98 localizes to both nuclear and
cytoplasmic sides of the nuclear pore and binds
to two distinct nucleoporin subcomplexes.
12590919 Functional analysis of site-directed
glycosylation mutants of the human equilibrative
12591939 The C-terminal domain phosphatase
and transcription elongation activities of FCP1
are regulated by phosphorylation.
12591950 JNK phosphorylation of Bim-related
members of the Bcl2 family induces
12594221 Identification of novel ERK2
substrates through use of an engineered kinase
and ATP analogs.
12600888 Activation of RhoA and inhibition of
myosin phosphatase as important components
in hypertension in vascular smooth muscle.
12601080 Signaling initiated by overexpression
of the fibroblast growth factor receptor-1
investigated by mass spectrometry.
12604610 The mammalian target of rapamycin
(mTOR) partner, raptor, binds the mTOR
substrates p70 S6 kinase and 4E-BP1 through
their TOR signaling (TOS) motif.
12604689 Selective tryptic cleavage at the
tethered ligand site of the amino terminal
domain of proteinase-activated receptor-2 in
12609826 Endopeptidases 220.127.116.11 and
24.16 in endothelial cells: potential role in
vasoactive peptide metabolism.
12609988 Profile-based data base scanning
for animal L-type lectins and characterization of
VIPL, a novel VIP36-like endoplasmic reticulum
12609995 Activation of cGMP-dependent
protein kinase by protein kinase C.
12612081 Regulation of insulin receptor
signaling by the protein tyrosine phosphatase
12612082 A novel RING finger protein, human
enhancer of invasion 10, alters mitotic
progression through regulation of cyclin B
12613668 Regulation of caldesmon activity by
Cdc2 kinase plays an important role in
maintaining membrane cortex integrity during
12615929 Sterol regulatory element-binding
proteins are negatively regulated through
SUMO-1 modification independent of the
ubiquitin/26 S proteasome pathway.
regulation of Kv2.1 Channel activity at tyrosine
124 by Src and by protein-tyrosine
12618428 14-3-3beta is a p90 ribosomal S6
kinase (RSK) isoform 1-binding protein that
negatively regulates RSK kinase activity.
12620231 The human Sir2 ortholog, SIRT2, is
an NAD+-dependent tubulin deacetylase.
12621041 Activation of transforming growth
factor-beta signaling by SUMO-1 modification
of tumor suppressor Smad4/DPC4.
12621058 Characterization of growth
factor-induced serine phosphorylation of tumor
necrosis factor-alpha converting enzyme and of
an alternatively translated polypeptide.
12621061 Signal transduction pathways
regulated by prolactin and Src result in different
conformations of activated Stat5b.
12624098 The inhibitory gamma subunit of the
type 6 retinal cGMP phosphodiesterase
functions to link c-Src and G-protein-coupled
receptor kinase 2 in a signaling unit that
regulates p42/p44 mitogen-activated protein
kinase by epidermal growth factor.
12624099 Adipose-specific expression,
phosphorylation of Ser794 in insulin receptor
substrate-1, and activation in diabetic animals
of salt-inducible kinase-2.
12626415 Glycosylation of human pancreatic
ribonuclease: differences between normal and
12626422 The underglycosylation of plasma
alpha 1-antitrypsin in congenital disorders of
glycosylation type I is not random.
12626508 Hypertonicity activates Na+/H+
exchange through Janus kinase 2 and
12628923 Protein kinase CK2 and protein
kinase D are associated with the COP9
12630910 Post-synaptic density-95 promotes
calcium/calmodulin-dependent protein kinase
II-mediated Ser847 phosphorylation of neuronal
nitric oxide synthase.
12631277 Disruption of structural and
functional integrity of alpha 2-macroglobulin by
Stat1 is required for the regulation of c-Myc,
cyclins, and p27Kip1 associated with
ATRA-induced G0/G1 arrest of U-937 cells.
12637502 Regulation of epidermal growth
factor-induced connexin 43 gap junction
communication by big mitogen-activated
protein kinase1/ERK5 but not ERK1/2 kinase
12637511 Specific beta1 integrin site
selectively regulates Akt/protein kinase B
signaling via local activation of protein
12637538 Tyrosine phosphorylation of protein
kinase D in the pleckstrin homology domain
leads to activation.
12639913 Regulation of melanocortin-4
receptor signaling: agonist-mediated
desensitization and internalization.
12640114 p120 Catenin-associated Fer and
Fyn tyrosine kinases regulate beta-catenin
Tyr-142 phosphorylation and
12640123 Structural requirements of SLP-76 in
signaling via the high-affinity immunoglobulin E
receptor (Fc epsilon RI) in mast cells.
12640464 PKCepsilon is a permissive link in
integrin-dependent IFN-gamma signalling that
facilitates JAK phosphorylation of STAT1.
12642610 The RasGAP-associated
endoribonuclease G3BP assembles stress
12651610 Cathepsin D specifically cleaves the
chemokines macrophage inflammatory
protein-1 alpha, macrophage inflammatory
protein-1 beta, and SLC that are expressed in
human breast cancer.
12654918 Serine phosphorylation negatively
regulates RhoA in vivo.
12657630 In vivo identification of inducible
phosphoacceptors in the IKKgamma/NEMO
subunit of human IkappaB kinase.
12659875 Transcriptional activity and DNA
binding of heat shock factor-1 involve
phosphorylation on threonine 142 by CK2.
12660173 Human Tousled like kinases are
targeted by an ATM- and Chk1-dependent
DNA damage checkpoint.
12665511 Two motifs in the translational
repressor PHAS-I required for efficient
phosphorylation by mammalian target of
rapamycin and for recognition by raptor.
12665592 Phosphorylation of serine 303 is a
prerequisite for the stress-inducible SUMO
modification of heat shock factor 1.
12665801 Exploring proteomes and analyzing
protein processing by mass spectrometric
identification of sorted N-terminal peptides.
12668660 Caspase cleavage product of
BAP31 induces mitochondrial fission through
endoplasmic reticulum calcium signals,
enhancing cytochrome c release to the cytosol.
12670890 The proteolytic processing of
pro-platelet-derived growth factor-A at
RRKR(86) by members of the proprotein
convertase family is functionally correlated to
platelet-derived growth factor-A-induced
functions and tumorigenicity.
12671685 Proteolytic cleavage of PDZD2
generates a secreted peptide containing two
12672959 Processing, localization, and
requirement of human separase for normal
12676583 Chk1 regulates the S phase
checkpoint by coupling the physiological
turnover and ionizing radiation-induced
accelerated proteolysis of Cdc25A.
12676647 Recent advances in mechanisms
regulating glucose oxidation at the level of the
pyruvate dehydrogenase complex by PDKs.
12676926 Cyclin-dependent kinases
phosphorylate p73 at threonine 86 in a cell
cycle-dependent manner and negatively
12679040 The polycomb protein Pc2 is a
12681492 Stimulation of the alpha1A
adrenergic receptor inhibits PDGF-induced
PDGF beta receptor Tyr751 phosphorylation
and PI 3-kinase activation.
12682012 PKA phosphorylates the p75
receptor and regulates its localization to lipid
12682077 Agonist-induced phosphorylation of
the serotonin 5-HT2C receptor regulates its
interaction with multiple PDZ protein 1.
12682249 Threonine phosphorylation sites in
the beta 2 and beta 7 leukocyte integrin
12682370 Phosphorylation of Kruppel-like
factor 5 (KLF5/IKLF) at the CBP interaction
region enhances its transactivation function.
12684437 Control of growth cone motility and
morphology by LIM kinase and Slingshot via
phosphorylation and dephosphorylation of
12686604 Functional significance of the
specific sites phosphorylated in desmin at
cleavage furrow: Aurora-B may phosphorylate
and regulate type III intermediate filaments
during cytokinesis coordinatedly with
12689593 Phosphorylation by aurora B
converts MgcRacGAP to a RhoGAP during
12692561 A method for the comprehensive
proteomic analysis of membrane proteins.
12697024 Okadaic acid-induced,
naringin-sensitive phosphorylation of glycine
N-methyltransferase in isolated rat
12697768 Accumulation of checkpoint protein
53BP1 at DNA breaks involves its binding to
phosphorylated histone H2AX.
12700239 CK2 phosphorylation of the
armadillo repeat region of beta-catenin
potentiates Wnt signaling.
12709442 Phosphorylation of human Rad9 is
required for genotoxin-activated checkpoint
12714602 Identification of MCM4 as a target of
the DNA replication block checkpoint system.
12717439 Chk2 activates E2F-1 in response to
12718890 Methylation of SPT5 regulates its
interaction with RNA polymerase II and
transcriptional elongation properties.
12724314 Identification and characterization of
a novel p300-mediated p53 acetylation site,
12727876 Cdc2-mediated phosphorylation of
Kid controls its distribution to spindle and
12729597 Stable isotope phospho-profiling of
fibrinogen and fetuin subunits by element mass
spectrometry coupled to capillary liquid
12730201 Ca2+-dependent phosphorylation of
syntaxin-1A by the death-associated protein
(DAP) kinase regulates its interaction with
12734187 Src-CrkII-C3G-dependent activation
of Rap1 switches growth hormone-stimulated
p44/42 MAP kinase and JNK/SAPK activities.
12737624 Pigment-epithelium-derived factor
(PEDF) occurs at a physiologically relevant
concentration in human blood: purification and
12738778 The activation of matriptase requires
its noncatalytic domains, serine protease
domain, and its cognate inhibitor.
12738781 Identification of a consensus motif
for Plk (Polo-like kinase) phosphorylation reveals
Myt1 as a Plk1 substrate.
12740371 AMP-activated protein kinase
regulates HNF4alpha transcriptional activity by
inhibiting dimer formation and decreasing
12740440 Structural and biochemical studies
of p21Ras S-nitrosylation and nitric
oxide-mediated guanine nucleotide exchange.
12741986 Serine 776 of ataxin-1 is critical for
polyglutamine-induced disease in SCA1
12743374 The phosphorylation of caveolin-2
on serines 23 and 36 modulates
caveolin-1-dependent caveolae formation.
12745091 Expression and phosphorylation of
the replication regulator protein geminin.
12747827 TOS motif-mediated raptor binding
regulates 4E-BP1 multisite phosphorylation and
12748172 Identification and characterization of
a nuclear interacting partner of anaplastic
lymphoma kinase (NIPA).
