⇩ The Human Genome Project, currently maintained
by the Genome Reference Consortium (GRC)
Genome Reference Consortium (Owner)
International Human Genome Sequencing Consortium
The human reference assembly defines a standard
upon which other whole genome studies are
based. Providing the best representation
of the human genome is essential for facilitating
continued progress in understanding and
improving human health. The Human Genome
Project (HGP) was an international research
collaboration coordinated by the U.S. Department
of Energy (DOE) and National Institutes
of Health (NIH) whose goals were to determine
the sequence of the human chromosomes and
identify and map all human genes. The project
began in 1988 when Congress funded both
the NIH and the DOE and was completed in
April of 2003. The HGP used a clone-oriented
approach to produce map data, clone reagents,
and the assembled human genome sequence.
The International Human Genome Sequencing
Consortium published the first draft of
the human genome, with the sequence 90%
complete, in the journal Nature in February
2001. The full sequence was completed in
April 2003. The HGP resulted in significant
technology, tool, and resource development
that continues to have a significant impact
on medicine and other life sciences. The
Genome Reference Consortium (GRC) was formed
in 2008 to maintain the reference assembly
for the human genome. The goals of this
group are to correct regions that are
misrepresented, to close remaining gaps,
and to produce alternative assemblies of
structurally variant loci. The consortium
does experimental work to address gaps or
sub-optimal sequence regions and has developed
the infrastructure to review and curate
assembly joins. The GRC consists of: The
Wellcome Trust Sanger Institute, The Genome
Center at Washington University, The European
Bioinformatics Institute and The National
Center for Biotechnology Information. The
public can see regions under review and
report genome problems at the GRC website,
human genome assembly submitted by the GRC
is available in GenBank under accession
ranges GL000001-GL000258 (the scaffolds),
and CM000663-CM000686 (the chromosomes).
11237011 Initial sequencing and analysis of the human genome.
15496913 Finishing the euchromatic sequence of the human genome.
15372022 The DNA sequence and comparative analysis of human chromosome 5.
12853948 The DNA sequence of human chromosome 7.
12508121 The DNA sequence and analysis of human chromosome 14.
11780052 The DNA sequence and comparative analysis of human chromosome 20.
10830953 The DNA sequence of human chromosome 21.
10591208 The DNA sequence of human chromosome 22.
12815422 The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes.
15164054 The DNA sequence and comparative analysis of human chromosome 10.
15164053 DNA sequence and analysis of human chromosome 9.
15057823 The DNA sequence and analysis of human chromosome 13.
14574404 The DNA sequence and analysis of human chromosome 6.
15057824 The DNA sequence and biology of human chromosome 19.
15616553 The sequence and analysis of duplication-rich human chromosome 16.
16554811 Human chromosome 11 DNA sequence and analysis including novel gene identification.
16541075 The finished DNA sequence of human chromosome 12.
16177791 DNA sequence and analysis of human chromosome 18.
15815621 Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
15772651 The DNA sequence of the human X chromosome.
16710414 The DNA sequence and biological annotation of human chromosome 1.
16641997 The DNA sequence, annotation and analysis of human chromosome 3.
16421571 DNA sequence and analysis of human chromosome 8.
16572171 Analysis of the DNA sequence and duplication history of human chromosome 15.
16625196 DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.
18477386 Finishing the finished human chromosome 22 sequence.
11687796 The AZFc region of the Y chromosome features massive palindromes and uniform recurrent deletions in infertile men.
15653831 Interchromosomal segmental duplications of the pericentromeric region on the human Y chromosome.
17573966 Detailed analysis of 15q11-q14 sequence corrects errors and gaps in the public access sequence to fully reveal large segmental duplications at breakpoints for Prader-Willi, Angelman, and inv dup(15) syndromes.
18193213 Variation analysis and gene annotation of eight MHC haplotypes: the MHC Haplotype Project.
18760392 Adaptive evolution of UGT2B17 copy-number variation.
19165922 Evolutionary toggling of the MAPT 17q21.31 inversion region.
19490611 Closing gaps in the human genome using sequencing by synthesis.
20534489 High-resolution human genome structure by single-molecule analysis.
21206914 Different patterns of evolution in the centromeric and telomeric regions of group A and B haplotypes of the human killer cell Ig-like receptor locus.
22482802 Resolving the breakpoints of the 17q21.31 microdeletion syndrome with next-generation sequencing.
23042453 DNA template strand sequencing of single-cells maps genomic rearrangements at high resolution.
23435088 Using population admixture to help complete maps of the human genome.
23541343 Complete haplotype sequence of the human immunoglobulin heavy-chain variable, diversity, and joining genes and characterization of allelic and copy-number variation.
23872635 Independent specialization of the human and mouse X chromosomes for the male germ line.
23932108 Mapping the human reference genome's missing sequence by three-way admixture in Latino genomes.
25326701 Palindromic GOLGA8 core duplicons promote chromosome 15q13.3 microdeletion and evolutionary instability.
14618296 Cytochrome P450 2D6: overview and update on pharmacology, genetics, biochemistry.
20183526 Genetic polymorphism in cytochrome P450 2D6 (CYP2D6): Population distribution of CYP2D6 activity.
12355084 Facioscapulohumeral muscular dystrophy is uniquely associated with one of the two variants of the 4q subtelomere.
17924332 Specific sequence variations within the 4q35 region are associated with facioscapulohumeral muscular dystrophy.
20206332 Worldwide population analysis of the 4q and 10q subtelomeres identifies only four discrete interchromosomal sequence transfers in human evolution.
20724583 A unifying genetic model for facioscapulohumeral muscular dystrophy.
7219534 Sequence and organization of the human mitochondrial genome.
10508508 Reanalysis and revision of the Cambridge reference sequence for human mitochondrial DNA.
18674749 Extensive copy-number variation of the human olfactory receptor gene family.
20729854 A large and complex structural polymorphism at 16p12.1 underlies microdeletion disease risk.
12173 Post-proline cleaving enzyme. Purification of this endopeptidase by affinity chromatography.
72068 Carbohydrate moiety of HLA antigens. Antigenic properties and amino acid sequences around the site of glycosylation.
116880 Effect of delta 9-tetrahydrocannabinol (THC) on female reproductive function.
146197 Chemical evidence that proteolytic cleavage causes the heterogeneity present in human ceruloplasmin preparations.
195962 Effects of altered thyroid function on galactosyl diacylglycerol metabolism in myelinating rat brain.
221492 Sequence of two phosphorylated sites in the catalytic subunit of bovine cardiac muscle adenosine 3':5'-monophosphate-dependent protein kinase.
278975 Specific phosphorylation at serine-283 of alpha tropomyosin from frog skeletal and rabbit skeletal and cardiac muscle.
325004 Limited pepsin digestion of human plasma albumin.
407930 Primary structure of human J chain: alignment of peptides from chemical and enzymatic hydrolyses.
479158 Carbohydrate of the human plasminogen variants. III. Structure of the O-glycosidically linked oligosaccharide unit.
518865 Complete amino acid sequence of a papain-solubilized human histocompatibility antigen, HLA-B7. 2. Sequence determination and search for homologies.
600212 [Viscosimetry in clinical practice].
602896 Cystitis emphysematosa.
838735 Complete covalent structure of statherin, a tyrosine-rich acidic peptide which inhibits calcium phosphate precipitation from human parotid saliva.
890569 Human pituitary thyrotropin. The primary structure of the alpha and beta subunits.
1056466 Antibiotic treatment of oral anaerobic infections.
1088347 [Study of the heterogenetic antigens in vaccinal preparations of V. cholerae].
1127890 Symptoms of stress in four societies.
1181841 Proceedings: Aneurysmal bone cysts of the spine.
1309762 Mechanism of desensitization of the epidermal growth factor receptor protein-tyrosine kinase.
1311327 Proteolytic inactivation of alpha 1-proteinase inhibitor and alpha 1-antichymotrypsin by oxidatively activated human neutrophil metalloproteinases.
1314426 Calcium-regulated phosphorylation within the leucine zipper of C/EBP beta.
1319925 Heterogeneous expression of four MAP kinase isoforms in human tissues.
1321150 Identification of the cAMP-dependent protein kinase and protein kinase C phosphorylation sites within the major intracellular domains of the beta 1, gamma 2S, and gamma 2L subunits of the gamma-aminobutyric acid type A receptor.
1322130 The two forms of bovine heart 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase result from alternative splicing.
1322891 Specific phosphorylation of a COOH-terminal site on the full-length form of the alpha 1 subunit of the skeletal muscle calcium channel by cAMP-dependent protein kinase.
1330687 p42 MAP kinase phosphorylation sites in microtubule-associated protein tau are dephosphorylated by protein phosphatase 2A1. Implications for Alzheimer's disease [corrected].
1332886 Identification of MAPKAP kinase 2 as a major enzyme responsible for the phosphorylation of the small mammalian heat shock proteins.
1334087 Unique autolytic cleavage of human myeloperoxidase. Implications for the involvement of active site MET409.
1334482 Function of the alpha 1 beta 2 gamma 2S gamma-aminobutyric acid type A receptor is modulated by protein kinase C via multiple phosphorylation sites.
1335366 FGF inactivates myogenic helix-loop-helix proteins through phosphorylation of a conserved protein kinase C site in their DNA-binding domains.
1347949 ERK1 and ERK2, two microtubule-associated protein 2 kinases, mediate the phosphorylation of tyrosine hydroxylase at serine-31 in situ.
1350383 Heteromeric NMDA receptors: molecular and functional distinction of subtypes.
1370477 Patterns of prohormone processing. Order revealed by a new procholecystokinin-derived peptide.
1373652 Sequential dephosphorylation of a multiply phosphorylated insulin receptor peptide by protein tyrosine phosphatases.
1374067 PKC epsilon-related kinase associates with and phosphorylates cytokeratin 8 and 18.
1375933 Nitric oxide synthase regulatory sites. Phosphorylation by cyclic AMP-dependent protein kinase, protein kinase C, and calcium/calmodulin protein kinase; identification of flavin and calmodulin binding sites.
1377674 Phosphorylation of the cystic fibrosis transmembrane conductance regulator.
1378617 Identification of Tyr-185 as the site of tyrosine autophosphorylation of recombinant mitogen-activated protein kinase p42mapk.
1380064 Cytokine RANTES released by thrombin-stimulated platelets is a potent attractant for human eosinophils.
1381905 Post-translational processing of membrane-associated recombinant human stem cell factor expressed in Chinese hamster ovary cells.
1382070 Identification of the two major epidermal growth factor-induced tyrosine phosphorylation sites in the microvillar core protein ezrin.
1387511 Generation of the neutrophil-activating peptide-2 by cathepsin G and cathepsin G-treated human platelets.
1400319 Post-translational modifications of p21rho proteins.
1400350 Casein kinase II phosphorylates p34cdc2 kinase in G1 phase of the HeLa cell division cycle.
1402651 Myristyl acylation of the tumor necrosis factor alpha precursor on specific lysine residues.
1425574 Reversible phosphorylation--dephosphorylation determines the localization of rab4 during the cell cycle.
1425701 Specific phosphorylation of the acidic central region of the N-myc protein by casein kinase II.
1426245 Prothymosin alpha is phosphorylated by casein kinase-2.
1451807 Natural human tumor necrosis factor beta (lymphotoxin). Variable O-glycosylation at Thr7, proteolytic processing, and allelic variation.
1454855 Characterization of the tumor suppressor protein p53 as a protein kinase C substrate and a S100b-binding protein.
1476071 [Topical timolol and blood-aqueous barrier permeability to protein in human eyes].
1498334 Role of individual gamma-carboxyglutamic acid residues of activated human protein C in defining its in vitro anticoagulant activity.
1505778 The site of nonenzymic glycation of human extracellular-superoxide dismutase in vitro.
1512232 Localization of O-GlcNAc modification on the serum response transcription factor.
1516134 Casein kinase II is a negative regulator of c-Jun DNA binding and AP-1 activity.
1518044 Sequences of 20 subunits of NADH:ubiquinone oxidoreductase from bovine heart mitochondria. Application of a novel strategy for sequencing proteins using the polymerase chain reaction.
1525182 Site-specific glycation of lens crystallins by ascorbic acid.
1527025 Identification of the autophosphorylation sites in rhodopsin kinase.
1530946 A strategy for isolation of cDNAs encoding proteins affecting human intestinal epithelial cell growth and differentiation: characterization of a novel gut-specific N-myristoylated annexin.
1533159 Recombinant human complement subcomponent C1s lacking beta-hydroxyasparagine, sialic acid, and one of its two carbohydrate chains still reassembles with C1q and C1r to form a functional C1 complex.
1533624 GAP-43, a protein associated with axon growth, is phosphorylated at three sites in cultured neurons and rat brain.
1545828 Alteration of a cyclic AMP-dependent protein kinase phosphorylation site in the c-Fos protein augments its transforming potential.
1551416 Effective activation of the proenzyme form of the urokinase-type plasminogen activator (pro-uPA) by the cysteine protease cathepsin L.
1553557 An amino acid mutation in a potassium channel that prevents inhibition by protein kinase C.
1556125 Cell-associated episialin is a complex containing two proteins derived from a common precursor.
1556128 Structure of heparin-binding EGF-like growth factor. Multiple forms, primary structure, and glycosylation of the mature protein.
1558967 The effect of leukocyte elastase on tissue factor pathway inhibitor.
1587862 Sequencing, cloning, and expression of human red cell-type acid phosphatase, a cytoplasmic phosphotyrosyl protein phosphatase.
1597471 Proprotein conversion is determined by a multiplicity of factors including convertase processing, substrate specificity, and intracellular environment. Cell type-specific processing of human prorenin by the convertase PC1.
1601129 Phosphorylation sequences in h-caldesmon from phorbol ester-stimulated canine aortas.
1610348 Phosphorylation of interleukin-6 at serine54: an early event in the secretory pathway in human fibroblasts.
1618861 Identification of palmitoylation sites on CD4, the human immunodeficiency virus receptor.
1627603 Human red cell acid phosphatase (ACP1): the primary structure of the two pairs of isozymes encoded by the ACP1*A and ACP1*C alleles.
1629222 Activation of human furin precursor processing endoprotease occurs by an intramolecular autoproteolytic cleavage.
1647028 Phosphorylation of protein 4.1 on tyrosine-418 modulates its function in vitro.
1648089 In vitro phosphorylation of the adipocyte lipid-binding protein (p15) by the insulin receptor. Effects of fatty acid on receptor kinase and substrate phosphorylation.
1654338 Connective tissue growth factor: a cysteine-rich mitogen secreted by human vascular endothelial cells is related to the SRC-induced immediate early gene product CEF-10.
1677563 A synthetic peptide substrate for initiation factor-2 kinases.
1689310 Tyrosine residues in bovine phospholipase C-gamma phosphorylated by the epidermal growth factor receptor in vitro.
1692828 Structural characterization of natural and recombinant human granulocyte colony-stimulating factors.
1694784 Location and characterization of the three carbohydrate prosthetic groups of human protein HC.
1706595 Endogenous cleavage of the Arg-379-Ala-380 bond in vitronectin results in a distinct conformational change which 'buries' Ser-378, its site of phosphorylation by protein kinase A.
1706616 Identification of autophosphorylation sites of HER2/neu.
1712480 Microtubule-associated protein 2 kinases, ERK1 and ERK2, undergo autophosphorylation on both tyrosine and threonine residues: implications for their mechanism of activation.
1713455 Novel serine phosphorylation occurs in the fibroblast form of pp60c-src from Y79 retinoblastoma cells.
1722201 CSK: a protein-tyrosine kinase involved in regulation of src family kinases.
1730617 Vertebrate lens alpha-crystallins are modified by O-linked N-acetylglucosamine.
1730718 Functional and structural analysis of VLA-4 integrin alpha 4 subunit cleavage.
1733926 The predominant form of secreted colony stimulating factor-1 is a proteoglycan.
1740119 Casein kinase II phosphorylation increases the rate of serum response factor-binding site exchange.
1740409 The cytoplasmic domain of tissue factor is phosphorylated by a protein kinase C-dependent mechanism.
1748630 A phosphorylation site located in the NH2-terminal domain of c-Myc increases transactivation of gene expression.
1756735 The retinoblastoma protein is phosphorylated on multiple sites by human cdc2.
1778989 Identification of full-sized forms of salivary (S-type) cystatins (cystatin SN, cystatin SA, cystatin S, and two phosphorylated forms of cystatin S) in human whole saliva and determination of phosphorylation sites of cystatin S.
1820200 Site-specific N-glycosylation of human chorionic gonadotrophin--structural analysis of glycopeptides by one- and two-dimensional 1H NMR spectroscopy.
1824699 Glycophospholipid membrane anchor attachment. Molecular analysis of the cleavage/attachment site.
1825608 Protein-induced inactivation and phosphorylation of rabbit muscle phosphofructokinase.
1827443 Protein kinase C phosphorylates the carboxyl terminus of the plasma membrane Ca(2+)-ATPase from human erythrocytes.
1828073 Phosphorylation of neuromodulin (GAP-43) by casein kinase II. Identification of phosphorylation sites and regulation by calmodulin.
1833648 Myc rescue of a mutant CSF-1 receptor impaired in mitogenic signalling.
1845981 Phosphorylation of the 48-kDa subunit of the glycine receptor by protein kinase C.
1848190 Phorbol-ester-induced phosphorylation of the beta 2-adrenergic receptor decreases its coupling to Gs.
1850098 The epidermal growth factor receptor phosphorylates GTPase-activating protein (GAP) at Tyr-460, adjacent to the GAP SH2 domains.
1851158 Nucleoside diphosphate kinase from human erythrocytes. Structural characterization of the two polypeptide chains responsible for heterogeneity of the hexameric enzyme.
1861080 Proteolysis of C3 on U937 cell plasma membranes. Purification of cathepsin G.
1900431 Tissue plasminogen activator has an O-linked fucose attached to threonine-61 in the epidermal growth factor domain.
1900515 Cathepsin B efficiently activates the soluble and the tumor cell receptor-bound form of the proenzyme urokinase-type plasminogen activator (Pro-uPA).
1919001 IL-1-converting enzyme requires aspartic acid residues for processing of the IL-1 beta precursor at two distinct sites and does not cleave 31-kDa IL-1 alpha.
1924301 Endocytosis by the asialoglycoprotein receptor is independent of cytoplasmic serine residues.
1939057 Phosphorylation by cdc2 kinase modulates DNA binding activity of high mobility group I nonhistone chromatin protein.
1939080 Thyroglobulin processing by thyroidal proteases. Major sites of cleavage by cathepsins B, D, and L.
1939094 Phosphorylation of the beta subunit of casein kinase II in human A431 cells. Identification of the autophosphorylation site and a site phosphorylated by p34cdc2.
1939112 Human red cell acid phosphatase (ACP1). The amino acid sequence of the two isozymes Bf and Bs encoded by the ACP1*B allele.
1956339 Protein kinase phosphorylation site sequences and consensus specificity motifs: tabulations.
1959628 Proteolytic activity and cleavage specificity of cathepsin E at the physiological pH as examined towards the B chain of oxidized insulin.
1973163 Phosphorylation of tyrosine hydroxylase in situ at serine 8, 19, 31, and 40.
1985196 Structural elements that regulate pp59c-fyn catalytic activity, transforming potential, and ability to associate with polyomavirus middle-T antigen.
1985906 Multisite phosphorylation of a synthetic peptide derived from the carboxyl terminus of the ribosomal protein S6.
1985907 Phosphorylation of cardiac and skeletal muscle calsequestrin isoforms by casein kinase II. Demonstration of a cluster of unique rapidly phosphorylated sites in cardiac calsequestrin.
1991173 Molecular characterization of erythrocyte glycophorin C variants.
1993068 Mapping of carbohydrate sites on the human insulin receptor.
1993171 Disulfide assignments in recombinant mouse and human interleukin 4.
1995645 Phosphorylation and subcellular distribution of calpastatin in human hematopoietic system cells.
1998697 Phosphorylation sites in human erythrocyte band 3 protein.
2005884 Biosynthesis of human fibroblast growth factor-5.
2006911 The principal site of glycation of human complement factor B.
2013294 Primary structure of a new actin-binding protein from human seminal plasma.
2013314 Inactivation of human cystatin C and kininogen by human cathepsin D.
2019585 Identification of phosphorylated sites in the mouse glucocorticoid receptor.
2033065 Glycosylation of human protein C affects its secretion, processing, functional activities, and activation by thrombin.
2040274 Nuclear transition protein 1 from ram elongating spermatids. Mass spectrometric characterization, primary structure and phosphorylation sites of two variants.
2040602 Inactivation of DNA polymerase beta by in vitro phosphorylation with protein kinase C.
2040636 Cooperative activation of human factor IX by the human extrinsic pathway of blood coagulation.
2046671 Mutation of serum response factor phosphorylation sites and the mechanism by which its DNA-binding activity is increased by casein kinase II.
2061332 Identification of renal cathepsin B as a human prorenin-processing enzyme.
2065054 Structures of the asparagine-289-linked oligosaccharides assembled on recombinant human plasminogen expressed in a Mamestra brassicae cell line (IZD-MBO503).
2065070 Three regions of erythrocyte band 3 protein are phosphorylated on tyrosines: characterization of the phosphorylation sites by solid phase sequencing combined with capillary electrophoresis.
2109157 Closely related glycosylation patterns of recombinant human IL-2 expressed in a CHO cell line and natural IL-2.
2112085 Proteolytic processing of the 600 kd low density lipoprotein receptor-related protein (LRP) occurs in a trans-Golgi compartment.
2114109 Ca2(+)-calmodulin-dependent protein kinase II phosphorylates various types of non-epithelial intermediate filament proteins.
2116318 Two phosphorylation sites on eIF-2 alpha.
2117608 Phosphate groups as substrate determinants for casein kinase I action.
2123345 Posttranslationally processed structure of the human platelet protein smg p21B: evidence for geranylgeranylation and carboxyl methylation of the C-terminal cysteine.
2129526 Primary structure of human placental 5'-nucleotidase and identification of the glycolipid anchor in the mature form.
2136742 The amino terminus of muscle tropomyosin is a major determinant for function.
2140056 Identification of the protein kinase C phosphorylation site in neuromodulin.
2153964 G-protein alpha-subunit expression, myristoylation, and membrane association in COS cells.
2155236 Phosphorylation sites linked to glial filament disassembly in vitro locate in a non-alpha-helical head domain.
2160950 Phosphorylation of smooth myosin light chain kinase by smooth muscle Ca2+/calmodulin-dependent multifunctional protein kinase.
2168396 Substrate- and kinase-directed regulation of phosphorylation of a cGMP-binding phosphodiesterase by cGMP.
2168407 Identification of membrane anchoring site of human renal dipeptidase and construction and expression of a cDNA for its secretory form.
2176601 Amino acid sequence of in vivo phosphorylation sites in the main intrinsic protein (MIP) of lens membranes.
2183353 Differential phosphorylation of c-Abl in cell cycle determined by cdc2 kinase and phosphatase activity.
2186807 Substrate specificity of recombinant human renal renin: effect of histidine in the P2 subsite on pH dependence.
2203348 The purification and characterization of recombinant human renin expressed in the human kidney cell line 293.
2209608 Primary structure of the bovine analogues to human apolipoproteins CII and CIII. Studies on isoforms and evidence for proteolytic processing.
2211721 Differential expression and distinct structure of 69- and 100-kDa forms of 2-5A synthetase in human cells treated with interferon.
2212658 Rapid nonlysosomal degradation of assembled HLA class II glycoproteins incorporating a mutant DR alpha-chain.
2217184 Identification and preliminary characterization of protein-cysteine farnesyltransferase.
2243102 The polylactosaminoglycans of human lysosomal membrane glycoproteins lamp-1 and lamp-2. Localization on the peptide backbones.
2249995 Site-directed mutagenesis of the m2 muscarinic acetylcholine receptor. Analysis of the role of N-glycosylation in receptor expression and function.
2269661 cDNA cloning reveals the molecular structure of a sperm surface protein, PH-20, involved in sperm-egg adhesion and the wide distribution of its gene among mammals.
2275556 Comparison of cathepsin L synthesized by normal and transformed cells at the gene, message, protein, and oligosaccharide levels.
2318846 Kinetic determination of the effects of ADP-ribosylation on the interaction of eukaryotic elongation factor 2 with ribosomes.
2318847 Interaction of heparin cofactor II with neutrophil elastase and cathepsin G.
2335219 Fatty acid acylation of lens fiber plasma membrane proteins. MP26 and alpha-crystallin are palmitoylated.
2344612 Mutations of phosphorylation sites in lamin A that prevent nuclear lamina disassembly in mitosis.
2361960 Structure of recombinant human interleukin 5 produced by Chinese hamster ovary cells.
2365696 Purification and characterization of catalytic fragments of phosphorylase kinase gamma subunit missing a calmodulin-binding domain.
2369897 Regulation of HMG-CoA reductase: identification of the site phosphorylated by the AMP-activated protein kinase in vitro and in intact rat liver.
2394722 Cloning and sequencing of a human pancreatic tumor mucin cDNA.
2394752 Protein kinase A phosphorylates retinal phosducin on serine 73 in situ.
2406364 Generation of the neutrophil-activating peptide NAP-2 from platelet basic protein or connective tissue-activating peptide III through monocyte proteases.
2413024 Studies on the phosphorylation of myelin basic protein by protein kinase C and adenosine 3':5'-monophosphate-dependent protein kinase.
2423119 Characterization of human platelet basic protein, a precursor form of low-affinity platelet factor 4 and beta-thromboglobulin.
2434496 Sulfation of a tyrosine residue in the plasmin-binding domain of alpha 2-antiplasmin.
2434500 Tyrosine kinase catalyzed phosphorylation and inactivation of the inhibitor protein of the cAMP-dependent protein kinase.
2437112 The reactive site of human alpha 2-antiplasmin.
2440681 Amino-acid sequence of human alpha 2-antiplasmin.
2449425 Phosphorylation sites of bovine brain myelin basic protein phosphorylated with Ca2+-calmodulin-dependent protein kinase from rat brain.
2456953 A discontinuous epitope on p36, the major substrate of src tyrosine-protein-kinase, brings the phosphorylation site into the neighbourhood of a consensus sequence for Ca2+/lipid-binding proteins.
2457390 Location of sites in human lipocortin I that are phosphorylated by protein tyrosine kinases and protein kinases A and C.
2478889 Ionomycin-regulated phosphorylation of the myeloid calcium-binding protein p14.
2493268 N-terminal sequence extension in the glycosylated forms of human pancreatic stone protein. The 5-oxoproline N-terminal chain is O-glycosylated on the 5th amino acid residue.
2496749 The single-chain form of tissue-type plasminogen activator has catalytic activity: studies with a mutant enzyme that lacks the cleavage site.
2498325 Glycosylation of human apolipoprotein E. The carbohydrate attachment site is threonine 194.
2500966 Domain- and sequence-specific phosphorylation of vimentin induces disassembly of the filament structure.
2504723 Platelet glycoprotein Ib beta is phosphorylated on serine 166 by cyclic AMP-dependent protein kinase.
2507633 The invariant chain is a phosphorylated subunit of class II molecules.
2511201 Identification of a disaccharide (Xyl-Glc) and a trisaccharide (Xyl2-Glc) O-glycosidically linked to a serine residue in the first epidermal growth factor-like domain of human factors VII and IX and protein Z and bovine protein Z.
2513186 Carbohydrate structure of recombinant human uterine tissue plasminogen activator expressed in mouse epithelial cells.
2531377 Endopeptidase-24.11 in human plasma degrades atrial natriuretic factor (ANF) to ANF(99-105/106-126).
2540197 Palmitoylation of the human beta 2-adrenergic receptor. Mutation of Cys341 in the carboxyl tail leads to an uncoupled nonpalmitoylated form of the receptor.
2543683 Mechanism of phosphorylation of the epidermal growth factor receptor at threonine 669.
2546149 Human placenta protein-tyrosine-phosphatase: amino acid sequence and relationship to a family of receptor-like proteins.
2548572 Primary structure of the cAMP-dependent phosphorylation site of the plasma membrane calcium pump.
2557337 Phosphorylation of DARPP-32, a dopamine- and cAMP-regulated phosphoprotein, by casein kinase II.
2584229 Structure of human lysosomal membrane glycoprotein 1. Assignment of disulfide bonds and visualization of its domain arrangement.
2584239 Identification of sites phosphorylated in bovine cardiac troponin I and troponin T by protein kinase C and comparative substrate activity of synthetic peptides containing the phosphorylation sites.
2663470 Myc oncoproteins are phosphorylated by casein kinase II.
2722853 Phosphorylation modulates the activity of glycine N-methyltransferase, a folate binding protein. In vitro phosphorylation is inhibited by the natural folate ligand.
2736261 Degradation of human gastrin and CCK by endopeptidase 24.11: differential behaviour of the sulphated and unsulphated peptides.
2753907 Molecular cloning and sequencing of the cDNA for human membrane-bound carboxypeptidase M. Comparison with carboxypeptidases A, B, H, and N.
2762314 Molecular cloning and expression of cDNA encoding a lumenal calcium binding glycoprotein from sarcoplasmic reticulum.
2806554 Identification of sites on chromosomal protein HMG-I phosphorylated by casein kinase II.
2808373 Normal rat kidney cells secrete both phosphorylated and nonphosphorylated forms of osteopontin showing different physiological properties.
2842767 Ca2+/calmodulin-dependent protein kinase II: identification of threonine-286 as the autophosphorylation site in the alpha subunit associated with the generation of Ca2+-independent activity.
2844809 cAMP-dependent protein kinase rapidly phosphorylates serine- 687 of the skeletal muscle receptor for calcium channel blockers.
2867902 Transglutaminase-sensitive glutamine residues of human plasma fibronectin revealed by studying its proteolytic fragments.
2874131 Clathrin-coated vesicles contain two protein kinase activities. Phosphorylation of clathrin beta-light chain by casein kinase II.
2880847 Lecithin:cholesterol acyltransferase. Functional regions and a structural model of the enzyme.
2900138 Identification by amino acid sequencing of three major regulatory phosphorylation sites on rat acetyl-CoA carboxylase.
2900140 Analysis of sites phosphorylated on acetyl-CoA carboxylase in response to insulin in isolated adipocytes. Comparison with sites phosphorylated by casein kinase-2 and the calmodulin-dependent multiprotein kinase.
2941417 Identification of lymphocyte integral membrane proteins as substrates for protein kinase C. Phosphorylation of the interleukin-2 receptor, class I HLA antigens, and T200 glycoprotein.
2946940 The protein-tyrosine kinase substrate p36 is also a substrate for protein kinase C in vitro and in vivo.
2962191 Structure and formation of microplasmin.
2972276 Hydrolysis of alpha-human atrial natriuretic peptide in vitro by human kidney membranes and purified endopeptidase-24.11. Evidence for a novel cleavage site.
2984676 Tumor-promoting phorbol diesters cause the phosphorylation of epidermal growth factor receptors in normal human fibroblasts at threonine-654.
2987962 Platelet-derived growth factor mimics phorbol diester action on epidermal growth factor receptor phosphorylation at threonine-654.
2991859 The structure and evolution of a 461 amino acid human protein C precursor and its messenger RNA, based upon the DNA sequence of cloned human liver cDNAs.
2991887 The nucleotide sequence of the gene for human protein C.
2996780 Protein kinase C phosphorylates pp60src at a novel site.
3026468 A new acylphosphatase isoenzyme from human erythrocytes: purification, characterization, and primary structure.
3053705 An islet amyloid peptide is derived from an 89-amino acid precursor by proteolytic processing.
3066525 Characterization of N-linked oligosaccharides attached to human renin expressed in COS cells.
3103680 Functional role of proteolytic cleavage at arginine-275 of human tissue plasminogen activator as assessed by site-directed mutagenesis.
3112145 Phosphorylation site of eukaryotic initiation factor 4E.
3118371 Amino acid sequences surrounding the cAMP-dependent and calcium/calmodulin-dependent phosphorylation sites in rat and bovine synapsin I.
3123586 Molecular cloning of a human apoC-III variant: Thr 74----Ala 74 mutation prevents O-glycosylation.
3126184 The precursor of interleukin-1 alpha is phosphorylated at residue serine 90.
3126346 Relationships between structure and function of tissue-type plasminogen activator.
3128543 Identification of the phosphorylation sites of clathrin light chain LCb.
3166978 Human tissue factor contains thioester-linked palmitate and stearate on the cytoplasmic half-cystine.
3198605 Cloning of cDNAs encoding human lysosomal membrane glycoproteins, h-lamp-1 and h-lamp-2. Comparison of their deduced amino acid sequences.
3212432 [Root resorption. The maintenance for many years of an incisor almost devoid of root].
3288503 Role of N-linked oligosaccharides attached to human renin expressed in COS cells.
3335520 Botulinum C2 toxin ADP-ribosylates cytoplasmic beta/gamma-actin in arginine 177.
3350146 Two adjacent cysteine residues in the C-terminal cytoplasmic fragment of bovine rhodopsin are palmitylated.
3417668 Ca2+/calmodulin-dependent protein kinase II. Identification of a regulatory autophosphorylation site adjacent to the inhibitory and calmodulin-binding domains.
3458201 Amino acid sequence of human plasma alpha 1B-glycoprotein: homology to the immunoglobulin supergene family.
3480538 Cloning, sequence analysis, and expression of the large subunit of the human lymphocyte activation antigen 4F2.
3493529 Human CSF-1: molecular cloning and expression of 4-kb cDNA encoding the human urinary protein.
3521732 Human plasma prekallikrein, a zymogen to a serine protease that contains four tandem repeats.
3525527 Human preproapolipoprotein C-II. Analysis of major plasma isoforms.
3542989 Complete amino acid sequence of human serum cholinesterase.
3542996 Characterization of pure human renal renin. Evidence for a subunit structure.
3667593 Structure of the carbohydrate moiety of human interferon-beta secreted by a recombinant Chinese hamster ovary cell line.
3680284 Glycation and inactivation of human Cu-Zn-superoxide dismutase. Identification of the in vitro glycated sites.
3756141 Human C1 inhibitor: primary structure, cDNA cloning, and chromosomal localization.
3759968 Sequence analysis of phospholamban. Identification of phosphorylation sites and two major structural domains.
3759977 Nonenzymatic glycosylation of albumin in vivo. Identification of multiple glycosylated sites.
3782093 Identification of two sites of sulfation of human heparin cofactor II.
3866610 Ia-associated invariant chain is fatty acylated before addition of sialic acid.
3917576 Amino terminal myristylation of the protein kinase p60src, a retroviral transforming protein.
3927292 Cloning and sequence analysis of cDNA for human cathepsin D.
3944102 Distribution of gamma-carboxyglutamic acid residues in partially carboxylated human prothrombins.
3944109 Identification of the site of sulfation of the fourth component of human complement.
3944116 Amino acid sequence of protein B23 phosphorylation site.
4055725 The primary structure of human tissue amyloid P component from a patient with primary idiopathic amyloidosis.
4092695 Phosphorylation and activation of hamster carbamyl phosphate synthetase II by cAMP-dependent protein kinase. A novel mechanism for regulation of pyrimidine nucleotide biosynthesis.
4226004 The peptide chains of human plasmin. Mechanism of activation of human plasminogen to plasmin.
4369265 The amino acid sequences of the phosphorylated sites in troponin-I from rabbit skeletal muscle.
4711474 Structure of 1 -acid glycoprotein. The complete amino acid sequence, multiple amino acid substitutions, and homology with the immunoglobulins.
4924231 Specific enzymic methylation of an arginine in the experimental allergic encephalomyelitis protein from human myelin.
5554303 Human fetal hemoglobin F 1. Acetylation status.
6150037 Phosphorylation of tyrosine hydroxylase by calmodulin-dependent multiprotein kinase.
6172423 The complete amino acid sequence of the rabbit P2 protein.
6196363 Phosphorylation of human choriogonadotropin. Stoichiometry and sites of phosphate incorporation.
6262777 Complete amino acid sequence of the catalytic subunit of bovine cardiac muscle cyclic AMP-dependent protein kinase.
6287816 Phosphorylation of cAMP-dependent protein kinase subunits.
6293815 Phosphorylation of the type-II regulatory subunit of cyclic-AMP-dependent protein kinase by glycogen synthase kinase 3 and glycogen synthase kinase 5.
6304688 HLA-A2 and HLA-B7 antigens are phosphorylated in vitro by rous sarcoma virus kinase (pp60v-src) at a tyrosine residue encoded in a highly conserved exon of the intracellular domain.