12748192 Phosphorylation of threonine 10 on
CKBBP1/SAG/ROC2/Rbx2 by protein kinase
CKII promotes the degradation of
IkappaBalpha and p27Kip1.
12750467 Targeting Ras signaling through
inhibition of carboxyl methylation: an
unexpected property of methotrexate.
12753909 Heregulin and HER2 signaling
selectively activates c-Src phosphorylation at
12754301 Protein tyrosine phosphatase
epsilon inhibits signaling by mitogen-activated
12754513 AKAP150 signaling complex
promotes suppression of the M-current by
12754519 Identification and quantification of
N-linked glycoproteins using hydrazide
chemistry, stable isotope labeling and mass
12756254 Recruitment of JNK to JIP1 and
JNK-dependent JIP1 phosphorylation regulates
JNK module dynamics and activation.
12757707 Interaction of Akt-phosphorylated
ataxin-1 with 14-3-3 mediates
neurodegeneration in spinocerebellar ataxia
12760422 Thr94 in bovine myelin basic protein
is a second phosphorylation site for 42-kDa
mitogen-activated protein kinase (ERK2).
12761178 Regulation of type 1 protein
phosphatase/inhibitor-2 complex by glycogen
synthase kinase-3beta in intact cells.
12763138 Erythropoietin-induced serine 727
phosphorylation of STAT3 in erythroid cells is
mediated by a MEK-, ERK-, and
12769842 Increased ezrin expression and
activation by CDK5 coincident with acquisition
of the senescent phenotype.
phosphorylation/dephosphorylation provides a
mechanism of molecular memory in WASP.
12769847 Phosphorylation of the WASP-VCA
domain increases its affinity for the Arp2/3
complex and enhances actin polymerization by
12769861 Opposed regulation of corepressor
CtBP by SUMOylation and PDZ binding.
12771940 ARHI is a Ras-related small
G-protein with a novel N-terminal extension that
inhibits growth of ovarian and breast cancers.
12773393 MSK2 and MSK1 mediate the
mitogen- and stress-induced phosphorylation
of histone H3 and HMG-14.
12777400 Catalase activity is regulated by
c-Abl and Arg in the oxidative stress response.
12787665 Functional domains of FOXJ2.
12788913 Reversal of the deoxyhypusine
synthesis reaction. Generation of spermidine or
homospermidine from deoxyhypusine by
12788955 A docking site in MKK4 mediates
high affinity binding to JNK MAPKs and
competes with similar docking sites in JNK
12789267 v-Src induces Shc binding to
tyrosine 63 in the cytoplasmic domain of the
LDL receptor-related protein 1.
12792650 Inhibition of caspase-9 through
phosphorylation at Thr 125 by ERK MAPK.
12794074 Phosphorylation by glycogen
synthase kinase-3 beta down-regulates Notch
activity, a link for Notch and Wnt pathways.
12794087 Activation of ERK induces
phosphorylation of MAPK phosphatase-7, a
JNK specific phosphatase, at Ser-446.
12796477 BMPs signal alternately through a
SMAD or FRAP-STAT pathway to regulate fate
choice in CNS stem cells.
12796778 14-3-3epsilon is important for
neuronal migration by binding to NUDEL: a
molecular explanation for Miller-Dieker
12801888 Phosphorylation of threonine 276 in
Smad4 is involved in transforming growth
factor-beta-induced nuclear accumulation.
12802062 Membrane targeting of Rab
GTPases is influenced by the prenylation motif.
12804768 Occludin phosphorylation:
identification of an occludin kinase in brain and
cell extracts as CK2.
12805216 The B cell-specific major raft protein,
Raftlin, is necessary for the integrity of lipid raft
and BCR signal transduction.
12805220 Activation of the tumour suppressor
kinase LKB1 by the STE20-like pseudokinase
12805407 Regulation of the Chk2 protein
kinase by oligomerization-mediated cis- and
12805550 Requirement of AMPA receptor
GluR2 phosphorylation for cerebellar long-term
12808093 Protein kinase B/Akt binds and
phosphorylates PED/PEA-15, stabilizing its
12808100 Hydrogen peroxide triggers nuclear
export of telomerase reverse transcriptase via
Src kinase family-dependent phosphorylation of
12809493 Hurpin is a selective inhibitor of
lysosomal cathepsin L and protects
keratinocytes from ultraviolet-induced
12809553 Phosphorylation of BATF regulates
DNA binding: a novel mechanism for AP-1
(activator protein-1) regulation.
12810701 The localization and phosphorylation
of p47 are important for Golgi
disassembly-assembly during the cell cycle.
12812918 Potential role of leucine metabolism
in the leucine-signaling pathway involving
12815053 M phase-specific phosphorylation of
BRCA2 by Polo-like kinase 1 correlates with the
dissociation of the BRCA2-P/CAF complex.
12817007 Activation of protein kinase C delta
12818176 JNK-mediated BIM phosphorylation
potentiates BAX-dependent apoptosis.
12818188 Identification of interleukin-8
converting enzyme as cathepsin L.
12819028 ASK1 associates with troponin T
and induces troponin T phosphorylation and
contractile dysfunction in cardiomyocytes.
12819195 Regulation of A + U-rich
element-directed mRNA turnover involving
reversible phosphorylation of AUF1.
12819209 Threonine 391 phosphorylation of
the human prolactin receptor mediates a novel
interaction with 14-3-3 proteins.
12824184 Cyclin-dependent kinase-5 is
involved in neuregulin-dependent activation of
phosphatidylinositol 3-kinase and Akt activity
mediating neuronal survival.
12829704 Identification of the p16-Arc subunit
of the Arp 2/3 complex as a substrate of
MAPK-activated protein kinase 2 by proteomic
12832492 Cdk5 regulates the organization of
Nestin and its association with p35.
12837278 Cofilin phosphorylation and actin
polymerization by NRK/NESK, a member of the
germinal center kinase family.
12839991 Structure and axon outgrowth
inhibitor binding of the Nogo-66 receptor and
12840024 A mitotic cascade of NIMA family
kinases. Nercc1/Nek9 activates the Nek6 and
12843408 The calpain system.
12851456 Protein kinase A phosphorylation
modulates transport of the polypyrimidine
12852788 Adaptor signalling proteins Grb2 and
Grb7 are recruited by human G6f, a novel
member of the immunoglobulin superfamily
encoded in the MHC.
12852850 Fertility and taxon-specific sperm
binding persist after replacement of mouse
sperm receptors with human homologs.
12852856 Polo-like kinase 1 regulates Nlp, a
centrosome protein involved in microtubule
12852857 A role for Plk1 phosphorylation of
NudC in cytokinesis.
12853467 14-3-3s regulate
fructose-2,6-bisphosphate levels by binding to
12853968 Phosphorylation of human Fen1 by
cyclin-dependent kinase modulates its role in
replication fork regulation.
12853976 Lats2, a putative tumor suppressor,
inhibits G1/S transition.
12855578 PIAS proteins promote SUMO-1
conjugation to STAT1.
12855954 Cdk5 is essential for synaptic vesicle
12857729 Cdk2-dependent phosphorylation of
the NF-Y transcription factor and its
involvement in the p53-p21 signaling pathway.
12857734 Oxidative damage to mitochondrial
complex I due to peroxynitrite: identification of
reactive tyrosines by mass spectrometry.
12860119 Phosphorylation of the N-terminal
domain regulates subcellular localization and
DNA binding properties of the peptidyl-prolyl
cis/trans isomerase hPar14.
12860403 Proteolytic cleavage of the EMR2
receptor requires both the extracellular stalk
and the GPS motif.
12860980 Multistep autoactivation of
asparaginyl endopeptidase in vitro and in vivo.
12861023 Proteomic identification of
14-3-3zeta as a mitogen-activated protein
kinase-activated protein kinase 2 substrate:
role in dimer formation and ligand binding.
12867358 Mutagenesis of the N-glycosylation
site of hNaSi-1 reduces transport activity.
12876286 CHOP transcription factor
phosphorylation by casein kinase 2 inhibits
12876325 Methylation and carbamylation of
12878163 Identification of Tyr900 in the kinase
domain of c-Kit as a Src-dependent
phosphorylation site mediating interaction with
12879005 Cleavage of metastasis suppressor
gene product KiSS-1 protein/metastin by
12881490 A Ras activation pathway dependent
on Syk phosphorylation of protein kinase C.
12881528 Ligand-induced vascular endothelial
growth factor receptor-3 (VEGFR-3)
heterodimerization with VEGFR-2 in primary
lymphatic endothelial cells regulates tyrosine
12885254 Adhesion-associated and
PKC-modulated changes in serine/threonine
phosphorylation of p120-catenin.
12886014 Polyserase-I, a human polyprotease
with the ability to generate independent serine
protease domains from a single translation
12888487 Mechanisms of P/CAF
12888562 Requirement of Cys399 for
processing of the human ecto-ATPase
(NTPDase2) and its implications for
determination of the activities of splice variants
of the enzyme.
12888622 Caspase cleavage of tau: linking
amyloid and neurofibrillary tangles in
12888867 Biochemical importance of
glycosylation of plasminogen activator
12893243 Centaurin-alpha(1) associates with
and is phosphorylated by isoforms of protein
12893824 Glutathione peroxidase 1 is
regulated by the c-Abl and Arg tyrosine
12897128 p21-Activated kinase 5 (Pak5)
localizes to mitochondria and inhibits apoptosis
by phosphorylating BAD.
12897141 The N and C termini of the splice
variants of the human mitogen-activated
protein kinase-interacting kinase Mnk2
determine activity and localization.
12904296 Cleavage of syndecan-1 by
membrane type matrix metalloproteinase-1
stimulates cell migration.
12907171 Expression of betaA2-crystallin in
12907688 Processing and localization of
ADAMTS-1 and proteolytic cleavage of versican
during cumulus matrix expansion and ovulation.
12911333 Allowed N-glycosylation sites on the
Kv1.2 potassium channel S1-S2 linker:
implications for linker secondary structure and
the glycosylation effect on channel function.
12911626 Regulation of the glutamate
transporter EAAT1 by the ubiquitin ligase
Nedd4-2 and the serum and
glucocorticoid-inducible kinase isoforms
SGK1/3 and protein kinase B.