6324166 cDNA clone for the human invariant gamma chain of class II histocompatibility antigens and its implications for the protein structure.
6330071 Amino acid sequence of the phosphorylation site of rat liver 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase.
6333425 HLA-A2 antigen phosphorylation in vitro by cyclic AMP-dependent protein kinase. Sites of phosphorylation and segmentation in class i major histocompatibility complex gene structure.
6351842 Action of human liver cathepsin B on the oxidized insulin B chain.
6371807 Structure of human hemopexin: O-glycosyl and N-glycosyl sites and unusual clustering of tryptophan residues.
6427007 Acetyl-blocked N-terminal structures of sorbitol and aldehyde dehydrogenases.
6427223 Natural human interferon-gamma. Complete amino acid sequence and determination of sites of glycosylation.
6430898 Human and murine class I MHC antigens share conserved serine 335, the site of HLA phosphorylation in vivo.
6433976 Tissue plasminogen activator: peptide analyses confirm an indirectly derived amino acid sequence, identify the active site serine residue, establish glycosylation sites, and localize variant differences.
6438100 The enzyme that cleaves apolipoprotein A-II upon in vitro incubation of human plasma high-density lipoprotein-3 with blood polymorphonuclear cells is an elastase.
6510521 Amino acid sequence of the N-terminal region of human hemopexin.
6572368 Structural and biological characteristics of connective tissue activating peptide (CTAP-III), a major human platelet-derived growth factor.
6572939 beta-Hydroxyaspartic acid in vitamin K-dependent protein C.
6582496 Single-chain structure of human ceruloplasmin: the complete amino acid sequence of the whole molecule.
6719396 The location of a second in vivo phosphorylation site in the A alpha-chain of human fibrinogen.
6725286 A vascular smooth muscle alpha-isoactin biosynthetic intermediate in BC3H1 cells. Identification of acetylcysteine at the NH2 terminus.
6772446 Glycogen synthase from rabbit skeletal muscle. Amino acid sequence at the sites phosphorylated by glycogen synthase kinase-3, and extension of the N-terminal sequence containing the site phosphorylated by phosphorylase kinase.
6812963 Alpha chain of HLA-DR transplantation antigens is a member of the same protein superfamily as the immunoglobulins.
6838832 Amino acid sequence analysis of the asparagine-288 region of the carbohydrate variants of human plasminogen.
6864486 Kinetics of the rapid modification of human serum albumin with trinitrobenzenesulfonate and localization of its site.
7238875 The site in human antithrombin for functional proteolytic cleavage by human thrombin.
7340337 Action of rat liver cathepsin L on glucagon.
7358733 Sites of nonenzymatic glycosylation of human hemoglobin A.
7477119 Brief report: impaired processing of prohormones associated with abnormalities of glucose homeostasis and adrenal function.
7477354 Phosphorylation of Raf by ceramide-activated protein kinase.
7479834 Mxi2, a mitogen-activated protein kinase that recognizes and phosphorylates Max protein.
7479855 Point mutation of the autophosphorylation site or in the nuclear location signal causes protein kinase A RII beta regulatory subunit to lose its ability to revert transformed fibroblasts.
7479976 Signal-induced degradation of I kappa B alpha requires site-specific ubiquitination.
7492318 Evaluation of the extent of the binding site in human tissue kallikrein by synthetic substrates with sequences of human kininogen fragments.
7493986 Primary structure of a gamma subunit of G protein, gamma 12, and its phosphorylation by protein kinase C.
7493990 Structural and functional consequences of mutations in 6-pyruvoyltetrahydropterin synthase causing hyperphenylalaninemia in humans. Phosphorylation is a requirement for in vivo activity.
7499230 Characterization of the mitotic specific phosphorylation site of histone H1. Absence of a consensus sequence for the p34cdc2/cyclin B kinase.
7499244 Differential sensitivity of interleukin-1 alpha and -beta precursor proteins to cleavage by calpain, a calcium-dependent protease.
7499337 Cell cycle phase-specific phosphorylation of human topoisomerase II alpha. Evidence of a role for protein kinase C.
7505568 Identification of the glycosylated sequons of human myelin-associated glycoprotein.
7507481 Membrane topology of aquaporin CHIP. Analysis of functional epitope-scanning mutants by vectorial proteolysis.
7509446 Autophosphorylation of the focal adhesion kinase, pp125FAK, directs SH2-dependent binding of pp60src.
7509796 Tyrosine residue 719 of the c-kit receptor is essential for binding of the P85 subunit of phosphatidylinositol (PI) 3-kinase and for c-kit-associated PI 3-kinase activity in COS-1 cells.
7512951 Identification of covalently bound amino-terminal myristic acid in endothelial nitric oxide synthase.
7512963 Insulin stimulates the phosphorylation of Tyr538 and the catalytic activity of PTP1C, a protein tyrosine phosphatase with Src homology-2 domains.
7513258 A multifunctional docking site mediates signaling and transformation by the hepatocyte growth factor/scatter factor receptor family.
7514605 Biogenesis and transmembrane topology of the CHIP28 water channel at the endoplasmic reticulum.
7515063 Regulation of c-Fgr protein kinase by c-Src kinase (CSK) and by polycationic effectors.
7516330 Internalization of fibroblast growth factor receptor is inhibited by a point mutation at tyrosine 766.
7518772 Phosphorylation of receptor protein-tyrosine phosphatase alpha on Tyr789, a binding site for the SH3-SH2-SH3 adaptor protein GRB-2 in vivo.
7522165 Interleukin-7 induces the association of phosphatidylinositol 3-kinase with the alpha chain of the interleukin-7 receptor.
7522656 Adhesive properties of osteopontin: regulation by a naturally occurring thrombin-cleavage in close proximity to the GRGDS cell-binding domain.
7523122 A unique autophosphorylation site in the platelet-derived growth factor alpha receptor from a heterodimeric receptor complex.
7523391 Matrix metalloproteinases degrade insulin-like growth factor-binding protein-3 in dermal fibroblast cultures.
7523394 Hydrolytic inactivation of a breast carcinoma cell-derived serpin by human stromelysin-3.
7523419 Identification of the major physiologic phosphorylation site of human keratin 18: potential kinases and a role in filament reorganization.
7524678 Expression of rat alpha-fetoprotein cDNA and its mutants in cultured mouse fibroblasts and identification of glycosylation sites related to electrophoretic variants.
7525550 Identification of tyrosine 620 as the major phosphorylation site of myelin-associated glycoprotein and its implication in interacting with signaling molecules.
7525582 Phosphorylation of the desmoplakin COOH terminus negatively regulates its interaction with keratin intermediate filament networks.
7525583 Regulation of p68 RNA helicase by calmodulin and protein kinase C.
7527558 Amino-terminal basic residues of Src mediate membrane binding through electrostatic interaction with acidic phospholipids.
7529874 Tyrosine phosphorylation of BCR by FPS/FES protein-tyrosine kinases induces association of BCR with GRB-2/SOS.
7529876 Tyrosine phosphorylation of focal adhesion kinase at sites in the catalytic domain regulates kinase activity: a role for Src family kinases.
7532004 Purification and structure-function analysis of native, PNGase F-treated, and endo-beta-galactosidase-treated CHIP28 water channels.
7535770 Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine.
7535778 Demonstration of functionally different interactions between phospholipase C-gamma and the two types of platelet-derived growth factor receptors.
7538124 Identification and mutational analysis of the glycosylation sites of human keratin 18.
7538844 Biochemical analysis of prostate specific antigen-proteolyzed insulin-like growth factor binding protein-3.
7539106 Phosphorylation of the human estrogen receptor on tyrosine 537 in vivo and by src family tyrosine kinases in vitro.
7539415 Secretory leucocyte protease inhibitor in the male genital tract: PSA-induced proteolytic processing in human semen and tissue localization.
7539802 Identification of the major phosphorylation sites for protein kinase C in kit/stem cell factor receptor in vitro and in intact cells.
7543024 Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation.
7544284 Site-specific and complete enzymic deglycosylation of the native human chorionic gonadotropin alpha-subunit.
7545675 Identification of a putative Syp substrate, the PDGF beta receptor.
7547927 Binding of prenylated and polybasic peptides to membranes: affinities and intervesicle exchange.
7556643 A novel tau-tubulin kinase from bovine brain.
7559455 Phosphorylation of Gz alpha by protein kinase C blocks interaction with the beta gamma complex.
7559469 Role of N-linked glycosylation in human osteonectin. Effect of carbohydrate removal by N-glycanase and site-directed mutagenesis on structure and binding of type V collagen.
7566346 Hyperphosphorylation of tau in PHF.
7575560 Development of a rapid approach to identification of tyrosine phosphorylation sites: application to PKC delta phosphorylated upon activation of the high affinity receptor for IgE in rat basophilic leukemia cells.
7578066 Preferred sites of glycosylphosphatidylinositol modification in folate receptors and constraints in the primary structure of the hydrophobic portion of the signal.
7578077 Isolation and structural characterization of different isoforms of the hypusine-containing protein eIF-5A from HeLa cells.
7578274 The protein kinase from mitotic human cells that phosphorylates Ser-209 on the casein kinase II beta-subunit is p34cdc2.
7592613 Structural analysis of the oligosaccharides derived from glycodelin, a human glycoprotein with potent immunosuppressive and contraceptive activities.
7592773 Phosphorylation of casein kinase II by p34cdc2. Identification of phosphorylation sites using phosphorylation site mutants in vitro.
7592818 Calpain cleavage of the cytoplasmic domain of the integrin beta 3 subunit.
7592967 Repetitive Ser-Gly sequences enhance heparan sulfate assembly in proteoglycans.
7592979 Constitutive activation of mitogen-activated protein kinase-activated protein kinase 2 by mutation of phosphorylation sites and an A-helix motif.
7595479 Modulation of a recombinant glycine transporter (GLYT1b) by activation of protein kinase C.
7598724 Phorbol ester stimulates rapid intracellular phosphorylation of glia maturation factor.
7599134 Partial glycosylation of antithrombin III asparagine-135 is caused by the serine in the third position of its N-glycosylation consensus sequence and is responsible for production of the beta-antithrombin III isoform with enhanced heparin affinity.
7613477 Site-specific detection and structural characterization of the glycosylation of human plasma proteins lecithin:cholesterol acyltransferase and apolipoprotein D using HPLC/electrospray mass spectrometry and sequential glycosidase digestion.
7613486 Glycosylation sites encoded by exon 2 of the human insulin receptor gene are not required for the oligomerization, ligand binding, or kinase activity of the insulin receptor.
7615564 Reactivation of phosphorylated actin depolymerizing factor and identification of the regulatory site.
7615569 Phosphorylation and activation of Ca(2+)-calmodulin-dependent protein kinase IV by Ca(2+)-calmodulin-dependent protein kinase Ia kinase. Phosphorylation of threonine 196 is essential for activation.
7625839 Carbonic anhydrase IV: role of removal of C-terminal domain in glycosylphosphatidylinositol anchoring and realization of enzyme activity.
7635160 Human topoisomerase II alpha is phosphorylated in a cell-cycle phase-dependent manner by a proline-directed kinase.
7641687 Human calcium-calmodulin dependent protein kinase I: cDNA cloning, domain structure and activation by phosphorylation at threonine-177 by calcium-calmodulin dependent protein kinase I kinase.
7642555 c-Myc is glycosylated at threonine 58, a known phosphorylation site and a mutational hot spot in lymphomas.
7642584 Identification of the major phosphorylation sites in human C5a anaphylatoxin receptor in vivo.
7642585 Truncated forms of the human prion protein in normal brain and in prion diseases.
7646439 Mechanisms of platelet activation by a stimulatory antibody: cross-linking of a novel platelet receptor for monoclonal antibody F11 with the Fc gamma RII receptor.
7657660 Phosphorylation and activation of the DNA binding activity of purified Stat1 by the Janus protein-tyrosine kinases and the epidermal growth factor receptor.
7657720 Role of glycosylation in the expression of human procathepsin D.
7664271 Association of the DF3/MUC1 breast cancer antigen with Grb2 and the Sos/Ras exchange protein.
7665596 Isolation of cDNA clones encoding eight different human G protein gamma subunits, including three novel forms designated the gamma 4, gamma 10, and gamma 11 subunits.
7673335 Ubiquitin-activating enzyme, E1, is phosphorylated in mammalian cells by the protein kinase Cdc2.
7675451 Mutation at tyrosine residue 1337 abrogates ligand-dependent transforming capacity of the FLT4 receptor.
7678037 Insulin regulates serine/threonine phosphorylation in activated human B lymphocytes.
7678248 Identification of the sites of phosphorylation in insulin-like growth factor binding protein-1. Regulation of its affinity by phosphorylation of serine 101.
7678701 Phosphorylation of Src mutants at Tyr 527 in fibroblasts does not correlate with in vitro phosphorylation by CSK.
7682059 In vitro tyrosine phosphorylation of PLC-gamma 1 and PLC-gamma 2 by src-family protein tyrosine kinases.
7683678 Isolation and primary structure of NGAL, a novel protein associated with human neutrophil gelatinase.
7687743 Molecular cloning, expression, and characterization of the human mitogen-activated protein kinase p44erk1.
7688466 The 64-kDa protein that associates with the platelet-derived growth factor receptor beta subunit via Tyr-1009 is the SH2-containing phosphotyrosine phosphatase Syp.
7690989 A single phosphotyrosine residue of Stat91 required for gene activation by interferon-gamma.
7691597 Receptor protein tyrosine phosphatase alpha activates pp60c-src and is involved in neuronal differentiation.
7691811 Activation of the SH2-containing phosphotyrosine phosphatase SH-PTP2 by its binding site, phosphotyrosine 1009, on the human platelet-derived growth factor receptor.
7691977 Fatty acid-binding protein from rat heart is phosphorylated on Tyr19 in response to insulin stimulation.
7694569 Matrix metalloproteinases cleave at two distinct sites on human cartilage link protein.
7706316 Microtubule-associated protein/microtubule affinity-regulating kinase (p110mark). A novel protein kinase that regulates tau-microtubule interactions and dynamic instability by phosphorylation at the Alzheimer-specific site serine 262.
7708691 Mutation of juxtamembrane tyrosine residue 1001 suppresses loss-of-function mutations of the met receptor in epithelial cells.
7713879 CAAX geranylgeranyl transferase transfers farnesyl as efficiently as geranylgeranyl to RhoB.
7721861 Expression, refolding, and autocatalytic proteolytic processing of the interleukin-1 beta-converting enzyme precursor.
7721869 The role of N-glycosylation in the targeting and activity of the GLYT1 glycine transporter.
7724583 Phosphorylation of ubiquitin-activating enzyme in cultured cells.
7727388 The disulfide linkages and glycosylation sites of the human natriuretic peptide receptor-C homodimer.
7731718 The motogenic and mitogenic responses to HGF are amplified by the Shc adaptor protein.
7731720 B-Raf protein isoforms interact with and phosphorylate Mek-1 on serine residues 218 and 222.
7737129 ATF-2 contains a phosphorylation-dependent transcriptional activation domain.
7743995 Regulation of the human WEE1Hu CDK tyrosine 15-kinase during the cell cycle.
7750576 Activation of the MAP kinase homologue RK requires the phosphorylation of Thr-180 and Tyr-182 and both residues are phosphorylated in chemically stressed KB cells.
7759517 Components of a new human protein kinase signal transduction pathway.
7775468 Structural basis for species-specific differences in the phosphorylation of Na,K-ATPase by protein kinase C.
7777512 Phosphorylation of the human leukemia inhibitory factor (LIF) receptor by mitogen-activated protein kinase and the regulation of LIF receptor function by heterologous receptor activation.
7782287 Mutagenesis studies of the phosphorylation sites of recombinant human pyruvate dehydrogenase. Site-specific regulation.
7790363 The human E48 antigen, highly homologous to the murine Ly-6 antigen ThB, is a GPI-anchored molecule apparently involved in keratinocyte cell-cell adhesion.
7797510 Identification and characterization of ICH-2, a novel member of the interleukin-1 beta-converting enzyme family of cysteine proteases.
7799959 Modulation of cellular thermoresistance and actin filament stability accompanies phosphorylation-induced changes in the oligomeric structure of heat shock protein 27.
7806540 A mutant insulin receptor induces formation of a Shc-growth factor receptor bound protein 2 (Grb2) complex and p21ras-GTP without detectable interaction of insulin receptor substrate 1 (IRS1) with Grb2. Evidence for IRS1-independent p21ras-GTP formation.
7814421 Hepsin, a putative membrane-associated serine protease, activates human factor VII and initiates a pathway of blood coagulation on the cell surface leading to thrombin formation.
7816602 Phosphorylation of the c-Fos and c-Jun HOB1 motif stimulates its activation capacity.
7822264 Identification of phosphorylation sites on glial fibrillary acidic protein for cdc2 kinase and Ca(2+)-calmodulin-dependent protein kinase II.
7827091 In vivo glycation of aldehyde reductase, a major 3-deoxyglucosone reducing enzyme: identification of glycation sites.
7836371 Phosphorylation of the N-formyl peptide receptor carboxyl terminus by the G protein-coupled receptor kinase, GRK2.
7836436 Contribution of aromatic moieties of tyrosine 133 and of the anionic subsite tryptophan 86 to catalytic efficiency and allosteric modulation of acetylcholinesterase.
7836437 Characterization of a mitochondrial metallopeptidase reveals neurolysin as a homologue of thimet oligopeptidase.
7873448 Hormone-induced hyperphosphorylation of specific phosphorylated sites in the mouse glucocorticoid receptor.
7876250 Post-translational processing of membrane-associated neu differentiation factor proisoforms expressed in mammalian cells.
7876254 Characterization of Rad, a new member of Ras/GTPase superfamily, and its regulation by a unique GTPase-activating protein (GAP)-like activity.
7889566 Specific recruitment of SH-PTP1 to the erythropoietin receptor causes inactivation of JAK2 and termination of proliferative signals.
7890696 14-3-3 alpha and delta are the phosphorylated forms of raf-activating 14-3-3 beta and zeta. In vivo stoichiometric phosphorylation in brain at a Ser-Pro-Glu-Lys MOTIF.
7890742 Primary structure of CD52.
7890750 Protein kinase C delta-specific phosphorylation of the elongation factor eEF-alpha and an eEF-1 alpha peptide at threonine 431.
7890771 Limited and defined truncation at the C terminus enhances receptor binding and degranulation activity of the neutrophil-activating peptide 2 (NAP-2). Comparison of native and recombinant NAP-2 variants.
7896811 Matrix metalloproteinase 7 (matrilysin) from human rectal carcinoma cells. Activation of the precursor, interaction with other matrix metalloproteinases and enzymic properties.
7901013 Phosphorylation and activation of human tyrosine hydroxylase in vitro by mitogen-activated protein (MAP) kinase and MAP-kinase-activated kinases 1 and 2.
7907095 Isolation and characterization of a novel acetyl-CoA carboxylase kinase from rat liver.
7909431 Phosphorylation by protein kinase C and cyclic AMP-dependent protein kinase of synthetic peptides derived from the linker region of human P-glycoprotein.
7915280 Critical phosphorylation sites for acetyl-CoA carboxylase activity.
7925280 Prolactin induces phosphorylation of Tyr694 of Stat5 (MGF), a prerequisite for DNA binding and induction of transcription.
7925482 Functional analysis of phosphorylation sites in human lamin A controlling lamin disassembly, nuclear transport and assembly.
7926007 Identification of serines-1035/1037 in the kinase domain of the insulin receptor as protein kinase C alpha mediated phosphorylation sites.
7929343 Phorbol ester stimulates phosphorylation on serine 1327 of the human insulin receptor.
7929371 Identification of Ser38 as the site in cardiac sarcoplasmic reticulum Ca(2+)-ATPase that is phosphorylated by Ca2+/calmodulin-dependent protein kinase.
7931292 Protein kinase FA/glycogen synthase kinase-3 alpha after heparin potentiation phosphorylates tau on sites abnormally phosphorylated in Alzheimer's disease brain.
7935360 Preparation and functional characterization of a catalytically active fragment of phosphorylase kinase.
7935386 Role of SH-PTP2, a protein-tyrosine phosphatase with Src homology 2 domains, in insulin-stimulated Ras activation.
7935391 Tyr-716 in the platelet-derived growth factor beta-receptor kinase insert is involved in GRB2 binding and Ras activation.
7944411 Identification, assay, and purification of a Cdc2-activating threonine-161 protein kinase from human cells.
7961692 Requirement for negative charge on "activation loop" of protein kinase C.
7961702 Palmitoylation of G protein-coupled receptor kinase, GRK6. Lipid modification diversity in the GRK family.
7961936 Identification by electrospray ionization mass spectrometry of the sites of tyrosine phosphorylation induced in activated Jurkat T cells on the protein tyrosine kinase ZAP-70.
7961967 Serine 1524 is a major site of phosphorylation on human topoisomerase II alpha protein in vivo and is a substrate for casein kinase II in vitro.
7961992 Tyrosine 1356 in the carboxyl-terminal tail of the HGF/SF receptor is essential for the transduction of signals for cell motility and morphogenesis.
7980522 Matrilysin is much more efficient than other matrix metalloproteinases in the proteolytic inactivation of alpha 1-antitrypsin.
7983041 Identification of phosphorylation sites unique to the B form of human progesterone receptor. In vitro phosphorylation by casein kinase II.
7983050 Visualization and function of vimentin phosphorylation by cdc2 kinase during mitosis.
7989361 The mechanism of inactivation of human factor V and human factor Va by activated protein C.
7991565 Rab geranylgeranyl transferase catalyzes the geranylgeranylation of adjacent cysteines in the small GTPases Rab1A, Rab3A, and Rab5A.
7997267 Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase.
7999001 Protein kinase C and cyclic AMP-dependent protein kinase phosphorylate phospholemman, an insulin and adrenaline-regulated membrane phosphoprotein, at specific sites in the carboxy terminal domain.
8002936 Molecular characterization of human stathmin expressed in Escherichia coli: site-directed mutagenesis of two phosphorylatable serines (Ser-25 and Ser-63).
8006040 Molecular structure of pulmonary surfactant protein D (SP-D).
8019440 The amino acid sequence and phosphorylation sites of a boar transition protein 1.
8024572 Identification of novel phosphorylation sites in the beta-subunit of translation initiation factor eIF-2.
8027066 The functions of the human insulin receptor are affected in different ways by mutation of each of the four N-glycosylation sites in the beta subunit.
8027075 Activation of human interstitial procollagenase through direct cleavage of the Leu83-Thr84 bond by mast cell chymase.
8034666 Identification of nuclear beta II protein kinase C as a mitotic lamin kinase.
8034726 Phosphorylation of Thr642 is an early event in the processing of newly synthesized protein kinase C beta 1 and is essential for its activation.
8041791 Protein-tyrosine-phosphatase SHPTP2 couples platelet-derived growth factor receptor beta to Ras.
8058322 In vitro phosphorylation of caveolin-rich membrane domains: identification of an associated serine kinase activity as a casein kinase II-like enzyme.
8058338 Protein kinase A phosphorylates cyclin D1 at three distinct sites within the cyclin box and at the C-terminus.
8061611 Conserved phosphorylation of serines in the Ser-X-Glu/Ser(P) sequences of the vitamin K-dependent matrix Gla protein from shark, lamb, rat, cow, and human.
8076689 Identification and hypotensive activity of proadrenomedullin N-terminal 20 peptide (PAMP).
8077654 Activation and serine phosphorylation of the p56lck protein tyrosine kinase in response to antigen receptor cross-linking in B lymphocytes.
8080473 Characterization of a 7.5-kDa protein kinase C substrate (RC3 protein, neurogranin) from rat brain.
8083223 Phosphorylation of PHAS-I by mitogen-activated protein (MAP) kinase. Identification of a site phosphorylated by MAP kinase in vitro and in response to insulin in rat adipocytes.
8084605 p56/p53lyn tyrosine kinase activation in mammalian cells treated with mitomycin C.
8087847 Phosphorylation of E2F-1 modulates its interaction with the retinoblastoma gene product and the adenoviral E4 19 kDa protein.
8094892 Phosphorylation and modulation of recombinant GluR6 glutamate receptors by cAMP-dependent protein kinase.
8097117 Site-directed mutagenesis of alpha-tubulin. Reductive methylation studies of the Lys 394 region.
8099443 Mammalian eukaryotic initiation factor 2 alpha kinases functionally substitute for GCN2 protein kinase in the GCN4 translational control mechanism of yeast.
8114715 Lck-dependent tyrosyl phosphorylation of the phosphotyrosine phosphatase SH-PTP1 in murine T cells.
8119945 Activation of p34cdc2 protein kinase by microinjection of human cdc25C into mammalian cells. Requirement for prior phosphorylation of cdc25C by p34cdc2 on sites phosphorylated at mitosis.
8119947 Molecular cloning of the human mucosal lymphocyte integrin alpha E subunit. Unusual structure and restricted RNA distribution.
8121489 The X-ray crystal structure of the membrane protein prostaglandin H2 synthase-1.
8125092 Cell-cycle-regulated phosphorylation of oncoprotein 18 on Ser16, Ser25 and Ser38.
8137421 JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain.
8139570 Regulation of cyclin D-dependent kinase 4 (cdk4) by cdk4-activating kinase.
8144599 Phospholipid-stimulated autophosphorylation activates the G protein-coupled receptor kinase GRK5.
8152805 Products of the TAL2 oncogene in leukemic T cells: bHLH phosphoproteins with DNA-binding activity.
8156998 Ligand-induced IFN gamma receptor tyrosine phosphorylation couples the receptor to its signal transduction system (p91).
8157000 Identification of the sites in MAP kinase kinase-1 phosphorylated by p74raf-1.
8163463 Transmembrane topology of the glutamate receptor subunit GluR6.
8163498 Identification of the phosphorylation site in vitro for cAMP-dependent protein kinase on the rat adipocyte cGMP-inhibited cAMP phosphodiesterase.
8163535 Core protein structure and sequence determine the site and presence of heparan sulfate and chondroitin sulfate on syndecan-1.
8175798 Determination of structural requirements for the interaction of Rab6 with RabGDI and Rab geranylgeranyltransferase.
8179825 Cloning and expression of the gene for the melanoma-associated ME20 antigen.
8180202 Glycosylation of human corticosteroid-binding globulin. Differential processing and significance of carbohydrate chains at individual sites.
8180207 Fluorescence studies of the location and membrane accessibility of the palmitoylation sites of rhodopsin.
8182057 cAMP- and cGMP-dependent protein kinase phosphorylation sites of the focal adhesion vasodilator-stimulated phosphoprotein (VASP) in vitro and in intact human platelets.
8188697 A transmembrane model for an ionotropic glutamate receptor predicted on the basis of the location of asparagine-linked oligosaccharides.
8194526 c-Abl kinase regulates the protein binding activity of c-Crk.
8195113 Dephosphorylation of osteopontin and bone sialoprotein by osteoclastic tartrate-resistant acid phosphatase. Modulation of osteoclast adhesion in vitro.
8195171 Direct interaction between Shc and the platelet-derived growth factor beta-receptor.
8195709 Isolation, cDNA cloning, and overexpression of a 33-kD cell surface glycoprotein that binds to the globular "heads" of C1q.
8206937 The catalytic subunit of protein phosphatase 2A is carboxyl-methylated in vivo.
8206977 Phosphorylation of the erythroid transcription factor GATA-1.
8221888 MKP-1 (3CH134), an immediate early gene product, is a dual specificity phosphatase that dephosphorylates MAP kinase in vivo.
8224842 Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain.
8226803 Activation of the zymogen of hepatocyte growth factor activator by thrombin.
8226933 Properties of MEKs, the kinases that phosphorylate and activate the extracellular signal-regulated kinases.
8227042 The phosphorylation and DNA binding of the DNA-binding domain of the orphan nuclear receptor NGFI-B.
8227063 Palmitoylation is required for signaling functions and membrane attachment of Gq alpha and Gs alpha.
8240296 Post-translational processing of progastrin: inhibition of cleavage, phosphorylation and sulphation by brefeldin A.
8243461 Identification of O-linked oligosaccharide chains in the activation peptides of blood coagulation factor X. The role of the carbohydrate moieties in the activation of factor X.
8245015 A serine phosphorylation of Nm23, and not its nucleoside diphosphate kinase activity, correlates with suppression of tumor metastatic potential.
8247524 Phosphorylation sites mapping in the N-terminal domain of c-myc modulate its transforming potential.
8247525 Identification of casein kinase II phosphorylation sites in Max: effects on DNA-binding kinetics of Max homo- and Myc/Max heterodimers.
8248197 Phosphorylation of the c-Fos transrepression domain by mitogen-activated protein kinase and 90-kDa ribosomal S6 kinase.
8253769 Proteolytic release of human angiotensin-converting enzyme. Localization of the cleavage site.
8253806 L-29, a soluble lactose-binding lectin, is phosphorylated on serine 6 and serine 12 in vivo and by casein kinase I.
8257432 The 50 kDa protein subunit of assembly polypeptide (AP) AP-2 adaptor from clathrin-coated vesicles is phosphorylated on threonine-156 by AP-1 and a soluble AP50 kinase which co-purifies with the assembly polypeptides.
8258691 Fc gamma RIIIA-mediated signaling involves src-family lck in human natural killer cells.
8262977 Iron-responsive element-binding protein. Phosphorylation by protein kinase C.
8272872 Association of transcription factor APRF and protein kinase Jak1 with the interleukin-6 signal transducer gp130.
8276756 Determination of carboxyl-terminal residue and disulfide bonds of MACIF (CD59), a glycosyl-phosphatidylinositol-anchored membrane protein.
8276855 Autocatalytic maturation of the prohormone convertase PC2.
8280063 N-glycosylation of human acetylcholinesterase: effects on activity, stability and biosynthesis.
8288564 Enzymatic methylation of recombinant heterogeneous nuclear RNP protein A1. Dual substrate specificity for S-adenosylmethionine:histone-arginine N-methyltransferase.
8288610 Dominant inhibitory mutants of ARF1 block endoplasmic reticulum to Golgi transport and trigger disassembly of the Golgi apparatus.
8288648 Molecular mechanism of the synergistic phosphorylation of phosphatase inhibitor-2. Cloning, expression, and site-directed mutagenesis of inhibitor-2.
8294430 Phosphorylation of serine 985 negatively regulates the hepatocyte growth factor receptor kinase.
8294455 In vitro analysis of microtubule assembly of isotypically pure tubulin dimers. Intrinsic differences in the assembly properties of alpha beta II, alpha beta III, and alpha beta IV tubulin dimers in the absence of microtubule-associated proteins.
8302603 Tyrosines1234-1235 are critical for activation of the tyrosine kinase encoded by the MET proto-oncogene (HGF receptor).
8308015 Phosphorylation of the human estrogen receptor. Identification of hormone-regulated sites and examination of their influence on transcriptional activity.
8313897 PI 3-kinase is a dual specificity enzyme: autoregulation by an intrinsic protein-serine kinase activity.
8316301 Regulation of NMDA receptor phosphorylation by alternative splicing of the C-terminal domain.
8321321 Protein kinase C alpha activates RAF-1 by direct phosphorylation.
8323280 N-linked sugar chain structure of recombinant human lymphotoxin produced by CHO cells: the functional role of carbohydrate as to its lectin-like character and clearance velocity.
8323299 Assignment of O-glycan attachment sites to the hinge-like regions of human lysosomal membrane glycoproteins lamp-1 and lamp-2.
8325847 Characterization of rabbit skeletal muscle glycogenin. Tyrosine 194 is essential for function.
8325880 Serine 25 of oncoprotein 18 is a major cytosolic target for the mitogen-activated protein kinase.
8327493 Characterization of site-specific mutants altered at protein kinase C beta 1 isozyme autophosphorylation sites.
8336134 Purification and chemical characterization of beta-trace protein from human cerebrospinal fluid: its identification as prostaglandin D synthase.
8344946 Glycosylation of mammalian neurofilaments. Localization of multiple O-linked N-acetylglucosamine moieties on neurofilament polypeptides L and M.
8346912 Isolation and biochemical characterization of procathepsin E from human erythrocyte membranes.
8347587 Specific glycosylation site mutations of the insulin receptor alpha subunit impair intracellular transport.
8348977 Determination of the disulphide bridge arrangement of bovine histidine-rich glycoprotein.
8349614 Identification of the major phosphorylation sites of the Raf-1 kinase.
8349691 Phosphorylation of the insulin receptor substrate IRS-1 by casein kinase II.
8349699 N-glycosylation of prostaglandin endoperoxide synthases-1 and -2 and their orientations in the endoplasmic reticulum.
8360179 Myristoylation of hippocalcin is linked to its calcium-dependent membrane association properties.
8366859 Efficient complement-mediated lysis of cells containing the CAMPATH-1 (CDw52) antigen.
8373790 Identification of the phosphorylation site on human erythrocyte band 7 integral membrane protein: implications for a monotopic protein structure.
8375503 Isoprenylation of Rab proteins possessing a C-terminal CaaX motif.
8376365 Multiple phosphorylation of stathmin. Identification of four sites phosphorylated in intact cells and in vitro by cyclic AMP-dependent protein kinase and p34cdc2.
8380342 Phosphorylation of serine 2843 in ryanodine receptor-calcium release channel of skeletal muscle by cAMP-, cGMP- and CaM-dependent protein kinase.
8382613 Modulation of the glycogen synthase kinase-3 family by tyrosine phosphorylation.
8384217 Activating transcription factor-1 can mediate Ca(2+)- and cAMP-inducible transcriptional activation.
8384717 Phosphorylation at threonine-235 by a ras-dependent mitogen-activated protein kinase cascade is essential for transcription factor NF-IL6.
8385099 The alpha-type 85-kDa subunit of phosphatidylinositol 3-kinase is phosphorylated at tyrosines 368, 580, and 607 by the insulin receptor.
8386634 Regulation of elongation factor-2 by multisite phosphorylation.
8389479 The growth factor-inducible immediate-early gene 3CH134 encodes a protein-tyrosine-phosphatase.
8390988 Phosphorylation of connexin-32 by protein kinase C prevents its proteolysis by mu-calpain and m-calpain.
8393577 Crystal structures of native and inhibited forms of human cathepsin D: implications for lysosomal targeting and drug design.
8394352 Activation of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase by G protein and tyrosine kinase oncoproteins.
8395513 Identification of phosphorylation sites in the recombinant catalytic subunit of cAMP-dependent protein kinase.
8404858 Multiple and cooperative phosphorylation events regulate the CREM activator function.
8405050 Association of the p56lck protein tyrosine kinase with the Fc gamma RIIIA/CD16 complex in human natural killer cells.
8407908 Cloning and characterization of the gene encoding the human platelet glycoprotein V. A member of the leucine-rich glycoprotein family cleaved during thrombin-induced platelet activation.
8407951 The carboxyl-terminal transactivation domain of human serum response factor contains DNA-activated protein kinase phosphorylation sites.
8413226 A growth factor-induced kinase phosphorylates the serum response factor at a site that regulates its DNA-binding activity.
8423803 Phosphorylation of the TAL1 oncoprotein by the extracellular-signal-regulated protein kinase ERK1.
8428596 Human Wee1 kinase inhibits cell division by phosphorylating p34cdc2 exclusively on Tyr15.
8429024 Analysis of Gz alpha by site-directed mutagenesis. Sites and specificity of protein kinase C-dependent phosphorylation.
8440392 Dephosphorylation of human p34cdc2 kinase on both Thr-14 and Tyr-15 by human cdc25B phosphatase.
8440735 Identification of 40 S ribosomal protein S6 phosphorylation sites in Swiss mouse 3T3 fibroblasts stimulated with serum.
8463287 Interaction of the human insulin receptor tyrosine kinase from the baculovirus expression system with protein kinase C in a cell-free system.
8463311 The adipocyte lipid-binding protein at 1.6-A resolution. Crystal structures of the apoprotein and with bound saturated and unsaturated fatty acids.
8464713 c-Jun is phosphorylated by the DNA-dependent protein kinase in vitro; definition of the minimal kinase recognition motif.
8475115 Lipid modifications of G proteins: alpha subunits are palmitoylated.
8477740 Identification of novel phosphorylation sites in murine A-type lamins.
8491187 Multi-site phosphorylation of the protein tyrosine phosphatase, PTP1B: identification of cell cycle regulated and phorbol ester stimulated sites of phosphorylation.
8494607 Glycosylation of active human renin is necessary for secretion: effect of targeted modifications of Asn-5 and Asn-75.
8496180 Insulin stimulates serine and tyrosine phosphorylation in the juxtamembrane region of the insulin receptor.
8499451 Expression of glycosylated and nonglycosylated human transferrin in mammalian cells. Characterization of the recombinant proteins with comparison to three commercially available transferrins.
8504096 Insulin receptor autophosphorylation. II. Determination of autophosphorylation sites by chemical sequence analysis and identification of the juxtamembrane sites.
8506364 Phosphorylation of Ser-42 and Ser-59 in the N-terminal region of the tyrosine kinase p56lck.
8513978 Glycosylation of Asn397 or Asn418 is required for normal insulin receptor biosynthesis and processing.
8524413 Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B.
8530377 Substrate specificities of the insulin and insulin-like growth factor 1 receptor tyrosine kinase catalytic domains.
8530385 N-glycans modulate in vivo and in vitro thyroid hormone synthesis. Study at the N-terminal domain of thyroglobulin.
8530412 Phosphorylation of the cytosolic domain of peptidylglycine alpha-amidating monooxygenase.
8542290 Cell signalling. Receptor orphans find a family.
8546712 The low-density-lipoprotein receptor-related protein (LRP) is processed by furin in vivo and in vitro.
8547318 Expression of recombinant elongation factor 1 beta from rabbit in Escherichia coli. Phosphorylation by casein kinase II.
8548803 Phosphorylation by p34cdc2 regulates spindle association of human Eg5, a kinesin-related motor essential for bipolar spindle formation in vivo.
8550552 Effect of tyrosine mutations on the kinase activity and transforming potential of an oncogenic human insulin-like growth factor I receptor.
8557106 Processing of pro-islet amyloid polypeptide (proIAPP) by the prohormone convertase PC2.
8557631 The beta-adrenergic receptor is a substrate for the insulin receptor tyrosine kinase.
8576110 Association of a 85-kDa serine kinase with activated fibroblast growth factor receptor-4.
8576253 Identification of important regions in the cytoplasmic juxtamembrane domain of type I receptor that separate signaling pathways of transforming growth factor-beta.
8592152 Casein kinase II phosphorylates the neural cell adhesion molecule L1.
8597870 Phosphorylation of the 26 kDa TNF precursor in monocytic cells and in transfected HeLa cells.
8601309 Site-specific phosphorylation of IkappaBalpha by a novel ubiquitination-dependent protein kinase activity.
8609233 Cloning, expression, and type II collagenolytic activity of matrix metalloproteinase-13 from human osteoarthritic cartilage.
8612628 A comparative study of the phosphotyrosyl phosphatase specificity of protein phosphatase type 2A and phosphotyrosyl phosphatase type 1B using phosphopeptides and the phosphoproteins p50/HS1, c-Fgr and Lyn.
8612821 A potential site of functional modulation by protein kinase A in the cardiac Ca2+ channel alpha 1C subunit.
8615697 Glycosylation in human thyroglobulin: location of the N-linked oligosaccharide units and comparison with bovine thyroglobulin.
8615762 PC8 [corrected], a new member of the convertase family.
8617237 Interleukin-2 activation of STAT5 requires the convergent action of tyrosine kinases and a serine/threonine kinase pathway distinct from the Raf1/ERK2 MAP kinase pathway.
8617742 Syk, activated by cross-linking the B-cell antigen receptor, localizes to the cytosol where it interacts with and phosphorylates alpha-tubulin on tyrosine.
8617789 Structural determinants in the platelet-derived growth factor alpha-receptor implicated in modulation of chemotaxis.
8617805 Structural and enzymatic aspects of rhodopsin phosphorylation.
8618850 Palmitoylation of the GluR6 kainate receptor.
8618896 Phosphotyrosine-independent binding of a 62-kDa protein to the src homology 2 (SH2) domain of p56lck and its regulation by phosphorylation of Ser-59 in the lck unique N-terminal region.
8619990 Phosphorylation of beta III-tubulin.
8619999 Phosphorylation of C8 and C9 subunits of the multicatalytic proteinase by casein kinase II and identification of the C8 phosphorylation sites by direct mutagenesis.
8621380 Oncogenic RET receptors display different autophosphorylation sites and substrate binding specificities.
8621423 Requirements for calcium and calmodulin in the calmodulin kinase activation cascade.
8621539 ERK3 is a constitutively nuclear protein kinase.
8621594 Phosphorylation of the ATP-sensitive, inwardly rectifying K+ channel, ROMK, by cyclic AMP-dependent protein kinase.
8621729 Selective activation of MEK1 but not MEK2 by A-Raf from epidermal growth factor-stimulated Hela cells.
8622669 MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway.
8622692 Casein kinase II phosphorylates I kappa B alpha at S-283, S-289, S-293, and T-291 and is required for its degradation.
8622701 Identification of six novel autophosphorylation sites on fibroblast growth factor receptor 1 and elucidation of their importance in receptor activation and signal transduction.
8622703 Inhibition of Bcr serine kinase by tyrosine phosphorylation.
8622893 A juxtamembrane autophosphorylation site in the Eph family receptor tyrosine kinase, Sek, mediates high affinity interaction with p59fyn.
8622969 Human vitamin D receptor phosphorylation by casein kinase II at Ser-208 potentiates transcriptional activation.
8624803 Growth and gene expression are predominantly controlled by distinct regions of the human IL-4 receptor.
8626374 Dominant negative stat3 mutant inhibits interleukin-6-induced Jak-STAT signal transduction.
8626492 Protein kinase A-dependent phosphorylation of GLUT2 in pancreatic beta cells.
8626512 Identification of plectin as a substrate of p34cdc2 kinase and mapping of a single phosphorylation site.
8626527 Differential regulation of retinoblastoma protein function by specific Cdk phosphorylation sites.
8626580 A novel Ca2+-binding protein, p22, is required for constitutive membrane traffic.
8626610 Regulated cleavage of sterol regulatory element binding proteins requires sequences on both sides of the endoplasmic reticulum membrane.
8626671 Phosphorylation of insulin receptor substrate-1 on multiple serine residues, 612, 632, 662, and 731, modulates insulin action.
8626720 Identification of the site in the cGMP-inhibited phosphodiesterase phosphorylated in adipocytes in response to insulin and isoproterenol.
8626767 Characterization of ERK1 activation site mutants and the effect on recognition by MEK1 and MEK2.
8626774 The sequence of human betaB1-crystallin cDNA allows mass spectrometric detection of betaB1 protein missing portions of its N-terminal extension.
8629002 Activation of BTK by a phosphorylation mechanism initiated by SRC family kinases.
8630736 Regulation of Btk function by a major autophosphorylation site within the SH3 domain.
8631738 Phosphorylation of Munc-18/n-Sec1/rbSec1 by protein kinase C: its implication in regulating the interaction of Munc-18/n-Sec1/rbSec1 with syntaxin.
8631817 Identification of a consensus cyclin-dependent kinase phosphorylation site unique to the nuclear form of human deoxyuridine triphosphate nucleotidohydrolase.
8631895 Processing and activation of CMH-1 by granzyme B.
8631898 Phosphorylation of microtubule-associated proteins MAP2 and MAP4 by the protein kinase p110mark. Phosphorylation sites and regulation of microtubule dynamics.
8631994 Characterization of the mitogen-activated protein kinase phosphorylation sites on the connexin-43 gap junction protein.
8632005 Phosphorylation of caveolin by src tyrosine kinases. The alpha-isoform of caveolin is selectively phosphorylated by v-Src in vivo.
8632909 Differential phosphorylations of Spi-B and Spi-1 transcription factors.
8633035 The phosphatase activity of carbonic anhydrase III is reversibly regulated by glutathiolation.
8635221 Removal of Arg141 from the alpha chain of human hemoglobin by carboxypeptidases N and M.
8635594 Identification of a cryptic protein kinase CK2 phosphorylation site in human complement protease Clr, and its use to probe intramolecular interaction.
8636128 Identification of phosphorylation sites of human 85-kDa cytosolic phospholipase A2 expressed in insect cells and present in human monocytes.
8636146 Metalloproteinase activity secreted by fibrogenic cells in the processing of prolysyl oxidase. Potential role of procollagen C-proteinase.
8636209 Role of CD3 gamma in T cell receptor assembly.
8639509 Dynamic O-GlcNAcylation of the small heat shock protein alpha B-crystallin.
8639568 Identification of insulin-stimulated phosphorylation sites on calmodulin.
8639592 Amino acid sequence and carbohydrate structure of a recombinant human tissue factor pathway inhibitor expressed in Chinese hamster ovary cells: one N-and two O-linked carbohydrate chains are located between Kunitz domains 2 and 3 and one N-linked carbohydrate chain is in Kunitz domain 2.
8639654 Mutagenesis of N-glycosylation sites in the human vasoactive intestinal peptide 1 receptor. Evidence that asparagine 58 or 69 is crucial for correct delivery of the receptor to plasma membrane.
8647260 Site-directed mutagenesis but not gamma-carboxylation of Glu-35 in factor VIIa affects the association with tissue factor.
8647855 Modulation of the SH2 binding specificity and kinase activity of Src by tyrosine phosphorylation within its SH2 domain.
8647860 Proteolytic activity of human osteoclast cathepsin K. Expression, purification, activation, and substrate identification.
8647875 Phosphorylation of human fascin inhibits its actin binding and bundling activities.
8650547 Stress-induced phosphorylation and activation of the transcription factor CHOP (GADD153) by p38 MAP Kinase.
8654373 Selective interaction of JNK protein kinase isoforms with transcription factors.
8657102 Mapping of the inducible IkappaB phosphorylation sites that signal its ubiquitination and degradation.
8657103 Phospholipase C-gamma1 interacts with conserved phosphotyrosyl residues in the linker region of Syk and is a substrate for Syk.
8662663 Phosphorylation of eIF-4E on serine 209 by protein kinase C is inhibited by the translational repressors, 4E-binding proteins.
8662759 Casein kinase II associates with Egr-1 and acts as a negative modulator of its DNA binding and transcription activities in NIH 3T3 cells.
8662852 Identification of the G protein-coupled receptor kinase phosphorylation sites in the human beta2-adrenergic receptor.
8663227 Phosphorylation and activation of a cAMP-specific phosphodiesterase by the cAMP-dependent protein kinase. Involvement of serine 54 in the enzyme activation.
8663255 Cellular mechanisms for human procollagenase-3 (MMP-13) activation. Evidence that MT1-MMP (MMP-14) and gelatinase a (MMP-2) are able to generate active enzyme.
8663267 Phosphorylation of purified bovine bone sialoprotein and osteopontin by protein kinases.
8663297 Degradation of interleukin 1beta by matrix metalloproteinases.
8663317 Calmodulin-dependent protein kinase II potentiates transcriptional activation through activating transcription factor 1 but not cAMP response element-binding protein.
8663332 The soluble catalytic domain of membrane type 1 matrix metalloproteinase cleaves the propeptide of progelatinase A and initiates autoproteolytic activation. Regulation by TIMP-2 and TIMP-3.
8663403 Phosphorylation of the MADS-Box transcription factor MEF2C enhances its DNA binding activity.
8663427 Autophosphorylation of the Fes tyrosine kinase. Evidence for an intermolecular mechanism involving two kinase domain tyrosine residues.
8663450 An activated epidermal growth factor receptor/Lck chimera restores early T cell receptor-mediated calcium response in a CD45-deficient T cell line.
8663493 Involvement of p90rsk in neurite outgrowth mediated by the cell adhesion molecule L1.
8664319 Cyclic AMP-dependent protein kinase phosphorylates residues in the C-terminal domain of the cardiac L-type calcium channel alpha1 subunit.
8668151 Identification of a binding site in c-Ab1 tyrosine kinase for the C-terminal repeated domain of RNA polymerase II.
8670172 Structural composition and functional characterization of soluble CD59: heterogeneity of the oligosaccharide and glycophosphoinositol (GPI) anchor revealed by laser-desorption mass spectrometric analysis.
8672508 Cell cycle-dependent phosphorylation of nucleoporins and nuclear pore membrane protein Gp210.
8674111 Tertiary structure of destrin and structural similarity between two actin-regulating protein families.
8674818 The post-translational processing and intracellular sorting of carboxypeptidase H in the islets of Langerhans.
8683601 Crystal structure of human trypsin 1: unexpected phosphorylation of Tyr151.
8683730 Prostate specific antigen cleaves parathyroid hormone-related protein in the PTH-like domain: inactivation of PTHrP-stimulated cAMP accumulation in mouse osteoblasts.
8687431 Proadrenomedullin N-terminal 20 peptide is rapidly cleaved by neutral endopeptidase.
8688081 Coupling of the RAS-MAPK pathway to gene activation by RSK2, a growth factor-regulated CREB kinase.
8692868 A human axillary odorant is carried by apolipoprotein D.
8692915 The stress response to ionizing radiation involoves c-Abl-dependent phosphorylation of SHPTP1.
8692946 Matrix metalloproteinase 2 releases active soluble ectodomain of fibroblast growth factor receptor 1.
8694767 Phosphorylation of GAP-43 (growth-associated protein of 43 kDa) by conventional, novel and atypical isotypes of the protein kinase C gene family: differences between oligopeptide and polypeptide phosphorylation.
8700888 Different interleukin 2 receptor beta-chain tyrosines couple to at least two signaling pathways and synergistically mediate interleukin 2-induced proliferation.
8702477 Identification of the major autophosphorylation sites of Nyk/Mer, an NCAM-related receptor tyrosine kinase.
8702538 A single N-linked glycosylation site is implicated in the regulation of ligand recognition by the I-type lectins CD22 and CD33.
8702662 Phosphorylation of SLP-76 by the ZAP-70 protein-tyrosine kinase is required for T-cell receptor function.
8702728 Functional importance of amino-terminal domain of Shc for interaction with insulin and epidermal growth factor receptors in phosphorylation-independent manner.
8702840 Cytoplasmic O-GlcNAc modification of the head domain and the KSP repeat motif of the neurofilament protein neurofilament-H.
8702879 Site-specific phosphorylation of synapsin I by mitogen-activated protein kinase and Cdk5 and its effects on physiological functions.
8707854 Identification of stromal cell products that interact with pre-B cells.
8749392 Protein kinase C is regulated in vivo by three functionally distinct phosphorylations.
8753751 Alteration of the hormonal bioactivity of parathyroid hormone-related protein (PTHrP) as a result of limited proteolysis by prostate-specific antigen.
8755496 In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains.
8756628 A single tyrosine of the interleukin-9 (IL-9) receptor is required for STAT activation, antiapoptotic activity, and growth regulation by IL-9.
8756631 In vivo and in vitro specificity of protein tyrosine kinases for immunoglobulin G receptor (FcgammaRII) phosphorylation.
8764598 In vitro phosphorylation of the cytoplasmic domain of the amyloid precursor protein by glycogen synthase kinase-3beta.
8774846 A comparison of the substrate specificity of MAPKAP kinase-2 and MAPKAP kinase-3 and their activation by cytokines and cellular stress.
8783018 Mass spectrometric characterization of glycosylated interferon-gamma variants separated by gel electrophoresis.
8797825 Tyrosine phosphorylation of I kappa B-alpha activates NF-kappa B without proteolytic degradation of I kappa B-alpha.
8798390 CD36 is palmitoylated on both N- and C-terminal cytoplasmic tails.
8798570 Ligand activation of ELK receptor tyrosine kinase promotes its association with Grb10 and Grb2 in vascular endothelial cells.
8798614 Elimination of potential sites of glycosylation fails to abrogate complement regulatory function of cell surface CD59.
8798667 Phosphorylation and inhibition of type III adenylyl cyclase by calmodulin-dependent protein kinase II in vivo.
8798697 Stimulation of tumor cell motility linked to phosphodiesterase catalytic site of autotaxin.
8798764 Regulation of the Lck SH2 domain by tyrosine phosphorylation.
8804068 The in vivo metabolism of cholecystokinin (CCK-8) is essentially ensured by aminopeptidase A.
8804412 CPP32/Yama/apopain cleaves the catalytic component of DNA-dependent protein kinase in the holoenzyme.
8810265 Site-directed mutagenesis of nm23-H1. Mutation of proline 96 or serine 120 abrogates its motility inhibitory activity upon transfection into human breast carcinoma cells.
8810272 Adducin regulation. Definition of the calmodulin-binding domain and sites of phosphorylation by protein kinases A and C.
8816475 Evidence for in vivo phosphorylation of the Grb2 SH2-domain binding site on focal adhesion kinase by Src-family protein-tyrosine kinases.
8816480 Identification of the mitogen-activated protein kinase phosphorylation sites on human Sos1 that regulate interaction with Grb2.
8824278 Dephosphorylation of serine 3 regulates nuclear translocation of cofilin.
8824296 Beta1,4-N-acetylgalactosaminyltransferase (GM2 synthase) is released from Golgi membranes as a neuraminidase-sensitive, disulfide-bonded dimer by a cathepsin D-like protease.
8843739 IGFBP-3 proteolysis by plasmin, thrombin, serum: heparin binding, IGF binding, and structure of fragments.
8845374 In vitro phosphorylation of the epidermal growth factor receptor autophosphorylation domain by c-src: identification of phosphorylation sites and c-src SH2 domain binding sites.
8846784 Identification of novel phosphorylation sites required for activation of MAPKAP kinase-2.
8848293 Antibody specific for phosphorylated AMPA-type glutamate receptors at GluR2 Ser-696.
8855939 Disulfide structure and N-glycosylation sites of an extracellular domain of granulocyte-colony stimulating factor receptor.
8856079 Replacement of Ser657 of protein kinase C-alpha by alanine leads to premature down regulation after phorbol-ester-induced translocation to the membrane.
8861947 Activation of cyclin E/CDK2 is coupled to site-specific autophosphorylation and ubiquitin-dependent degradation of cyclin E.
8864963 Functional and metabolic differences between elastase-generated fragments of human lipoprotein[a] and apolipoprotein[a].
8869556 Purification and characterization of human endopeptidase 220.127.116.11. Comparison with the porcine counterpart indicates a unique cleavage site on neurotensin.
8870657 Heterogeneity in utilization of N-glycosylation sites Asn624 and Asn138 in human lactoferrin: a study with glycosylation-site mutants.
8875975 Proline-rich sequences mediate the interaction of the Arg protein tyrosine kinase with Crk.
8876196 The cytokine-activated tyrosine kinase JAK2 activates Raf-1 in a p21ras-dependent manner.
8885240 Characterization and determination of the biological activities of noncleavable high molecular weight forms of inhibin A and activin A.
8885868 Protein kinase C mu (PKC mu) associates with the B cell antigen receptor complex and regulates lymphocyte signaling.
8886014 Ser-27, Tyr-10 and Tyr-7 in the alpha-chain of pig stomach H+,K(+)-ATPase as Ca(2+)-dependent phosphorylatable sites by intrinsic and extrinsic protein kinases.
8887554 FGF and stress regulate CREB and ATF-1 via a pathway involving p38 MAP kinase and MAPKAP kinase-2.
8887659 Autophosphorylation sites participate in the activation of the double-stranded-RNA-activated protein kinase PKR.
8898866 Mapping of a regulatory important site for protein kinase C phosphorylation in the N-terminal domain of annexin II.
8900201 The Ced-3/interleukin 1beta converting enzyme-like homolog Mch6 and the lamin-cleaving enzyme Mch2alpha are substrates for the apoptotic mediator CPP32.
8910387 Characterization of the AMP-activated protein kinase kinase from rat liver and identification of threonine 172 as the major site at which it phosphorylates AMP-activated protein kinase.
8910476 Osteopontin N-terminal domain contains a cryptic adhesive sequence recognized by alpha9beta1 integrin.
8910478 Cysteines 153 and 154 of transmembrane transforming growth factor-alpha are palmitoylated and mediate cytoplasmic protein association.
8910482 Antibacterial activity of glycosylated and phosphorylated chromogranin A-derived peptide 173-194 from bovine adrenal medullary chromaffin granules.
8917518 Independent regulation of JNK/p38 mitogen-activated protein kinases by metabolic oxidative stress in the liver.
8939955 Threonine 1342 in human topoisomerase IIalpha is phosphorylated throughout the cell cycle.
8940068 Sequential phosphorylation by mitogen-activated protein kinase and glycogen synthase kinase 3 represses transcriptional activation by heat shock factor-1.
8940081 Grb7 is a downstream signaling component of platelet-derived growth factor alpha- and beta-receptors.
8940173 Src phosphorylates the insulin-like growth factor type I receptor on the autophosphorylation sites. Requirement for transformation by src.
8941336 Focal adhesion kinase tyrosine-861 is a major site of phosphorylation by Src.
8942648 Peptide, disulfide, and glycosylation mapping of recombinant human thrombopoietin from ser1 to Arg246.
8943232 Processing of beta-amyloid precursor protein by cathepsin D.
8943344 A novel membrane glycoprotein, SHPS-1, that binds the SH2-domain-containing protein tyrosine phosphatase SHP-2 in response to mitogens and cell adhesion.
8943348 Phosphorylation of tyrosine 720 in the platelet-derived growth factor alpha receptor is required for binding of Grb2 and SHP-2 but not for activation of Ras or cell proliferation.
8943850 CD10/neutral endopeptidase 24.11 is phosphorylated by casein kinase II and coassociates with other phosphoproteins including the lyn src-related kinase.
8945479 Structural basis for activation of human lymphocyte kinase Lck upon tyrosine phosphorylation.
8947046 Phosphorylation of Ser165 in TGF-beta type I receptor modulates TGF-beta1-induced cellular responses.
8950790 Thrombin-activated human platelets release two NAP-2 variants that stimulate polymorphonuclear leukocytes.
8954982 Casein kinase 2 phosphorylates recombinant human spermidine/spermine N1-acetyltransferase on both serine and threonine residues.
8955135 Co-expression with BCR induces activation of the FES tyrosine kinase and phosphorylation of specific N-terminal BCR tyrosine residues.
8959326 Multiple in vivo phosphorylated tyrosine phosphatase SHP-2 engages binding to Grb2 via tyrosine 584.
8960373 Functional analysis of phosphorylation at serine 532 of human c-Myb by MAP kinase.
8962078 Molecular ordering of the Fas-apoptotic pathway: the Fas/APO-1 protease Mch5 is a CrmA-inhibitable protease that activates multiple Ced-3/ICE-like cysteine proteases.
8971927 Identification of the site of glycation of human insulin.
8973632 Biosynthesis and N-glycosylation of human interferon-gamma. Asn25 and Asn97 differ markedly in how efficiently they are glycosylated and in their oligosaccharide composition.
8978814 Lamin proteolysis facilitates nuclear events during apoptosis.
8978818 A role for N-myristoylation in protein targeting: NADH-cytochrome b5 reductase requires myristic acid for association with outer mitochondrial but not ER membranes.
8980254 Lineage- and differentiation stage-specific expression of LSM-1 (LPAP), a possible substrate for CD45, in human hematopoietic cells.
8992971 Analysis of CD28 cytoplasmic tail tyrosine residues as regulators and substrates for the protein tyrosine kinases, EMT and LCK.
8995217 LSP1 is the major substrate for mitogen-activated protein kinase-activated protein kinase 2 in human neutrophils.
8999860 The regulatory Ser262 of microtubule-associated protein tau is phosphorylated by phosphorylase kinase.
8999969 Identification of an actin binding region and a protein kinase C phosphorylation site on human fascin.
9001210 The human Myt1 kinase preferentially phosphorylates Cdc2 on threonine 14 and localizes to the endoplasmic reticulum and Golgi complex.
9003781 The consensus motif for phosphorylation by cyclin D1-Cdk4 is different from that for phosphorylation by cyclin A/E-Cdk2.
9006104 Structural characterization by mass spectrometry of hemoglobin adducts formed after in vivo exposure to methyl bromide.
9012831 BAP-135, a target for Bruton's tyrosine kinase in response to B cell receptor engagement.
9013710 Inhibition of protein dephosphorylation results in the accumulation of splicing snRNPs and coiled bodies within the nucleolus.
9016641 Phosphorylation of ATF-1 enhances its DNA binding and transcription of the Na,K-ATPase alpha 1 subunit gene promoter.
9016807 Phosphorylation of growth factor receptor binding protein-2 by pp60c-src tyrosine kinase.
9020112 Interactions of mast cell tryptase with thrombin receptors and PAR-2.
9020188 Stat2 is a transcriptional activator that requires sequence-specific contacts provided by stat1 and p48 for stable interaction with DNA.
9023104 tRNAscan-SE: a program for improved detection of transfer RNA genes in genomic sequence.
9029153 Cdk2-dependent phosphorylation of Id2 modulates activity of E2A-related transcription factors.
9030579 Transcriptional activation by peroxisome proliferator-activated receptor gamma is inhibited by phosphorylation at a consensus mitogen-activated protein kinase site.
9030583 Characterization of protein kinase A and protein kinase C phosphorylation of the N-methyl-D-aspartate receptor NR1 subunit using phosphorylation site-specific antibodies.
9030585 Targeting of SCG10 to the area of the Golgi complex is mediated by its NH2-terminal region.
9030586 Protein kinase A (PKA)- and protein kinase C-phosphorylated glia maturation factor promotes the catalytic activity of PKA.
9030603 In vitro assay and characterization of the farnesylation-dependent prelamin A endoprotease.
9030777 Phosphorylation of vitronectin on Ser362 by protein kinase C attenuates its cleavage by plasmin.
9032240 Expression of constitutively active alpha-PAK reveals effects of the kinase on actin and focal complexes.
9038134 Regulation of the low molecular weight phosphotyrosine phosphatase by phosphorylation at tyrosines 131 and 132.
9038175 Sequence-specific DNA binding and transcription factor phosphorylation by Ku Autoantigen/DNA-dependent protein kinase. Phosphorylation of Ser-527 of the rat glucocorticoid receptor.
9038210 Direct association of Csk homologous kinase (CHK) with the diphosphorylated site Tyr568/570 of the activated c-KIT in megakaryocytes.
9045708 Phosphorylation of a vesicular monoamine transporter by casein kinase II.
9047237 Regulation of Vav-SLP-76 binding by ZAP-70 and its relevance to TCR zeta/CD3 induction of interleukin-2.
9053848 Tyrosine 207 in CRKL is the BCR/ABL phosphorylation site.
9054419 The glycosylation of the complement regulatory protein, human erythrocyte CD59.
9054441 Evidence for a novel O-linked sialylated trisaccharide on Ser-248 of human plasminogen 2.
9054461 Phosphorylation of human keratin 8 in vivo at conserved head domain serine 23 and at epidermal growth factor-stimulated tail domain serine 431.
9060467 Rapid plasma membrane anchoring of newly synthesized p59fyn: selective requirement for NH2-terminal myristoylation and palmitoylation at cysteine-3.
9069290 Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation.
9072970 Nuclear export of NF-ATc enhanced by glycogen synthase kinase-3.
9074495 The putative cell cycle gene, enhancer of rudimentary, encodes a highly conserved protein found in plants and animals.
9076588 Identification of peptide fragments generated by digestion of bovine and human osteocalcin with the lysosomal proteinases cathepsin B, D, L, H, and S.
9079638 Ligand-induced desensitization of the human CXC chemokine receptor-2 is modulated by multiple serine residues in the carboxyl-terminal domain of the receptor.
9091312 Identification of Raf-1 Ser621 kinase activity from NIH 3T3 cells as AMP-activated protein kinase.
9092573 Identification of phosphorylation sites in the translational regulator, PHAS-I, that are controlled by insulin and rapamycin in rat adipocytes.
9092810 Characterization of prostate-specific antigen proteolytic activity on its major physiological substrate, the sperm motility inhibitor precursor/semenogelin I.
9092949 Retargeting of cytosolic proteins to the plasma membrane by the Lck protein tyrosine kinase dual acylation motif.
9096689 Antisense src expression inhibits tyrosine phosphorylation of Shc and its association with Grb2 and Sos which leads to MAP kinase activation in U937 human leukemia cells.
9099667 Phosphorylation of glial fibrillary acidic protein at the same sites by cleavage furrow kinase and Rho-associated kinase.
9099669 Identification of protein kinase C phosphorylation sites on bovine rhodopsin.
9099694 A 180-kDa protein kinase seems to be responsible for the phosphorylation of prothymosin alpha observed in proliferating cells.
9099755 Autophosphorylation of activation loop tyrosines regulates signaling by the TRK nerve growth factor receptor.
9108473 DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis.
9109541 The neuronal calcium-sensor protein VILIP modulates cyclic AMP accumulation in stably transfected C6 glioma cells: amino-terminal myristoylation determines functional activity.
9109552 Phosphorylation and activation of brain tryptophan hydroxylase: identification of serine-58 as a substrate site for protein kinase A.
9109675 Phosphorylation of Alzheimer beta-amyloid precursor-like proteins.
9111002 Polymorphonuclear cells isolated from human peripheral blood cleave lipoprotein(a) and apolipoprotein(a) at multiple interkringle sites via the enzyme elastase. Generation of mini-Lp(a) particles and apo(a) fragments.
9111020 Regulation by cAMP of post-translational processing and subcellular targeting of endothelial nitric-oxide synthase (type 3) in cardiac myocytes.
9111058 Target-dependent effect of phosphorylation on the DNA binding activity of the TAL1/SCL oncoprotein.
9111318 Activation of Jak2 catalytic activity requires phosphorylation of Y1007 in the kinase activation loop.
9113412 T cell signalling through CD73.
9115255 Phosphorylation and O-glycosylation sites of bovine chromogranin A from adrenal medullary chromaffin granules and their relationship with biological activities.
9115440 The crystal structure of an intact human Max-DNA complex: new insights into mechanisms of transcriptional control.
9121430 Tyrosine phosphorylation sites at amino acids 239 and 240 of Shc are involved in epidermal growth factor-induced mitogenic signaling that is distinct from Ras/mitogen-activated protein kinase activation.
9121492 Identification of growth hormone receptor (GHR) tyrosine residues required for GHR phosphorylation and JAK2 and STAT5 activation.
9122198 Dissecting the thrombopoietin receptor: functional elements of the Mpl cytoplasmic domain.
9126608 Purification, characterization, and in vitro phosphorylation of the neuron-specific membrane-associated protein SCG10.
9128250 Regulated membrane localization of Tiam1, mediated by the NH2-terminal pleckstrin homology domain, is required for Rac-dependent membrane ruffling and C-Jun NH2-terminal kinase activation.
9136927 The TGF-beta family mediator Smad1 is phosphorylated directly and activated functionally by the BMP receptor kinase.
9139732 Differential phosphorylation of the retinoblastoma protein by G1/S cyclin-dependent kinases.
9141461 Cdc25 protein phosphatases in cell proliferation.
9146608 Prostate specific antigen in benign prostatic hyperplasia: purification and characterization.
9148753 Degradation of decorin by matrix metalloproteinases: identification of the cleavage sites, kinetic analyses and transforming growth factor-beta1 release.
9148770 Identification of csk tyrosine phosphorylation sites and a tyrosine residue important for kinase domain structure.
9148944 Contraction-induced changes in acetyl-CoA carboxylase and 5'-AMP-activated kinase in skeletal muscle.
9153193 Casein kinase II-mediated phosphorylation of the C terminus of Sp1 decreases its DNA binding activity.
9155017 Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2.
9155018 MNK1, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates.
9155020 D-myo-inositol 1,4,5-trisphosphate 3-kinase A is activated by receptor activation through a calcium:calmodulin-dependent protein kinase II phosphorylation mechanism.
9155023 Positive and negative regulation of type II TGF-beta receptor signal transduction by autophosphorylation on multiple serine residues.
9158146 alpha-Mannosidosis: functional cloning of the lysosomal alpha-mannosidase cDNA and identification of a mutation in two affected siblings.
9162089 SHP1 and SHP2 protein-tyrosine phosphatases associate with betac after interleukin-3-induced receptor tyrosine phosphorylation. Identification of potential binding sites and substrates.
9162092 Characterization of the mitogen-activated protein kinase kinase 4 (MKK4)/c-Jun NH2-terminal kinase 1 and MKK3/p38 pathways regulated by MEK kinases 2 and 3. MEK kinase 3 activates MKK3 but does not cause activation of p38 kinase in vivo.
9166747 Functional role of amino-terminal serine16 and serine27 of G alphaZ in receptor and effector coupling.
9168116 Ataxia telangiectasia mutant protein activates c-Abl tyrosine kinase in response to ionizing radiation.
9169414 Characterization of Lnk. An adaptor protein expressed in lymphocytes.
9169442 Rhodopsin phosphorylation sites and their role in arrestin binding.
9169454 The type II transforming growth factor-beta receptor autophosphorylates not only on serine and threonine but also on tyrosine residues.
9171348 Translocation of the Csk homologous kinase (Chk/Hyl) controls activity of CD36-anchored Lyn tyrosine kinase in thrombin-stimulated platelets.
9173929 Presenilin proteins undergo heterogeneous endoproteolysis between Thr291 and Ala299 and occur as stable N- and C-terminal fragments in normal and Alzheimer brain tissue.
9174053 ALK, the chromosome 2 gene locus altered by the t(2;5) in non-Hodgkin's lymphoma, encodes a novel neural receptor tyrosine kinase that is highly related to leukocyte tyrosine kinase (LTK)
9174342 Structure and assembly of the catalytic region of human complement protease C1r: a three-dimensional model based on chemical cross-linking and homology modeling.
9175863 Interaction of the G-protein G11alpha with receptors and phosphoinositidase C: the contribution of G-protein palmitoylation and membrane association.
9178760 Intracellular signaling of the Ufo/Axl receptor tyrosine kinase is mediated mainly by a multi-substrate docking-site.
9178913 Bcr phosphorylated on tyrosine 177 binds Grb2.
9182531 Regulation of platelet plasma membrane Ca2+-ATPase by cAMP-dependent and tyrosine phosphorylation.
9182757 A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway.
9183006 The in vitro phosphorylation of p53 by calcium-dependent protein kinase C--characterization of a protein-kinase-C-binding site on p53.
9190208 Cyclin D1/Cdk4 regulates retinoblastoma protein-mediated cell cycle arrest by site-specific phosphorylation.
9191055 Recognition of activated CSF-1 receptor in breast carcinomas by a tyrosine 723 phosphospecific antibody.
9192730 HSDJ, a human homolog of DnaJ, is farnesylated and is involved in protein import into mitochondria.
9192873 Cyclin E-CDK2 is a regulator of p27Kip1.
9195912 Alternative splicing of the high affinity cAMP-specific phosphodiesterase (PDE7A) mRNA in human skeletal muscle and heart.
9195949 Tyr624 and Tyr628 in insulin receptor substrate-2 mediate its association with the insulin receptor.
9199329 Mitogen-activated and cyclin-dependent protein kinases selectively and differentially modulate transcriptional enhancement by the glucocorticoid receptor.
9199504 Phosphorylation of microtubule-associated protein tau by stress-activated protein kinases.
9201958 Serine-578 is a major phosphorylation locus in human plasma plasminogen.
9208935 Sequence specificity of C-terminal Src kinase (CSK)--a comparison with Src-related kinases c-Fgr and Lyn.
9211903 Stress, apoptosis, and mitosis induce phosphorylation of human keratin 8 at Ser-73 in tissues and cultured cells.
9214631 IkappaB alpha is a target for the mitogen-activated 90 kDa ribosomal S6 kinase.
9218798 Activation of the novel stress-activated protein kinase SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6); comparison of its substrate specificity with that of other SAP kinases.
9221902 Molecular characterization and pharmacological properties of the human P2X3 purinoceptor.
9224808 Palmitoylation of the V2 vasopressin receptor.
9232196 Comparison of the hydrolysis of the three types of natriuretic peptides by human kidney neutral endopeptidase 24.11.
9233763 Involvement of caspase-4(-like) protease in Fas-mediated apoptotic pathway.
9233798 Juxtamembrane tyrosine residues couple the Eph family receptor EphB2/Nuk to specific SH2 domain proteins in neuronal cells.
9234708 Phosphorylation of Raf-1 serine 338-serine 339 is an essential regulatory event for Ras-dependent activation and biological signaling.
9235942 Phosphorylation by p34cdc2 protein kinase regulates binding of the kinesin-related motor HsEg5 to the dynactin subunit p150.
9238677 Cell-to-cell transfer of glycosylphosphatidylinositol-anchored membrane proteins during sperm maturation.
9242537 Human neutrophil elastase activates human factor V but inactivates thrombin-activated human factor V.
9242710 Phosphorylation and calmodulin binding of the metabotropic glutamate receptor subtype 5 (mGluR5) are antagonistic in vitro.