12912980 Differential contribution of inhibitory
phosphorylation of CDC2 and CDK2 for
unperturbed cell cycle control and DNA integrity
12912989 Target of rapamycin (TOR)-signaling
and RAIP motifs play distinct roles in the
mammalian TOR-dependent phosphorylation of
initiation factor 4E-binding protein 1.
12914934 S-nitrosation of Cys-800 of
HIF-1alpha protein activates its interaction with
p300 and stimulates its transcriptional activity.
12917345 Acetylation-mediated transcriptional
activation of the ETS protein ER81 by p300,
P/CAF, and HER2/Neu.
12923183 T cell receptor engagement leads to
the recruitment of IBP, a novel guanine
nucleotide exchange factor, to the
12925766 Exploring the functional interactions
between Aurora B, INCENP, and survivin in
12926989 Dephosphorylation of histone
gamma-H2AX during repair of DNA
double-strand breaks in mammalian cells and
its inhibition by calyculin A.
12930825 Phosphorylation of SNAP-23 in
activated human platelets.
12930845 Phosphorylation of serine 13 is
required for the proper function of the Hsp90
12931194 Transcription factor IIB acetylates
itself to regulate transcription.
12933808 CaMKII-dependent phosphorylation
regulates SAP97/NR2A interaction.
12935886 Identification and characterization of
novel components of a
Ca2+/calmodulin-dependent protein kinase
cascade in HeLa cells.
12939163 N-Glycosylation and conserved
cysteine residues in RAMP3 play a critical role
for the functional expression of CRLR/RAMP3
apolipoprotein E4 causes Alzheimer's
disease-like neurodegeneration and behavioral
deficits in transgenic mice.
12941695 Functional analysis of C-TAK1
substrate binding and identification of PKP2 as
a new C-TAK1 substrate.
12947093 Phosphorylation of serine 337 of
NF-kappaB p50 is critical for DNA binding.
12949938 Effect of carbohydrate moieties on
the folate hydrolysis activity of the prostate
specific membrane antigen.
12950257 Gelatinase B/MMP-9 and neutrophil
collagenase/MMP-8 process the chemokines
human GCP-2/CXCL6, ENA-78/CXCL5 and
mouse GCP-2/LIX and modulate their
12950453 Physiological regulation of
Munc18/nSec1 phosphorylation on serine-313.
12953056 The junctional adhesion molecule
(JAM) family members JAM-2 and JAM-3
associate with the cell polarity protein PAR-3: a
possible role for JAMs in endothelial cell
12953068 The UIM domain of Hrs couples
receptor sorting to vesicle formation.
12955071 Suppression of Tousled-like kinase
activity after DNA damage or replication block
requires ATM, NBS1 and Chk1.
12962325 Characterization and analysis of
posttranslational modifications of the human
large cytoplasmic ribosomal subunit proteins by
mass spectrometry and Edman sequencing.
12962630 The structure of the extracellular
region of human hepsin reveals a serine
protease domain and a novel scavenger
receptor cysteine-rich (SRCR) domain.
12962704 Inhibition of the catalytic activity of
rhodanese by S-nitrosylation using nitric oxide
12963847 Regulation of human Cdc25A
stability by Serine 75 phosphorylation is not
sufficient to activate a S phase checkpoint.
12972425 Src phosphorylates Cas on tyrosine
253 to promote migration of transformed cells.
12972555 Spy1 interacts with p27Kip1 to allow
12972610 Hes6 promotes cortical
neurogenesis and inhibits Hes1 transcription
repression activity by multiple mechanisms.
12972619 Phosphorylation of the
carboxyl-terminal transactivation domain of
c-Fos by extracellular signal-regulated kinase
mediates the transcriptional activation of AP-1
and cellular transformation induced by
platelet-derived growth factor.
14500673 Eosinophil major basic protein
stimulates neutrophil superoxide production by
a class IA phosphoinositide 3-kinase and
protein kinase C-zeta-dependent pathway.
14500712 PIAS1-mediated sumoylation of
focal adhesion kinase activates its
14506255 Biochemical properties of the
Cdc42-associated tyrosine kinase ACK1.
Substrate specificity, authphosphorylation, and
interaction with Hck.
14507913 Phosphorylation screening identifies
translational initiation factor 4GII as an
intracellular target of
Ca(2+)/calmodulin-dependent protein kinase I.
14512875 p38 MAPK mediates fibrogenic
signal through Smad3 phosphorylation in rat
14517306 Tyrosine phosphorylation of
plakoglobin causes contrary effects on its
association with desmosomes and adherens
junction components and modulates
14521955 Proteolytic processing of
(TAF/angiomodulin/mac25) modulates its
14522980 Identification and characterization of
GCP16, a novel acylated Golgi protein that
interacts with GCP170.
14522994 SHP-2 regulates SOCS-1-mediated
Janus kinase-2 ubiquitination/degradation
downstream of the prolactin receptor.
14523239 Protein kinase C phosphorylation
sensitizes but does not activate the capsaicin
receptor transient receptor potential vanilloid 1
14527438 Carbon monoxide
neurotransmission activated by CK2
phosphorylation of heme oxygenase-2.
14527952 Modification of promyelocytic
leukemia zinc finger protein (PLZF) by SUMO-1
conjugation regulates its transcriptional
14532120 SCF(HOS) ubiquitin ligase mediates
the ligand-induced down-regulation of the
14532170 AMPK activity and isoform protein
expression are similar in muscle of obese
subjects with and without type 2 diabetes.
14532276 Characterization of recombinant
skeletal muscle (Ser-2843) and cardiac muscle
(Ser-2809) ryanodine receptor phosphorylation
14536078 Multisite phosphorylation by Cdk2
and GSK3 controls cyclin E degradation.
14551197 Physical and functional interaction
between Hck tyrosine kinase and guanine
nucleotide exchange factor C3G results in
apoptosis, which is independent of C3G
14551205 Cell cycle-regulated phosphorylation
of hamartin, the product of the tuberous
sclerosis complex 1 gene, by cyclin-dependent
kinase 1/cyclin B.
14551213 Constitutively active Galpha16
stimulates STAT3 via a c-Src/JAK- and
14557276 The SH3 domain-containing adaptor
HIP-55 mediates c-Jun N-terminal kinase
activation in T cell receptor signaling.
14559918 PIASgamma represses the
transcriptional activation induced by the nuclear
14560030 Molecular mechanism for a role of
SHP2 in epidermal growth factor receptor
14565989 Exercise increases
Ca2+-calmodulin-dependent protein kinase II
activity in human skeletal muscle.
14573606 Mechanism of p21-activated kinase
6-mediated inhibition of androgen receptor
14573609 Secretion of heparanase protein is
regulated by glycosylation in human tumor cell
14576165 Phosphorylation of presenilin 1 at
the caspase recognition site regulates its
proteolytic processing and the progression of
14576464 Identification and functional analysis
of truncated human glutamic acid
14578350 Role of p38alpha Map kinase in
Type I interferon signaling.
14583471 Direct activation of pro-matrix
leukolysin/membrane-type 6 matrix
metalloproteinase/matrix metalloproteinase 25
at the asn(109)-Tyr bond.
14585847 Protein phosphatase 2Cbeta
association with the IkappaB kinase complex is
involved in regulating NF-kappaB activity.
14592976 Notch-induced E2A ubiquitination
and degradation are controlled by MAP kinase
14597612 p42, a novel cyclin-dependent
kinase-activating kinase in mammalian cells.
14600148 Cells previously desensitized to type
1 interferons display different mechanisms of
activation of stat-dependent gene expression
from naïve cells.
14608369 AP-1 recruitment to VAMP4 is
modulated by phosphorylation-dependent
binding of PACS-1.
14608379 Regulator of G-protein signaling-2
mediates vascular smooth muscle relaxation
and blood pressure.
14612398 Positive and negative regulation of
the cardiovascular transcription factor KLF5 by
p300 and the oncogenic regulator SET through
interaction and acetylation on the DNA-binding
14613924 5'-AMP-activated protein kinase
activity and protein expression are regulated by
endurance training in human skeletal muscle.
14615979 A proteomic approach for
quantitation of phosphorylation using stable
isotope labeling in cell culture.
14622975 Functional characterization of Narc
1, a novel proteinase related to proteinase K.
14623863 S100C/A11 is a key mediator of
Ca(2+)-induced growth inhibition of human
14623875 Characterization of cyclin L2, a novel
cyclin with an arginine/serine-rich domain:
phosphorylation by DYRK1A and colocalization
with splicing factors.
14630912 Phosphorylation of vanilloid receptor
1 by Ca2+/calmodulin-dependent kinase II
regulates its vanilloid binding.
14633678 Inactivation of a histone
methyltransferase by mutations in human
14633983 The phosphorylation state of an
autoregulatory domain controls
PACS-1-directed protein traffic.
14633989 Role of acetylated human
AP-endonuclease (APE1/Ref-1) in regulation of
the parathyroid hormone gene.
14636059 Functional diversity of endothelin
pathways in human lung fibroblasts may be
based on structural diversity of the endothelin
14636557 Taspase1: a threonine aspartase
required for cleavage of MLL and proper HOX
14636580 PKA, PKC, and the protein
phosphatase 2A influence HAND factor
function: a mechanism for tissue-specific
14641008 Molecular mechanisms regulating
hormone-sensitive lipase and lipolysis.
14645242 J Biol Chem. 2004 Feb
13;279(7):5405-12. Epub 2003 Nov 25.
14654844 Protein kinase C switches the Raf
kinase inhibitor from Raf-1 to GRK-2.
14654845 Release of eIF6 (p27BBP) from the
60S subunit allows 80S ribosome assembly.
14657023 Growth inhibition by the mammalian
SWI-SNF subunit Brm is regulated by
14661060 Cbl-c suppresses v-Src-induced
transformation through ubiquitin-dependent
14663150 Protein phosphatase 2C binds
selectively to and dephosphorylates
metabotropic glutamate receptor 3.
14673166 S-nitrosylation of IRP2 regulates its
stability via the ubiquitin-proteasome pathway.
14679216 J Biol Chem. 2004 Mar
12;279(11):10765-75. Epub 2003 Dec 16.
14685260 Regulation of InsP3 receptor activity
by neuronal Ca2+-binding proteins.
14699159 Underglycosylation of ATF6 as a
novel sensing mechanism for activation of the
unfolded protein response.
14701738 Phosphorylation of critical serine
residues in Gem separates cytoskeletal
reorganization from down-regulation of calcium
14701748 Negative regulation of histone
deacetylase 8 activity by cyclic AMP-dependent
protein kinase A.
14701874 SUMO modification of a novel
MAR-binding protein, SATB2, modulates
immunoglobulin mu gene expression.
14707132 Characterization of OSR1, a
member of the mammalian Ste20p/germinal
center kinase subfamily.
14709557 Stimulation of the AMP-activated
protein kinase leads to activation of eukaryotic
elongation factor 2 kinase and to its
phosphorylation at a novel site, serine 398.
14711813 Identification of RET
autophosphorylation sites by mass
14712216 H4(D10S170), a gene frequently
rearranged with RET in papillary thyroid
carcinomas: functional characterization.
14729942 Identification of phosphoproteins
and their phosphorylation sites in the WEHI-231
B lymphoma cell line.
14729945 Regulation of phosphoinositide
3-kinase by its intrinsic serine kinase activity in
14734545 Substrate requirements of the
oxygen-sensing asparaginyl hydroxylase
factor-inhibiting hypoxia-inducible factor.
14739293 Adhesion or plasmin regulates
tyrosine phosphorylation of a novel membrane
domain-containing protein 1 in epithelia.
14739304 A novel proteomic approach for
specific identification of tyrosine kinase
substrates using [13C]tyrosine.
14741103 Cdk5 phosphorylation of
doublecortin ser297 regulates its effect on
14744859 Human mitotic spindle-associated
protein PRC1 inhibits MgcRacGAP activity
toward Cdc42 during the metaphase.
14749323 Role of glycosylation in the organic
anion transporter OAT1.
14749719 p41-Arc subunit of human Arp2/3
complex is a p21-activated kinase-1-interacting
14751930 A novel plasma proteinase
potentiates alpha2-antiplasmin inhibition of
14753741 Isolation of a human homolog of
osteoclast inhibitory lectin that inhibits the
formation and function of osteoclasts.
14760718 Screening for N-glycosylated
proteins by liquid chromatography mass
14762214 Improved detection of hydrophilic
phosphopeptides using graphite powder
microcolumns and mass spectrometry:
evidence for in vivo doubly phosphorylated
dynamin I and dynamin III.
14764098 Nonlysine-analog plasminogen
modulators promote autoproteolytic generation
of plasmin(ogen) fragments with angiostatin-like
14766232 Interaction of human MUC1 and
beta-catenin is regulated by Lck and ZAP-70 in
activated Jurkat T cells.
14871477 Alkylation of protein disulfide
isomerase by the episulfonium ion derived from
the glutathione conjugate of 1,2-dichloroethane
and mass spectrometric characterization of the
14963018 Evidence of STAT1 phosphorylation
modulated by MAPKs, MEK1 and MSK1.
14965474 TIAF1 and p53 functionally interact
in mediating apoptosis and silencing of TIAF1
abolishes nuclear translocation of serine
14966296 Site-selective regulation of
platelet-derived growth factor beta receptor
tyrosine phosphorylation by T-cell protein
14970177 N-linked glycosylation is required for
optimal function of Kaposi's sarcoma
herpesvirus-encoded, but not cellular,
14970201 p21-activated kinase 1
phosphorylates and regulates 14-3-3 binding to
GEF-H1, a microtubule-localized Rho exchange
14970221 Thr2446 is a novel mammalian
target of rapamycin (mTOR) phosphorylation
site regulated by nutrient status.
14973229 Decreased phosphorylation of
NMDA receptor type 1 at serine 897 in brains of
patients with Schizophrenia.
14983059 Regulation of canonical transient
receptor potential isoform 3 (TRPC3) channel
by protein kinase G.
14990569 J Biol Chem. 2004 May
7;279(19):19643-8. Epub 2004 Feb 27.
14996911 EGFR signaling to p120-catenin
through phosphorylation at Y228.
14997482 Identification and characterization of
phosphorylated proteins in the human pituitary.
15001356 Phage-peptide display identifies the
interferon-responsive, death-activated protein
kinase family as a novel modifier of MDM2 and
15003508 Association of CPI-17 with protein
kinase C and casein kinase I.
15004546 Regulation of the p300 HAT domain
via a novel activation loop.
15010469 Phosphorylation of histone H2A
inhibits transcription on chromatin templates.
15012588 Structural analysis and tissue
localization of human C4.4A: a protein
homologue of the urokinase receptor.
15014043 Phosphorylation of RCC1 in mitosis
is essential for producing a high RanGTP
concentration on chromosomes and for spindle
assembly in mammalian cells.
15016818 Protein phosphatase-2C alpha as a
positive regulator of insulin sensitivity through
direct activation of phosphatidylinositol 3-kinase
in 3T3-L1 adipocytes.
15016915 DAXX interacts with heat shock
factor 1 during stress activation and enhances
its transcriptional activity.
15024056 Forkhead box M1B transcriptional
activity requires binding of Cdk-cyclin
complexes for phosphorylation-dependent
recruitment of p300/CBP coactivators.
15024086 A novel mTOR-regulated
phosphorylation site in elongation factor 2
kinase modulates the activity of the kinase and
its binding to calmodulin.
15028714 Regulation of Smad4 sumoylation
and transforming growth factor-beta signaling
by protein inhibitor of activated STAT1.
15030318 The T-cell protein tyrosine
phosphatase is phosphorylated on Ser-304 by
cyclin-dependent protein kinases in mitosis.
15037601 YSK1 is activated by the Golgi
matrix protein GM130 and plays a role in cell
migration through its substrate 14-3-3zeta.
15037656 The interaction of specific peptide
aptamers with the DNA binding domain and the
dimerization domain of the transcription factor
Stat3 inhibits transactivation and induces
apoptosis in tumor cells.
15039438 Proteasomal degradation of
N-acetyltransferase 1 is prevented by
acetylation of the active site cysteine: a
mechanism for the slow acetylator phenotype
and substrate-dependent down-regulation.
15044018 The islet-specific
implicated in diabetes, is a glycoprotein
embedded in the endoplasmic reticulum
15050367 Alpha- and beta- cleavages of the
amino-terminus of the cellular prion protein.
15051728 Formin homology domain protein
(FHOD1) is a cyclic GMP-dependent protein
kinase I-binding protein and substrate in
vascular smooth muscle cells.
15070730 Functional association between
Wwox tumor suppressor protein and p73, a
15070733 M-phase kinases induce
phospho-dependent ubiquitination of somatic
Wee1 by SCFbeta-TrCP.
15073171 Insertion sequence 1 of
muscle-specific calpain, p94, acts as an
15073328 Direct regulation of CREB
transcriptional activity by ATM in response to
15081397 KIBRA is a novel substrate for
protein kinase Czeta.
15082798 CK2 controls multiple protein
kinases by phosphorylating a kinase-targeting
molecular chaperone, Cdc37.
15087450 Proteolysis of the mismatch repair
protein MLH1 by caspase-3 promotes DNA
15099517 Gene-specific modulation of TAF10
function by SET9-mediated methylation.
15099520 A cathepsin L isoform that is devoid
of a signal peptide localizes to the nucleus in S
phase and processes the CDP/Cux
15116093 Phosphorylation of p53 on Thr55 by
ERK2 is necessary for doxorubicin-induced p53
activation and cell death.
15121872 Tyrosine 813 is a site of JAK2
autophosphorylation critical for activation of
JAK2 by SH2-B beta.
15128762 Cutting edge: TREM-like
transcript-1, a platelet immunoreceptor
tyrosine-based inhibition motif encoding
costimulatory immunoreceptor that enhances,
rather than inhibits, calcium signaling via
15128871 Phosphorylation of CDC25B by
Aurora-A at the centrosome contributes to the
15138252 VHY, a novel myristoylated
testis-restricted dual specificity protein
phosphatase related to VHX.
15138260 Transforming growth factor-beta
stimulates p300-dependent RUNX3 acetylation,
which inhibits ubiquitination-mediated
15140192 N-linked glycosylation sites of the
motor protein prestin: effects on membrane
targeting and electrophysiological function.
15143187 Autophosphorylation of JAK2 on
tyrosines 221 and 570 regulates its activity.
15143188 Tyrosine phosphorylation of Jak2 in
the JH2 domain inhibits cytokine signaling.
15144186 Robust phosphoproteomic profiling
of tyrosine phosphorylation sites from human T
cells using immobilized metal affinity
chromatography and tandem mass
15147202 Protein phosphorylation of human
brain glutamic acid decarboxylase (GAD)65 and
GAD67 and its physiological implications.
15150265 Human SAD1 kinase is involved in
UV-induced DNA damage checkpoint function.
15152093 Identification of the N-glycosylation
sites on glutamate carboxypeptidase II
necessary for proteolytic activity.
15158451 Phosphorylation of the mitochondrial
protein Sab by stress-activated protein kinase
15159397 BRCA1-BARD1 complexes are
required for p53Ser-15 phosphorylation and a
G1/S arrest following ionizing radiation-induced
15175427 Acetylation of the human DNA
glycosylase NEIL2 and inhibition of its activity.
15178331 Suppression of the caspase
cleavage of beta-amyloid precursor protein by
its cytoplasmic phosphorylation.
15189448 DREG, a developmentally regulated
G protein-coupled receptor containing two
conserved proteolytic cleavage sites.
15190079 B23/nucleophosmin serine 4
phosphorylation mediates mitotic functions of
polo-like kinase 1.
15192080 Small ubiquitin-like modifier 1
(SUMO-1) modification of the synergy control
motif of Ad4 binding protein/steroidogenic
factor 1 (Ad4BP/SF-1) regulates synergistic
transcription between Ad4BP/SF-1 and Sox9.
15192089 Regulation of insulin signaling
through reversible oxidation of the
protein-tyrosine phosphatases TC45 and
15192091 Argininosuccinate synthetase is
reversibly inactivated by S-nitrosylation in vitro
and in vivo.
15193260 Dynein light chain 1, a p21-activated
kinase 1-interacting substrate, promotes
15194694 Phosphorylation and regulation of
DNA ligase IV stability by DNA-dependent
15206927 Tyrosine phosphorylation of
calponins. Inhibition of the interaction with
15210690 Tobacco-specific nitrosamine
promotes functional cooperation of Bcl2 and
c-Myc through phosphorylation in regulating cell
survival and proliferation.