9244383 Serine phosphorylation of syndecan-2 proteoglycan cytoplasmic domain.
9244386 Glycosylation of bile-salt-stimulated lipase from human milk: comparison of native and recombinant forms.
9247274 cAMP-dependent regulation of cardiac L-type Ca2+ channels requires membrane targeting of PKA and phosphorylation of channel subunits.
9252332 Caspase-3-mediated cleavage of protein kinase C theta in induction of apoptosis.
9252406 Association of the multisubstrate docking protein Gab1 with the hepatocyte growth factor receptor requires a functional Grb2 binding site involving tyrosine 1356.
9254654 Src homology 2 protein tyrosine phosphatase (SHPTP2)/Src homology 2 phosphatase 2 (SHP2) tyrosine phosphatase is a positive regulator of the interleukin 5 receptor signal transduction pathways leading to the prolongation of eosinophil survival.
9257712 Multiple tyrosine residues in the intracellular domain of the common beta subunit of the interleukin 5 receptor are involved in activation of STAT5.
9257865 Selective conversion of big endothelins to tracheal smooth muscle-constricting 31-amino acid-length endothelins by chymase from human mast cells.
9261102 Activation of caspase-2 in apoptosis.
9261109 Activation of type IV procollagenases by human tumor-associated trypsin-2.
9261115 Src kinase activity is regulated by the SHP-1 protein-tyrosine phosphatase.
9266968 Ligand-independent activation of fibroblast growth factor receptor-2 by carboxyl terminal alterations.
9268380 Human Myt1 is a cell cycle-regulated kinase that inhibits Cdc2 but not Cdk2 activity.
9271440 Dual requirement for a newly identified phosphorylation site in p70s6k.
9271576 A critical role for tapasin in the assembly and function of multimeric MHC class I-TAP complexes.
9275067 Proteolysis of insulin-like growth factors (IGF) and IGF binding proteins by cathepsin D.
9275097 Cholecystokinin (CCK) levels are greatly reduced in the brains but not the duodenums of Cpe(fat)/Cpe(fat) mice: a regional difference in the involvement of carboxypeptidase E (Cpe) in pro-CCK processing.
9276160 Characterization of kininogenase activity of an acidic proteinase isolated from human kidney.
9278383 Phosphorylation of the PEST domain of IkappaBbeta regulates the function of NF-kappaB/IkappaBbeta complexes.
9278461 Proteolytic cleavage of the mdm2 oncoprotein during apoptosis.
9278511 Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25.
9278512 Mitotic and G2 checkpoint control: regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216.
9287346 Identification of the membrane receptor binding domain of thyroglobulin. Insights into quality control of thyroglobulin biosynthesis.
9288740 Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain.
9295285 Substrate specificities of three members of the human UDP-N-acetyl-alpha-D-galactosamine:Polypeptide N-acetylgalactosaminyltransferase family, GalNAc-T1, -T2, and -T3.
9295302 Membrane topology of the multidrug resistance protein (MRP). A study of glycosylation-site mutants reveals an extracytosolic NH2 terminus.
9295322 Phosphorylation of four amino acid residues in the carboxyl terminus of the rat somatostatin receptor subtype 3 is crucial for its desensitization and internalization.
9295339 Sites of UV-induced phosphorylation of the p34 subunit of replication protein A from HeLa cells.
9298992 Caspase cleavage of keratin 18 and reorganization of intermediate filaments during epithelial cell apoptosis.
9305909 Posttranslational modifications of the 5'-AMP-activated protein kinase beta1 subunit.
9305920 Identification of serine 643 of protein kinase C-delta as an important autophosphorylation site for its enzymatic activity.
9310187 The BASP1 family of myristoylated proteins abundant in axonal termini. Primary structure analysis and physico-chemical properties.
9312058 Induced N- and C-terminal cleavage of p53: a core fragment of p53, generated by interaction with damaged DNA, promotes cleavage of the N-terminus of full-length p53, whereas ssDNA induces C-terminal cleavage of p53.
9312100 Agonist-induced desensitization of the mu opioid receptor is determined by threonine 394 preceded by acidic amino acids in the COOH-terminal tail.
9312162 Lck phosphorylates the activation loop tyrosine of the Itk kinase domain and activates Itk kinase activity.
9315091 Phosphorylation of the Src substrate Sam68 by Cdc2 during mitosis.
9315635 Dual mechanisms for the inhibition of E2F binding to RB by cyclin-dependent kinase-mediated RB phosphorylation.
9323209 Caspase-3-generated fragment of gelsolin: effector of morphological change in apoptosis.
9334240 Involvement of caspase-1 and caspase-3 in the production and processing of mature human interleukin 18 in monocytic THP.1 cells.
9335504 Opposing BMP and EGF signalling pathways converge on the TGF-beta family mediator Smad1.
9337875 Characterization of iduronate sulphatase mutants affecting N-glycosylation sites and the cysteine-84 residue.
9337997 Proteolytic fragments of insulin-like growth factor binding protein-3: N-terminal sequences and relationships between structure and biological activity.
9341152 Biosynthesis, distinct post-translational modifications, and functional characterization of lymphoma proprotein convertase.
9341188 The prooncoprotein EWS binds calmodulin and is phosphorylated by protein kinase C through an IQ domain.
9343410 O glycosylation of an Sp1-derived peptide blocks known Sp1 protein interactions.
9343414 STAT3 serine phosphorylation by ERK-dependent and -independent pathways negatively modulates its tyrosine phosphorylation.
9344465 Interaction of matrix metalloproteinases-2 and -9 with pregnancy zone protein and alpha2-macroglobulin.
9346908 TbetaRI phosphorylation of Smad2 on Ser465 and Ser467 is required for Smad2-Smad4 complex formation and signaling.
9349507 p53 is phosphorylated in vitro and in vivo by the delta and epsilon isoforms of casein kinase 1 and enhances the level of casein kinase 1 delta in response to topoisomerase-directed drugs.
9349529 Characterization of the palmitoylation domain of SNAP-25.
9351815 Regulation of stability and function of the epithelial Na+ channel (ENaC) by ubiquitination.
9351817 The large subunit of replication factor C is a substrate for caspase-3 in vitro and is cleaved by a caspase-3-like protease during Fas-mediated apoptosis.
9351825 Cross-cascade activation of ERKs and ternary complex factors by Rho family proteins.
9353289 Phosphorylation by neuronal cdc2-like protein kinase promotes dimerization of Tau protein in vitro.
9353319 Characterization of NEDD8, a developmentally down-regulated ubiquitin-like protein.
9353340 Characterization of the phosphorylation sites involved in G protein-coupled receptor kinase- and protein kinase C-mediated desensitization of the alpha1B-adrenergic receptor.
9355737 Stat1 associates with c-kit and is activated in response to stem cell factor.
9355745 Protein tyrosine phosphatase 1B interacts with and is tyrosine phosphorylated by the epidermal growth factor receptor.
9360944 Angiostatin-converting enzyme activities of human matrilysin (MMP-7) and gelatinase B/type IV collagenase (MMP-9).
9360956 14-3-3 is phosphorylated by casein kinase I on residue 233. Phosphorylation at this site in vivo regulates Raf/14-3-3 interaction.
9360968 Butylated hydroxyanisole and its metabolite tert-butylhydroquinone differentially regulate mitogen-activated protein kinases. The role of oxidative stress in the activation of mitogen-activated protein kinases by phenolic antioxidants.
9360983 Tyrosine phosphorylation of Crk-associated substrates by focal adhesion kinase. A putative mechanism for the integrin-mediated tyrosine phosphorylation of Crk-associated substrates.
9361003 Dentatorubral pallidoluysian atrophy (DRPLA) protein is cleaved by caspase-3 during apoptosis.
9363897 Tyrosine phosphorylation of the EGF receptor by the kinase Jak2 is induced by growth hormone.
9365923 The unusual amino acid triplet Asn-Ile-Cys is a glycosylation consensus site in human alpha-lactalbumin.
9366517 Inhibition of the DNA-binding and transcriptional repression activity of the Wilms' tumor gene product, WT1, by cAMP-dependent protein kinase-mediated phosphorylation of Ser-365 and Ser-393 in the zinc finger domain.
9368003 Specific proteolysis of the kinase protein kinase C-related kinase 2 by caspase-3 during apoptosis. Identification by a novel, small pool expression cloning strategy.
9368023 Serpin-derived peptide substrates for investigating the substrate specificity of human tissue kallikreins hK1 and hK2.
9368760 3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase.
9369230 Disturbed progastrin processing in carboxypeptidase E-deficient fat mice.
9371782 The phosphorylation state of the FIGQY tyrosine of neurofascin determines ankyrin-binding activity and patterns of cell segregation.
9374467 Nuclear accumulation of NFAT4 opposed by the JNK signal transduction pathway.
9374536 Expression, purification, and regulation of two isoforms of the inositol 1,4,5-trisphosphate 3-kinase.
9374542 Mitogenic activation, phosphorylation, and nuclear translocation of protein kinase Bbeta.
9380693 Transforming growth factor beta-induced phosphorylation of Smad3 is required for growth inhibition and transcriptional induction in epithelial cells.
9381178 Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt.
9384584 BMK1/ERK5 regulates serum-induced early gene expression through transcription factor MEF2C.
9388255 Clathrin-mediated endocytosis of the beta-adrenergic receptor is regulated by phosphorylation/dephosphorylation of beta-arrestin1.
9388490 Tyrosine residues 239 and 240 of Shc are phosphatidylinositol 4,5-bisphosphate-dependent phosphorylation sites by c-Src.
9389649 Mediation of NGF signaling by post-translational inhibition of HES-1, a basic helix-loop-helix repressor of neuronal differentiation.
9391116 Distinct tyrosine phosphorylation sites in JAK3 kinase domain positively and negatively regulate its enzymatic activity.
9395403 Conversion of Bcl-2 to a Bax-like death effector by caspases.
9395448 Characterization of substrate phosphorylation and use of calmodulin mutants to address implications from the enzyme crystal structure of calmodulin-dependent protein kinase I.
9395533 Regulation of leukotriene A4 hydrolase activity in endothelial cells by phosphorylation.
9398320 MAP4 is the in vivo substrate for CDC2 kinase in HeLa cells: identification of an M-phase specific and a cell cycle-independent phosphorylation site in MAP4.
9405425 Separate domains of the human fas ligand dictate self-association and receptor binding.
9405468 The mammalian target of rapamycin phosphorylates sites having a (Ser/Thr)-Pro motif and is activated by antibodies to a region near its COOH terminus.
9405642 Phosphorylation of the immunosuppressant FK506-binding protein FKBP52 by casein kinase II: regulation of HSP90-binding activity of FKBP52.
9407077 Properties and phosphorylation sites of baculovirus-expressed nuclear inhibitor of protein phosphatase-1 (NIPP-1).
9407116 The Src family kinase Hck interacts with Bcr-Abl by a kinase-independent mechanism and phosphorylates the Grb2-binding site of Bcr.
9417067 Identification of novel phosphorylation sites in hormone-sensitive lipase that are phosphorylated in response to isoproterenol and govern activation properties in vitro.
9418861 Myotonic dystrophy kinase-related Cdc42-binding kinase acts as a Cdc42 effector in promoting cytoskeletal reorganization.
9418908 Pex19p, a farnesylated protein essential for peroxisome biogenesis.
9422780 Processing and activation of pro-interleukin-16 by caspase-3.
9425062 Posttranslational modifications of human inter-alpha-inhibitor: identification of glycans and disulfide bridges in heavy chains 1 and 2.
9425276 PDGF-induced phosphorylation of Tyr28 in the N-terminus of Fyn affects Fyn activation.
9427642 3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro.
9428684 Human amyloid precursor-like protein 1--cDNA cloning, ectopic expression in COS-7 cells and identification of soluble forms in the cerebrospinal fluid.
9430688 Identification of regulatory phosphorylation sites in mitogen-activated protein kinase (MAPK)-activated protein kinase-1a/p90rsk that are inducible by MAPK.
9433921 The role of N-terminal glycosylation in the human oxytocin receptor.
9435230 Modulation of cell death by Bcl-XL through caspase interaction.
9444958 Gab1 coupling to the HGF/Met receptor multifunctional docking site requires binding of Grb2 and correlates with the transforming potential.
9446569 Activation of P2Y2 receptors by UTP and ATP stimulates mitogen-activated kinase activity through a pathway that involves related adhesion focal tyrosine kinase and protein kinase C.
9446654 The p85 and p110 subunits of phosphatidylinositol 3-kinase-alpha are substrates, in vitro, for a constitutively associated protein tyrosine kinase in platelets.
9450956 Recognition signal for C-mannosylation of Trp-7 in RNase 2 consists of sequence Trp-x-x-Trp.
9452388 Autophosphorylation at Thr286 of the alpha calcium-calmodulin kinase II in LTP and learning.
9453548 Peripherin is tyrosine-phosphorylated at its carboxyl-terminal tyrosine.
9456324 Rho-kinase phosphorylates COOH-terminal threonines of ezrin/radixin/moesin (ERM) proteins and regulates their head-to-tail association.
9461559 Regulation of Rad51 function by c-Abl in response to DNA damage.
9461588 Modification of phosphatidylinositol 3-kinase SH2 domain binding properties by Abl- or Lck-mediated tyrosine phosphorylation at Tyr-688.
9463386 Direct triggering of the type I interferon system by virus infection: activation of a transcription factor complex containing IRF-3 and CBP/p300.
9465032 RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1.
9465305 Sequence characterization of a newly identified human alpha-tubulin gene (TUBA2).
9467953 Requirement of two specific tyrosine residues for the catalytic activity of Bcr serine/threonine kinase.
9468292 Regulation of eukaryotic initiation factor eIF2B: glycogen synthase kinase-3 phosphorylates a conserved serine which undergoes dephosphorylation in response to insulin.
9468497 Identification of the phosphorylation sites of cytosolic phospholipase A2 in agonist-stimulated human platelets and HeLa cells.
9468501 Autocatalytic processing of recombinant human procathepsin L. Contribution of both intermolecular and unimolecular events in the processing of procathepsin L in vitro.
9468536 Transgenic approaches to define the functional role of dual site phospholamban phosphorylation.
9473672 cDNA cloning of a novel trypsin inhibitor with similarity to pathogenesis-related proteins, and its frequent expression in human brain cancer cells.
9480911 Interaction in vitro of the product of the c-Crk-II proto-oncogene with the insulin-like growth factor I receptor.
9484232 Peroxynitrite-mediated inactivation of manganese superoxide dismutase involves nitration and oxidation of critical tyrosine residues.
9485375 Human mast cell tryptase fibrinogenolysis: kinetics, anticoagulation mechanism, and cell adhesion disruption.
9485474 Galpha12 requires acylation for its transforming activity.
9488723 DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139.
9490415 Immunoreceptor DAP12 bearing a tyrosine-based activation motif is involved in activating NK cells.
9491897 Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior.
9507031 p125Fak focal adhesion kinase is a substrate for the insulin and insulin-like growth factor-I tyrosine kinase receptors.
9512493 Activation of protein kinase B beta and gamma isoforms by insulin in vivo and by 3-phosphoinositide-dependent protein kinase-1 in vitro: comparison with protein kinase B alpha.
9516414 Amino-terminal truncation of chemokines by CD26/dipeptidyl-peptidase IV. Conversion of RANTES into a potent inhibitor of monocyte chemotaxis and HIV-1-infection.
9516463 Protein kinase C-theta phosphorylation of moesin in the actin-binding sequence.
9516479 Analysis of Grb7 recruitment by heregulin-activated erbB receptors reveals a novel target selectivity for erbB3.
9520446 NF-kappaB-inducing kinase activates IKK-alpha by phosphorylation of Ser-176.
9520483 Mechanism of nicotinic acetylcholine receptor cluster formation by rapsyn.
9524113 Phosphorylation of human keratin 18 serine 33 regulates binding to 14-3-3 proteins.
9525956 Identification of in vitro phosphorylation sites in the growth cone protein SCG10. Effect Of phosphorylation site mutants on microtubule-destabilizing activity.
9525959 Identification and partial characterization of factor Va heavy chain kinase from human platelets.
9528769 pp90rsk1 regulates estrogen receptor-mediated transcription through phosphorylation of Ser-167.
9528781 SHP-1 binds and negatively modulates the c-Kit receptor by interaction with tyrosine 569 in the c-Kit juxtamembrane domain.
9528799 Autophosphorylation in the activation loop is required for full kinase activity in vivo of human and yeast eukaryotic initiation factor 2alpha kinases PKR and GCN2.
9528953 Insulin-like growth factor-binding protein-5 is cleaved by physiological concentrations of thrombin.
9531288 Asymmetrical phosphorylation and function of immunoreceptor tyrosine-based activation motif tyrosines in B cell antigen receptor signal transduction.
9535738 Mutations which abolish phosphorylation of the TRAF-binding domain of TNF receptor 2 enhance receptor-mediated NF-kappa B activation.
9535845 Physical and functional interactions between receptor-like protein-tyrosine phosphatase alpha and p59fyn.
9535905 Identification of a domain on the beta-subunit of the rod cGMP-gated cation channel that mediates inhibition by calcium-calmodulin.
9535906 Caspase cleavage of gene products associated with triplet expansion disorders generates truncated fragments containing the polyglutamine tract.
9535909 Regulation of connexin-43 gap junctional intercellular communication by mitogen-activated protein kinase.
9538022 Structure/function analyses of recombinant variants of human factor Xa: factor Xa incorporation into prothrombinase on the thrombin-activated platelet surface is not mimicked by synthetic phospholipid vesicles.
9543386 C-TAK1 protein kinase phosphorylates human Cdc25C on serine 216 and promotes 14-3-3 protein binding.
9544990 N-glycosylation of the prolactin receptor is not required for activation of gene transcription but is crucial for its cell surface targeting.
9545236 Caspase-mediated activation and induction of apoptosis by the mammalian Ste20-like kinase Mst1.
9545332 A role for the insulin-interleukin (IL)-4 receptor motif of the IL-4 receptor alpha-chain in regulating activation of the insulin receptor substrate 2 and signal transducer and activator of transcription 6 pathways. Analysis by mutagenesis.
9546424 Identification of Tyr-762 in the platelet-derived growth factor alpha-receptor as the binding site for Crk proteins.
9546672 Sequential phosphorylation of Tau by glycogen synthase kinase-3beta and protein kinase A at Thr212 and Ser214 generates the Alzheimer-specific epitope of antibody AT100 and requires a paired-helical-filament-like conformation.
9548733 Generation of an angiostatin-like fragment from plasminogen by stromelysin-1 (MMP-3).
9548757 Cross-class inhibition of the cysteine proteinases cathepsins K, L, and S by the serpin squamous cell carcinoma antigen 1: a kinetic analysis.
9556568 Regulation of syndecan-4 phosphorylation in vivo.
9558113 Posttranslational modifications affect the activity of the human monocyte chemotactic proteins MCP-1 and MCP-2: identification of MCP-2(6-76) as a natural chemokine inhibitor.
9560226 Activation of protein tyrosine kinase PYK2 by the m1 muscarinic acetylcholine receptor.
9565595 Phosphorylation of vimentin by Rho-associated kinase at a unique amino-terminal site that is specifically phosphorylated during cytokinesis.
9565682 Characterization of tau phosphorylation in glycogen synthase kinase-3beta and cyclin dependent kinase-5 activator (p23) transfected cells.
9566874 Stat3 activation by Src induces specific gene regulation and is required for cell transformation.
9566916 Protein tyrosine phosphatase 1B antagonizes signalling by oncoprotein tyrosine kinase p210 bcr-abl in vivo.
9566918 Virus-dependent phosphorylation of the IRF-3 transcription factor regulates nuclear translocation, transactivation potential, and proteasome-mediated degradation.
9571186 Regulation of the p53 protein by protein kinase C alpha and protein kinase C zeta.
9572267 Palmitoylation of neurofascin at a site in the membrane-spanning domain highly conserved among the L1 family of cell adhesion molecules.
9572875 Identification of O-glycosylation sites and partial characterization of carbohydrate structure and disulfide linkages of human insulin-like growth factor binding protein 6.
9576847 Molecular cloning, expression and catalytic activity of a human AKR7 member of the aldo-keto reductase superfamily: evidence that the major 2-carboxybenzaldehyde reductase from human liver is a homologue of rat aflatoxin B1-aldehyde reductase.
9576926 Plasma membrane localization is required for RGS4 function in Saccharomyces cerevisiae.
9578462 Activation of the precursor of human stromelysin 2 and its interactions with other matrix metalloproteinases.
9578468 Delayed production of biologically active O-glycosylated forms of human eotaxin by tumor-necrosis-factor-alpha-stimulated dermal fibroblasts.
9580567 Hyaluronan-dependent cell migration can be blocked by a CD44 cytoplasmic domain peptide containing a phosphoserine at position 325.
9584194 Cell cycle-regulated processing of HEF1 to multiple protein forms differentially targeted to multiple subcellular compartments.
9585407 Nuclear localization of cyclin B1 controls mitotic entry after DNA damage.
9586635 Granzyme B directly and efficiently cleaves several downstream caspase substrates: implications for CTL-induced apoptosis.
9592082 Mitogen-activated protein kinases (Erk1,2) phosphorylate Lys-Ser-Pro (KSP) repeats in neurofilament proteins NF-H and NF-M.
9593687 Caspase-mediated cleavage of the ubiquitin-protein ligase Nedd4 during apoptosis.
9600099 Multiple phosphorylation of chicken protein tyrosine phosphatase 1 and human protein tyrosine phosphatase 1B by casein kinase II and p60c-src in vitro.
9607320 Proteolytic cleavage of HsRad51 during apoptosis.
9614189 The endogenous and cell cycle-dependent phosphorylation of tau protein in living cells: implications for Alzheimer's disease.
9618465 Cloning and characterization of human protease-activated receptor 4.
9620884 Human alpha-galactosidase A: glycosylation site 3 is essential for enzyme solubility.
9624142 Identification and characterization of the major phosphorylation sites of the B-type natriuretic peptide receptor.
9626554 Prolactin (PRL) and its receptor: actions, signal transduction pathways and phenotypes observed in PRL receptor knockout mice.
9628863 Mapping the interaction between GRASP65 and GM130, components of a protein complex involved in the stacking of Golgi cisternae.
9628874 PRAK, a novel protein kinase regulated by the p38 MAP kinase.
9630228 Intramolecular masking of nuclear import signal on NF-AT4 by casein kinase I and MEKK1.
9632142 Complex formation between EphB2 and Src requires phosphorylation of tyrosine 611 in the EphB2 juxtamembrane region.
9632781 Binding of Shp2 tyrosine phosphatase to FRS2 is essential for fibroblast growth factor-induced PC12 cell differentiation.
9632797 Tyrosine 1101 of Tie2 is the major site of association of p85 and is required for activation of phosphatidylinositol 3-kinase and Akt.
9637505 HLA-G isoforms produced by placental cytotrophoblasts and found in amniotic fluid are due to unusual glycosylation.
9642263 Human ADAM 12 (meltrin alpha) is an active metalloprotease.
9642276 Caspases cleave focal adhesion kinase during apoptosis to generate a FRNK-like polypeptide.
9642287 Phosphorylation of CrkII adaptor protein at tyrosine 221 by epidermal growth factor receptor.
9642293 Conserved in vivo phosphorylation of calnexin at casein kinase II sites as well as a protein kinase C/proline-directed kinase site.
9651578 Autoactivation of procaspase-9 by Apaf-1-mediated oligomerization.
9651683 The kit receptor promotes cell survival via activation of PI 3-kinase and subsequent Akt-mediated phosphorylation of Bad on Ser136.
9655255 Formation of a stable src-AFAP-110 complex through either an amino-terminal or a carboxy-terminal SH2-binding motif.
9655398 Cofilin phosphorylation by LIM-kinase 1 and its role in Rac-mediated actin reorganization.
9658162 Tyrosine phosphorylation of selected secretory carrier membrane proteins, SCAMP1 and SCAMP3, and association with the EGF receptor.
9659899 The discoidin domain receptor tyrosine kinases are activated by collagen.
9659901 Differential roles of p300 and PCAF acetyltransferases in muscle differentiation.
9660939 Cleavage of p21Cip1/Waf1 and p27Kip1 mediates apoptosis in endothelial cells through activation of Cdk2: role of a caspase cascade.
9660947 Selective inhibition of NFAT activation by a peptide spanning the calcineurin targeting site of NFAT.
9670964 Regulation of apoptosis by tyrosine-containing domains of IL-4R alpha: Y497 and Y713, but not the STAT6-docking tyrosines, signal protection from apoptosis.
9671712 A cloning method for caspase substrates that uses the yeast two-hybrid system: cloning of the antiapoptotic gene gelsolin.
9674711 Tyrosine-614, the major autophosphorylation site of the receptor tyrosine kinase HEK2, functions as multi-docking site for SH2-domain mediated interactions.
9677202 Fidelity of T cell activation through multistep T cell receptor zeta phosphorylation.
9677319 Effects of phosphorylation on function of the Rad GTPase.
9677337 Glycosylation pattern of human inter-alpha-inhibitor heavy chains.
9677359 Cytoplasmic domains of the human granulocyte-macrophage colony-stimulating factor (GM-CSF) receptor beta chain (hbetac) responsible for human GM-CSF-induced myeloid cell differentiation.
9677371 Identification of amino acid residues critical for the Src-homology 2 domain-dependent docking of Stat2 to the interferon alpha receptor.
9679146 Adducin is an in vivo substrate for protein kinase C: phosphorylation in the MARCKS-related domain inhibits activity in promoting spectrin-actin complexes and occurs in many cells, including dendritic spines of neurons.
9685404 Tyrosine 474 of ZAP-70 is required for association with the Shc adaptor and for T-cell antigen receptor-dependent gene activation.
9685505 Casein kinase II interacts with the bZIP domains of several transcription factors.
9687510 Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB.
9689060 Autoregulation of the Raf-1 serine/threonine kinase.
9689078 MEKK1 activates both IkappaB kinase alpha and IkappaB kinase beta.
9694850 Mutation of a Shc binding site tyrosine residue in ErbB3/HER3 blocks heregulin-dependent activation of mitogen-activated protein kinase.
9694881 Role of N-glycosylation in human angiotensinogen.
9694885 Cytotoxic T lymphocyte-assisted suicide. Caspase 3 activation is primarily the result of the direct action of granzyme B.
9694886 Protein kinase C phosphorylation of threonine at position 888 in Ca2+o-sensing receptor (CaR) inhibits coupling to Ca2+ store release.
9697832 FRIP, a hematopoietic cell-specific rasGAP-interacting protein phosphorylated in response to cytokine stimulation.
9705209 Caspase-mediated fragmentation of calpain inhibitor protein calpastatin during apoptosis.
9705322 A novel sphingosine-dependent protein kinase (SDK1) specifically phosphorylates certain isoforms of 14-3-3 protein.
9705354 Tyrosine phosphorylation of c-ErbB-2 is regulated by the cellular form of prostatic acid phosphatase in human prostate cancer cells.
9710204 Roles of Lck, Syk and ZAP-70 tyrosine kinases in TCR-mediated phosphorylation of the adapter protein Shc.
9710583 Phosphorylation of nuclear MyoD is required for its rapid degradation.
9710607 14-3-3 proteins are required for maintenance of Raf-1 phosphorylation and kinase activity.
9716136 Protein kinase C regulates the nuclear localization of diacylglycerol kinase-zeta.
9719562 Rab11a is modified in vivo by isoprenoid geranylgeranyl.
9721103 Direct phosphorylation of IkappaB by IKKalpha and IKKbeta: discrimination between free and NF-kappaB-bound substrate.
9721757 Endothelin induces a calcium-dependent phosphorylation of PEA-15 in intact astrocytes: identification of Ser104 and Ser116 phosphorylated, respectively, by protein kinase C and calcium/calmodulin kinase II in vitro.
9722526 Regulation of erythroid Krüppel-like factor (EKLF) transcriptional activity by phosphorylation of a protein kinase casein kinase II site within its interaction domain.
9722557 Phosphorylation of the prostacyclin receptor during homologous desensitization. A critical role for protein kinase c.
9727491 Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors.
9729044 LAT palmitoylation: its essential role in membrane microdomain targeting and tyrosine phosphorylation during T cell activation.
9733650 A model of Cdc25 phosphatase catalytic domain and Cdk-interaction surface based on the presence of a rhodanese homology domain.
9733784 Phosphorylation of vitronectin by casein kinase II. Identification of the sites and their promotion of cell adhesion and spreading.
9733788 Phosphotyrosine 1173 mediates binding of the protein-tyrosine phosphatase SHP-1 to the epidermal growth factor receptor and attenuation of receptor signaling.
9734360 SUMO-1 modification of IkappaBalpha inhibits NF-kappaB activation.
9735171 Phosphorylation of tau at both Thr 231 and Ser 262 is required for maximal inhibition of its binding to microtubules.
9736715 Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase.
9738012 A functional role for mitochondrial protein kinase Calpha in Bcl2 phosphorylation and suppression of apoptosis.
9738469 Biosynthetic processing and quaternary interactions of proprotein convertase SPC4 (PACE4).
9741627 A requirement for caveolin-1 and associated kinase Fyn in integrin signaling and anchorage-dependent cell growth.
9742107 Molecular determinants of NF-kappaB-inducing kinase action.
9742969 Tyrosine phosphorylation of the Wiskott-Aldrich syndrome protein by Lyn and Btk is regulated by CDC42.
9744860 DNA damage activates p53 through a phosphorylation-acetylation cascade.
9744883 Active MAP kinase in mitosis: localization at kinetochores and association with the motor protein CENP-E.
9748166 Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1.
9748228 Specific activation of Smad1 signaling pathways by the BMP7 type I receptor, ALK2.
9748248 The role of tyrosine phosphorylation of cortactin in the locomotion of endothelial cells.
9748270 Two forms of collagen XVII in keratinocytes. A full-length transmembrane protein and a soluble ectodomain.
9751498 A protease-resistant form of insulin-like growth factor (IGF) binding protein 4 inhibits IGF-1 actions.
9751706 Proteolytic activation of PKN by caspase-3 or related protease during apoptosis.
9756909 Identification of three major sentrinization sites in PML.
9756938 The COOH-terminal tyrosine phosphorylation sites on IRS-1 bind SHP-2 and negatively regulate insulin signaling.
9757569 Effects of glycosylation of the residue at position 14 in ovine angiotensinogen on the human renin reaction.
9764820 The Tek/Tie2 receptor signals through a novel Dok-related docking protein, Dok-R.
9765199 The complexity of p53 modulation: emerging patterns from divergent signals.
9766811 Native thrombopoietin: structure and function.
9768757 The structure of HLA-DM, the peptide exchange catalyst that loads antigen onto class II MHC molecules during antigen presentation.
9768837 Phosphorylation and inhibition of olfactory adenylyl cyclase by CaM kinase II in Neurons: a mechanism for attenuation of olfactory signals.
9771888 Tau is phosphorylated by GSK-3 at several sites found in Alzheimer disease and its biological activity markedly inhibited only after it is prephosphorylated by A-kinase.
9774477 Association of GAP-43 with detergent-resistant membranes requires two palmitoylated cysteine residues.
9774483 Differential and cooperative polysialylation of the neural cell adhesion molecule by two polysialyltransferases, PST and STX.
9784398 Gustin from human parotid saliva is carbonic anhydrase VI.
9786864 Human leptin receptor. Determination of disulfide structure and N-glycosylation sites of the extracellular domain.
9786869 Cleavage and activation of p21-activated protein kinase gamma-PAK by CPP32 (caspase 3). Effects of autophosphorylation on activity.
9789013 Identification of two distinct human SMC protein complexes involved in mitotic chromosome dynamics.
9790917 The Src-like tyrosine kinase Hck is activated by granulocyte colony-stimulating factor (G-CSF) and docks to the activated G-CSF receptor.
9792637 Purification and cloning of PZR, a binding protein and putative physiological substrate of tyrosine phosphatase SHP-2.
9792645 Tumor necrosis factor-alpha activation of nuclear transcription factor-kappaB in marrow macrophages is mediated by c-Src tyrosine phosphorylation of Ikappa Balpha.
9794236 Autophosphorylation of Src and Yes blocks their inactivation by Csk phosphorylation.
9797370 Modulation of the cleavage of the gastrin precursor by prohormone phosphorylation.
9798950 Brain beta-spectrin phosphorylation: phosphate analysis and identification of threonine-347 as a heparin-sensitive protein kinase phosphorylation site.
9798985 Platelet glycoprotein Ia* is the processed form of multimerin--isolation and determination of N-terminal sequences of stored and released forms.
9799125 Caspase 3 specifically cleaves p21WAF1/CIP1 in the earlier stage of apoptosis in SK-HEP-1 human hepatoma cells.
9799234 Kit signaling through PI 3-kinase and Src kinase pathways: an essential role for Rac1 and JNK activation in mast cell proliferation.
9804419 Structural basis for activation of the titin kinase domain during myofibrillogenesis.
9804763 p40(phox) is phosphorylated on threonine 154 and serine 315 during activation of the phagocyte NADPH oxidase. Implication of a protein kinase c-type kinase in the phosphorylation process.
9804779 Differential control of the phosphorylation state of proline-juxtaposed serine residues Ser725 of Stat5a and Ser730 of Stat5b in prolactin-sensitive cells.
9804834 Casein kinase II catalyzes a mitotic phosphorylation on threonine 1342 of human DNA topoisomerase IIalpha, which is recognized by the 3F3/2 phosphoepitope antibody.
9806882 Insulin-stimulated kinase from rat fat cells that phosphorylates initiation factor 4E-binding protein 1 on the rapamycin-insensitive site (serine-111).
9812896 Regulation of cell death protease caspase-9 by phosphorylation.
9813138 Resting lymphocyte kinase (Rlk/Txk) phosphorylates the YVKM motif and regulates PI 3-kinase binding to T-cell antigen CTLA-4.
9813144 Calcium/calmodulin-dependent protein kinase II controls integrin alpha5beta1-mediated cell adhesion through the integrin cytoplasmic domain associated protein-1alpha.
9819383 Nucleophosmin-anaplastic lymphoma kinase of large-cell anaplastic lymphoma is a constitutively active tyrosine kinase that utilizes phospholipase C-gamma to mediate its mitogenicity.
9819408 Interaction of glycogen synthase kinase 3beta with the DF3/MUC1 carcinoma-associated antigen and beta-catenin.
9819420 Coordinate regulation of IkappaB kinases by mitogen-activated protein kinase kinase kinase 1 and NF-kappaB-inducing kinase.
9819435 Identification and characterization of pancreatic eukaryotic initiation factor 2 alpha-subunit kinase, PEK, involved in translational control.
9820500 Syk- and Lyn-dependent phosphorylation of Syk on multiple tyrosines following B cell activation includes a site that negatively regulates signaling.
9820826 Human carbon catabolite repressor protein (CCR4)-associative factor 1: cloning, expression and characterization of its interaction with the B-cell translocation protein BTG1.
9822657 Components of a calmodulin-dependent protein kinase cascade. Molecular cloning, functional characterization and cellular localization of Ca2+/calmodulin-dependent protein kinase kinase beta.
9823899 The protein kinase Pak3 positively regulates Raf-1 activity through phosphorylation of serine 338.
9827566 NADH:ubiquinone oxidoreductase from bovine heart mitochondria: sequence of a novel 17.2-kDa subunit.
9829964 CREB is a regulatory target for the protein kinase Akt/PKB.
9832145 New phosphorylation sites identified in hyperphosphorylated tau (paired helical filament-tau) from Alzheimer's disease brain using nanoelectrospray mass spectrometry.
9832503 Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization.
9832630 Human erythrocyte bisphosphoglycerate mutase: inactivation by glycation in vivo and in vitro.
9837919 Role of asparagine-linked oligosaccharides in protein folding, membrane targeting, and thyrotropin and autoantibody binding of the human thyrotropin receptor.
9837922 Regulation of TFII-I activity by phosphorylation.
9840932 The cell-cycle regulated transcription factor B-Myb is phosphorylated by cyclin A/Cdk2 at sites that enhance its transactivation properties.
9840943 Cyclin E2, a novel human G1 cyclin and activating partner of CDK2 and CDK3, is induced by viral oncoproteins.
9843217 ATM associates with and phosphorylates p53: mapping the region of interaction.
9852066 Phosphorylation and O-glycosylation sites of human chromogranin A (CGA79-439) from urine of patients with carcinoid tumors.
9852126 Identification of the sites of N-linked glycosylation on the human calcium receptor and assessment of their role in cell surface expression and signal transduction.
9853757 Functional interaction between InsP3 receptors and store-operated Htrp3 channels.
9856983 Phosphorylation of moesin by rho-associated kinase (Rho-kinase) plays a crucial role in the formation of microvilli-like structures.
9857012 Characterization of human glycogenin-2, a self-glucosylating initiator of liver glycogen metabolism.
9857068 Cbl-mediated negative regulation of the Syk tyrosine kinase. A critical role for Cbl phosphotyrosine-binding domain binding to Syk phosphotyrosine 323.
9858547 Identification of constitutive and ras-inducible phosphorylation sites of KSR: implications for 14-3-3 binding, mitogen-activated protein kinase binding, and KSR overexpression.
9858576 Identification of the in vivo casein kinase II phosphorylation site within the homeodomain of the cardiac tisue-specifying homeobox gene product Csx/Nkx2.5.
9867809 Effect of phosphorylation on activities of Rap1A to interact with Raf-1 and to suppress Ras-dependent Raf-1 activation.
9867848 The carboxyl-terminal region of biliary glycoprotein controls its tyrosine phosphorylation and association with protein-tyrosine phosphatases SHP-1 and SHP-2 in epithelial cells.
9872331 Repression of Stat3 activity by activation of mitogen-activated protein kinase (MAPK).
9878069 Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4E.
9880482 Src-mediated tyrosine phosphorylation of dynamin is required for beta2-adrenergic receptor internalization and mitogen-activated protein kinase signaling.
9883900 Isolation and characterization of circulating 13-kDa C-terminal fragments of human insulin-like growth factor binding protein-5.
9884403 Glycosylation sites and site-specific glycosylation in human Tamm-Horsfall glycoprotein.
9885575 PRC1: a human mitotic spindle-associated CDK substrate protein required for cytokinesis.
9886053 Molecular cloning and regional distribution of a human proton receptor subunit with biphasic functional properties.
9889196 Phosphorylation of mammalian CDC6 by cyclin A/CDK2 regulates its subcellular localization.
9889198 Regulation of IL-4 expression by the transcription factor JunB during T helper cell differentiation.
9890970 Fyn associates with Cbl and phosphorylates tyrosine 731 in Cbl, a binding site for phosphatidylinositol 3-kinase.
9891054 p53 sites acetylated in vitro by PCAF and p300 are acetylated in vivo in response to DNA damage.
9891755 Recent advances in protein methylation: enzymatic methylation of nucleic acid binding proteins.
9892009 Roles of pathway-specific and inhibitory Smads in activin receptor signaling.
9920899 Metalloprotease-disintegrin MDC9: intracellular maturation and catalytic activity.
9928950 Prorenin processing by cathepsin B in vitro and in transfected cells.
9930733 Differential phosphorylation of syntaxin and synaptosome-associated protein of 25 kDa (SNAP-25) isoforms.
9933589 Truncation of macrophage-derived chemokine by CD26/ dipeptidyl-peptidase IV beyond its predicted cleavage site affects chemotactic activity and CC chemokine receptor 4 interaction.
9933635 Caspase-mediated cleavage of DNA topoisomerase I at unconventional sites during apoptosis.
9973379 Regulation of cytotoxic T lymphocyte-associated molecule-4 by Src kinases.
9973453 Cutting edge: the CD45 tyrosine phosphatase is an inhibitor of Lck activity in thymocytes.
9988270 Activating SRC mutation in a subset of advanced human colon cancers.
9990022 Mammalian subtilisin/kexin isozyme SKI-1: A widely expressed proprotein convertase with a unique cleavage specificity and cellular localization.
9990288 Ribonucleotide reductase R2 protein is phosphorylated at serine-20 by P34cdc2 kinase.
10022118 Caspase-mediated cleavage of p21Waf1/Cip1 converts cancer cells from growth arrest to undergoing apoptosis.
10022904 Activation of IkappaB kinase beta by protein kinase C isoforms.
10023679 Phosphorylation of the DNA repair protein APE/REF-1 by CKII affects redox regulation of AP-1.
10026263 Factor VIIa/tissue factor generates a form of factor V with unchanged specific activity, resistance to activation by thrombin, and increased sensitivity to activated protein C.
10029531 Human cathepsin V functional expression, tissue distribution, electrostatic surface potential, enzymatic characterization, and chromosomal localization.
10037717 Tyrosine 319, a newly identified phosphorylation site of ZAP-70, plays a critical role in T cell antigen receptor signaling.
10037747 Cellular localization and role of prohormone convertases in the processing of pro-melanin concentrating hormone in mammals.
10037773 Intracellular proteolytic processing of the heavy chain of rat pre-alpha-inhibitor. The COOH-terminal propeptide is required for coupling to bikunin.
10049997 The glutamate receptor ion channels.
10066732 Nitric oxide inhibits caspase-3 by S-nitrosation in vivo.
10066782 Disulfide bond structure and N-glycosylation sites of the extracellular domain of the human interleukin-6 receptor.
10067969 Modifications to rat lens major intrinsic protein in selenite-induced cataract.
10068651 Gab-family adapter proteins act downstream of cytokine and growth factor receptors and T- and B-cell antigen receptors.
10068673 Involvement of wiskott-aldrich syndrome protein in B-cell cytoplasmic tyrosine kinase pathway.
10069390 Identification of caspases that cleave presenilin-1 and presenilin-2. Five presenilin-1 (PS1) mutations do not alter the sensitivity of PS1 to caspases.
10069512 Muscarinic cholinergic signaling in cardiac myocytes: dynamic targeting of M2AChR to sarcolemmal caveolae and eNOS activation.
10069803 The multisubstrate docking site of the MET receptor is dispensable for MET-mediated RAS signaling and cell scattering.
10072438 Two novel genes in the center of the 11p15 imprinted domain escape genomic imprinting.
10072540 Mutations of the type A domain of complement factor B that promote high-affinity C3b-binding.
10075701 Multisite autophosphorylation of p21-activated protein kinase gamma-PAK as a function of activation.
10075741 c-Src-mediated phosphorylation of the epidermal growth factor receptor on Tyr845 and Tyr1101 is associated with modulation of receptor function.
10076184 Characterisation of recombinant glycosylation variants of insulin-like growth factor binding protein-3.
10080942 Structural requirements of a human deoxyribonuclease II for the development of the active enzyme form, revealed by site-directed mutagenesis.
10082566 Role for caspase-mediated cleavage of Rad51 in induction of apoptosis by DNA damage.
10085087 Correlations in palmitoylation and multiple phosphorylation of rat bradykinin B2 receptor in Chinese hamster ovary cells.
10085121 MEKK-1, a component of the stress (stress-activated protein kinase/c-Jun N-terminal kinase) pathway, can selectively activate Smad2-mediated transcriptional activation in endothelial cells.
10085131 Differential effects of CC chemokines on CC chemokine receptor 5 (CCR5) phosphorylation and identification of phosphorylation sites on the CCR5 carboxyl terminus.
10085140 ATF-2 is a common nuclear target of Smad and TAK1 pathways in transforming growth factor-beta signaling.
10087256 A conserved biogenesis pathway for nucleoporins: proteolytic processing of a 186-kilodalton precursor generates Nup98 and the novel nucleoporin, Nup96.
10089882 Tyrosine sulfation of the amino terminus of CCR5 facilitates HIV-1 entry.
10090741 Phosphorylation that detaches tau protein from microtubules (Ser262, Ser214) also protects it against aggregation into Alzheimer paired helical filaments.
10092231 Inhibition of myosin light chain kinase by p21-activated kinase.
10092517 Identification of NEDD8-conjugation site in human cullin-2.
10092522 The proto-oncogene p120(Cbl) is a downstream substrate of the Hck protein-tyrosine kinase.
10095772 Identification of cyclin A/Cdk2 phosphorylation sites in B-Myb.
10095777 Isolation of the CXC chemokines ENA-78, GRO alpha and GRO gamma from tumor cells and leukocytes reveals NH2-terminal heterogeneity. Functional comparison of different natural isoforms.
10096020 Tip60 acetylates six lysines of a specific class in core histones in vitro.
10102268 Slit proteins bind Robo receptors and have an evolutionarily conserved role in repulsive axon guidance.
10102273 Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor.
10102815 Two distinct cytokines released from a human aminoacyl-tRNA synthetase.
10103059 Cleavage of transcription factor SP1 by caspases during anti-IgM-induced B-cell apoptosis.
10187779 Macrophage metalloelastase, MMP-12, cleaves human apolipoprotein(a) in the linker region between kringles IV-4 and IV-5. Potential relevance to lipoprotein(a) biology.
10187789 Inhibition of the Ca2+/calmodulin-dependent protein kinase I cascade by cAMP-dependent protein kinase.
10187842 Regulation of the transcriptional activity of the peroxisome proliferator-activated receptor alpha by phosphorylation of a ligand-independent trans-activating domain.
10191262 Activation of serum- and glucocorticoid-regulated protein kinase by agonists that activate phosphatidylinositide 3-kinase is mediated by 3-phosphoinositide-dependent protein kinase-1 (PDK1) and PDK2.
10195142 Tyrosine kinase potentiates NMDA receptor currents by reducing tonic zinc inhibition.
10195894 Positive and negative regulation of IkappaB kinase activity through IKKbeta subunit phosphorylation.
10195903 Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD.
10197530 Synaptic targeting of the postsynaptic density protein PSD-95 mediated by lipid and protein motifs.
10197981 A mechanism of repression of TGFbeta/ Smad signaling by oncogenic Ras.
10200531 Proteolytic cleavage of ras GTPase-activating protein during apoptosis.
10201980 Phosphorylation of CD19 Y484 and Y515, and linked activation of phosphatidylinositol 3-kinase, are required for B cell antigen receptor-mediated activation of Bruton's tyrosine kinase.
10202152 Phosphorylation by G1-specific cdk-cyclin complexes activates the nucleolar transcription factor UBF.
10204117 The connective tissue growth factor/cysteine-rich 61/nephroblastoma overexpressed (CCN) family.
10205168 Serine and tyrosine phosphorylations cooperate in Raf-1, but not B-Raf activation.
10206955 The myeloid-specific sialic acid-binding receptor, CD33, associates with the protein-tyrosine phosphatases, SHP-1 and SHP-2.
10206975 Suppression of Kir2.3 activity by protein kinase C phosphorylation of the channel protein at threonine 53.
10206983 Inhibition of T cell signaling by mitogen-activated protein kinase-targeted hematopoietic tyrosine phosphatase (HePTP).
10207045 Dual specificity protein kinase activity of testis-specific protein kinase 1 and its regulation by autophosphorylation of serine-215 within the activation loop.
10207050 Cumulative effect of phosphorylation of pRB on regulation of E2F activity.
10207070 Specific acetylation of chromosomal protein HMG-17 by PCAF alters its interaction with nucleosomes.
10209029 Phosphorylation of adducin by Rho-kinase plays a crucial role in cell motility.
10209036 SHP2-interacting transmembrane adaptor protein (SIT), a novel disulfide-linked dimer regulating human T cell activation.
10209959 Prostatic human kallikrein 2 inactivates and complexes with plasminogen activator inhibitor-1.
10210201 Identification of Tyr438 as the major in vitro c-Src phosphorylation site in human gelsolin: a mass spectrometric approach.
10212242 Stress-activated protein kinase-3 interacts with the PDZ domain of alpha1-syntrophin. A mechanism for specific substrate recognition.
10212258 Radiation-induced assembly of Rad51 and Rad52 recombination complex requires ATM and c-Abl.
10212274 Characterization of the major physiologic phosphorylation site of human keratin 19 and its role in filament organization.
10214954 Biochemical analysis of interleukin-2 receptor beta chain phosphorylation by p56(lck).
10217147 Direct control of the Forkhead transcription factor AFX by protein kinase B.
10218588 The cleavage site specificity of human prostate specific antigen for insulin-like growth factor binding protein-3.
10224060 Akt protein kinase enhances human telomerase activity through phosphorylation of telomerase reverse transcriptase subunit.
10224081 Unusual sites of arginine methylation in Poly(A)-binding protein II and in vitro methylation by protein arginine methyltransferases PRMT1 and PRMT3.
10224087 Extracellular regulated kinases (ERK) 1 and ERK2 are authentic substrates for the dual-specificity protein-tyrosine phosphatase VHR. A novel role in down-regulating the ERK pathway.
10224464 Novel autocrine and paracrine loops of the stem cell factor/chymase network.
10226025 PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2.
10229237 Enhanced inhibition of hepatitis B virus production by asialoglycoprotein receptor-directed interferon.
10229683 Complex formation between deoxyhypusine synthase and its protein substrate, the eukaryotic translation initiation factor 5A (eIF5A) precursor.
10230405 Phosphorylation of the nuclear receptor SF-1 modulates cofactor recruitment: integration of hormone signaling in reproduction and stress.
10318803 The tumor suppressor EXT-like gene EXTL2 encodes an alpha1, 4-N-acetylhexosaminyltransferase that transfers N-acetylgalactosamine and N-acetylglucosamine to the common glycosaminoglycan-protein linkage region. The key enzyme for the chain initiation of heparan sulfate.
10318843 Tyrosine 319 in the interdomain B of ZAP-70 is a binding site for the Src homology 2 domain of Lck.
10318861 Activation of C3G guanine nucleotide exchange factor for Rap1 by phosphorylation of tyrosine 504.
10318869 MAPKAP kinase 2 phosphorylates serum response factor in vitro and in vivo.
10318905 From HER2/Neu signal cascade to androgen receptor and its coactivators: a novel pathway by induction of androgen target genes through MAP kinase in prostate cancer cells.
10327653 Phylogenetically conserved CK-II phosphorylation site of the murine homeodomain protein Hoxb-6.
10329716 Regulated interaction of protein kinase Cdelta with the heterogeneous nuclear ribonucleoprotein K protein.
10330160 Expression of the p56(Lck) Y505F mutation in CD45-deficient mice rescues thymocyte development.
10333484 Structural elements within the methylation loop (residues 112-117) and EF hands III and IV of calmodulin are required for Lys(115) trimethylation.
10334944 Overexpression of wild-type and catalytically inactive forms of GRK2 and GRK6 fails to alter the agonist-induced phosphorylation of the C5a receptor (CD88): evidence that GRK6 is autophosphorylated in COS-7 cells.
10338112 Cysteine 29 is the major palmitoylation site on stomatin.
10339425 Rapamycin-sensitive phosphorylation of PKC on a carboxy-terminal site by an atypical PKC complex.
10339564 Multistep regulation of DNA replication by Cdk phosphorylation of HsCdc6.
10347142 Feedback regulation of beta-arrestin1 function by extracellular signal-regulated kinases.
10347170 Ca2+/calmodulin-dependent kinase II phosphorylates the epidermal growth factor receptor on multiple sites in the cytoplasmic tail and serine 744 within the kinase domain to regulate signal generation.
10348343 The double-stranded RNA activated protein kinase PKR physically associates with the tumor suppressor p53 protein and phosphorylates human p53 on serine 392 in vitro.
10350471 Proteolysis of blood coagulation factor VIII by the factor VIIa-tissue factor complex: generation of an inactive factor VIII cofactor.
10350489 Regulation of PTP1B via glutathionylation of the active site cysteine 215.
10357815 Serum and glucocorticoid-inducible kinase (SGK) is a target of the PI 3-kinase-stimulated signaling pathway.
10358014 Negative regulation of the forkhead transcription factor FKHR by Akt.
10358049 Crystal structure of human gastric lipase and model of lysosomal acid lipase, two lipolytic enzymes of medical interest.
10359578 BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth.
10362354 Regulation and function of protein kinase B and MAP kinase activation by the IL-5/GM-CSF/IL-3 receptor.
10364159 Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism.
10364201 Calnexin interaction with N-glycosylation mutants of a polytopic membrane glycoprotein, the human erythrocyte anion exchanger 1 (band 3).
10364220 Structure and function of human prepro-orexin gene.
10364224 Identification of the cell cycle regulator VCP (p97/CDC48) as a substrate of the band 4.1-related protein-tyrosine phosphatase PTPH1.
10364453 Identification and characterization of a myristylated and palmitylated serine/threonine protein kinase.
10368301 Crystal structure of the kinase domain of human vascular endothelial growth factor receptor 2: a key enzyme in angiogenesis.
10372802 Intensification of growth factor receptor signalling by phorbol treatment of ligand-primed cells implies a dimer-stabilizing effect of protein kinase C-dependent juxtamembrane domain phosphorylation.
10373416 CAST, a novel CD3epsilon-binding protein transducing activation signal for interleukin-2 production in T cells.
10373465 Phosphorylation at the cyclin-dependent kinases site (Thr85) of parathyroid hormone-related protein negatively regulates its nuclear localization.
10373500 ADAMTS-1 is an active metalloproteinase associated with the extracellular matrix.
10373531 Tyrosine phosphorylation of the proto-oncoprotein Raf-1 is regulated by Raf-1 itself and the phosphatase Cdc25A.
10373534 BRCA1 is phosphorylated at serine 1497 in vivo at a cyclin-dependent kinase 2 phosphorylation site.
10376603 Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation.
10377264 Identification of Tyr-703 and Tyr-936 as the primary association sites for Grb2 and Grb7 in the c-Kit/stem cell factor receptor.
10386950 Molecular cloning of testican-2: defining a novel calcium-binding proteoglycan family expressed in brain.
10386995 Glycosylation sites flank phosphorylation sites on synapsin I: O-linked N-acetylglucosamine residues are localized within domains mediating synapsin I interactions.
10391251 p73 is regulated by tyrosine kinase c-Abl in the apoptotic response to DNA damage.
10391677 SHP-2 binds to Tyr763 and Tyr1009 in the PDGF beta-receptor and mediates PDGF-induced activation of the Ras/MAP kinase pathway and chemotaxis.
10398585 Serine 32 and serine 36 of IkappaBalpha are directly phosphorylated by protein kinase CKII in vitro.
10400690 Regulation of neuronal nitric-oxide synthase by calmodulin kinases.
10400703 PTEN interactions with focal adhesion kinase and suppression of the extracellular matrix-dependent phosphatidylinositol 3-kinase/Akt cell survival pathway.
10403367 The small GTPases Rab5a, Rab5b and Rab5c are differentially phosphorylated in vitro.
10403822 Casein kinase 2 binds to and phosphorylates BRCA1.
10405182 Mutational analysis of sites in the translational regulator, PHAS-I, that are selectively phosphorylated by mTOR.
10409727 Mol Cell Biol. 1999 Aug;19(8):5363-72.
10409742 Kinase suppressor of Ras forms a multiprotein signaling complex and modulates MEK localization.
10411623 Site-directed removal of N-glycosylation sites in human gastric lipase.
10411640 Enzymatic action of human glandular kallikrein 2 (hK2). Substrate specificity and regulation by Zn2+ and extracellular protease inhibitors.
10411906 Suppression of apoptosis signal-regulating kinase 1-induced cell death by 14-3-3 proteins.
10412982 Endomembrane trafficking of ras: the CAAX motif targets proteins to the ER and Golgi.
10415030 CD45 negatively regulates lyn activity by dephosphorylating both positive and negative regulatory tyrosine residues in immature B cells.
10421793 IKK-i, a novel lipopolysaccharide-inducible kinase that is related to IkappaB kinases.
10428479 Cathepsin L is capable of truncating cystatin C of 11 N-terminal amino acids.
10428862 Independent SH2-binding sites mediate interaction of Dok-related protein with RasGTPase-activating protein and Nck.
10428966 Residues phosphorylated by TFIIH are required for E2F-1 degradation during S-phase.
10432301 Caspase-mediated cleavage of eukaryotic translation initiation factor subunit 2alpha.
10435619 Cleavage and relocation of the tyrosine kinase P59FYN during Fas-mediated apoptosis in T lymphocytes.
10436156 Requirement of Rsk-2 for epidermal growth factor-activated phosphorylation of histone H3.
10438520 Caspase-6 role in apoptosis of human neurons, amyloidogenesis, and Alzheimer's disease.
10438732 Proteolytic processing of big endothelin-3 by the kell blood group protein.
10439036 Evidence for an important role of serine 16 and its phosphorylation in the stabilization of c-Mos.
10441128 Phosphorylation and activation of phospholipase D1 by protein kinase C in vivo: determination of multiple phosphorylation sites.
10441130 Identification of the sites phosphorylated by cyclic AMP-dependent protein kinase on the beta 2 subunit of L-type voltage-dependent calcium channels.
10441371 Distinct but dispensable N-glycosylation of human CD69 proteins.
10445857 Biological and biochemical properties of Ret with kinase domain mutations identified in multiple endocrine neoplasia type 2B and familial medullary thyroid carcinoma.
10446129 The prostacyclin receptor is isoprenylated. Isoprenylation is required for efficient receptor-effector coupling.
10446210 G protein-coupled receptor kinase 6A phosphorylates the Na(+)/H(+) exchanger regulatory factor via a PDZ domain-mediated interaction.
10446219 Protein kinase C delta associates with and phosphorylates Stat3 in an interleukin-6-dependent manner.
10448092 The DNA-binding and transcriptional activities of MAZ, a myc-associated zinc finger protein, are regulated by casein kinase II.
10449420 Phosphorylation of splicing factor SF1 on Ser20 by cGMP-dependent protein kinase regulates spliceosome assembly.
10449753 Leptin receptor activation of SH2 domain containing protein tyrosine phosphatase 2 modulates Ob receptor signal transduction.
10454575 Insulin-induced phosphorylation and activation of cyclic nucleotide phosphodiesterase 3B by the serine-threonine kinase Akt.
10455013 Phosphorylation of Ser-241 is essential for the activity of 3-phosphoinositide-dependent protein kinase-1: identification of five sites of phosphorylation in vivo.
10455026 Palmitoylation of the recombinant human A1 adenosine receptor: enhanced proteolysis of palmitoylation-deficient mutant receptors.
10467162 Mutational analysis of the regulatory mechanism of PKN: the regulatory region of PKN contains an arachidonic acid-sensitive autoinhibitory domain.
10469173 Changes in nuclear morphology during apoptosis correlate with vimentin cleavage by different caspases located either upstream or downstream of Bcl-2 action.
10469655 NF-kappaB p105 is a target of IkappaB kinases and controls signal induction of Bcl-3-p50 complexes.
10469656 The nucleosomal response associated with immediate-early gene induction is mediated via alternative MAP kinase cascades: MSK1 as a potential histone H3/HMG-14 kinase.
10473631 Insulin-induced stimulation of Na+,K(+)-ATPase activity in kidney proximal tubule cells depends on phosphorylation of the alpha-subunit at Tyr-10.
10477722 Identification of a 14-3-3 binding sequence in the common beta chain of the granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-3 (IL-3), and IL-5 receptors that is serine-phosphorylated by GM-CSF.
10479448 Mammalian BMP-1/Tolloid-related metalloproteinases, including novel family member mammalian Tolloid-like 2, have differential enzymatic activities and distributions of expression relevant to patterning and skeletogenesis.
10479680 Neuronal interleukin-16 (NIL-16): a dual function PDZ domain protein.
10480872 The CLK family kinases, CLK1 and CLK2, phosphorylate and activate the tyrosine phosphatase, PTP-1B.
10480873 Protein phosphatase 2C inactivates F-actin binding of human platelet moesin.
10480933 90-kDa ribosomal S6 kinase is phosphorylated and activated by 3-phosphoinositide-dependent protein kinase-1.
10482988 SHC and SHIP phosphorylation and interaction in response to activation of the FLT3 receptor.
10485710 NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase.
10488096 SHP-1 regulates Lck-induced phosphatidylinositol 3-kinase phosphorylation and activity.
10490026 Acinus is a caspase-3-activated protein required for apoptotic chromatin condensation.
10490839 The transmembranal and cytoplasmic forms of protein tyrosine phosphatase epsilon physically associate with the adaptor molecule Grb2.
10498895 Phosphorylation at Tyr-838 in the kinase domain of EphA8 modulates Fyn binding to the Tyr-615 site by enhancing tyrosine kinase activity.
10500146 Regulation of cyclin-dependent kinase 5 catalytic activity by phosphorylation.
10501226 Phosphorylation of serine-880 in GluR2 by protein kinase C prevents its C terminus from binding with glutamate receptor-interacting protein.
10504264 Transient palmitoylation supports H-Ras membrane binding but only partial biological activity.
10508159 Cathepsin D targeted by acid sphingomyelinase-derived ceramide.
10508618 Recruitment of Dok-R to the EGF receptor through its PTB domain is required for attenuation of Erk MAP kinase activation.
10512690 Inflammation-related neutrophil proteases, cathepsin G and elastase, function as insulin-like growth factor binding protein proteases.
10518318 Arginine methylation of a glycine and arginine rich peptide derived from sequences of human FMRP and fibrillarin.
10521265 Partial glycosylation of Asn2181 in human factor V as a cause of molecular and functional heterogeneity. Modulation of glycosylation efficiency by mutagenesis of the consensus sequence for N-linked glycosylation.
10521396 Cleavage of the death domain kinase RIP by caspase-8 prompts TNF-induced apoptosis.
10521483 Identification of Tek/Tie2 binding partners. Binding to a multifunctional docking site mediates cell survival and migration.
10521505 Serine phosphorylation and negative regulation of Stat3 by JNK.
10521512 Regulation of bad phosphorylation and association with Bcl-x(L) by the MAPK/Erk kinase.
10523317 The replication factory targeting sequence/PCNA-binding site is required in G(1) to control the phosphorylation status of DNA ligase I.
10523642 JSAP1, a novel jun N-terminal protein kinase (JNK)-binding protein that functions as a Scaffold factor in the JNK signaling pathway.
10531036 Regulation of ARNO nucleotide exchange by a PH domain electrostatic switch.
10531052 Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE.
10531334 Serine 19 of human 6-pyruvoyltetrahydropterin synthase is phosphorylated by cGMP protein kinase II.
10533983 The TrkB receptor tyrosine kinase regulates cellular proliferation via signal transduction pathways involving SHC, PLCgamma, and CBL.
10537138 Role of N-linked glycosylation on the function and expression of the human secretin receptor.
10537323 Signaling pathways and structural domains required for phosphorylation of EMS1/cortactin.
10541800 Cloning of a new lectin-like receptor expressed on human NK cells.
10542228 The role of DOC-2/DAB2 protein phosphorylation in the inhibition of AP-1 activity. An underlying mechanism of its tumor-suppressive function in prostate cancer.
10542239 Identification of inhibitory autophosphorylation sites in casein kinase I epsilon.
10542248 Biosynthesis of vascular endothelial growth factor-D involves proteolytic processing which generates non-covalent homodimers.
10542257 The interferon-induced double-stranded RNA-activated protein kinase PKR will phosphorylate serine, threonine, or tyrosine at residue 51 in eukaryotic initiation factor 2alpha.
10542266 Heregulin induces phosphorylation of BRCA1 through phosphatidylinositol 3-Kinase/AKT in breast cancer cells.
10544291 Neuron-specific Cdk5 kinase is responsible for mitosis-independent phosphorylation of c-Src at Ser75 in human Y79 retinoblastoma cells.
10548550 Characterization of the structure and regulation of two novel isoforms of serum- and glucocorticoid-induced protein kinase.
10550055 Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks.
10551811 Regulation of c-Myc through phosphorylation at Ser-62 and Ser-71 by c-Jun N-terminal kinase.
10551839 The four terminal components of the complement system are C-mannosylated on multiple tryptophan residues.
10556562 Carbohydrate moieties in human secretory component.
10556651 Process of carboxylation of glutamic acid residues in the gla domain of human des-gamma-carboxyprothrombin.
10557092 The physical association and phosphorylation of Cdc25C protein phosphatase by Prk.
10559204 Human JIK, a novel member of the STE20 kinase family that inhibits JNK and is negatively regulated by epidermal growth factor.
10559254 The kinesin-like motor protein KIF1C occurs in intact cells as a dimer and associates with proteins of the 14-3-3 family.
10559936 Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics.
10559944 Crosstalk between cAMP-dependent kinase and MAP kinase through a protein tyrosine phosphatase.
10564259 Mechanisms of G2 arrest in response to overexpression of p53.
10564664 Caspase-3 and caspase-7 but not caspase-6 cleave Gas2 in vitro: implications for microfilament reorganization during apoptosis.
10567342 Functional regulation of L-type calcium channels via protein kinase A-mediated phosphorylation of the beta(2) subunit.
10567568 Glycogen synthase kinase 3 is an insulin-regulated C/EBPalpha kinase.
10567572 BCL-2 is phosphorylated and inactivated by an ASK1/Jun N-terminal protein kinase pathway normally activated at G(2)/M.
10567720 Kinetic mechanism and ATP-binding site reactivity of p38gamma MAP kinase.
10570155 An Eph receptor regulates integrin activity through R-Ras.
10570256 Cutting edge: SLP-76 cooperativity with FYB/FYN-T in the Up-regulation of TCR-driven IL-2 transcription requires SLP-76 binding to FYB at Tyr595 and Tyr651.
10571231 A phospho-switch controls the dynamic association of synapsins with synaptic vesicles.
10572014 Multiple in vivo tyrosine phosphorylation sites in EphB receptors.
10574913 Feedback inhibition of G protein-coupled receptor kinase 2 (GRK2) activity by extracellular signal-regulated kinases.
10574929 The novel kinase peptidylglycine alpha-amidating monooxygenase cytosolic interactor protein 2 interacts with the cytosolic routing determinants of the peptide processing enzyme peptidylglycine alpha-amidating monooxygenase.
10574931 Functional interaction between SHPTP1 and the Lyn tyrosine kinase in the apoptotic response to DNA damage.
10574968 Balance between activities of Rho kinase and type 1 protein phosphatase modulates turnover of phosphorylation and dynamics of desmin/vimentin filaments.
10576742 Phosphorylation and regulation of Raf by Akt (protein kinase B).
10579917 Signaling via vascular endothelial growth factor receptors.
10581160 A GSK3beta phosphorylation site in axin modulates interaction with beta-catenin and Tcf-mediated gene expression.
10582246 Control of NF-kappa B transcriptional activation by signal induced proteolysis of I kappa B alpha.
10587587 Ser298 of MITF, a mutation site in Waardenburg syndrome type 2, is a phosphorylation site with functional significance.
10593981 Phosphorylation of B-Myb regulates its transactivation potential and DNA binding.
10601309 Inhibitory phosphorylation site for Rho-associated kinase on smooth muscle myosin phosphatase.
10601311 Evidence that 3-phosphoinositide-dependent protein kinase-1 mediates phosphorylation of p70 S6 kinase in vivo at Thr-412 as well as Thr-252.
10602493 Caspase-mediated cleavage and functional changes of hematopoietic progenitor kinase 1 (HPK1).
10604470 Ghrelin is a growth-hormone-releasing acylated peptide from stomach.
10604473 Phosphorylation of DARPP-32 by Cdk5 modulates dopamine signalling in neurons.
10604721 Generation of angiostatin-like fragments from plasminogen by prostate-specific antigen.
10605825 In vitro processing of amyloid precursor protein by cathepsin D.
10606744 Protein kinase CK1 is a p53-threonine 18 kinase which requires prior phosphorylation of serine 15.
10608806 Substrate specificities and identification of putative substrates of ATM kinase family members.
10608812 Human rabaptin-5 is selectively cleaved by caspase-3 during apoptosis.
10608901 Palmitoylation of a conserved cysteine in the regulator of G protein signaling (RGS) domain modulates the GTPase-activating activity of RGS4 and RGS10.
10617468 Reduced MAP kinase phosphatase-1 degradation after p42/p44MAPK-dependent phosphorylation.
10617630 Constitutive phosphorylation of the Parkinson's disease associated alpha-synuclein.
10617634 Akt protein kinase inhibits Rac1-GTP binding through phosphorylation at serine 71 of Rac1.
10617656 Cytosolic tyrosine dephosphorylation of STAT5. Potential role of SHP-2 in STAT5 regulation.
10618483 Palmitoylation occurs at cysteine 347 and cysteine 351 of the dopamine D(1) receptor.
10618498 Phosphorylation of the Spi-B transcription factor reduces its intrinsic stability.
10619020 Acetylation of MyoD directed by PCAF is necessary for the execution of the muscle program.
10620507 14-3-3 isotypes facilitate coupling of protein kinase C-zeta to Raf-1: negative regulation by 14-3-3 phosphorylation.
10625670 Five members of a novel Ca(2+)-binding protein (CABP) subfamily with similarity to calmodulin.
10629060 Interaction of a mitogen-activated protein kinase signaling module with the neuronal protein JIP3.
10635327 Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1.
10635333 Phosphorylation of rat serine 105 or mouse threonine 217 in C/EBP beta is required for hepatocyte proliferation induced by TGF alpha.
10636877 Architecture of high mobility group protein I-C.DNA complex and its perturbation upon phosphorylation by Cdc2 kinase.
10637231 A nuclear tyrosine phosphorylation circuit: c-Jun as an activator and substrate of c-Abl and JNK.
10640736 Phosphorylation of FADD/ MORT1 at serine 194 and association with a 70-kDa cell cycle-regulated protein kinase.
10642499 The regulation of AMP-activated protein kinase by phosphorylation.
10642527 LKB1, a novel serine/threonine protein kinase and potential tumour suppressor, is phosphorylated by cAMP-dependent protein kinase (PKA) and prenylated in vivo.
10644439 Identification of FLRT1, FLRT2, and FLRT3: a novel family of transmembrane leucine-rich repeat proteins.
10644685 Biosynthesis and enzymatic characterization of human SKI-1/S1P and the processing of its inhibitory prosegment.
10644693 The human Cdc14 phosphatases interact with and dephosphorylate the tumor suppressor protein p53.
10644707 Identification of a human brain-specific isoform of mammalian STE20-like kinase 3 that is regulated by cAMP-dependent protein kinase.
10646852 A novel form of prostate-specific antigen transcript produced by alternative splicing.
10648599 Extracellular signal-regulated kinase binds to TFII-I and regulates its activation of the c-fos promoter.
10648825 Phosphorylation of the skeletal muscle glycogen-targetting subunit of protein phosphatase 1 in response to adrenaline in vivo.
10650937 The effect of phosphorylation by casein kinase 2 on the activity of insulin-like growth factor-binding protein-3.
10652353 Rho-associated kinase ROCK activates LIM-kinase 1 by phosphorylation at threonine 508 within the activation loop.
10652356 Regulation of protein kinase Ctheta function during T cell activation by Lck-mediated tyrosine phosphorylation.
10653665 Phosphorylation of recombinant human ATP:citrate lyase by cAMP-dependent protein kinase abolishes homotropic allosteric regulation of the enzyme by citrate and increases the enzyme activity. Allosteric activation of ATP:citrate lyase by phosphorylated sugars.
10656688 Cell cycle regulated expression and phosphorylation of hpttg proto-oncogene product.
10656693 c-Myb acetylation at the carboxyl-terminal conserved domain by transcriptional co-activator p300.
10660534 Resting lymphocyte kinase (Rlk/Txk) targets lymphoid adaptor SLP-76 in the cooperative activation of interleukin-2 transcription in T-cells.
10660621 Phosphorylation of steroid receptor coactivator-1. Identification of the phosphorylation sites and phosphorylation through the mitogen-activated protein kinase pathway.
10660622 Polysialyltransferase-1 autopolysialylation is not requisite for polysialylation of neural cell adhesion molecule.
10669731 Nck-interacting Ste20 kinase couples Eph receptors to c-Jun N-terminal kinase and integrin activation.
10669745 Tyrosine phosphorylation mediates both activation and downmodulation of the biological activity of Vav.
10669763 Posttranslational modification of Bcl-2 facilitates its proteasome-dependent degradation: molecular characterization of the involved signaling pathway.
10671526 Binding and phosphorylation of a novel male germ cell-specific cGMP-dependent protein kinase-anchoring protein by cGMP-dependent protein kinase Ialpha.
10671544 Apoptotic cleavage of scaffold attachment factor A (SAF-A) by caspase-3 occurs at a noncanonical cleavage site.
10671552 Casein kinase II phosphorylation of E-cadherin increases E-cadherin/beta-catenin interaction and strengthens cell-cell adhesion.
10671558 Direct cleavage by the calcium-activated protease calpain can lead to inactivation of caspases.
10672017 Changes in integrity and association of eukaryotic protein synthesis initiation factors during apoptosis.
10673501 The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites.
10675528 Prothymosin alpha fragmentation in apoptosis.
10677483 Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein.
10679026 Palmitoylation of apolipoprotein B is required for proper intracellular sorting and transport of cholesteroyl esters and triglycerides.
10679189 Evidence for the carboxyl methylation of nuclear lamin-B in the pancreatic beta cell.
10681522 Dissecting the interaction of SHP-2 with PZR, an immunoglobulin family protein containing immunoreceptor tyrosine-based inhibitory motifs.