15221008 The M-CSF receptor substrate and
interacting protein FMIP is governed in its
subcellular localization by protein kinase
C-mediated phosphorylation, and thereby
potentiates M-CSF-mediated differentiation.
15225631 Interaction of filamin A with the
integrin beta 7 cytoplasmic domain: role of
alternative splicing and phosphorylation.
15225643 The phosphorylation status and
anti-apoptotic activity of Bcl-2 are regulated by
ERK and protein phosphatase 2A on the
15228384 The plasma membrane translocation
of diacylglycerol kinase delta1 is negatively
regulated by conventional protein kinase
C-dependent phosphorylation at Ser-22 and
Ser-26 within the pleckstrin homology domain.
15229287 The phosphorylation of vinculin on
tyrosine residues 100 and 1065, mediated by
SRC kinases, affects cell spreading.
15234964 Phosphorylation of Mnk1 by
caspase-activated Pak2/gamma-PAK inhibits
phosphorylation and interaction of eIF4G with
15241418 Cyclin-dependent kinases regulate
the antiproliferative function of Smads.
15241487 MCL1 is phosphorylated in the PEST
region and stabilized upon ERK activation in
viable cells, and at additional sites with
cytotoxic okadaic acid or taxol.
15247228 Complexity of translationally
controlled transcription factor Sp3 isoform
15249683 Binding of platelet glycoprotein
Ibalpha to von Willebrand factor domain A1
stimulates the cleavage of the adjacent domain
A2 by ADAMTS13.
protein kinase I inhibits neuronal nitric-oxide
synthase activity through serine 741
15253423 Identification of phosphorylation
sites in protein kinase A substrates using
artificial neural networks and mass
15253667 Open tubular immobilized metal ion
affinity chromatography combined with MALDI
MS and MS/MS for identification of protein
15269224 Regulation of SHP-1 tyrosine
phosphatase in human platelets by serine
phosphorylation at its C terminus.
15271996 Proteomic identification of
Bcl2-associated athanogene 2 as a novel
MAPK-activated protein kinase 2 substrate.
15272016 In vitro modification of human
centromere protein CENP-C fragments by
small ubiquitin-like modifier (SUMO) protein:
definitive identification of the modification sites
by tandem mass spectrometry analysis of the
15273251 Site-specific acetylation of the fetal
globin activator NF-E4 prevents its
ubiquitination and regulates its interaction with
the histone deacetylase, HDAC1.
15273717 Regulation of caspase-6 and FLIP
by the AMPK family member ARK5.
15280020 hOLF44, a secreted glycoprotein
with distinct expression pattern, belongs to an
uncharacterized olfactomedin-like subfamily
newly identified by phylogenetic analysis.
15280358 ZNF76, a novel transcriptional
repressor targeting TATA-binding protein, is
modulated by sumoylation.
15286081 Dok-6, a Novel p62 Dok family
member, promotes Ret-mediated neurite
15302935 Large-scale characterization of
HeLa cell nuclear phosphoproteins.
15308774 A tagging-via-substrate technology
for detection and proteomics of farnesylated
15322115 Protein kinase Cdelta regulates
apoptosis via activation of STAT1.
15324659 aPKC acts upstream of PAR-1b in
both the establishment and maintenance of
mammalian epithelial polarity.
15327768 Mechanism of
phosphorylation-dependent binding of APC to
beta-catenin and its role in beta-catenin
15337770 Phosphorylation and specific
ubiquitin acceptor sites are required for
ubiquitination and degradation of the IFNAR1
subunit of type I interferon receptor.
15342917 Tumor-promoting phorbol esters
and activated Ras inactivate the tuberous
sclerosis tumor suppressor complex via p90
ribosomal S6 kinase.
15345747 Phosphoproteomic analysis of the
developing mouse brain.
15350534 Identification and molecular
characterization of Mnk1b, a splice variant of
human MAP kinase-interacting kinase Mnk1.
15356145 Phosphorylation of Grb2-associated
binder 2 on serine 623 by ERK MAPK regulates
its association with the phosphatase SHP-2
and decreases STAT5 activation.
15364919 Protein kinase C Theta inhibits
insulin signaling by phosphorylating IRS1 at
15367659 Protein kinases C and D mediate
agonist-dependent cardiac hypertrophy through
nuclear export of histone deacetylase 5.
15367677 FANCG is phosphorylated at serines
383 and 387 during mitosis.
15368451 Keratin 8 and 18
hyperphosphorylation is a marker of
progression of human liver disease.
15375214 A phosphorylation site in Bruton's
tyrosine kinase selectively regulates B cell
calcium signaling efficiency by altering
phospholipase C-gamma activation.
15379552 Identification of major ERK-related
phosphorylation sites in Gab1.
15380617 Regulation of Chk2 phosphorylation
by interaction with protein phosphatase 2A via
its B' regulatory subunit.
15383283 Selective phosphorylations of the
SRC-3/AIB1 coactivator integrate genomic
reponses to multiple cellular signaling
15385675 Prohaptoglobin is proteolytically
cleaved in the endoplasmic reticulum by the
complement C1r-like protein.
15448144 Arginine 260 of the amino-terminal
domain of NR1 subunit is critical for tissue-type
plasminogen activator-mediated enhancement
of N-methyl-D-aspartate receptor signaling.
15451423 ATR-dependent phosphorylation of
ATRIP in response to genotoxic stress.
15454081 The CREB coactivator TORC2
functions as a calcium- and cAMP-sensitive
15459208 Inhibition of gap junction activity
through the release of the C1B domain of
protein kinase Cgamma (PKCgamma) from
14-3-3: identification of PKCgamma-binding
15461668 Genes Cells. 2004
15466214 Changes in androgen receptor
nongenotropic signaling correlate with transition
of LNCaP cells to androgen independence.
15469825 Human SirT1 interacts with histone
H1 and promotes formation of facultative
15471854 MUC1 membrane trafficking is
modulated by multiple interactions.
15485879 Phosphorylation of annexin I by
15494733 Focal adhesion kinase in netrin-1
15498570 N-glycosylation is required for
efficient secretion of a novel human secreted
15504032 Tyrosine phosphorylation of
caveolin-2 at residue 27: differences in the
spatial and temporal behavior of
phospho-Cav-2 (pY19 and pY27).
15507434 Sumoylation of MITF and its related
family members TFE3 and TFEB.
15522235 Tyrosine phosphatase epsilonM
stimulates migration and survival of porcine
aortic endothelial cells by activating c-Src.
interferon-gamma production by human
peripheral blood T cells is regulated by
mammalian target of rapamycin (mTOR).
15525512 Phosphorylation of Cdc20 by Bub1
provides a catalytic mechanism for APC/C
inhibition by the spindle checkpoint.
15527798 A novel site of AKT-mediated
phosphorylation in the human MDM2
15534001 The ERBB4/HER4 receptor tyrosine
kinase regulates gene expression by functioning
as a STAT5A nuclear chaperone.
15537541 Structure of the Cand1-Cul1-Roc1
complex reveals regulatory mechanisms for the
assembly of the multisubunit cullin-dependent
15541388 Characterization of a MAPKK-like
protein kinase TOPK.
15545601 Activation of RasGRP3 by
phosphorylation of Thr-133 is required for B cell
receptor-mediated Ras activation.
15546918 PKA phosphorylation of Src
mediates Rap1 activation in NGF and cAMP
signaling in PC12 cells.
15549133 Phosphorylation of XPB helicase
regulates TFIIH nucleotide excision repair
15549731 IREM-1 is a novel inhibitory receptor
expressed by myeloid cells.
15556646 Catalytic domains of tyrosine
kinases determine the phosphorylation sites
15557335 Src phosphorylation of Alix/AIP1
modulates its interaction with binding partners
and antagonizes its activities.
15561713 NF-kappaB- and C/EBPbeta-driven
interleukin-1beta gene expression and
PAK1-mediated caspase-1 activation play
essential roles in interleukin-1beta release from
15570572 Automated immobilized metal affinity
chromatography/electrospray ionization mass
spectrometry platform for profiling protein
15572666 PIAS-1 is a checkpoint regulator
which affects exit from G1 and G2 by
sumoylation of p73.
15580310 17beta-Estradiol upregulates and
activates WOX1/WWOXv1 and
WOX2/WWOXv2 in vitro: potential role in
cancerous progression of breast and prostate
to a premetastatic state in vivo.
15581361 Requirements for pYXXM motifs in
Cbl for binding to the p85 subunit of
phosphatidylinositol 3-kinase and Crk, and
activation of atypical protein kinase C and
glucose transport during insulin action in
15581622 Protein kinase Akt/PKB
phosphorylates heme oxygenase-1 in vitro and
15588985 Substrate-trapping techniques in the
identification of cellular PTP targets.
15591058 BMP-1/Tolloid-like metalloproteases
process endorepellin, the angiostatic C-terminal
fragment of perlecan.
15592455 Immunoaffinity profiling of tyrosine
phosphorylation in cancer cells.
15595731 Characterization of phosphorylation
sites on histone H1 isoforms by tandem mass
15606899 Beta-amyloid protein converting
enzyme 1 and brain-specific type II membrane
protein BRI3: binding partners processed by
15610029 Phosphoregulation of mixed-lineage
kinase 1 activity by multiple phosphorylation in
the activation loop.
15611095 Modulation of erythrocyte
membrane mechanical function by protein 4.1
15616124 Posttranslational N-glycosylation
takes place during the normal processing of
human coagulation factor VII.
15616583 Bidirectional signals transduced by
DAPK-ERK interaction promote the apoptotic
effect of DAPK.
15632081 Coordinated regulation of insulin
signaling by the protein tyrosine phosphatases
PTP1B and TCPTP.
15632084 Extracellular signal-regulated kinases
phosphorylate mitogen-activated protein kinase
phosphatase 3/DUSP6 at serines 159 and 197,
two sites critical for its proteasomal
15632193 SIRT1 deacetylation and repression
of p300 involves lysine residues 1020/1024
within the cell cycle regulatory domain 1.