10681529 Cysteine-rich protein 2, a novel substrate for cGMP kinase I in enteric neurons and intestinal smooth muscle.
10681541 The Chk1 protein kinase and the Cdc25C regulatory pathways are targets of the anticancer agent UCN-01.
10683417 The neuronal EF-hand calcium-binding protein visinin-like protein-3 is expressed in cerebellar Purkinje cells and shows a calcium-dependent membrane association.
10688651 Etk, a Btk family tyrosine kinase, mediates cellular transformation by linking Src to STAT3 activation.
10694430 Regulation of microphthalmia-associated transcription factor MITF protein levels by association with the ubiquitin-conjugating enzyme hUBC9.
10698938 A phosphotyrosine displacement mechanism for activation of Src by PTPalpha.
10699974 Intestinal cell kinase (ICK) localizes to the crypt region and requires a dual phosphorylation site found in map kinases.
10702256 SPACRCAN, a novel human interphotoreceptor matrix hyaluronan-binding proteoglycan synthesized by photoreceptors and pinealocytes.
10702316 FKBP12-rapamycin-associated protein (FRAP) autophosphorylates at serine 2481 under translationally repressive conditions.
10702794 The MAP-kinase ERK2 is a specific substrate of the protein tyrosine phosphatase HePTP.
10706702 Systematic analysis of the role of CD19 cytoplasmic tyrosines in enhancement of activation in Daudi human B cells: clustering of phospholipase C and Vav and of Grb2 and Sos with different CD19 tyrosines.
10708851 S-nitrosylated human alpha(1)-protease inhibitor.
10710543 Prostaglandin E(2) interaction with AVP: effects on AQP2 phosphorylation and distribution.
10712510 Caspase-mediated cleavage of p130cas in etoposide-induced apoptotic Rat-1 cells.
10715123 Detailed analysis of the phosphorylation of the human La (SS-B) autoantigen. (De)phosphorylation does not affect its subcellular distribution.
10715136 Activation of JNK3 alpha 1 requires both MKK4 and MKK7: kinetic characterization of in vitro phosphorylated JNK3 alpha 1.
10715549 Additional N-glycosylation at Asn(13) rescues the human LHbeta-subunit from disulfide-linked aggregation.
10716671 The human two domain trefoil protein, TFF2, is glycosylated in vivo in the stomach.
10722662 The roles of carbohydrate chains of the beta-subunit on the functional expression of gastric H(+),K(+)-ATPase.
10722755 The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307).
10723127 Activation of NF-kappa B by the dsRNA-dependent protein kinase, PKR involves the I kappa B kinase complex.
10724175 hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response.
10727525 Agonist-dependent modulation of G protein-coupled receptor kinase 2 by mitogen-activated protein kinases.
10727951 Structural characterization of the oligosaccharide chains of human alpha1-microglobulin from urine and amniotic fluid.
10728420 Human connexin40 gap junction channels are modulated by cAMP.
10734073 Identification of caspase 3-mediated cleavage and functional alteration of eukaryotic initiation factor 2alpha in apoptosis.
10734227 Distinct versus redundant properties among members of the INK4 family of cyclin-dependent kinase inhibitors.
10734310 Sustained recruitment of phospholipase C-gamma to Gab1 is required for HGF-induced branching tubulogenesis.
10737616 Phosphorylation sites on tau identified by nanoelectrospray mass spectrometry: differences in vitro between the mitogen-activated protein kinases ERK2, c-Jun N-terminal kinase and P38, and glycogen synthase kinase-3beta.
10739259 Phosphorylation and subcellular redistribution of high mobility group proteins 14 and 17, analyzed by mass spectrometry.
10744722 Caffeine abolishes the mammalian G(2)/M DNA damage checkpoint by inhibiting ataxia-telangiectasia-mutated kinase activity.
10744726 Tumor necrosis factor-alpha-converting enzyme is required for cleavage of erbB4/HER4.
10747894 The C-terminal RG dipeptide repeats of the spliceosomal Sm proteins D1 and D3 contain symmetrical dimethylarginines, which form a major B-cell epitope for anti-Sm autoantibodies.
10747897 Stress-induced activation of protein kinase CK2 by direct interaction with p38 mitogen-activated protein kinase.
10747909 Galpha 13 requires palmitoylation for plasma membrane localization, Rho-dependent signaling, and promotion of p115-RhoGEF membrane binding.
10747914 Prenylation-dependent association of protein-tyrosine phosphatases PRL-1, -2, and -3 with the plasma membrane and the early endosome.
10747973 c-Jun NH2-terminal kinase targeting and phosphorylation of heat shock factor-1 suppress its transcriptional activity.
10748018 Phosphorylation of myosin light chain kinase by p21-activated kinase PAK2.
10749680 The Shc-related adaptor protein, Sck, forms a complex with the vascular-endothelial-growth-factor receptor KDR in transfected cells.
10753652 Skeletal muscle CaMKII enriches in nuclei and phosphorylates myogenic factor SRF at multiple sites.
10753910 Rho GTPase control of protein kinase C-related protein kinase activation by 3-phosphoinositide-dependent protein kinase.
10753971 Acetylation of novel sites in the nucleosomal binding domain of chromosomal protein HMG-14 by p300 alters its interaction with nucleosomes.
10756055 N-linked glycosylation of CXCR4 masks coreceptor function for CCR5-dependent human immunodeficiency virus type 1 isolates.
10760275 Membrane-associated GAIP is a phosphoprotein and can be phosphorylated by clathrin-coated vesicles.
10764745 Regulation of complex formation of POB1/epsin/adaptor protein complex 2 by mitotic phosphorylation.
10764799 Selective attenuation of metabolic branch of insulin receptor down-signaling by high glucose in a hepatoma cell line, HepG2 cells.
10766777 Phosphorylation of dynamin I on Ser-795 by protein kinase C blocks its association with phospholipids.
10769174 Shedding of somatic angiotensin-converting enzyme (ACE) is inefficient compared with testis ACE despite cleavage at identical stalk sites.
10770929 Inhibiting caspase cleavage of huntingtin reduces toxicity and aggregate formation in neuronal and nonneuronal cells.
10770950 Regulation of phospholipid scramblase activity during apoptosis and cell activation by protein kinase Cdelta.
10772824 The RGG domain in hnRNP A2 affects subcellular localization.
10772927 Phosphorylation of the 105-kDa heat shock proteins, HSP105alpha and HSP105beta, by casein kinase II.
10777477 Histone deacetylases specifically down-regulate p53-dependent gene activation.
10779345 Multiple mechanisms control phosphorylation of PHAS-I in five (S/T)P sites that govern translational repression.
10779355 IkappaB kinase alpha (IKKalpha) regulation of IKKbeta kinase activity.
10779504 p300 and p300/cAMP-response element-binding protein-associated factor acetylate the androgen receptor at sites governing hormone-dependent transactivation.
10779545 5-lipoxygenase is phosphorylated by p38 kinase-dependent MAPKAP kinases.
10783893 NAK is an IkappaB kinase-activating kinase.
10787408 Identification of p130cas as an in vivo substrate of receptor protein-tyrosine phosphatase alpha.
10791974 Caspase-2 is localized at the Golgi complex and cleaves golgin-160 during apoptosis.
10792047 Phosphorylation of protein kinase N by phosphoinositide-dependent protein kinase-1 mediates insulin signals to the actin cytoskeleton.
10799478 Membrane type 4 matrix metalloproteinase (MMP17) has tumor necrosis factor-alpha convertase activity but does not activate pro-MMP2.
10799545 Evidence that Llck-mediated phosphorylation of p56dok and p62dok may play a role in CD2 signaling.
10799548 Hck enhances the adherence of lipopolysaccharide-stimulated macrophages via Cbl and phosphatidylinositol 3-kinase.
10801418 Acetylation of importin-alpha nuclear import factors by CBP/p300.
10805734 Interaction between PAK and nck: a template for Nck targets and role of PAK autophosphorylation.
10805738 p38 and extracellular signal-regulated kinases regulate the myogenic program at multiple steps.
10805756 Phosphorylation of SOX9 by cyclic AMP-dependent protein kinase A enhances SOX9's ability to transactivate a Col2a1 chondrocyte-specific enhancer.
10805801 Molecular basis for a link between complement and the vascular complications of diabetes.
10806207 Control sites of ribosomal S6 kinase B and persistent activation through tumor necrosis factor.
10809756 Interactions between the exocytic and endocytic pathways in polarized Madin-Darby canine kidney cells.
10811661 Phosphorylation of human gp130 at Ser-782 adjacent to the Di-leucine internalization motif. Effects on expression and signaling.
10816433 The m3 muscarinic acetylcholine receptor is coupled to mitogen-activated protein kinase via protein kinase C and epidermal growth factor receptor kinase.
10816555 Deletion of the serotonin 5-HT2C receptor PDZ recognition motif prevents receptor phosphorylation and delays resensitization of receptor responses.
10816571 Interaction between endothelial differentiation-related factor-1 and calmodulin in vitro and in vivo.
10818093 Phosphorylation of collapsin response mediator protein-2 by Rho-kinase. Evidence for two separate signaling pathways for growth cone collapse.
10821277 ATF-2 has intrinsic histone acetyltransferase activity which is modulated by phosphorylation.
10821673 Effects of the N-linked glycans on the 3D structure of the free alpha-subunit of human chorionic gonadotropin.
10821867 Site-selective dephosphorylation of the platelet-derived growth factor beta-receptor by the receptor-like protein-tyrosine phosphatase DEP-1.
10823823 Cleavage of the actin-capping protein alpha -adducin at Asp-Asp-Ser-Asp633-Ala by caspase-3 is preceded by its phosphorylation on serine 726 in cisplatin-induced apoptosis of renal epithelial cells.
10828960 Monoclonal antibody light chain with prothrombinase activity.
10830164 PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts.
10830966 Neurotoxicity induces cleavage of p35 to p25 by calpain.
10831592 Localization of disulfide bonds in the cystine knot domain of human von Willebrand factor.
10833263 Studies on the phosphorylation of protein kinase B by Ca(2+)/calmodulin-dependent protein kinases.
10837138 Platelet-derived growth factor-mediated signaling through the Shb adaptor protein: effects on cytoskeletal organization.
10837251 Cyclic AMP regulates the HERG K(+) channel by dual pathways.
10837486 BAD Ser-155 phosphorylation regulates BAD/Bcl-XL interaction and cell survival.
10838074 Phosphorylation-dependent activation of TAK1 mitogen-activated protein kinase kinase kinase by TAB1.
10839544 Functional link between ataxia-telangiectasia and Nijmegen breakage syndrome gene products.
10839545 ATM phosphorylation of Nijmegen breakage syndrome protein is required in a DNA damage response.
10842184 Negative regulation of growth hormone receptor/JAK2 signaling by signal regulatory protein alpha.
10842319 Janus kinase 2 is associated with a box 1-like motif and phosphorylates a critical tyrosine residue in the cytoplasmic region of cytotoxic T lymphocyte associated molecule-4.
10844023 Phosphorylated syntaxin 1 is localized to discrete domains along a subset of axons.
10846177 Human Cdc7-related kinase complex. In vitro phosphorylation of MCM by concerted actions of Cdks and Cdc7 and that of a criticial threonine residue of Cdc7 bY Cdks.
10846184 Src-mediated tyrosine phosphorylation of NR2 subunits of N-methyl-D-aspartate receptors protects from calpain-mediated truncation of their C-terminal domains.
10849446 Big mitogen-activated kinase regulates multiple members of the MEF2 protein family.
10851017 Relationship between contact inhibition and intranuclear S100C of normal human fibroblasts.
10851066 Interaction between protein tyrosine phosphatase and protein tyrosine kinase is involved in androgen-promoted growth of human prostate cancer cells.
10851246 Regulation of human endothelial cell focal adhesion sites and migration by cGMP-dependent protein kinase I.
10852915 Farnesyl transferase inhibitors block the farnesylation of CENP-E and CENP-F and alter the association of CENP-E with the microtubules.
10852916 Synucleins are a novel class of substrates for G protein-coupled receptor kinases.
10852918 Activation of Ca2+/calmodulin-dependent protein kinase II within post-synaptic dendritic spines of cultured hippocampal neurons.
10859319 Matrix metalloproteinases cleave tissue factor pathway inhibitor. Effects on coagulation.
10864201 ATM protein and p53-serine 15 phosphorylation in ataxia-telangiectasia (AT) patients and at heterozygotes.
10866324 Role for ATM in DNA damage-induced phosphorylation of BRCA1.
10866658 Phosphorylation of the PTEN tail regulates protein stability and function.
10866685 The B56alpha regulatory subunit of protein phosphatase 2A is a target for regulation by double-stranded RNA-dependent protein kinase PKR.
10866806 Mutational analysis of arginine 177 in the nucleotide binding site of beta-actin.
10867018 Regulation of protein kinase D by multisite phosphorylation. Identification of phosphorylation sites by mass spectrometry and characterization by site-directed mutagenesis.
10869359 Negative regulation of the serine/threonine kinase B-Raf by Akt.
10871288 Phosphorylation of connexin43 on serine368 by protein kinase C regulates gap junctional communication.
10871631 Torsin A and its torsion dystonia-associated mutant forms are lumenal glycoproteins that exhibit distinct subcellular localizations.
10871840 Identification of Grb10 as a direct substrate for members of the Src tyrosine kinase family.
10874031 Inhibition of neuronal nitric-oxide synthase by calcium/ calmodulin-dependent protein kinase IIalpha through Ser847 phosphorylation in NG108-15 neuronal cells.
10877842 Thrombocidins, microbicidal proteins from human blood platelets, are C-terminal deletion products of CXC chemokines.
10878002 Properdin, the positive regulator of complement, is highly C-mannosylated.
10880354 Regulation of BAD by cAMP-dependent protein kinase is mediated via phosphorylation of a novel site, Ser155.
10880513 SHP2 mediates the protective effect of interleukin-6 against dexamethasone-induced apoptosis in multiple myeloma cells.
10884347 The C-terminal regulatory domain of p53 contains a functional docking site for cyclin A.
10887202 Characterization of Alzheimer's beta -secretase protein BACE. A pepsin family member with unusual properties.
10889209 Glycosylation of GIRK1 at Asn119 and ROMK1 at Asn117 has different consequences in potassium channel function.
10891503 Identification of the cytolinker plectin as a major early in vivo substrate for caspase 8 during CD95- and tumor necrosis factor receptor-mediated apoptosis.
10893227 The low pH in trans-Golgi triggers autocatalytic cleavage of pre-alpha -inhibitor heavy chain precursor.
10893432 Molecular analysis of the sodium/iodide symporter: impact on thyroid and extrathyroid pathophysiology.
10896159 Cables links Cdk5 and c-Abl and facilitates Cdk5 tyrosine phosphorylation, kinase upregulation, and neurite outgrowth.
10896916 Alpha(2) adrenoceptors regulate proliferation of human intestinal epithelial cells.
10896934 Threonine phosphorylation of the beta 3 integrin cytoplasmic tail, at a site recognized by PDK1 and Akt/PKB in vitro, regulates Shc binding.
10898738 VACM-1, a cullin gene family member, regulates cellular signaling.
10899625 Angiotensin II generation by mast cell alpha- and beta-chymases.
10903717 FDF03, a novel inhibitory receptor of the immunoglobulin superfamily, is expressed by human dendritic and myeloid cells.
10910062 A direct linkage between the phosphoinositide 3-kinase-AKT signaling pathway and the mammalian target of rapamycin in mitogen-stimulated and transformed cells.
10910078 Mirk protein kinase is a mitogen-activated protein kinase substrate that mediates survival of colon cancer cells.
10910365 Functional link of BRCA1 and ataxia telangiectasia gene product in DNA damage response.
10910956 A potential mechanism for fumonisin B(1)-mediated hepatocarcinogenesis: cyclin D1 stabilization associated with activation of Akt and inhibition of GSK-3beta activity.
10911985 Synergistic coupling of histone H3 phosphorylation and acetylation in response to epidermal growth factor stimulation.
10911986 Phosphorylation of serine 10 in histone H3 is functionally linked in vitro and in vivo to Gcn5-mediated acetylation at lysine 14.
10915800 MAP kinases Erk1/2 phosphorylate sterol regulatory element-binding protein (SREBP)-1a at serine 117 in vitro.
10918587 Transformation and Stat activation by derivatives of FGFR1, FGFR3, and FGFR4.
10921917 Cell volume-dependent phosphorylation of proteins of the cortical cytoskeleton and cell-cell contact sites. The role of Fyn and FER kinases.
10921922 Intracellular signaling mechanisms leading to synergistic effects of endothelin-1 and stem cell factor on proliferation of cultured human melanocytes. Cross-talk via trans-activation of the tyrosine kinase c-kit receptor.
10922374 KT5823 inhibits cGMP-dependent protein kinase activity in vitro but not in intact human platelets and rat mesangial cells.
10922491 Acylation of Galpha(13) is important for its interaction with thrombin receptor, transforming activity and actin stress fiber formation.
10930399 Matrix metalloproteinases collagenase-2, macrophage elastase, collagenase-3, and membrane type 1-matrix metalloproteinase impair clotting by degradation of fibrinogen and factor XII.
10931181 Processing of synthetic pro-islet amyloid polypeptide (proIAPP) 'amylin' by recombinant prohormone convertase enzymes, PC2 and PC3, in vitro.
10931940 BACE2, a beta -secretase homolog, cleaves at the beta site and within the amyloid-beta region of the amyloid-beta precursor protein.
10933394 CD19 regulates Src family protein tyrosine kinase activation in B lymphocytes through processive amplification.
10934191 Modulation of the catalytic activity of the Src family tyrosine kinase Hck by autophosphorylation at a novel site in the unique domain.
10934208 Dephosphorylation of human cyclin-dependent kinases by protein phosphatase type 2C alpha and beta 2 isoforms.
10936190 Neuron-specific phosphorylation of Alzheimer's beta-amyloid precursor protein by cyclin-dependent kinase 5.
10940639 Structure-function and biological role of betacellulin.
10942405 Sequential phosphorylation of protein band 3 by Syk and Lyn tyrosine kinases in intact human erythrocytes: identification of primary and secondary phosphorylation sites.
10942766 Mitotic phosphorylation of DNA topoisomerase II alpha by protein kinase CK2 creates the MPM-2 phosphoepitope on Ser-1469.
10942774 Mammalian target of rapamycin-dependent phosphorylation of PHAS-I in four (S/T)P sites detected by phospho-specific antibodies.
10944113 Mechanism of regulation of the hypoxia-inducible factor-1 alpha by the von Hippel-Lindau tumor suppressor protein.
10944526 CREB-binding protein/p300 activates MyoD by acetylation.
10945988 Association of immature hypophosphorylated protein kinase cepsilon with an anchoring protein CG-NAP.
10945993 Phosphorylation of protein kinase Cdelta on distinct tyrosine residues regulates specific cellular functions.
10945997 cAMP-dependent protein kinase phosphorylation of EVL, a Mena/VASP relative, regulates its interaction with actin and SH3 domains.
10947801 Localization and targeting of SCG10 to the trans-Golgi apparatus and growth cone vesicles.
10947989 Inflammation dampened by gelatinase A cleavage of monocyte chemoattractant protein-3.
10949026 14-3-3 proteins and survival kinases cooperate to inactivate BAD by BH3 domain phosphorylation.
10949034 Activation of estrogen receptor alpha by S118 phosphorylation involves a ligand-dependent interaction with TFIIH and participation of CDK7.
10951572 The human vaccinia-related kinase 1 (VRK1) phosphorylates threonine-18 within the mdm-2 binding site of the p53 tumour suppressor protein.
10953014 Tyrosine phosphorylation of Eps15 is required for ligand-regulated, but not constitutive, endocytosis.
10954418 Membrane localization and biological activity of SNAP-25 cysteine mutants in insulin-secreting cells.
10954746 Relative role of heme nitrosylation and beta-cysteine 93 nitrosation in the transport and metabolism of nitric oxide by hemoglobin in the human circulation.
10958788 Cross-linking of wild-type and mutant alpha 2-antiplasmins to fibrin by activated factor XIII and by a tissue transglutaminase.
10959835 Dab1 tyrosine phosphorylation sites relay positional signals during mouse brain development.
10961862 Cleavage by CD26/dipeptidyl peptidase IV converts the chemokine LD78beta into a most efficient monocyte attractant and CCR1 agonist.
10961885 Importance of the MKK6/p38 pathway for interleukin-12-induced STAT4 serine phosphorylation and transcriptional activity.
10961987 Phosphorylation of the beta-galactoside-binding protein galectin-3 modulates binding to its ligands.
10962009 Activation of hepatocyte growth factor and urokinase/plasminogen activator by matriptase, an epithelial membrane serine protease.
10963790 alpha(2)-plasmin inhibitor is a substrate for tissue transglutaminase: an in vitro study.
10966857 Translational regulation of proinsulin biosynthesis and proinsulin conversion in the pancreatic beta-cell.
10967118 Inactivation of plasminogen activator inhibitor-1 by specific proteolysis with stromelysin-1 (MMP-3).
10969042 A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9.
10969067 The neuropeptide processing enzyme EC 18.104.22.168 is modulated by protein kinase A phosphorylation.
10970850 Ezrin function is required for ROCK-mediated fibroblast transformation by the Net and Dbl oncogenes.
10973490 Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro.
10975838 Serine 6 of Lck tyrosine kinase: a critical site for Lck myristoylation, membrane localization, and function in T lymphocytes.
10978165 Posttranslationally processed forms of the human chemokine HCC-1.
10978167 Proteolysis of the exodomain of recombinant protease-activated receptors: prediction of receptor activation or inactivation by MALDI mass spectrometry.
10978177 Identification of major tyrosine phosphorylation sites in the human insulin receptor substrate Gab-1 by insulin receptor kinase in vitro.
10978317 Serine 727 phosphorylation and activation of cytosolic phospholipase A2 by MNK1-related protein kinases.
10980603 SPAK, a STE20/SPS1-related kinase that activates the p38 pathway.
10982389 Exposure at the cell surface is required for gas3/PMP22 To regulate both cell death and cell spreading: implication for the Charcot-Marie-Tooth type 1A and Dejerine-Sottas diseases.
10982844 Regulation of STAT1 nuclear export by Jak1.
10986281 Brevican is degraded by matrix metalloproteinases and aggrecanase-1 (ADAMTS4) at different sites.
10993082 TFIIH is negatively regulated by cdk8-containing mediator complexes.
10993892 Erk1/2-dependent phosphorylation of Galpha-interacting protein stimulates its GTPase accelerating activity and autophagy in human colon cancer cells.
10993906 Identification of a novel immunoreceptor tyrosine-based activation motif-containing molecule, STAM2, by mass spectrometry and its involvement in growth factor and cytokine receptor signaling pathways.
10995762 p21-activated kinase (PAK1) is phosphorylated and activated by 3-phosphoinositide-dependent kinase-1 (PDK1).
10998058 Caspase-3 mediated cleavage of HsRad51 at an unconventional site.
10998246 N-terminal sequences direct the autophosphorylation states of the FER tyrosine kinases in vivo.
10998417 Identification and cloning of Kidins220, a novel neuronal substrate of protein kinase D.
11004509 Functional cloning and mutational analysis of the human cDNA for phosphoacetylglucosamine mutase: identification of the amino acid residues essential for the catalysis.
11004567 Phosphohexose isomerase/autocrine motility factor/neuroleukin/maturation factor is a multifunctional phosphoprotein.
11007774 Identification of protein-tyrosine phosphatase 1B as the major tyrosine phosphatase activity capable of dephosphorylating and activating c-Src in several human breast cancer cell lines.
11007883 Phosphorylation of the AMPA receptor subunit GluR2 differentially regulates its interaction with PDZ domain-containing proteins.
11016947 Activation of atypical protein kinase C zeta by caspase processing and degradation by the ubiquitin-proteasome system.
11017939 Production and characterization of novel anti-prostate-specific antigen (PSA) monoclonal antibodies that do not detect internally cleaved Lys145-Lys146 inactive PSA.
11018042 Specific activation of LIM kinase 2 via phosphorylation of threonine 505 by ROCK, a Rho-dependent protein kinase.
11018520 MSK1 is required for CREB phosphorylation in response to mitogens in mouse embryonic stem cells.
11020388 Phosphorylation of p300 at serine 89 by protein kinase C.
11023497 Neutrophil gelatinase B potentiates interleukin-8 tenfold by aminoterminal processing, whereas it degrades CTAP-III, PF-4, and GRO-alpha and leaves RANTES and MCP-2 intact.
11024037 Regulation of Cbl molecular interactions by the co-receptor molecule CD43 in human T cells.
11024467 Crystal structure of S-glutathiolated carbonic anhydrase III.
11027273 ets-2 is a target for an akt (Protein kinase B)/jun N-terminal kinase signaling pathway in macrophages of motheaten-viable mutant mice.
11027280 Inactivation of smad-transforming growth factor beta signaling by Ca(2+)-calmodulin-dependent protein kinase II.
11027412 Enzymatic action of prostate-specific antigen (PSA or hK3): substrate specificity and regulation by Zn(2+), a tight-binding inhibitor.
11029056 Phosphorylation-dependent localization of microtubule-associated protein MAP2c to the actin cytoskeleton.
11030334 Concerted dephosphorylation of the transcription factor NFAT1 induces a conformational switch that regulates transcriptional activity.
11032419 Regulation of DNA binding activity of the ligand-activated aryl hydrocarbon receptor by tyrosine phosphorylation.
11032800 Post-translational hydroxylation at the N-terminus of the prion protein reveals presence of PPII structure in vivo.
11032810 Activation of B-Raf kinase requires phosphorylation of the conserved residues Thr598 and Ser601.
11034606 FIST/HIPK3: a Fas/FADD-interacting serine/threonine kinase that induces FADD phosphorylation and inhibits fas-mediated Jun NH(2)-terminal kinase activation.
11035810 Phosphorylation and inactivation of glycogen synthase kinase 3 by protein kinase A.
11039908 The mitotic serine/threonine kinase Aurora2/AIK is regulated by phosphorylation and degradation.
11040053 Identification of G protein-coupled receptor kinase 2 phosphorylation sites responsible for agonist-stimulated delta-opioid receptor phosphorylation.
11042170 Domain-dependent function of the rasGAP-binding protein p62Dok in cell signaling.
11042191 Phosphorylation of GRK2 by protein kinase C abolishes its inhibition by calmodulin.
11042209 The SH2 domain containing tyrosine phosphatase-1 down-regulates activation of Lyn and Lyn-induced tyrosine phosphorylation of the CD19 receptor in B cells.
11042212 Regulation of apoptosis by phosphatidylinositol 4,5-bisphosphate inhibition of caspases, and caspase inactivation of phosphatidylinositol phosphate 5-kinases.
11042679 Neuroblastoma specific effects of DR-nm23 and its mutant forms on differentiation and apoptosis.
11042683 The effector loop and prenylation site of R-Ras are involved in the regulation of integrin function.
11042694 The ternary complex factor Net contains two distinct elements that mediate different responses to MAP kinase signalling cascades.
11046142 Multiple C-terminal lysine residues target p53 for ubiquitin-proteasome-mediated degradation.
11050185 Phosphorylation near nuclear localization signal regulates nuclear import of adenomatous polyposis coli protein.
11052978 AMPK signaling in contracting human skeletal muscle: acetyl-CoA carboxylase and NO synthase phosphorylation.
11053038 Molecular and functional properties of two-pore-domain potassium channels.
11053353 Mutagenesis analysis of human SM22: characterization of actin binding.
11053428 The kinase activation loop is the key to mixed lineage kinase-3 activation via both autophosphorylation and hematopoietic progenitor kinase 1 phosphorylation.
11060296 Cleavage of the amino terminus of the prion protein by reactive oxygen species.
11060299 Threonine 180 is required for G-protein-coupled receptor kinase 3- and beta-arrestin 2-mediated desensitization of the mu-opioid receptor in Xenopus oocytes.
11060308 Glutathiolation of proteins by glutathione disulfide S-oxide derived from S-nitrosoglutathione. Modifications of rat brain neurogranin/RC3 and neuromodulin/GAP-43.
11062054 Changes in protein kinase C epsilon phosphorylation status and intracellular localization as 3T3 and 3T6 fibroblasts grow to confluency and quiescence: a role for phosphorylation at ser-729?
11062067 Synergistic activation of stress-activated protein kinase 1/c-Jun N-terminal kinase (SAPK1/JNK) isoforms by mitogen-activated protein kinase kinase 4 (MKK4) and MKK7.
11062248 Molecular cloning and characterization of the human protein kinase D2. A novel member of the protein kinase D family of serine threonine kinases.
11063592 Mutations of serine 236-237 and tyrosine 302 residues in the human lipoxin A4 receptor intracellular domains result in sustained signaling.
11067847 Characterization of a prostate-specific tyrosine phosphatase by mutagenesis and expression in human prostate cancer cells.
11067851 C-mannosylation and O-fucosylation of the thrombospondin type 1 module.
11069302 Regulation of apoptosis at cell division by p34cdc2 phosphorylation of survivin.
11075717 The functional significance of Shc in insulin signaling as a substrate of the insulin receptor.
11076522 Role of tyrosine sulfation and serine phosphorylation in the processing of procholecystokinin to amidated cholecystokinin and its secretion in transfected AtT-20 cells.
11076937 Cleavage and shedding of E-cadherin after induction of apoptosis.
11078729 Caveolin-1 binding to endoplasmic reticulum membranes and entry into the regulated secretory pathway are regulated by serine phosphorylation. Protein sorting at the level of the endoplasmic reticulum.
11080633 Structure of the Tie2 RTK domain: self-inhibition by the nucleotide binding loop, activation loop, and C-terminal tail.
11081517 Signal-dependent nuclear export of a histone deacetylase regulates muscle differentiation.
11085743 Initiation of apoptosis by granzyme B requires direct cleavage of bid, but not direct granzyme B-mediated caspase activation.
11085925 Activation of human prolegumain by cleavage at a C-terminal asparagine residue.
11085981 Heterologous activation of protein kinase C stimulates phosphorylation of delta-opioid receptor at serine 344, resulting in beta-arrestin- and clathrin-mediated receptor internalization.
11094089 Multiple lysine mutations in the C-terminal domain of p53 interfere with MDM2-dependent protein degradation and ubiquitination.
11095503 Postsynaptic targeting of MAGUKs mediated by distinct N-terminal domains.
11098060 TRAF1 is a substrate of caspases activated during tumor necrosis factor receptor-alpha-induced apoptosis.
11098061 Determination of the disulfide structure and N-glycosylation sites of the extracellular domain of the human signal transducer gp130.
11099506 Identification of the protein C/activated protein C binding sites on the endothelial cell protein C receptor. Implications for a novel mode of ligand recognition by a major histocompatibility complex class 1-type receptor.
11101516 Transmembrane transforming growth factor-alpha tethers to the PDZ domain-containing, Golgi membrane-associated protein p59/GRASP55.
11102515 Self-association of coilin reveals a common theme in nuclear body localization.
11104670 The C-terminus of NIPP1 (nuclear inhibitor of protein phosphatase-1) contains a novel binding site for protein phosphatase-1 that is controlled by tyrosine phosphorylation and RNA binding.
11104692 Dynamic palmitoylation of lymphoma proprotein convertase prolongs its half-life, but is not essential for trans-Golgi network localization.
11104755 Substitution of a glycogen synthase kinase-3beta phosphorylation site in presenilin 1 separates presenilin function from beta-catenin signaling.
11104762 Phosphorylation of tau is regulated by PKN.
11104776 Protein kinase C activation modulates alpha-calmodulin kinase II binding to NR2A subunit of N-methyl-D-aspartate receptor complex.
11106428 Identification of IkappaBalpha as a substrate of Fas-associated phosphatase-1.
11106648 Essential tyrosine residues for interaction of the non-receptor protein-tyrosine phosphatase PTP1B with N-cadherin.
11113134 Amphiphysin 1 binds the cyclin-dependent kinase (cdk) 5 regulatory subunit p35 and is phosphorylated by cdk5 and cdc2.
11113184 Reciprocal activation by cyclin-dependent kinases 2 and 7 is directed by substrate specificity determinants outside the T loop.
11114197 Activation of the myocyte enhancer factor-2 transcription factor by calcium/calmodulin-dependent protein kinase-stimulated binding of 14-3-3 to histone deacetylase 5.
11114308 Differential regulation of the uridine nucleotide-activated P2Y4 and P2Y6 receptors. SER-333 and SER-334 in the carboxyl terminus are involved in agonist-dependent phosphorylation desensitization and internalization of the P2Y4 receptor.
11114888 Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress.
11115400 Novel properties of the protein kinase CK2-site-regulated nuclear- localization sequence of the interferon-induced nuclear factor IFI 16.
11115496 Identification of internal autoproteolytic cleavage sites within the prosegments of recombinant procathepsin B and procathepsin S. Contribution of a plausible unimolecular autoproteolytic event for the processing of zymogens belonging to the papain family.
11116148 Insulin suppresses transactivation by CAAT/enhancer-binding proteins beta (C/EBPbeta). Signaling to p300/CREB-binding protein by protein kinase B disrupts interaction with the major activation domain of C/EBPbeta.
11118213 TAZ: a novel transcriptional co-activator regulated by interactions with 14-3-3 and PDZ domain proteins.
11118214 P/CAF-mediated acetylation regulates the function of the basic helix-loop-helix transcription factor TAL1/SCL.
11120811 The c-Abl tyrosine kinase is regulated downstream of the B cell antigen receptor and interacts with CD19.
11121408 Differential effects of leukocyte common antigen-related protein on biochemical and biological activities of RET-MEN2A and RET-MEN2B mutant proteins.
11133752 Posttranslational modifications of recombinant myotube-synthesized human factor IX.
11134009 A critical role for phosphoinositide 3-kinase upstream of Gab1 and SHP2 in the activation of ras and mitogen-activated protein kinases by epidermal growth factor.
11134016 J Biol Chem. 2001 Mar 30;276(13):9733-41. Epub 2000 Dec 27.
11135364 Differences in phosphorylation of human and chicken stathmin by MAP kinase.
11139588 Phosphatidylinositol 3-kinase/AKT-mediated activation of estrogen receptor alpha: a new model for anti-estrogen resistance.
11146653 Participation of ATM in insulin signalling through phosphorylation of eIF-4E-binding protein 1.
11148205 Phosphorylation of the oncofetal variant of the human bile salt-dependent lipase. identification of phosphorylation site and relation with secretion process.
11152457 The angiotensin II-dependent nuclear translocation of Stat1 is mediated by the Jak2 protein motif 231YRFRR.
11152665 The c-Src tyrosine kinase regulates signaling of the human DF3/MUC1 carcinoma-associated antigen with GSK3 beta and beta-catenin.
11152678 Biosynthesis and post-translational processing of the precursor to brain-derived neurotrophic factor.
11154262 The mitogen-activated protein kinase signal-integrating kinase Mnk2 is a eukaryotic initiation factor 4E kinase with high levels of basal activity in mammalian cells.
11154276 Akt phosphorylates and negatively regulates apoptosis signal-regulating kinase 1.
11154281 Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a).
11154691 Stimulation of NF-E2 DNA binding by CREB-binding protein (CBP)-mediated acetylation.
11156376 HER-2/neu promotes androgen-independent survival and growth of prostate cancer cells through the Akt pathway.
11158290 Shared pathways of IkappaB kinase-induced SCF(betaTrCP)-mediated ubiquitination and degradation for the NF-kappaB precursor p105 and IkappaBalpha.
11158295 SH2 domain-mediated interaction of inhibitory protein tyrosine kinase Csk with protein tyrosine phosphatase-HSCF.
11158305 Identification of a major cyclic AMP-dependent protein kinase A phosphorylation site within the cytoplasmic tail of the low-density lipoprotein receptor-related protein: implication for receptor-mediated endocytosis.
11159935 Congenital insensitivity to pain with anhidrosis (CIPA): effect of TRKA (NTRK1) missense mutations on autophosphorylation of the receptor tyrosine kinase for nerve growth factor.
11160423 Densin-180 forms a ternary complex with the (alpha)-subunit of Ca2+/calmodulin-dependent protein kinase II and (alpha)-actinin.
11160818 Serine phosphorylation of focal adhesion kinase in interphase and mitosis: a possible role in modulating binding to p130(Cas).
11160957 Cognitive impairment in Coffin-Lowry syndrome correlates with reduced RSK2 activation.
11162250 Proapoptotic effects of tau cleavage product generated by caspase-3.
11162423 Glycosylation effect on membrane domain (GEM) involved in cell adhesion and motility: a preliminary note on functional alpha3, alpha5-CD82 glycosylation complex in ldlD 14 cells.
11162588 Frap-dependent serine phosphorylation of IRS-1 inhibits IRS-1 tyrosine phosphorylation.
11162638 Activated Fyn phosphorylates alpha-synuclein at tyrosine residue 125.
11163076 N-linked carbohydrate on human leukocyte antigen-C and recognition by natural killer cell inhibitory receptors.
11163214 Cytoskeletal protein PSTPIP1 directs the PEST-type protein tyrosine phosphatase to the c-Abl kinase to mediate Abl dephosphorylation.
11165260 Identification of the main ubiquitination site in human erythroid alpha-spectrin.
11169414 Induction, binding specificity and function of human ICOS.
11171059 Phosphorylation of elongation factor-2 kinase on serine 499 by cAMP-dependent protein kinase induces Ca2+/calmodulin-independent activity.
11175347 NO activation of fos promoter elements requires nuclear translocation of G-kinase I and CREB phosphorylation but is independent of MAP kinase activation.
11179223 Securin degradation is mediated by fzy and fzr, and is required for complete chromatid separation but not for cytokinesis.
11181075 Caspase-cleaved TRAF1 negatively regulates the antiapoptotic signals of TRAF2 during TNF-induced cell death.
11181181 Inward rectifier potassium channel Kir2.2 is associated with synapse-associated protein SAP97.
11181701 Activation of the COOH-terminal Src kinase (Csk) by cAMP-dependent protein kinase inhibits signaling through the T cell receptor.
11181841 Characterization of the in vitro phosphorylation of human tau by tau protein kinase II (cdk5/p20) using mass spectrometry.
11201744 CD45 is a JAK phosphatase and negatively regulates cytokine receptor signalling.
11222751 Sp1 phosphorylation regulates inducible expression of platelet-derived growth factor B-chain gene via atypical protein kinase C-zeta.
11223155 Influence of the somatostatin receptor sst2 on growth factor signal cascades in human glioma cells.
11223514 Structure of fibroblast growth factor 9 shows a symmetric dimer with unique receptor- and heparin-binding interfaces.
11226282 BLNK mediates Syk-dependent Btk activation.
11226831 Glycosylation of the murine estrogen receptor-alpha.
11230133 Autophosphorylation restrains the apoptotic activity of DRP-1 kinase by controlling dimerization and calmodulin binding.
11231586 ERK phosphorylation drives cytoplasmic accumulation of hnRNP-K and inhibition of mRNA translation.
11232563 An hPer2 phosphorylation site mutation in familial advanced sleep phase syndrome.
11237874 'Shed' furin: mapping of the cleavage determinants and identification of its C-terminus.
11238922 HIRA, the human homologue of yeast Hir1p and Hir2p, is a novel cyclin-cdk2 substrate whose expression blocks S-phase progression.
11239454 Interaction of the Fanconi anemia proteins and BRCA1 in a common pathway.
11239464 RING finger mutations that abolish c-Cbl-directed polyubiquitination and downregulation of the EGF receptor are insufficient for cell transformation.
11239468 NF-kappaB-inducing kinase regulates the processing of NF-kappaB2 p100.
11241273 Rapid inactivation of stromal cell-derived factor-1 by cathepsin G associated with lymphocytes.
11241286 Dendritic cells as a major source of macrophage-derived chemokine/CCL22 in vitro and in vivo.
11242082 Polo-like kinase 1 phosphorylates cyclin B1 and targets it to the nucleus during prophase.
11246872 The prohormone convertase enzyme 2 (PC2) is essential for processing pro-islet amyloid polypeptide at the NH2-terminal cleavage site.
11248093 The dependence receptor DCC (deleted in colorectal cancer) defines an alternative mechanism for caspase activation.
11252893 The many substrates and functions of ATM.
11254654 BMK1 mediates growth factor-induced cell proliferation through direct cellular activation of serum and glucocorticoid-inducible kinase.
11254678 Cutting edge: differential signaling requirements for activation of assembled cyclin D3-cdk4 complexes in B-1 and B-2 lymphocyte subsets.
11257227 Arginine methylation of STAT1 modulates IFNalpha/beta-induced transcription.
11257495 A new family of small, palmitoylated, membrane-associated proteins, characterized by the presence of a cysteine-rich hydrophobic motif.
11258932 S100A7, S100A10, and S100A11 are transglutaminase substrates.
11259409 Identification of new JNK substrate using ATP pocket mutant JNK and a corresponding ATP analogue.
11259586 p38 mitogen-activated protein kinase-dependent activation of protein phosphatases 1 and 2A inhibits MEK1 and MEK2 activity and collagenase 1 (MMP-1) gene expression.
11264294 Pregnancy-associated plasma protein-A2 (PAPP-A2), a novel insulin-like growth factor-binding protein-5 proteinase.
11266453 A novel chromatin protein, distantly related to histone H2A, is largely excluded from the inactive X chromosome.
11274386 Akt phosphorylates and regulates the orphan nuclear receptor Nur77.
11277933 Human phosphatidylinositol 4-kinase isoform PI4K92. Expression of the recombinant enzyme and determination of multiple phosphorylation sites.
11278268 Effects of the NIK aly mutation on NF-kappaB activation by the Epstein-Barr virus latent infection membrane protein, lymphotoxin beta receptor, and CD40.
11278283 MST, a physiological caspase substrate, highly sensitizes apoptosis both upstream and downstream of caspase activation.
11278298 Phosphorylation and regulation of G-protein-activated phospholipase C-beta 3 by cGMP-dependent protein kinases.
11278340 Interaction of hematopoietic progenitor kinase 1 and c-Abl tyrosine kinase in response to genotoxic stress.
11278381 Sumo-1 modification regulates the DNA binding activity of heat shock transcription factor 2, a promyelocytic leukemia nuclear body associated transcription factor.
11278424 Calsenilin is a substrate for caspase-3 that preferentially interacts with the familial Alzheimer's disease-associated C-terminal fragment of presenilin 2.
11278446 ATM-dependent phosphorylation of human Rad9 is required for ionizing radiation-induced checkpoint activation.
11278469 Regulation of membrane targeting of the G protein-coupled receptor kinase 2 by protein kinase A and its anchoring protein AKAP79.
11278470 Protein kinase C alpha -mediated negative feedback regulation is responsible for the termination of insulin-like growth factor I-induced activation of nuclear phospholipase C beta1 in Swiss 3T3 cells.
11278486 The mechanism of PAK activation. Autophosphorylation events in both regulatory and kinase domains control activity.
11278496 Taf(II) 250 phosphorylates human transcription factor IIA on serine residues important for TBP binding and transcription activity.
11278523 Phosphorylation of Ser363, Thr370, and Ser375 residues within the carboxyl tail differentially regulates mu-opioid receptor internalization.
11278541 Mitotic reorganization of the intermediate filament protein nestin involves phosphorylation by cdc2 kinase.
11278559 Versican V1 proteolysis in human aorta in vivo occurs at the Glu441-Ala442 bond, a site that is cleaved by recombinant ADAMTS-1 and ADAMTS-4.
11278572 Cdc42 is a substrate for caspases and influences Fas-induced apoptosis.
11278730 A family of 16-kDa pancreatic secretory stress proteins form highly organized fibrillar structures upon tryptic activation.
11278782 Both phosphorylation and caspase-mediated cleavage contribute to regulation of the Ste20-like protein kinase Mst1 during CD95/Fas-induced apoptosis.
11278789 MAP kinases mediate UVB-induced phosphorylation of histone H3 at serine 28.
11278797 Proteolytic activation of ETK/Bmx tyrosine kinase by caspases.
11278835 Inhibition of insulin-induced activation of Akt by a kinase-deficient mutant of the epsilon isozyme of protein kinase C.
11278841 Phosphorylation regulates intracellular trafficking of beta-secretase.
11278902 Marked differences between metalloproteases meprin A and B in substrate and peptide bond specificity.
11278906 Exposure on cell surface and extensive arginine methylation of ewing sarcoma (EWS) protein.
11278964 Ataxia telangiectasia mutated (ATM) kinase and ATM and Rad3 related kinase mediate phosphorylation of Brca1 at distinct and overlapping sites. In vivo assessment using phospho-specific antibodies.
11278991 Specific phosphorylation of nucleophosmin on Thr(199) by cyclin-dependent kinase 2-cyclin E and its role in centrosome duplication.
11279024 J Biol Chem. 2001 Jun 8;276(23):20436-43. Epub 2001 Mar 13.
11279095 Unique disulfide bond structures found in ST8Sia IV polysialyltransferase are required for its activity.
11279131 The beta-amyloid precursor protein APP is tyrosine-phosphorylated in cells expressing a constitutively active form of the Abl protoncogene.
11279194 Molecular cloning and characterization of a novel (Na+,K+)/H+ exchanger localized to the trans-Golgi network.
11279195 Phosphorylation of centrin during the cell cycle and its role in centriole separation preceding centrosome duplication.
11279201 Identification of reelin-induced sites of tyrosyl phosphorylation on disabled 1.
11279232 Signal transduction pathways involved in phosphorylation and activation of p70S6K following exposure to UVA irradiation.
11283002 Identification of amino acid residues in bone morphogenetic protein-1 important for procollagen C-proteinase activity.
11283254 Jun NH2-terminal kinase phosphorylation of p53 on Thr-81 is important for p53 stabilization and transcriptional activities in response to stress.
11283605 Phosphorylation of Snapin by PKA modulates its interaction with the SNARE complex.
11284693 Posttranslational modifications of microfibril associated glycoprotein-1 (MAGP-1).
11287604 Phosphorylation of nuclear phospholipase C beta1 by extracellular signal-regulated kinase mediates the mitogenic action of insulin-like growth factor I.
11290523 Regulation of endothelial cell barrier function by calcium/calmodulin-dependent protein kinase II.
11290735 Tuberin phosphorylation regulates its interaction with hamartin. Two proteins involved in tuberous sclerosis.
11290787 Identification of novel functional regions important for the activity of HOXB7 in mammalian cells.
11292861 Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation.
11292862 HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing.
11294838 Specific dephosphorylation of the Lck tyrosine protein kinase at Tyr-394 by the SHP-1 protein-tyrosine phosphatase.
11294867 Activation and functional characterization of the mosaic receptor SorLA/LR11.
11294897 Identification of tyrosine residues in constitutively activated fibroblast growth factor receptor 3 involved in mitogenesis, Stat activation, and phosphatidylinositol 3-kinase activation.
11294912 Cofilin phosphorylation by protein kinase testicular protein kinase 1 and its role in integrin-mediated actin reorganization and focal adhesion formation.
11297520 Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell vrowth.
11298456 The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis.
11303872 Chemical synthesis of lymphotactin: a glycosylated chemokine with a C-terminal mucin-like domain.
11307817 The amino acid sequence in fibrin responsible for high affinity thrombin binding.
11311120 The kinase DYRK1A phosphorylates the transcription factor FKHR at Ser329 in vitro, a novel in vivo phosphorylation site.
11311121 The kinase DYRK phosphorylates protein-synthesis initiation factor eIF2Bepsilon at Ser539 and the microtubule-associated protein tau at Thr212: potential role for DYRK as a glycogen synthase kinase 3-priming kinase.
11313365 Regulation of protein kinase B/Akt-serine 473 phosphorylation by integrin-linked kinase: critical roles for kinase activity and amino acids arginine 211 and serine 343.
11313457 Common properties of nuclear body protein SP100 and TIF1alpha chromatin factor: role of SUMO modification.
11313464 JAK2 activates TFII-I and regulates its interaction with extracellular signal-regulated kinase.
11313479 Inhibition of nuclear import by protein kinase B (Akt) regulates the subcellular distribution and activity of the forkhead transcription factor AFX.
11313925 Constitutive c-Myb amino-terminal phosphorylation and DNA binding activity uncoupled during entry and passage through the cell cycle.
11314030 Activation of the focal adhesion kinase signaling pathway by structural alterations in the carboxyl-terminal region of c-Crk II.
11316748 The insulin-like growth factor I receptor-induced interaction of insulin receptor substrate-4 and Crk-II.
11316808 Prodomain processing of Asp1 (BACE2) is autocatalytic.
11319549 Beam me up, Scottie! TREK channels swing both ways.
11320080 Neuronal Cdc2-like protein kinase (Cdk5/p25) is associated with protein phosphatase 1 and phosphorylates inhibitor-2.
11320094 Membrane topology of the ATP binding cassette transporter ABCR and its relationship to ABC1 and related ABCA transporters: identification of N-linked glycosylation sites.
11323410 Post-translational processing of bovine chondromodulin-I.
11323411 Phosphotyrosines 627 and 659 of Gab1 constitute a bisphosphoryl tyrosine-based activation motif (BTAM) conferring binding and activation of SHP2.
11325525 KN-93 inhibition of G protein signaling is independent of the ability of Ca2+/calmodulin-dependent protein kinase II to phosphorylate phospholipase Cbeta3 on 537-Ser.
11325528 Regulation of the ErbB3 binding protein Ebp1 by protein kinase C.
11327826 Human recombinant pro-dipeptidyl peptidase I (cathepsin C) can be activated by cathepsins L and S but not by autocatalytic processing.
11328818 Identification and characterization of S2V, a novel putative siglec that contains two V set Ig-like domains and recruits protein-tyrosine phosphatases SHPs.
11331285 Modulation of the G protein regulator phosducin by Ca2+/calmodulin-dependent protein kinase II phosphorylation and 14-3-3 protein binding.
11331603 ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage.
11331782 Granzymes A and B directly cleave lamins and disrupt the nuclear lamina during granule-mediated cytolysis.
11331870 Regulation of the PH-domain-containing tyrosine kinase Etk by focal adhesion kinase through the FERM domain.
11331881 PDGF-D is a specific, protease-activated ligand for the PDGF beta-receptor.
11333986 Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase.
11335711 Sequential activation of Rac-1, SEK-1/MKK-4, and protein kinase Cdelta is required for interleukin-6-induced STAT3 Ser-727 phosphorylation and transactivation.
11336675 Crystal structure of the 14-3-3zeta:serotonin N-acetyltransferase complex. a role for scaffolding in enzyme regulation.
11337490 Inhibition of the catalytic activity of cell adhesion kinase beta by protein-tyrosine phosphatase-PEST-mediated dephosphorylation.
11337501 Binding of double-stranded RNA to protein kinase PKR is required for dimerization and promotes critical autophosphorylation events in the activation loop.
11340065 Activation of LIM kinases by myotonic dystrophy kinase-related Cdc42-binding kinase alpha.
11341784 Identification of MUC1 proteolytic cleavage sites in vivo.
11342557 HSP22, a new member of the small heat shock protein superfamily, interacts with mimic of phosphorylated HSP27 ((3D)HSP27).
11342590 Sulfated tyrosines contribute to the formation of the C5a docking site of the human C5a anaphylatoxin receptor.
11343707 Phosphorylation of murine homeodomain protein Dlx3 by protein kinase C.
11344269 Cloning and characterization of FGF23 as a causative factor of tumor-induced osteomalacia.
11350938 Protein kinase PKR is required for platelet-derived growth factor signaling of c-fos gene expression via Erks and Stat3.
11353545 Requirements for activation and RAFT localization of the T-lymphocyte kinase Rlk/Txk.
11356849 Effect of mutation and phosphorylation of type I keratins on their caspase-mediated degradation.
11359875 Interaction of phosphorylated tyrosine hydroxylase with 14-3-3 proteins: evidence for a phosphoserine 40-dependent association.
11368773 Mapping the Zap-70 phosphorylation sites on LAT (linker for activation of T cells) required for recruitment and activation of signalling proteins in T cells.
11369760 CD44-initiated cell spreading induces Pyk2 phosphorylation, is mediated by Src family kinases, and is negatively regulated by CD45.
11369769 The cytoskeletal/non-muscle isoform of alpha-actinin is phosphorylated on its actin-binding domain by the focal adhesion kinase.
11371618 Phosphorylation and microtubule association of the Opitz syndrome protein mid-1 is regulated by protein phosphatase 2A via binding to the regulatory subunit alpha 4.
11373296 Identification of phosphorylation sites for Bruton's tyrosine kinase within the transcriptional regulator BAP/TFII-I.
11375993 Osteopontin, a novel substrate for matrix metalloproteinase-3 (stromelysin-1) and matrix metalloproteinase-7 (matrilysin).
11376433 Preparation and application of antibodies to phosphoamino acid sequences.
11378439 Phosphorylation of the Fas associated factor FAF1 by protein kinase CK2 and identification of serines 289 and 291 as the in vitro phosphorylation sites.
11381077 Membrane-type 1 matrix metalloproteinase cleaves CD44 and promotes cell migration.
11381116 Phosphorylation sites of protein kinase C delta in H2O2-treated cells and its activation by tyrosine kinase in vitro.
11382764 Identification of Src phosphorylation sites in the catenin p120ctn.
11387207 Ezrin is a downstream effector of trafficking PKC-integrin complexes involved in the control of cell motility.
11387210 A single autophosphorylation site on KDR/Flk-1 is essential for VEGF-A-dependent activation of PLC-gamma and DNA synthesis in vascular endothelial cells.
11387340 Serum response factor cleavage by caspases 3 and 7 linked to apoptosis in human BJAB cells.
11389975 Glycosylation of human CRLR at Asn123 is required for ligand binding and signaling.
11390389 c-Abl tyrosine kinase binds and phosphorylates phospholipid scramblase 1.
11390394 Kinetic investigation of chemokine truncation by CD26/dipeptidyl peptidase IV reveals a striking selectivity within the chemokine family.
11390408 The hCds1 (Chk2)-FHA domain is essential for a chain of phosphorylation events on hCds1 that is induced by ionizing radiation.
11390657 Molecular cloning of ILP-2, a novel member of the inhibitor of apoptosis protein family.
11395479 SET-related cell division autoantigen-1 (CDA1) arrests cell growth.
11396978 Identification of a novel phosphorylation site in human androgen receptor by mass spectrometry.
11397791 Phosphorylation of Thr(495) regulates Ca(2+)/calmodulin-dependent endothelial nitric oxide synthase activity.
11399775 Phosphorylation of a novel myosin binding subunit of protein phosphatase 1 reveals a conserved mechanism in the regulation of actin cytoskeleton.
11401470 Identification of Ser(1275) and Ser(1309) as autophosphorylation sites of the human insulin receptor in intact cells.
11404460 Akt suppresses androgen-induced apoptosis by phosphorylating and inhibiting androgen receptor.
11406587 Direct cleavage of the human DNA fragmentation factor-45 by granzyme B induces caspase-activated DNase release and DNA fragmentation.
11408587 Mitotic phosphorylation of Golgi reassembly stacking protein 55 by mitogen-activated protein kinase ERK2.
11409876 Nuclear extracellular signal-regulated kinase 2 phosphorylates p53 at Thr55 in response to doxorubicin.
11410590 Serum- and glucocorticoid-inducible kinase SGK phosphorylates and negatively regulates B-Raf.
11413148 Transcription factor STAT5A is a substrate of Bruton's tyrosine kinase in B cells.
11416124 Phosphorylation of MafA is essential for its transcriptional and biological properties.
11416205 Mutations within a furin consensus sequence block proteolytic release of ectodysplasin-A and cause X-linked hypohidrotic ectodermal dysplasia.
11418126 Proposed lipocalin fold for apolipoprotein M based on bioinformatics and site-directed mutagenesis.
11418599 Cofilin phosphorylation and actin reorganization activities of testicular protein kinase 2 and its predominant expression in testicular Sertoli cells.
11418864 ATR/ATM-mediated phosphorylation of human Rad17 is required for genotoxic stress responses.
11420704 Sequential two-step cleavage of the retinoblastoma protein by caspase-3/-7 during etoposide-induced apoptosis.
11422372 Proteolytic processing of a human salivary proline-rich protein precursor by proprotein convertases.
11423543 Heterogeneous fatty acylation of Src family kinases with polyunsaturated fatty acids regulates raft localization and signal transduction.
11423904 Caspase cleavage of vimentin disrupts intermediate filaments and promotes apoptosis.
11425860 Gas6 anti-apoptotic signaling requires NF-kappa B activation.
11427888 Structure of GSK3beta reveals a primed phosphorylation mechanism.
11430825 Regulation of human flap endonuclease-1 activity by acetylation through the transcriptional coactivator p300.
11432792 Analysis of tyrosine phosphorylation-dependent protein-protein interactions in TrkB-mediated intracellular signaling using modified yeast two-hybrid system.
11432835 Rsk2 allosterically activates estrogen receptor alpha by docking to the hormone-binding domain.
11433379 Structural and functional dissection of the cytoplasmic domain of the transmembrane adaptor protein SIT (SHP2-interacting transmembrane adaptor protein).
11435427 Cathepsin B, L, and S cleave and inactivate secretory leucoprotease inhibitor.
11437602 [W206R]-procaspase 3: an inactivatable substrate for caspase 8.
11438522 Actin cytoskeletal association of cytohesin-1 is regulated by specific phosphorylation of its carboxyl-terminal polybasic domain.
11438643 Transcription factor AP-2alpha is preferentially cleaved by caspase 6 and degraded by proteasome during tumor necrosis factor alpha-induced apoptosis in breast cancer cells.
11438671 Mitotic phosphorylation prevents the binding of HMGN proteins to chromatin.
11439109 Autocatalytic tyrosine-phosphorylation of protein kinase CK2 alpha and alpha' subunits: implication of Tyr182.
11443111 Phosphorylation and nuclear translocation of a regulator of G protein signaling (RGS10).
11444831 A novel secreted tumor antigen with a glycosylphosphatidylinositol-anchored structure ubiquitously expressed in human cancers.
11445557 Regulation of Akt/PKB activation by tyrosine phosphorylation.
11447113 Positive and negative regulation of Raf kinase activity and function by phosphorylation.
11447121 Phosphorylation of serine 230 promotes inducible transcriptional activity of heat shock factor 1.
11447134 Complete analysis of the glycosylation and disulfide bond pattern of human beta-hexosaminidase B by MALDI-MS.
11447212 Interaction of farnesylated PRL-2, a protein-tyrosine phosphatase, with the beta-subunit of geranylgeranyltransferase II.
11448957 Characterization of sequence determinants within the carboxyl-terminal domain of chemokine receptor CCR5 that regulate signaling and receptor internalization.
11451954 Polymeric chains of SUMO-2 and SUMO-3 are conjugated to protein substrates by SAE1/SAE2 and Ubc9.
11451957 Palmitoylation of caveolin-1 at a single site (Cys-156) controls its coupling to the c-Src tyrosine kinase: targeting of dually acylated molecules (GPI-linked, transmembrane, or cytoplasmic) to caveolae effectively uncouples c-Src and caveolin-1 (TYR-14).
11459832 Selective induction of E2F1 in response to DNA damage, mediated by ATM-dependent phosphorylation.
11459840 The role of tyrosine residues in fibroblast growth factor receptor 1 signaling in PC12 cells. Systematic site-directed mutagenesis in the endodomain.
11459942 PAS kinase: an evolutionarily conserved PAS domain-regulated serine/threonine kinase.
11460167 TAK1 is a ubiquitin-dependent kinase of MKK and IKK.
11461922 Nitric oxide inhibits ornithine decarboxylase via S-nitrosylation of cysteine 360 in the active site of the enzyme.
11463356 Ca(2+)/calmodulin-dependent protein kinase mediates the phosphorylation of CD44 required for cell migration on hyaluronan.
11463380 CREB binding protein recruitment to the transcription complex requires growth factor-dependent phosphorylation of its GF box.
11463840 SATB1 cleavage by caspase 6 disrupts PDZ domain-mediated dimerization, causing detachment from chromatin early in T-cell apoptosis.
11466320 In vivo tyrosine phosphorylation sites of activated ephrin-B1 and ephB2 from neural tissue.
11470801 Identification of a novel kinesin-related protein, KRMP1, as a target for mitotic peptidyl-prolyl isomerase Pin1.
11470874 Cleavage of the Bloom's syndrome gene product during apoptosis by caspase-3 results in an impaired interaction with topoisomerase IIIalpha.
11477070 DJ-1 positively regulates the androgen receptor by impairing the binding of PIASx alpha to the receptor.
11479297 Acetylation of steroidogenic factor 1 protein regulates its transcriptional activity and recruits the coactivator GCN5.
11481331 Identification of tyrosine phosphorylation sites on 3-phosphoinositide-dependent protein kinase-1 and their role in regulating kinase activity.
11483158 Glycogen synthase kinase3 beta phosphorylates serine 33 of p53 and activates p53's transcriptional activity.
11483516 Promoting bone morphogenetic protein signaling through negative regulation of inhibitory Smads.
11483589 The epidermal growth factor receptor regulates interaction of the human DF3/MUC1 carcinoma antigen with c-Src and beta-catenin.
11485553 Regulation of pyruvate dehydrogenase activity through phosphorylation at multiple sites.
11485561 Polyamine analogues inhibit the ubiquitination of spermidine/spermine N1-acetyltransferase and prevent its targeting to the proteasome for degradation.
11485566 Roles of the juxtamembrane and extracellular domains of angiotensin-converting enzyme in ectodomain shedding.
11486000 Site specificity of four pyruvate dehydrogenase kinase isoenzymes toward the three phosphorylation sites of human pyruvate dehydrogenase.
11487578 Axin-dependent phosphorylation of the adenomatous polyposis coli protein mediated by casein kinase 1epsilon.
11489887 Characterization of a novel mammalian SUMO-1/Smt3-specific isopeptidase, a homologue of rat axam, which is an axin-binding protein promoting beta-catenin degradation.
11498053 Multiple phosphorylation of rhodopsin and the in vivo chemistry underlying rod photoreceptor dark adaptation.
11498590 Coordination of a transcriptional switch by HMGI(Y) acetylation.
11499613 Characterization of glycated hemoglobin in diabetic patients: usefulness of electrospray mass spectrometry in monitoring the extent and distribution of glycation.
11500040 The N-terminal internal region of BLM is required for the formation of dots/rod-like structures which are associated with SUMO-1.
11500362 Eukaryotic initiation factor 2B: identification of multiple phosphorylation sites in the epsilon-subunit and their functions in vivo.
11500363 A novel method to identify protein kinase substrates: eEF2 kinase is phosphorylated and inhibited by SAPK4/p38delta.
11500364 Regulation of elongation factor 2 kinase by p90(RSK1) and p70 S6 kinase.
11500511 The fate of desmosomal proteins in apoptotic cells.
11500516 Multiple ErbB-2/Neu Phosphorylation Sites Mediate Transformation through Distinct Effector Proteins.
11502179 Purification and characterization of a soluble bioactive amino-terminal extracellular domain of the human thyrotropin receptor.
11502742 Protein kinase C regulates the phosphorylation and cellular localization of occludin.
11502746 Phosphorylation of Ser(19) alters the conformation of tyrosine hydroxylase to increase the rate of phosphorylation of Ser(40).
11502795 Characterization of human FSH isoforms reveals a nonglycosylated beta-subunit in addition to the conventional glycosylated beta-subunit.
11504915 A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus.
11506178 Phosphorylation and activation of protein tyrosine phosphatase (PTP) 1B by insulin receptor.
11507039 Phosphatidylinositol-3-OH Kinase (PI3K)/AKT2, activated in breast cancer, regulates and is induced by estrogen receptor alpha (ERalpha) via interaction between ERalpha and PI3K.
11507089 Four tyrosine residues in phospholipase C-gamma 2, identified as Btk-dependent phosphorylation sites, are required for B cell antigen receptor-coupled calcium signaling.
11509661 Acetylation of nuclear hormone receptor-interacting protein RIP140 regulates binding of the transcriptional corepressor CtBP.
11510412 Phosphorylation by PKA of a site unique to B-Raf kinase.
11513602 Mechanistic effects of autophosphorylation on receptor tyrosine kinase catalysis: enzymatic characterization of Tie2 and phospho-Tie2.
11514563 Identification of a caspase-9 substrate and detection of its cleavage in programmed cell death during mouse development.
11514593 v-Src phosphorylation of connexin 43 on Tyr247 and Tyr265 disrupts gap junctional communication.
11514608 B cell adaptor containing src homology 2 domain (BASH) links B cell receptor signaling to the activation of hematopoietic progenitor kinase 1.
11516622 Membrane-targeting is critical for the phosphorylation of Vav2 by activated EGF receptor.
11517222 Dual regulation of mammalian myosin VI motor function.
11517230 Determination of bradykinin B2 receptor in vivo phosphorylation sites and their role in receptor function.
11517287 Expression and function of the HSD-3.8 gene encoding a testis-specific protein.
11518718 Murine notch homologs (N1-4) undergo presenilin-dependent proteolysis.
11526478 Cleavage of Fyn and Lyn in their N-terminal unique regions during induction of apoptosis: a new mechanism for Src kinase regulation.
11532001 The role of Thr160 phosphorylation of Cdk2 in substrate recognition.
11533025 Phosphorylation of the integrin alpha 4 cytoplasmic domain regulates paxillin binding.
11535131 Targeting of the transcription factor Max during apoptosis: phosphorylation-regulated cleavage by caspase-5 at an unusual glutamic acid residue in position P1.
11544253 G6b, a novel immunoglobulin superfamily member encoded in the human major histocompatibility complex, interacts with SHP-1 and SHP-2.
11546794 Heregulin-dependent activation of phosphoinositide 3-kinase and Akt via the ErbB2/ErbB3 co-receptor.
11546811 Phosphorylation of the human ubiquitin-conjugating enzyme, CDC34, by casein kinase 2.
11551902 Insulin receptor-mediated p62dok tyrosine phosphorylation at residues 362 and 398 plays distinct roles for binding GTPase-activating protein and Nck and is essential for inhibiting insulin-stimulated activation of Ras and Akt.
11551919 DNA damage-dependent and -independent phosphorylation of the hRad9 checkpoint protein.
11551930 Plk3 functionally links DNA damage to cell cycle arrest and apoptosis at least in part via the p53 pathway.
11551945 Cell type-specific inhibition of the ETS transcription factor ER81 by mitogen-activated protein kinase-activated protein kinase 2.
11551979 S-Nitrosylation of mitochondrial caspases.
11555634 Structure-function analysis of phytanoyl-CoA 2-hydroxylase mutations causing Refsum's disease.
11555640 Translation inhibition in apoptosis: caspase-dependent PKR activation and eIF2-alpha phosphorylation.
11555652 Proteasome-mediated glucocorticoid receptor degradation restricts transcriptional signaling by glucocorticoids.
11557734 Proteomic analysis of pharmacologically preconditioned cardiomyocytes reveals novel phosphorylation of myosin light chain 1.
11562345 Transcription regulation by histone methylation: interplay between different covalent modifications of the core histone tails.
11566027 Purification and characterization of the human PDE4A catalytic domain (PDE4A330-723) expressed in Sf9 cells.
11571266 Biologically active APRIL is secreted following intracellular processing in the Golgi apparatus by furin convertase.
11571274 ATM phosphorylates histone H2AX in response to DNA double-strand breaks.
11572860 Docking protein Gab2 is phosphorylated by ZAP-70 and negatively regulates T cell receptor signaling by recruitment of inhibitory molecules.
11574070 Regulation of Ca(2+)/calmodulin-dependent protein kinase kinase alpha by cAMP-dependent protein kinase: I. Biochemical analysis.
11577080 Phosphorylation of Ser2078 modulates the Notch2 function in 32D cell differentiation.
11579085 The pro-apoptotic function of death-associated protein kinase is controlled by a unique inhibitory autophosphorylation-based mechanism.
11579209 Phosphorylation of PTP1B at Ser(50) by Akt impairs its ability to dephosphorylate the insulin receptor.
11581251 Stimulation of lipolysis and hormone-sensitive lipase via the extracellular signal-regulated kinase pathway.
11583622 Phosphorylation of bid by casein kinases I and II regulates its cleavage by caspase 8.
11583630 Akt-mediated phosphorylation of the G protein-coupled receptor EDG-1 is required for endothelial cell chemotaxis.
11584018 Phosphorylation of the CCAAT displacement protein (CDP)/Cux transcription factor by cyclin A-Cdk1 modulates its DNA binding activity in G(2).
11588171 An NMDA receptor signaling complex with protein phosphatase 2A.
11591706 Double prenylation by RabGGTase can proceed without dissociation of the mono-prenylated intermediate.
11591726 Identification of sequences within the gamma-carboxylase that represent a novel contact site with vitamin K-dependent proteins and that are required for activity.
11593427 Involvement of Jak2 tyrosine phosphorylation in Bcr-Abl transformation.
11594778 Phosphorylation of human N-myristoyltransferase by N-myristoylated SRC family tyrosine kinase members.
11597569 Sequestration and phosphorylation of the prostaglandin E2 EP4 receptor: dependence on the C-terminal tail.
11598012 PKCbeta modulates antigen receptor signaling via regulation of Btk membrane localization.
11602244 The AP-1 repressor, JDP2, is a bona fide substrate for the c-Jun N-terminal kinase.
11602246 Signalling of GPI-anchored CD157 via focal adhesion kinase in MCA102 fibroblasts.
11602581 Histone deacetylase 1 phosphorylation promotes enzymatic activity and complex formation.
11604394 Phosphorylation of Pak1 by the p35/Cdk5 kinase affects neuronal morphology.
11604405 Phosphorylation of cysteine string protein by protein kinase A. Implications for the modulation of exocytosis.
11604491 Trophic factor withdrawal: p38 mitogen-activated protein kinase activates NHE1, which induces intracellular alkalinization.
11604510 RasGAP-associated endoribonuclease G3Bp: selective RNA degradation and phosphorylation-dependent localization.
11604997 Molecular cloning and characterization of human WNT3.
11606045 Heterogeneity in the phosphorylation of human death receptors by p42(mapk/erk2).
11606564 Phosphorylation of Ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action.
11668633 Mutation screening at the RNA level of the STK11/LKB1 gene in Peutz-Jeghers syndrome reveals complex splicing abnormalities and a novel mRNA isoform (STK11 c.597(insertion mark)598insIVS4).
11672523 hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase.
11675505 Regulation of NMDA receptors by cyclin-dependent kinase-5.
11676480 Physical and functional interactions between protein tyrosine phosphatase alpha, PI 3-kinase, and PKCdelta.
11676606 Determination of carbohydrate structures N-linked to soluble CD154 and characterization of the interactions of CD40 with CD154 expressed in Pichia pastoris and Chinese hamster ovary cells.
11683421 Phosphorylation of MAP4 affects microtubule properties and cell cycle progression.
11684694 Phosphorylation of MEK1 by cdk5/p35 down-regulates the mitogen-activated protein kinase pathway.
11687586 RGC-32 increases p34CDC2 kinase activity and entry of aortic smooth muscle cells into S-phase.
11687594 Tyrosine phosphorylation mapping of the epidermal growth factor receptor signaling pathway.
11689432 Dok-R plays a pivotal role in angiopoietin-1-dependent cell migration through recruitment and activation of Pak.
11689443 Negative feedback regulation of ASK1 by protein phosphatase 5 (PP5) in response to oxidative stress.
11689449 A specific lysine in c-Jun is required for transcriptional repression by E1A and is acetylated by p300.
11689711 Regulation of the Forkhead transcription factor AFX by Ral-dependent phosphorylation of threonines 447 and 451.
11689934 Effect of DNA damage on a BRCA1 complex.
11690653 Delineation of the minimal catalytic domain of human Galbeta1-3GalNAc alpha2,3-sialyltransferase (hST3Gal I).
11691836 Hierarchical phosphorylation of the translation inhibitor 4E-BP1.
11696579 Hyperglycemia inhibits endothelial nitric oxide synthase activity by posttranslational modification at the Akt site.
11696592 Functional cloning of Src-like adapter protein-2 (SLAP-2), a novel inhibitor of antigen receptor signaling.
11698596 Stimulation of endothelin B receptors in astrocytes induces cAMP response element-binding protein phosphorylation and c-fos expression via multiple mitogen-activated protein kinase signaling pathways.
11698641 Phosphorylation of UBF at serine 388 is required for interaction with RNA polymerase I and activation of rDNA transcription.
11698644 Glucose and cAMP regulate the L-type pyruvate kinase gene by phosphorylation/dephosphorylation of the carbohydrate response element binding protein.
11701639 Apolipoprotein E: far more than a lipid transport protein.
11706042 MD-2 and TLR4 N-linked glycosylations are important for a functional lipopolysaccharide receptor.
11707464 Akt (protein kinase B) negatively regulates SEK1 by means of protein phosphorylation.
11709713 UV-radiation induces dose-dependent regulation of p53 response and modulates p53-HDM2 interaction in human fibroblasts.