15632195 Functional characterization of human
RSK4, a new 90-kDa ribosomal S6 kinase,
reveals constitutive activation in most cell
15637053 Differential regulation of
phosphoglucose isomerase/autocrine motility
factor activities by protein kinase CK2
15644316 Human S-nitroso oxymyoglobin is a
store of vasoactive nitric oxide.
15649887 Activation of Stat3
sequence-specific DNA binding and
transcription by p300/CREB-binding
15652488 GSK-3beta regulates
phosphorylation of CRMP-2 and neuronal
15654952 Breaking the connection: caspase 6
disconnects intermediate filament-binding
domain of periplakin from its actin-binding
15657060 c-Abl tyrosine kinase regulates
caspase-9 autocleavage in the apoptotic
response to DNA damage.
15659405 CK2 phosphorylates SSRP1 and
inhibits its DNA-binding activity.
15659558 Phosphotyrosine proteomic study of
interferon alpha signaling pathway using a
combination of immunoprecipitation and
immobilized metal affinity chromatography.
15664191 Regulation of Raf-1 by direct
15665856 The cell-cycle checkpoint kinase
Chk1 is required for mammalian homologous
15670817 Differentiative pathway activated by
3-aminobenzamide, an inhibitor of PARP, in
human osteosarcoma MG-63 cells.
15670829 Identification of proteins interacting
with the RNAPII FCP1 phosphatase: FCP1
forms a complex with arginine
methyltransferase PRMT5 and it is a substrate
for PRMT5-mediated methylation.
15677445 Distinct turnover of alternatively
spliced isoforms of the RET kinase receptor
mediated by differential recruitment of the Cbl
15687492 Protein kinase CK1alpha regulates
mRNA binding by heterogeneous nuclear
ribonucleoprotein C in response to physiologic
levels of hydrogen peroxide.
15688026 Cooperation and selectivity of the
two Grb2 binding sites of p52Shc in T-cell
antigen receptor signaling to Ras family
GTPases and Myc-dependent survival.
15689152 Mechanism of CDK5/p25 binding by
15696159 JNK phosphorylation of 14-3-3
proteins regulates nuclear targeting of c-Abl in
the apoptotic response to DNA damage.
15696169 Selective regulation of tumor
necrosis factor-induced Erk signaling by Src
family kinases and the T cell protein tyrosine
dependent phosphorylation of Artemis in
response to DNA damage.
15728359 Phosphorylation of spinophilin by
ERK and cyclin-dependent PK 5 (Cdk5).
kinase can phosphorylate the cyclic AMP
response element binding protein, CREB.
15738637 Receptor-type protein tyrosine
phosphatase epsilon (PTPepsilonM) is a
negative regulator of insulin signaling in primary
hepatocytes and liver.
15743820 Removal of C-terminal SRC kinase
from the immune synapse by a new binding
15744310 Nutrient control of glucose
homeostasis through a complex of PGC-1alpha
15752768 Characterization of two
non-testis-specific CABYR variants that bind to
GSK3beta with a proline-rich extensin-like
15754012 Molecular evolution of Wnt2b
15781465 Channel function is dissociated from
the intrinsic kinase activity and
autophosphorylation of TRPM7/ChaK1.
15782174 Identifying and quantifying in vivo
methylation sites by heavy methyl SILAC.
15788536 Phosphorylation of Hdmx mediates
its Hdm2- and ATM-dependent degradation in
response to DNA damage.
15791647 Involvement of protein kinase PKN1
in G2/M delay caused by arsenite.
15800651 3',5'-cyclic nucleotide
phosphodiesterase 11A: localization in human
15805470 Histone deacetylase 3 (HDAC3)
activity is regulated by interaction with protein
serine/threonine phosphatase 4.
15807535 N-Linked glycosylation of the human
ABC transporter ABCG2 on asparagine 596 is
not essential for expression, transport activity,
or trafficking to the plasma membrane.
15835917 Phosphorylation of the human Fhit
tumor suppressor on tyrosine 114 in
Escherichia coli and unexpected steady state
kinetics of the phosphorylated forms.
15837948 Phosphorylation of GATA2 by Akt
increases adipose tissue differentiation and
reduces adipose tissue-related inflammation: a
novel pathway linking obesity to
15845350 Src kinase regulation by
phosphorylation and dephosphorylation.
15851026 Phosphorylation and functional
inactivation of TSC2 by Erk implications for
tuberous sclerosis and cancer pathogenesis.
15851471 Platelet endothelial aggregation
receptor 1 (PEAR1), a novel epidermal growth
factor repeat-containing transmembrane
receptor, participates in platelet
15878163 The death domain-associated
protein modulates activity of the transcription
15879431 Post-translational modification of
nuclear co-repressor receptor-interacting
protein 140 by acetylation.
15886098 RIN1 is an ABL tyrosine kinase
activator and a regulator of epithelial-cell
adhesion and migration.
15894802 Protein kinase C phosphorylation of
the metabotropic glutamate receptor mGluR5
on Serine 839 regulates Ca2+ oscillations.
15899889 Phosphorylation of mammalian
target of rapamycin (mTOR) at Ser-2448 is
mediated by p70S6 kinase.
15905173 Identification of S6 kinase 1 as a
novel mammalian target of rapamycin
15905176 Phosphorylation of claudin-3 at
threonine 192 by cAMP-dependent protein
kinase regulates tight junction barrier function in
ovarian cancer cells.
15910747 Determination of site-specificity of
S-glutathionylated cellular proteins.
15951569 Time-resolved mass spectrometry
of tyrosine phosphorylation sites in the
epidermal growth factor receptor signaling
network reveals dynamic modules.
15951807 S-nitrosylated GAPDH initiates
apoptotic cell death by nuclear translocation
following Siah1 binding.
15952790 Identification of tyrosine residues on
ELMO1 that are phosphorylated by the
Src-family kinase Hck.
15952796 Phosphorylation of Grb10 by
mitogen-activated protein kinase: identification
of Ser150 and Ser476 of human Grb10zeta as
major phosphorylation sites.
15963462 Phosphorylation and binding partner
analysis of the TSC1-TSC2 complex.
15964553 TSSK5, a novel member of the
testis-specific serine/threonine kinase family,
phosphorylates CREB at Ser-133, and
stimulates the CRE/CREB responsive pathway.
15987703 LKB1 interacts with and
phosphorylates PTEN: a functional link between
two proteins involved in cancer predisposing
16001085 HIV-1 Tat targets Tip60 to impair
the apoptotic cell response to genotoxic
16006563 Sequential phosphorylation mediates
receptor- and kinase-induced inhibition of
TREK-1 background potassium channels.
16007225 Adhesion signaling by a novel mitotic
substrate of src kinases.
16014719 Tyrosine 394 is phosphorylated in
Alzheimer's paired helical filament tau and in
fetal tau with c-Abl as the candidate tyrosine
16024724 Regulation of human
methylenetetrahydrofolate reductase by
16027158 Phosphorylation of coronin 1B by
protein kinase C regulates interaction with
Arp2/3 and cell motility.
16027164 Dephosphorylation of Ser-226
facilitates plasma membrane retention of Ntcp.
16045749 BCR kinase phosphorylates 14-3-3
Tau on residue 233.
16051222 Endosomal proteolysis of insulin-like
growth factor-I at its C-terminal D-domain by
16055064 PICK1 interacts with ABP/GRIP to
regulate AMPA receptor trafficking.
16055720 WW domains provide a platform for
the assembly of multiprotein networks.
16061179 Phosphorylation of FADD at serine
194 by CKIalpha regulates its nonapoptotic
16061477 B-aggressive lymphoma family
proteins have unique domains that modulate
transcription and exhibit poly(ADP-ribose)
16083266 Extended Range Proteomic Analysis
(ERPA): a new and sensitive LC-MS platform
for high sequence coverage of complex
proteins with extensive post-translational
modifications-comprehensive analysis of
beta-casein and epidermal growth factor
16083285 Global phosphoproteome of HT-29
human colon adenocarcinoma cells.
16087181 The role of PKCalpha and RLIP76 in
transport-mediated doxorubicin-resistance in
16094384 Quantitative phosphoproteome
analysis using a dendrimer conjugation
chemistry and tandem mass spectrometry.
16094730 Protein kinase activity of
phosphoinositide 3-kinase regulates
beta-adrenergic receptor endocytosis.
16097765 Mapping of phosphorylation sites by
a multi-protease approach with specific
phosphopeptide enrichment and
16098147 Transcriptional activity of
megakaryoblastic leukemia 1 (MKL1) is
repressed by SUMO modification.
16098514 Analysis of mTOR signaling by the
small G-proteins, Rheb and RhebL1.
16105548 Pleiotrophin stimulates tyrosine
phosphorylation of beta-adducin through
inactivation of the transmembrane receptor
protein tyrosine phosphatase beta/zeta.
16107690 Phosphatidylinositol 3-kinase/Akt
induced by erythropoietin renders the erythroid
differentiation factor GATA-1 competent for
TIMP-1 gene transactivation.
16123041 Cleavage of claspin by caspase-7
during apoptosis inhibits the Chk1 pathway.
16123141 Molecular characterization of ring
finger protein 11.
16129408 Phosphorylation inhibits
DNA-binding of alternatively spliced aryl
hydrocarbon receptor nuclear translocator.
16131083 Identification of phosphorylation
sites in insulin receptor substrate-1 by
hypothesis-driven high-performance liquid
tandem mass spectrometry.
16135791 Epidermal growth factor-dependent
phosphorylation of the GGA3 adaptor protein
regulates its recruitment to membranes.
16135815 Rapid estrogen-induced
phosphorylation of the SRC-3 coactivator
occurs in an extranuclear complex containing
16138080 Phosphorylation of EEA1 by p38
MAP kinase regulates mu opioid receptor
16139227 Akt/PKB regulates actin organization
and cell motility via Girdin/APE.
16141410 Glycogen synthase kinase 3beta
inhibits myocardin-dependent transcription and
hypertrophy induction through site-specific
16153436 Direct phosphorylation of
proliferative and survival pathway proteins by
16156666 Identification and characterization of
ERK MAP kinase phosphorylation sites in
16157583 A protein kinase C/Ras/ERK
signaling pathway activates myeloid fibronectin
receptors by altering beta1 integrin sialylation.
16162500 Features of the catalytic domains
and C termini of the MAPK signal-integrating
kinases Mnk1 and Mnk2 determine their
differing activities and regulatory properties.
16163388 ATM and Chk2-dependent
phosphorylation of MDMX contribute to p53
activation after DNA damage.
16179258 Higher-order substrate recognition
of eIF2alpha by the RNA-dependent protein
16179349 Tyrosine phosphorylation of sam68
by breast tumor kinase regulates intranuclear
localization and cell cycle progression.
16186108 Tyrosine 740 phosphorylation of
discoidin domain receptor 2 by Src stimulates
intramolecular autophosphorylation and Shc
signaling complex formation.
16186805 The 44 kDa Pim-1 kinase directly
interacts with tyrosine kinase Etk/BMX and
protects human prostate cancer cells from
apoptosis induced by chemotherapeutic drugs.
16188906 Regulation of HSL serine
phosphorylation in skeletal muscle and adipose
16195223 Hyperphosphorylation of
JNK-interacting protein 1, a protein associated
with Alzheimer disease.
16199863 Abl kinases regulate actin comet tail
elongation via an N-WASP-dependent pathway.
16199882 Phosphorylation of beta-catenin by
cyclic AMP-dependent protein kinase stabilizes
beta-catenin through inhibition of its
16204230 Regulation of the interaction of Pak2
with Cdc42 via autophosphorylation of serine
16210244 Mapping post-translational
modifications of the histone variant MacroH2A1
using tandem mass spectrometry.
16212419 Phosphoproteome analysis of HeLa
cells using stable isotope labeling with amino
acids in cell culture (SILAC).
16212962 HIPK2 inhibits both MDM2 gene and
protein by, respectively, p53-dependent and
16223362 Nur77 is phosphorylated in cells by
RSK in response to mitogenic stimulation.
16224021 Akt-mediated phosphorylation of
EZH2 suppresses methylation of lysine 27 in
16247472 Phosphorylation of the cytokinesis
regulator ECT2 at G2/M phase stimulates
association of the mitotic kinase Plk1 and
accumulation of GTP-bound RhoA.
16252004 Critical role of novel Thr-219
autophosphorylation for the cellular function of
PKCtheta in T lymphocytes.
16253990 Increased proliferation and altered
growth factor dependence of human mammary
epithelial cells overexpressing the Gab2
16272144 Regulation of intracellular localization
and transcriptional activity of FOXO4 by protein
kinase B through phosphorylation at the motif
sites conserved among the FOXO family.
16278218 Phosphorylation of HSF1 by
MAPK-activated protein kinase 2 on serine 121,
inhibits transcriptional activity and promotes
16280322 In vitro transport of membrane
proteins to peroxisomes by shuttling receptor
16286467 Interleukin-1beta induction of
NFkappaB is partially regulated by
H2O2-mediated activation of
16286470 Cooperation of ERK and SCFSkp2
for MKP-1 destruction provides a positive
feedback regulation of proliferating signaling.
16287866 Regulation of caspase 9 through
phosphorylation by protein kinase C zeta in
response to hyperosmotic stress.
16291744 Phosphorylated alpha-actinin and
protein-tyrosine phosphatase 1B coregulate the
disassembly of the focal adhesion kinase x Src
complex and promote cell migration.
16293623 DNA replication stress-induced
phosphorylation of cyclic AMP response
element-binding protein mediated by ATM.
16293633 The AT-hook of the chromatin
architectural transcription factor high mobility
group A1a is arginine-methylated by protein
arginine methyltransferase 6.
16299313 Ectophosphorylation of CD36
regulates cytoadherence of Plasmodium
falciparum to microvascular endothelium under
16306228 14-3-3 cooperates with LKB1 to
regulate the activity and localization of QSK and
16319058 Binding of manumycin A inhibits
IkappaB kinase beta activity.
16325853 Phosphorylation on Ser106
modulates the cellular functions of the SHOX
16326706 Shp-1 mediates the antiproliferative
activity of tissue inhibitor of metalloproteinase-2
in human microvascular endothelial cells.
16330544 Chaperoning checkpoint kinase 1
(Chk1), an Hsp90 client, with purified
16338927 Identification of p122RhoGAP
(deleted in liver cancer-1) Serine 322 as a
substrate for protein kinase B and ribosomal S6
kinase in insulin-stimulated cells.
16342939 Prevention of MKK6-dependent
activation by binding to p38alpha MAP kinase.
16351573 Biochem J. 2006 Mar 1;394(Pt
16354680 Nutrients suppress
phosphatidylinositol 3-kinase/Akt signaling via
raptor-dependent mTOR-mediated insulin
receptor substrate 1 phosphorylation.
16354698 Akt-mediated YB-1 phosphorylation
activates translation of silent mRNA species.
16362057 Histone demethylation by a family of
JmjC domain-containing proteins.
16364302 P70 S6 kinase mediates tau
phosphorylation and synthesis.
16365045 The low density lipoprotein
receptor-related protein 6 interacts with
glycogen synthase kinase 3 and attenuates
16373505 Tyrosine phosphorylation acts as a
molecular switch to full-scale activation of the
eIF2alpha RNA-dependent protein kinase.
16374512 DNA-damage-responsive acetylation
of pRb regulates binding to E2F-1.
16376338 Protein kinase A phosphorylates and
regulates dimerization of 14-3-3 epsilon.
16397300 Functional role of NF-IL6beta and its
sumoylation and acetylation modifications in
promoter activation of cyclooxygenase 2 gene.
16399764 Identification of sites of mannose
6-phosphorylation on lysosomal proteins.
16403219 Pim kinases phosphorylate multiple
sites on Bad and promote 14-3-3 binding and
dissociation from Bcl-XL.
16407227 Phosphorylation and transactivation
of Pax6 by homeodomain-interacting protein
16407301 Phosphorylation of serine 526 is
required for MEKK3 activity, and association
with 14-3-3 blocks dephosphorylation.
16413544 Induction of apoptosis by p110C
requires mitochondrial translocation of the
proapoptotic BCL-2 family member BAD.
16415881 Structural basis for the methylation
site specificity of SET7/9.
16426576 CK2-dependent C-terminal
phosphorylation at T300 directs the nuclear
transport of TSPY protein.
16427064 Analysis on heat stress-induced
hyperphosphorylation of stathmin at serine 37
in Jurkat cells by means of two-dimensional gel
electrophoresis and tandem mass
16428449 Inhibition of DNA binding by
differential sumoylation of heat shock factors.
16428860 Phosphorylation of RanGAP1
stabilizes its interaction with Ran and RanBP1.
16429130 Regulation of ubiquitin-binding
proteins by monoubiquitination.
16442531 Repression of SOX6 transcriptional
activity by SUMO modification.
phosphorylation and degradation of
SRC-3/AIB1 and RARalpha-mediated
16461343 Identification of substrates of human
protein-tyrosine phosphatase PTPN22.
sumoylation of MEF2C negatively regulates its
16482222 Ubiquitylation of leptin receptor
OB-Ra regulates its clathrin-mediated
16488976 Proteinase 3 is an IL-32 binding
16511560 Regulation of MDMX nuclear import
and degradation by Chk2 and 14-3-3.
16511572 14-3-3gamma binds to MDMX that
is phosphorylated by UV-activated Chk1,
resulting in p53 activation.
16512921 The protein kinase DYRK1A
phosphorylates the splicing factor
SF3b1/SAP155 at Thr434, a novel in vivo
16517729 Signaling through mutants of the IgA
receptor CD89 and consequences for Fc
receptor gamma-chain interaction.
16519687 Site-specific phosphorylation of
MCM4 during the cell cycle in mammalian cells.
16537915 Uncleaved TFIIA is a substrate for
taspase 1 and active in transcription.
16540648 Phosphorylation of nucleotide
excision repair factor xeroderma pigmentosum
group A by ataxia telangiectasia mutated and
Rad3-related-dependent checkpoint pathway
promotes cell survival in response to UV
16543145 Glycogen synthase kinase-3
regulates mitochondrial outer membrane
permeabilization and apoptosis by
destabilization of MCL-1.
16543730 DOCA-induced phosphorylation of
glycogen synthase kinase 3beta.
16552184 CDK9 phosphorylates p53 on serine
residues 33, 315 and 392.
16554819 The prolyl isomerase Pin1 regulates
amyloid precursor protein processing and
16556605 Posttranslational N-myristoylation is
required for the anti-apoptotic activity of human
tGelsolin, the C-terminal caspase cleavage
product of human gelsolin.
16565220 Phosphoproteome analysis of the
human mitotic spindle.
16582606 Phosphorylation of RIalpha by
cyclin-dependent kinase CDK 2/cyclin E
modulates the dissociation of the
16582879 Interaction with Grb14 results in
site-specific regulation of tyrosine
phosphorylation of the insulin receptor.
16603397 Prolonged rapamycin treatment
inhibits mTORC2 assembly and Akt/PKB.
16636147 Activity of TSC2 is inhibited by
AKT-mediated phosphorylation and membrane
16648260 Identification of S-nitrosylation
motifs by site-specific mapping of the
S-nitrosocysteine proteome in human vascular
smooth muscle cells.
16648821 c-Abl acetylation by histone
acetyltransferases regulates its
16669787 Functional interactions of the
SPAK/OSR1 kinases with their upstream
activator WNK1 and downstream substrate
16682416 Reversible post-translational
modification of proteins by nitrated fatty acids
16723391 Regulation of hypermutation by
activation-induced cytidine deaminase
16729043 Phosphotyrosine interactome of the
ErbB-receptor kinase family.
16753148 Polo-like kinase 1 regulates mitotic
arrest after UV irradiation through
dephosphorylation of p53 and inducing p53
16760428 Phosphorylation- and
polo-box-dependent binding of Plk1 to Bub1 is
required for the kinetochore localization of Plk1.
16760434 Phosphorylation of focal adhesion
kinase (FAK) on Ser732 is induced by
rho-dependent kinase and is essential for
proline-rich tyrosine kinase-2-mediated
phosphorylation of FAK on Tyr407 in response
to vascular endothelial growth factor.
16763549 Glycosaminoglycan modification of
neuropilin-1 modulates VEGFR2 signaling.
16763566 The mTOR/PI3K and MAPK
pathways converge on eIF4B to control its
phosphorylation and activity.
16777849 Physical and functional interaction of
Fyn tyrosine kinase with a brain-enriched Rho
GTPase-activating protein TCGAP.
16782707 Huntingtin phosphorylation sites
mapped by mass spectrometry. Modulation of
cleavage and toxicity.
16785428 Phosphoproteomic analysis of
Her2/neu signaling and inhibition.
16794575 Trans-activation of the
DNA-damage signalling protein kinase Chk2 by
16799092 Dynamic profiling of the
post-translational modifications and interaction
partners of epidermal growth factor receptor
signaling after stimulation by epidermal growth
factor using Extended Range Proteomic
16803888 Rheb inhibits C-raf activity and
16807684 Phosphoproteomic analysis of the
16810323 FGF-2 protects small cell lung
cancer cells from apoptosis through a complex
involving PKCepsilon, B-Raf and S6K2.
16825424 Identification of phosphorylation
sites in GIT1.
16825425 Cortactin phosphorylation sites
mapped by mass spectrometry.
16837009 A dimeric kinase assembly
underlying autophosphorylation in the p21
16837464 STOP-like protein 21 is a novel
member of the STOP family, revealing a Golgi
localization of STOP proteins.
16843263 HER2 kinase domain mutation
results in constitutive phosphorylation and
activation of HER2 and EGFR and resistance to
EGFR tyrosine kinase inhibitors.
16858395 The amino-terminal B-Raf-specific
region mediates calcium-dependent homo- and
hetero-dimerization of Raf.
16858402 Involvement of novel
autophosphorylation sites in ATM activation.
16858404 Histone methyltransferase Suv39h1
represses MyoD-stimulated myogenic
16862120 Phosphorylation of WAVE1 regulates
actin polymerization and dendritic spine
16862148 FilGAP, a Rho- and ROCK-regulated
GAP for Rac binds filamin A to control actin
16874301 A novel mitochondrial ubiquitin ligase
plays a critical role in mitochondrial dynamics.
16895919 CFBP is a novel
tyrosine-phosphorylated protein that might
function as a regulator of CIN85/CD2AP.
16899217 Magicin associates with the
Src-family kinases and is phosphorylated upon
16906133 Autophosphorylation at serine 1987
is dispensable for murine Atm activation in vivo.
16917505 Direct binding of p85 to sst2
somatostatin receptor reveals a novel
mechanism for inhibiting PI3K pathway.
16917507 Roles of HIPK1 and HIPK2 in AML1-
and p300-dependent transcription,
hematopoiesis and blood vessel formation.
16921383 Orai1 is an essential pore subunit of
the CRAC channel.
16938345 Evidence of LAT as a dual substrate
for Lck and Syk in T lymphocytes.
16956611 CRM1 mediates nuclear export of
HDAC7 independently of HDAC7
phosphorylation and association with 14-3-3s.
16963136 An ITIM-like motif within the CCK2
receptor sequence required for interaction with
SHP-2 and the activation of the AKT pathway.
16963448 Repeated phosphopeptide motifs in
human Claspin are phosphorylated by Chk1
and mediate Claspin function.
16966330 Phosphorylation of Tyr1214 within
VEGFR-2 triggers the recruitment of Nck and
activation of Fyn leading to SAPK2/p38
activation and endothelial cell migration in
response to VEGF.
16977309 A PACS-1, GGA3 and CK2 complex
regulates CI-MPR trafficking.
17000644 Distinct and overlapping sets of
SUMO-1 and SUMO-2 target proteins revealed
by quantitative proteomics.
17006543 Mdm2 is involved in the
ubiquitination and degradation of
G-protein-coupled receptor kinase 2.
17024177 The phosphorylation status of
PAS-B distinguishes HIF-1alpha from
HIF-2alpha in NBS1 repression.
17027227 The N-terminal SH2 domain of the
tyrosine phosphatase, SHP-2, is essential for
Jak2-dependent signaling via the angiotensin II
type AT1 receptor.
17043054 Mass spectrometric mapping of
linker histone H1 variants reveals multiple
acetylations, methylations, and phosphorylation
as well as differences between cell culture and
17053781 Suppression of receptor interacting
protein 140 repressive activity by protein
17053782 C-terminal phosphorylation controls
the stability and function of p27kip1.
17066076 Regulation of MBD1-mediated
transcriptional repression by SUMO and PIAS
17078951 PKA modulates GSK-3beta- and
cdk5-catalyzed phosphorylation of tau in site-
and kinase-specific manners.
17081983 Global, in vivo, and site-specific
phosphorylation dynamics in signaling
17088250 Phosphorylation of a threonine
unique to the short C-terminal isoform of
betaII-spectrin links regulation of alpha-beta
spectrin interaction to neuritogenesis.
17097642 Regulation of RKIP binding to the
N-region of the Raf-1 kinase.
17098746 FBXO11 promotes the Neddylation
of p53 and inhibits its transcriptional activity.
17108971 Repression of p53 activity by
17110336 E4F1 is an atypical ubiquitin ligase
that modulates p53 effector functions
independently of degradation.
17110929 MDMX regulation of p53 response to
17116872 Phosphorylation and cleavage of
presenilin-associated rhomboid-like protein
(PARL) promotes changes in mitochondrial
17139249 GSK-3beta-regulated interaction of
BICD with dynein is involved in microtubule
anchorage at centrosome.
17157788 Che-1 phosphorylation by ATM/ATR
and Chk2 kinases activates p53 transcription
and the G2/M checkpoint.
17159907 Palmitoylation of CD95 facilitates
formation of SDS-stable receptor aggregates
that initiate apoptosis signaling.
17159908 Palmitoylation is required for efficient
Fas cell death signaling.
17192257 Proteomics analysis of protein
kinases by target class-selective
prefractionation and tandem mass
17203073 aPKC-mediated phosphorylation
regulates asymmetric membrane localization of
the cell fate determinant Numb.
17205062 The role of proline-rich protein
tyrosine kinase 2 in differentiation-dependent
signaling in human epidermal keratinocytes.
17208333 Modulation of beta-catenin by
cyclin-dependent kinase 6 in Wnt-stimulated
17210579 Apoptosis signal-regulating kinase
(ASK) 2 functions as a mitogen-activated
protein kinase kinase kinase in a heteromeric
complex with ASK1.
17215513 Aurora-B regulates RNA
17218255 Modeling of a human circadian
mutation yields insights into clock regulation by
17220478 Proteomics analysis of the
interactome of N-myc downstream regulated
gene 1 and its interactions with the androgen
response program in prostate cancer cells.
17229891 DYRK1A autophosphorylation on
serine residue 520 modulates its kinase activity
via 14-3-3 binding.
17245430 A specific PP2A regulatory subunit,
B56gamma, mediates DNA damage-induced
dephosphorylation of p53 at Thr55.
17254966 Cdk-inhibitory activity and stability of
p27Kip1 are directly regulated by oncogenic
17254967 p27 phosphorylation by Src
regulates inhibition of cyclin E-Cdk2.
17254968 PRAK is essential for ras-induced
senescence and tumor suppression.
17274640 A limited screen for protein
interactions reveals new roles for protein
phosphatase 1 in cell cycle control and
17290217 Role of activation of
PIP5Kgamma661 by AP-2 complex in synaptic
17290218 Death effector domain DEDa, a
self-cleaved product of caspase-8/Mch5,
translocates to the nucleus by binding to
ERK1/2 and upregulates procaspase-8
expression via a p53-dependent mechanism.
17290227 Subcellular localization of Grb2 by
the adaptor protein Dok-3 restricts the intensity
of Ca2+ signaling in B cells.
17290288 Interferons induce tyrosine
phosphorylation of the eIF2alpha kinase PKR
through activation of Jak1 and Tyk2.
17293345 Biochemical and functional
characterization of Orai proteins.
17310145 A ubiquitin ligase transfers
preformed polyubiquitin chains from a
conjugating enzyme to a substrate.
17318175 Protein phosphatase 1 regulates
assembly and function of the beta-catenin
17322306 Phosphopeptide enrichment by
aliphatic hydroxy acid-modified metal oxide
chromatography for nano-LC-MS/MS in
17363905 Phosphorylation and ubiquitination of
the IkappaB kinase complex by two distinct
17380123 A new p38 MAP kinase-regulated
transcriptional coactivator that stimulates
17382325 Modulation of p300 binding by
posttranslational modifications of the C-terminal
activation domain of hypoxia-inducible
17408621 Cyclin B1/Cdk1 binds and
phosphorylates Filamin A and regulates its
ability to cross-link actin.
17426253 Growth stimulation of non-small cell
lung cancer cell lines by antibody against
epidermal growth factor receptor promoting
formation of ErbB2/ErbB3 heterodimers.
17460694 FANCI is a second
monoubiquitinated member of the Fanconi
17486112 Roles of ATM and NBS1 in
chromatin structure modulation and DNA
double-strand break repair.
17525332 ATM and ATR substrate analysis
reveals extensive protein networks responsive
to DNA damage.
17525340 Abraxas and RAP80 form a BRCA1
protein complex required for the DNA damage
17540171 Proinflammatory stimuli induce
IKKalpha-mediated phosphorylation of PIAS1 to
restrict inflammation and immunity.
17540172 L3MBTL1, a
histone-methylation-dependent chromatin lock.
17540176 The tumor suppressor PP2A Abeta
regulates the RalA GTPase.
17558413 Determination of the sites of tyrosine
O-sulfation in peptides and proteins.
17662948 Regulation of Pax3 by proteasomal
degradation of monoubiquitinated protein in
skeletal muscle progenitors.
17684059 Calcineurin is essential for
depolarization-induced nuclear translocation
and tyrosine phosphorylation of PYK2 in
18083107 Global survey of phosphotyrosine
signaling identifies oncogenic kinases in lung
18691969 Ubc9 sumoylation regulates SUMO
18707152 Phosphorylation of SUMO-1 occurs
in vivo and is conserved through evolution.
19117447 Profiling of endogenous serum
phosphorylated peptides by titanium (IV)
immobilized mesoporous silica particles
enrichment and MALDI-TOFMS detection.
19508227 Glycosylation of tetraspanin Tspan-1
at four distinct sites promotes its transition
through the endoplasmic reticulum.
27803192 Interchromosomal core duplicons
drive both evolutionary instability and disease
susceptibility of the Chromosome 8p23.1
23990606 The shared genomic architecture of
human nucleolar organizer regions.