11711533 PSTPIP is a substrate of PTP-PEST and serves as a scaffold guiding PTP-PEST toward a specific dephosphorylation of WASP.
11713246 Transforming growth factor-beta 1 regulates Kir2.3 inward rectifier K+ channels via phospholipase C and protein kinase C-delta in reactive astrocytes from adult rat brain.
11713277 Nerve growth factor stimulates multisite tyrosine phosphorylation and activation of the atypical protein kinase C's via a src kinase pathway.
11713579 FAS-associated factor 1 interacts with protein kinase CK2 in vivo upon apoptosis induction.
11714793 J Immunol. 2001 Dec 1;167(11):6292-302.
11714842 Role of apoA-II in lipid metabolism and atherosclerosis: advances in the study of an enigmatic protein.
11717309 Identification of a novel phosphorylation site, Ser-170, as a regulator of bad pro-apoptotic activity.
11719502 p21-activated kinase links Rac/Cdc42 signaling to merlin.
11719549 FIGQY phosphorylation defines discrete populations of L1 cell adhesion molecules at sites of cell-cell contact and in migrating neurons.
11720283 Symmetrical dimethylation of arginine residues in spliceosomal Sm protein B/B' and the Sm-like protein LSm4, and their interaction with the SMN protein.
11723131 Phosphorylation of beta3 integrin controls ligand binding strength.
11723139 Ceramide-induced inhibition of Akt is mediated through protein kinase Czeta: implications for growth arrest.
11726507 Nuclear export of phosphorylated C/EBPbeta mediates the inhibition of albumin expression by TNF-alpha.
11726515 Tyrosine phosphorylation of Grb2 by Bcr/Abl and epidermal growth factor receptor: a novel regulatory mechanism for tyrosine kinase signaling.
11731474 PIASy, a nuclear matrix-associated SUMO E3 ligase, represses LEF1 activity by sequestration into nuclear bodies.
11733001 ik3-1/Cables is a substrate for cyclin-dependent kinase 3 (cdk 3).
11733037 Distinct regulatory mechanism for p70 S6 kinase beta from that for p70 S6 kinase alpha.
11733498 Interaction between active Pak1 and Raf-1 is necessary for phosphorylation and activation of Raf-1.
11733580 Sialylated O-glycans and sulfated tyrosines in the NH2-terminal domain of CC chemokine receptor 5 contribute to high affinity binding of chemokines.
11739740 Erk5 participates in neuregulin signal transduction and is constitutively active in breast cancer cells overexpressing ErbB2.
11741533 Cytokine stimulation of energy expenditure through p38 MAP kinase activation of PPARgamma coactivator-1.
11741535 Mutation of the c-Cbl TKB domain binding site on the Met receptor tyrosine kinase converts it into a transforming protein.
11741541 An immediate response of ribosomal transcription to growth factor stimulation in mammals is mediated by ERK phosphorylation of UBF.
11741879 Protein kinase C (PKC)eta-mediated PKC mu activation modulates ERK and JNK signal pathways.
11741894 Different domains of the mitogen-activated protein kinases ERK3 and ERK2 direct subcellular localization and upstream specificity in vivo.
11741957 A lipid-regulated docking site on vinculin for protein kinase C.
11741999 Biosynthetic processing of the pro-alpha 1(V)2pro-alpha 2(V) collagen heterotrimer by bone morphogenetic protein-1 and furin-like proprotein convertases.
11742978 Polarized trafficking and surface expression of the AQP4 water channel are coordinated by serial and regulated interactions with different clathrin-adaptor complexes.
11742982 Phosphorylation of Nedd4-2 by Sgk1 regulates epithelial Na(+) channel cell surface expression.
11744621 Multiple phosphorylation of alpha-synuclein by protein tyrosine kinase Syk prevents eosin-induced aggregation.
11744634 The polysialyltransferase ST8Sia II/STX: posttranslational processing and role of autopolysialylation in the polysialylation of neural cell adhesion molecule.
11744745 Phosphorylation of Ser(982) in the sodium bicarbonate cotransporter kNBC1 shifts the HCO(3)(-) : Na(+) stoichiometry from 3 : 1 to 2 : 1 in murine proximal tubule cells.
11747312 Release and degradation of angiotensin I and angiotensin II from angiotensinogen by neutrophil serine proteinases.
11748222 Functional interaction between coactivators CBP/p300, PCAF, and transcription factor FKLF2.
11749387 Glycogen synthase kinase-3: properties, functions, and regulation.
11751582 Methylation at arginine 17 of histone H3 is linked to gene activation.
11751874 The prosequence of human lactase-phlorizin hydrolase modulates the folding of the mature enzyme.
11751923 Novel activation of STAT5b in response to epidermal growth factor.
11751924 Cell surface glycoprotein PZR is a major mediator of concanavalin A-induced cell signaling.
11751973 Mast cell alpha-chymase reduces IgE recognition of birch pollen profilin by cleaving antibody-binding epitopes.
11755217 Caspase 7 can cleave tumor necrosis factor receptor-I (p60) at a non-consensus motif, in vitro.
11756412 AKT/PKB phosphorylation of p21Cip/WAF1 enhances protein stability of p21Cip/WAF1 and promotes cell survival.
11756446 Biosynthesis and cellular trafficking of the convertase SKI-1/S1P: ectodomain shedding requires SKI-1 activity.
11756469 CENP-A is phosphorylated by Aurora B kinase and plays an unexpected role in completion of cytokinesis.
11756552 PAK5, a new brain-specific kinase, promotes neurite outgrowth in N1E-115 cells.
11772397 Phosphorylation of the protein kinase C-theta activation loop and hydrophobic motif regulates its kinase activity, but only activation loop phosphorylation is critical to in vivo nuclear-factor-kappaB induction.
11773076 The hemopexin-like C-terminal domain of membrane type 1 matrix metalloproteinase regulates proteolysis of a multifunctional protein, gC1qR.
11773080 Distinct residues in the carboxyl tail mediate agonist-induced desensitization and internalization of the human dopamine D1 receptor.
11777913 Phosphorylation of 4E-BP1 is mediated by the p38/MSK1 pathway in response to UVB irradiation.
11779865 Endosomal proteolysis of internalized insulin at the C-terminal region of the B chain by cathepsin D.
11780126 Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis.
11781100 The Protein-tyrosine-phosphatase SHP2 is phosphorylated on serine residues 576 and 591 by protein kinase C isoforms alpha, beta 1, beta 2, and eta.
11781324 The intermediate filament protein keratin 8 is a novel cytoplasmic substrate for c-Jun N-terminal kinase.
11781820 Phosphorylation and structure-based functional studies reveal a positive and a negative role for the activation loop of the c-Abl tyrosine kinase.
11782427 PKB-mediated negative feedback tightly regulates mitogenic signalling via Gab2.
11788583 Keratin 8 phosphorylation by p38 kinase regulates cellular keratin filament reorganization: modulation by a keratin 1-like disease causing mutation.
11801256 Decreased intracellular degradation of insulin-like growth factor binding protein-3 in cathepsin L-deficient fibroblasts.
11802788 The human homologue of the yeast polyubiquitination factor Ufd2p is cleaved by caspase 6 and granzyme B during apoptosis.
11804956 Proteolytic processing of human zona pellucida proteins.
11805112 Interactions of beta and gamma ENaC with Nedd4 can be facilitated by an ERK-mediated phosphorylation.
11805122 Phosphorylation of stargazin by protein kinase A regulates its interaction with PSD-95.
11806999 Molecular dissection of the signaling and costimulatory functions of CD150 (SLAM): CD150/SAP binding and CD150-mediated costimulation.
11812650 Molecular interactions of SHP1 and SHP2 in IL-3-signalling.
11812771 KEPI, a PKC-dependent protein phosphatase 1 inhibitor regulated by morphine.
11815627 Hydrolysis of biological peptides by human angiotensin-converting enzyme-related carboxypeptidase.
11818338 An intact NEDD8 pathway is required for Cullin-dependent ubiquitylation in mammalian cells.
11818507 Requirement of Ca(2+) and PKCdelta for Janus kinase 2 activation by angiotensin II: involvement of PYK2.
11818547 Casein kinase I phosphorylates and destabilizes the beta-catenin degradation complex.
11823425 Cyclin-dependent kinase 5 prevents neuronal apoptosis by negative regulation of c-Jun N-terminal kinase 3.
11823465 Tumor necrosis factor-alpha converting enzyme (TACE) regulates epidermal growth factor receptor ligand availability.
11823643 Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch.
11825621 Mutational analysis of sites in sepiapterin reductase phosphorylated by Ca2+/calmodulin-dependent protein kinase II.
11832478 Caspase-2 induces apoptosis by releasing proapoptotic proteins from mitochondria.
11834745 Peroxynitrite-induced nitration of tyrosine hydroxylase: identification of tyrosines 423, 428, and 432 as sites of modification by matrix-assisted laser desorption ionization time-of-flight mass spectrometry and tyrosine-scanning mutagenesis.
11835310 Nerve growth factor-mediated increases in protein methylation occur predominantly at type I arginine methylation sites and involve protein arginine methyltransferase 1.
11836243 Differential use of myristoyl groups on neuronal calcium sensor proteins as a determinant of spatio-temporal aspects of Ca2+ signal transduction.
11836499 BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage.
11839738 Protein kinase C-delta (PKC-delta ) is activated by type I interferons and mediates phosphorylation of Stat1 on serine 727.
11839743 IKK-i and TBK-1 are enzymatically distinct from the homologous enzyme IKK-2: comparative analysis of recombinant human IKK-i, TBK-1, and IKK-2.
11840332 MDMX stability is regulated by p53-induced caspase cleavage in NIH3T3 mouse fibroblasts.
11842186 Arsenite-induced Cdc25C degradation is through the KEN-box and ubiquitin-proteasome pathway.
11844797 Arachidonic acid promotes phosphorylation of 5-lipoxygenase at Ser-271 by MAPK-activated protein kinase 2 (MK2).
11846800 Tyrosine sulfation and N-glycosylation of human heparin cofactor II from plasma and recombinant Chinese hamster ovary cells and their effects on heparin binding.
11847099 Tyrosine sulfation is required for agonist recognition by glycoprotein hormone receptors.
11850402 PABP1 identified as an arginine methyltransferase substrate using high-density protein arrays.
11850617 CEACAM1 regulates insulin clearance in liver.
11853558 Identification and characterization of four novel phosphorylation sites (Ser31, Ser325, Thr336 and Thr366) on LKB1/STK11, the protein kinase mutated in Peutz-Jeghers cancer syndrome.
11854294 Platelet-derived growth factor (PDGF)-induced tyrosine phosphorylation of the low density lipoprotein receptor-related protein (LRP). Evidence for integrated co-receptor function betwenn LRP and the PDGF.
11854437 Caspase-dependent cleavage of carbamoyl phosphate synthetase II during apoptosis.
11855827 Phosphorylation of the N-terminal and C-terminal CD3-epsilon-ITAM tyrosines is differentially regulated in T cells.
11855836 Phosphorylation of Fanconi anemia protein, FANCA, is regulated by Akt kinase.
11859414 Yeast two-hybrid screening using constitutive-active caspase-7 as bait in the identification of PA28gamma as an effector caspase substrate.
11861764 Survivin exists in immunochemically distinct subcellular pools and is involved in spindle microtubule function.
11861906 Phosphorylation of mammalian translation initiation factor 5 (eIF5) in vitro and in vivo.
11864601 Association of CBP/p300 acetylase and thymine DNA glycosylase links DNA repair and transcription.
11864968 Purification, cloning, and characterization of Nek8, a novel NIMA-related kinase, and its candidate substrate Bicd2.
11865049 Control of intracellular dynamics of mammalian period proteins by casein kinase I epsilon (CKIepsilon) and CKIdelta in cultured cells.
11870081 SAMP32, a testis-specific, isoantigenic sperm acrosomal membrane-associated protein.
11870224 Ephrin-A5 induces rounding, blebbing and de-adhesion of EphA3-expressing 293T and melanoma cells by CrkII and Rho-mediated signalling.
11875057 ATM mediates phosphorylation at multiple p53 sites, including Ser(46), in response to ionizing radiation.
11875070 ERK8, a new member of the mitogen-activated protein kinase family.
11875078 Caspase proteolysis of the cohesin component RAD21 promotes apoptosis.
11877257 Processing of the lipocalin alpha(1)-microglobulin by hemoglobin induces heme-binding and heme-degradation properties.
11877377 SMC1 is a downstream effector in the ATM/NBS1 branch of the human S-phase checkpoint.
11877389 Glucocorticoids inhibit cell cycle progression in differentiating osteoblasts via glycogen synthase kinase-3beta.
11877440 Protein kinase C delta regulates function of the DF3/MUC1 carcinoma antigen in beta-catenin signaling.
11877451 Regulation of arrestin-3 phosphorylation by casein kinase II.
11882902 Structure of the HP1 chromodomain bound to histone H3 methylated at lysine 9.
11883897 Kinetic properties of p53 phosphorylation by the human vaccinia-related kinase 1.
11883936 Nuclear receptor and apoptosis initiator NGFI-B is a substrate for kinase ERK2.
11884385 Direct phosphorylation of capsaicin receptor VR1 by protein kinase Cepsilon and identification of two target serine residues.
11884598 Convergence of multiple signaling cascades at glycogen synthase kinase 3: Edg receptor-mediated phosphorylation and inactivation by lysophosphatidic acid through a protein kinase C-dependent intracellular pathway.
11893489 Histone H2A variants H2AX and H2AZ.
11895474 Phosphorylation and reorganization of vimentin by p21-activated kinase (PAK).
11895774 Adducin in platelets: activation-induced phosphorylation by PKC and proteolysis by calpain.
11897663 Plk1 promotes nuclear translocation of human Cdc25C during prophase.
11901158 Phosphorylation of threonine 68 promotes oligomerization and autophosphorylation of the Chk2 protein kinase via the forkhead-associated domain.
11901164 CD46 is phosphorylated at tyrosine 354 upon infection of epithelial cells by Neisseria gonorrhoeae.
11903055 Protein kinase A enhances, whereas glycogen synthase kinase-3 beta inhibits, the activity of the exon 2-encoded transactivator domain of heterogeneous nuclear ribonucleoprotein D in a hierarchical fashion.
11903056 Glycosylation and epitope mapping of the 5T4 glycoprotein oncofoetal antigen.
11904303 p59Hck isoform induces F-actin reorganization to form protrusions of the plasma membrane in a Cdc42- and Rac-dependent manner.
11904305 Identification of two Sp1 phosphorylation sites for p42/p44 mitogen-activated protein kinases: their implication in vascular endothelial growth factor gene transcription.
11904443 Dominant-interfering forms of MEF2 generated by caspase cleavage contribute to NMDA-induced neuronal apoptosis.
11906178 Revised structure of the active form of human deoxyribonuclease IIalpha.
11907260 Palmitoylation of tetraspanin proteins: modulation of CD151 lateral interactions, subcellular distribution, and integrin-dependent cell morphology.
11907583 TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2.
11909529 The T cell protein tyrosine phosphatase is a negative regulator of janus family kinases 1 and 3.
11909853 Regulation of TRAF2 signaling by self-induced degradation.
11909961 SKAP55 coupled with CD45 positively regulates T-cell receptor-mediated gene transcription.
11909973 HMG2 interacts with the nucleosome assembly protein SET and is a target of the cytotoxic T-lymphocyte protease granzyme A.
11909979 MSK1 and MSK2 are required for the mitogen- and stress-induced phosphorylation of CREB and ATF1 in fibroblasts.
11910029 Mass spectrometric analysis of the kinetics of in vivo rhodopsin phosphorylation.
11911831 TL1A is a TNF-like ligand for DR3 and TR6/DcR3 and functions as a T cell costimulator.
11912203 Hydroxylation and glycosylation of the four conserved lysine residues in the collagenous domain of adiponectin. Potential role in the modulation of its insulin-sensitizing activity.
11914378 Regulation of an activated S6 kinase 1 variant reveals a novel mammalian target of rapamycin phosphorylation site.
11916978 Protein kinase C (PKC) delta regulates PKCalpha activity in a Syndecan-4-dependent manner.
11920685 Activation of apoptosis signal-regulating kinase 1 by the stress-induced activating phosphorylation of pre-formed oligomer.
11921352 Functional interaction of G protein-coupled receptors of the adrenomedullin peptide family with accessory receptor-activity-modifying proteins (RAMP).
11923282 Regulation of metallothionein transcription by the metal-responsive transcription factor MTF-1: identification of signal transduction cascades that control metal-inducible transcription.
11923305 Mitotic activation of protein-tyrosine phosphatase alpha and regulation of its Src-mediated transforming activity by its sites of protein kinase C phosphorylation.
11925442 Mitosis-specific activation of LIM motif-containing protein kinase and roles of cofilin phosphorylation and dephosphorylation in mitosis.
11927607 Src-mediated coupling of focal adhesion kinase to integrin alpha(v)beta5 in vascular endothelial growth factor signaling.
11928826 Apolipoprotein(a): structure-function relationship at the lysine-binding site and plasminogen activator cleavage site.
11931630 Integrin-linked kinase phosphorylates the myosin phosphatase target subunit at the inhibitory site in platelet cytoskeleton.
11931757 Human origin recognition complex large subunit is degraded by ubiquitin-mediated proteolysis after initiation of DNA replication.
11934902 c-Src-dependent transcriptional activation of TFII-I.
11940572 ErbB-2 activates Stat3 alpha in a Src- and JAK2-dependent manner.
11940573 Interactions between protein kinase CK2 and Pin1. Evidence for phosphorylation-dependent interactions.
11940581 Protein kinase C-alpha and protein kinase C-epsilon are required for Grb2-associated binder-1 tyrosine phosphorylation in response to platelet-derived growth factor.
11944890 Phytochemical inhibition of interleukin-4-activated Stat6 and expression of VCAM-1.
11948414 Hepatocyte growth factor/scatter factor activates the ETS1 transcription factor by a RAS-RAF-MEK-ERK signaling pathway.
11948419 Motif analysis of the tumor suppressor gene MMAC/PTEN identifies tyrosines critical for tumor suppression and lipid phosphatase activity.
11953308 14-3-3 amplifies and prolongs adrenergic stimulation of HERG K+ channel activity.
11953316 Caspase-6 gene disruption reveals a requirement for lamin A cleavage in apoptotic chromatin condensation.
11953320 Regulation of the ubiquitin-conjugating enzyme hHR6A by CDK-mediated phosphorylation.
11955010 The role of MeH73 in actin polymerization and ATP hydrolysis.
11955436 Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism.
11956190 Sphingosine 1-phosphate induces membrane ruffling and increases motility of human umbilical vein endothelial cells via vascular endothelial growth factor receptor and CrkII.
11956222 Identification of 14-3-3zeta as a protein kinase B/Akt substrate.
11959144 Dephosphorylation of PKCdelta by protein phosphatase 2Ac and its inhibition by nucleotides.
11959841 SETDB1: a novel KAP-1-associated histone H3, lysine 9-specific methyltransferase that contributes to HP1-mediated silencing of euchromatic genes by KRAB zinc-finger proteins.
11960013 IRAK-4: a novel member of the IRAK family with the properties of an IRAK-kinase.
11960997 SUMO-1 modification of histone deacetylase 1 (HDAC1) modulates its biological activities.
11969422 Identification of in vivo phosphorylation sites of MLK3 by mass spectrometry and phosphopeptide mapping.
11970865 Phosphorylation of CBP mediates transcriptional activation by neural activity and CaM kinase IV.
11971190 Mechanism of constitutive activation of FLT3 with internal tandem duplication in the juxtamembrane domain.
11971877 Mutations in CD2BP1 disrupt binding to PTP PEST and are responsible for PAPA syndrome, an autoinflammatory disorder.
11971957 Cyclic AMP-dependent kinase regulates Raf-1 kinase mainly by phosphorylation of serine 259.
11971963 c-Abl tyrosine kinase regulates the human Rad9 checkpoint protein in response to DNA damage.
11972023 Requirement of Ca2+ and CaMKII for Stat1 Ser-727 phosphorylation in response to IFN-gamma.
11973335 Acetylation of beta-catenin by CREB-binding protein (CBP).
11976320 Inhibition of interleukin-1beta -induced NF-kappa B activation by calcium/calmodulin-dependent protein kinase kinase occurs through Akt activation associated with interleukin-1 receptor-associated kinase phosphorylation and uncoupling of MyD88.
11976329 The death domain of NF-kappa B1 p105 is essential for signal-induced p105 proteolysis.
11976341 Activation of ZAP-70 through specific dephosphorylation at the inhibitory Tyr-292 by the low molecular weight phosphotyrosine phosphatase (LMPTP).
11976726 SH3-dependent stimulation of Src-family kinase autophosphorylation without tail release from the SH2 domain in vivo.
11980723 Two novel phosphorylation sites on FKHR that are critical for its nuclear exclusion.
11983428 Stromal interaction molecule 1 (STIM1), a transmembrane protein with growth suppressor activity, contains an extracellular SAM domain modified by N-linked glycosylation.
11983687 Striatal enriched phosphatase 61 dephosphorylates Fyn at phosphotyrosine 420.
11983694 Src-dependent phosphorylation of the epidermal growth factor receptor on tyrosine 845 is required for zinc-induced Ras activation.
11986329 Proteinases of the bone morphogenetic protein-1 family convert procollagen VII to mature anchoring fibril collagen.
11986331 Autophosphorylation of the mammalian multifunctional protein that initiates de novo pyrimidine biosynthesis.
11994045 Phosphorylation and activation of mitogen- and stress-activated protein kinase-1 in adult rat cardiac myocytes by G-protein-coupled receptor agonists requires both extracellular-signal-regulated kinase and p38 mitogen-activated protein kinase.
11994282 Inhibition of Src family kinases blocks epidermal growth factor (EGF)-induced activation of Akt, phosphorylation of c-Cbl, and ubiquitination of the EGF receptor.
11994312 Tip60 and histone deacetylase 1 regulate androgen receptor activity through changes to the acetylation status of the receptor.
11997497 APS facilitates c-Cbl tyrosine phosphorylation and GLUT4 translocation in response to insulin in 3T3-L1 adipocytes.
11997508 Cyclic AMP blocks cell growth through Raf-1-dependent and Raf-1-independent mechanisms.
11997522 Phosphorylation of NFATc4 by p38 mitogen-activated protein kinases.
12000743 Deciphering the phosphorylation "code" of the glucocorticoid receptor in vivo.
12000759 Ionomycin-activated calpain triggers apoptosis. A probable role for Bcl-2 family members.
12000790 Axin-mediated CKI phosphorylation of beta-catenin at Ser 45: a molecular switch for the Wnt pathway.
12004072 Polypyrimidine tract-binding proteins are cleaved by caspase-3 during apoptosis.
12004076 Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling.
12006387 Role of isoprenylcysteine carboxyl methyltransferase in tumor necrosis factor-alpha stimulation of expression of vascular cell adhesion molecule-1 in endothelial cells.
12006572 Palmitoylation of KChIP splicing variants is required for efficient cell surface expression of Kv4.3 channels.
12006580 Distinct phosphorylation events regulate p130- and p107-mediated repression of E2F-4.
12006586 In vivo phosphorylation of insulin receptor substrate 1 at serine 789 by a novel serine kinase in insulin-resistant rodents.
12006600 Intracellular activation of human adamalysin 19/disintegrin and metalloproteinase 19 by furin occurs via one of the two consecutive recognition sites.
12011079 Src-dependent tyrosine phosphorylation regulates dynamin self-assembly and ligand-induced endocytosis of the epidermal growth factor receptor.
12015328 Androgen receptor phosphorylation. Regulation and identification of the phosphorylation sites.
12016211 The structure of human prokallikrein 6 reveals a novel activation mechanism for the kallikrein family.
12021372 Fatty acid modification of the coxsackievirus and adenovirus receptor.
12023952 The presence of a single tyrosine residue at the carboxyl domain of vascular endothelial growth factor receptor-2/FLK-1 regulates its autophosphorylation and activation of signaling molecules.
12023960 Molecular basis for the substrate specificity of NIMA-related kinase-6 (NEK6). Evidence that NEK6 does not phosphorylate the hydrophobic motif of ribosomal S6 protein kinase and serum- and glucocorticoid-induced protein kinase in vivo.
12024051 Chk2 activation and phosphorylation-dependent oligomerization.
12032545 A novel PKC-regulated mechanism controls CD44 ezrin association and directional cell motility.
12034737 The role of post-translational modifications of the CXCR4 amino terminus in stromal-derived factor 1 alpha association and HIV-1 entry.
12034741 Molecular characterization of hCTR1, the human copper uptake protein.
12037680 CK2-dependent phosphorylation of the E2 ubiquitin conjugating enzyme UBC3B induces its interaction with beta-TrCP and enhances beta-catenin degradation.
12039864 Phosphorylation status modulates Bcl-2 function during glucocorticoid-induced apoptosis in T lymphocytes.
12042304 Phosphotyrosine-specific phosphatase PTP-SL regulates the ERK5 signaling pathway.
12048203 J Biol Chem. 2002 Aug 16;277(33):29973-82. Epub 2002 Jun 4.
12048211 Role of MAP kinases in the 1,25-dihydroxyvitamin D3-induced transactivation of the rat cytochrome P450C24 (CYP24) promoter. Specific functions for ERK1/ERK2 and ERK5.
12050114 Phosphorylation of three regulatory serines of Tob by Erk1 and Erk2 is required for Ras-mediated cell proliferation and transformation.
12051714 Characterisation of the phosphorylation of beta-catenin at the GSK-3 priming site Ser45.
12052829 Serine/threonine phosphorylation of ShcA. Regulation of protein-tyrosine phosphatase-pest binding and involvement in insulin signaling.
12052863 c-Src-mediated phosphorylation of hnRNP K drives translational activation of specifically silenced mRNAs.
12052891 Caspase processing and nuclear export of CTP:phosphocholine cytidylyltransferase alpha during farnesol-induced apoptosis.
12054501 Human serum and glucocorticoid-inducible kinase-like kinase (SGKL) phosphorylates glycogen syntheses kinase 3 beta (GSK-3beta) at serine-9 through direct interaction.
12056836 Cyclin-dependent kinase-5/p35 phosphorylates Presenilin 1 to regulate carboxy-terminal fragment stability.
12058028 The stress-activated protein kinases p38 alpha and JNK1 stabilize p21(Cip1) by phosphorylation.
12058031 Human mannose 6-phosphate-uncovering enzyme is synthesized as a proenzyme that is activated by the endoprotease furin.
12058066 The RNA binding activity of a ribosome biogenesis factor, nucleophosmin/B23, is modulated by phosphorylation with a cell cycle-dependent kinase and by association with its subtype.
12058067 Extracellular signal-regulated kinase phosphorylates tumor necrosis factor alpha-converting enzyme at threonine 735: a potential role in regulated shedding.
12060738 Shotgun identification of protein modifications from protein complexes and lens tissue.
12062094 The IGF-1/Akt pathway is neuroprotective in Huntington's disease and involves Huntingtin phosphorylation by Akt.
12062403 Primary sequence determinants responsible for site-selective dephosphorylation of the PDGF beta-receptor by the receptor-like protein tyrosine phosphatase DEP-1.
12063245 Multiple domains of MCIP1 contribute to inhibition of calcineurin activity.
12063277 Role of glycosylation in cell surface expression and stability of HERG potassium channels.
12064478 Cdk5 phosphorylates p53 and regulates its activity.
12069854 Early-glycation of apolipoprotein E: effect on its binding to LDL receptor, scavenger receptor A and heparan sulfates.
12070155 Natural truncation of the chemokine MIP-1 beta /CCL4 affects receptor specificity but not anti-HIV-1 activity.
12071973 Cellular stresses profoundly inhibit protein synthesis and modulate the states of phosphorylation of multiple translation factors.
12072434 Transcription factor AP-2 interacts with the SUMO-conjugating enzyme UBC9 and is sumolated in vivo.
12077128 Threonine 308 within a putative casein kinase 2 site of the cytoplasmic tail of leukotriene B(4) receptor (BLT1) is crucial for ligand-induced, G-protein-coupled receptor-specific kinase 6-mediated desensitization.
12077184 Cyclin-dependent kinase 5 phosphorylates disabled 1 independently of Reelin signaling.
12077256 Negative feedback regulation of the tumor suppressor PTEN by phosphoinositide-induced serine phosphorylation.
12077416 Identification of signal peptide peptidase, a presenilin-type aspartic protease.
12081135 Evidence of autophosphorylation in Txk: Y91 is an autophosphorylation site.
12082086 cGMP-dependent protein kinase I beta physically and functionally interacts with the transcriptional regulator TFII-I.
12082107 The specificity of extracellular signal-regulated kinase 2 dephosphorylation by protein phosphatases.
12084709 Pctaire1 interacts with p35 and is a novel substrate for Cdk5/p35.
12086603 Convergence of the fanconi anemia and ataxia telangiectasia signaling pathways.
12087059 N-glycans of sphingosine 1-phosphate receptor Edg-1 regulate ligand-induced receptor internalization.
12089143 cAMP inhibition of Akt is mediated by activated and phosphorylated Rap1b.
12091337 Prostaglandin-E2 enhances EPO-mediated STAT5 transcriptional activity by serine phosphorylation of CREB.
12091386 p38 kinase regulates nitric oxide-induced apoptosis of articular chondrocytes by accumulating p53 via NFkappa B-dependent transcription and stabilization by serine 15 phosphorylation.
12091389 Src-induced phosphorylation of caveolin-2 on tyrosine 19. Phospho-caveolin-2 (Tyr(P)19) is localized near focal adhesions, remains associated with lipid rafts/caveolae, but no longer forms a high molecular mass hetero-oligomer with caveolin-1.
12093745 Formation of an hER alpha-COUP-TFI complex enhances hER alpha AF-1 through Ser118 phosphorylation by MAPK.
12095911 PTEN blocks insulin-mediated ETS-2 phosphorylation through MAP kinase, independently of the phosphoinositide 3-kinase pathway.
12096136 C-mannosylation and o-fucosylation of thrombospondin type 1 repeats.
12096713 Activation of Pyk2/RAFTK induces tyrosine phosphorylation of alpha-synuclein via Src-family kinases.
12097137 Inducible nitric oxide synthase (NOS2) expressed in septic patients is nitrated on selected tyrosine residues: implications for enzymic activity.
12105188 Integrin (alpha 6 beta 4) regulation of eIF-4E activity and VEGF translation: a survival mechanism for carcinoma cells.
12107159 Caspase activation of mammalian sterile 20-like kinase 3 (Mst3). Nuclear translocation and induction of apoptosis.
12107172 Nuclear localization of CDC25B1 and serine 146 integrity are required for induction of mitosis.
12107178 The germ cell-specific transcription factor ALF. Structural properties and stabilization of the TATA-binding protein (TBP)-DNA complex.
12110582 Chk1 is activated transiently and targets Cdc25A for degradation at the Xenopus midblastula transition.
12110584 Tyrosine phosphorylation of Mdm2 by c-Abl: implications for p53 regulation.
12110590 Growth factors can activate ATF2 via a two-step mechanism: phosphorylation of Thr71 through the Ras-MEK-ERK pathway and of Thr69 through RalGDS-Src-p38.
12111733 Checking in on Cds1 (Chk2): A checkpoint kinase and tumor suppressor.
12112843 Identification of the phosphotyrosine proteome from thrombin activated platelets.
12114015 Wnt signal transduction: kinase cogs in a nano-machine?
12117418 Structural and functional characterization of tissue factor pathway inhibitor following degradation by matrix metalloproteinase-8.
12119061 A p130Cas tyrosine phosphorylated substrate domain decoy disrupts v-crk signaling.
12119297 Peptide substrate specificities and protein cleavage sites of human endometase/matrilysin-2/matrix metalloproteinase-26.
12119401 Glutathionylation of human thioredoxin: a possible crosstalk between the glutathione and thioredoxin systems.
12119563 Molecular cloning and characterization of OSR1 on human chromosome 2p24.
12121988 Regulation of the nonreceptor tyrosine kinase Brk by autophosphorylation and by autoinhibition.
12123746 Identification of two C-terminal amino acids, Ser(355) and Thr(357), required for short-term homologous desensitization of mu-opioid receptors.
12124386 The role of Asp-462 in regulating Akt activity.
12130691 Oxidative stress decreases G protein-coupled receptor kinase 2 in lymphocytes via a calpain-dependent mechanism.
12133000 Evidence that the dephosphorylation of Ser(535) in the epsilon-subunit of eukaryotic initiation factor (eIF) 2B is insufficient for the activation of eIF2B by insulin.
12135369 The tumor necrosis factor-alpha converting enzyme (TACE): a unique metalloproteinase with highly defined substrate selectivity.
12135390 ADP-ribosylation and functional effects of Pseudomonas exoenzyme S on cellular RalA.
12138165 Identification of threonine 66 as a functionally critical residue of the interleukin-1 receptor-associated kinase.
12138178 Identification of a nuclear Stat1 protein tyrosine phosphatase.
12138194 Regulation of estrogen receptor nuclear export by ligand-induced and p38-mediated receptor phosphorylation.
12138205 Akt-dependent phosphorylation specifically regulates Cot induction of NF-kappa B-dependent transcription.
12144530 Small ubiquitin-related modifier-1 (SUMO-1) modification of the glucocorticoid receptor.
12147342 Sequence determinants on the NR2A and NR2B subunits of NMDA receptor responsible for specificity of phosphorylation by CaMKII.
12147701 A-kinase anchoring protein AKAP220 binds to glycogen synthase kinase-3beta (GSK-3beta ) and mediates protein kinase A-dependent inhibition of GSK-3beta.
12149126 Endogenous mono-ADP-ribosylation of the free Gbetagamma prevents stimulation of phosphoinositide 3-kinase-gamma and phospholipase C-beta2 and is activated by G-protein-coupled receptors.
12149192 Matrix metalloproteinase processing of monocyte chemoattractant proteins generates CC chemokine receptor antagonists with anti-inflammatory properties in vivo.
12149243 Sumoylation of topoisomerase I is involved in its partitioning between nucleoli and nucleoplasm and its clearing from nucleoli in response to camptothecin.
12149249 Direct identification of tyrosine 474 as a regulatory phosphorylation site for the Akt protein kinase.
12149654 Caspase-3 mediated cleavage of BRCA1 during UV-induced apoptosis.
12150915 Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway.
12150977 Modification of Daxx by small ubiquitin-related modifier-1.
12151401 Tyrosine phosphorylation of Kv1.2 modulates its interaction with the actin-binding protein cortactin.
12153558 Phosphorylation of calmodulin. Functional implications.
12154078 Regulation of the CDK-related protein kinase PCTAIRE-1 and its possible role in neurite outgrowth in Neuro-2A cells.
12162494 Induction of transcriptional activity of the cyclic adenosine monophosphate response element binding protein by parathyroid hormone and epidermal growth factor in osteoblastic cells.
12162751 Characterization of PDK2 activity against protein kinase B gamma.
12163482 Ligand-independent activation of the androgen receptor by interleukin-6 and the role of steroid receptor coactivator-1 in prostate cancer cells.
12167161 MBLR, a new RING finger protein resembling mammalian Polycomb gene products, is regulated by cell cycle-dependent phosphorylation.
12167624 Nopp140 is a mediator of the protein kinase A signaling pathway that activates the acute phase response alpha1-acid glycoprotein gene.
12167714 Plk phosphorylation regulates the microtubule-stabilizing protein TCTP.
12171600 Stress-induced regulation of eukaryotic elongation factor 2 kinase by SB 203580-sensitive and -insensitive pathways.
12171601 Glycosylation of human proteinase-activated receptor-2 (hPAR2): role in cell surface expression and signalling.
12171910 Arginine methylation of STAT1 regulates its dephosphorylation by T cell protein tyrosine phosphatase.
12171911 Structure of mitogen-activated protein kinase-activated protein (MAPKAP) kinase 2 suggests a bifunctional switch that couples kinase activation with nuclear export.
12171918 Nonpalmitoylated human asialoglycoprotein receptors recycle constitutively but are defective in coated pit-mediated endocytosis, dissociation, and delivery of ligand to lysosomes.
12175333 N-glycosylation is required for full enzymic activity of the murine galactosylceramide sulphotransferase.
12175915 Analysis of membrane topology of the human reduced folate carrier protein by hemagglutinin epitope insertion and scanning glycosylation insertion mutagenesis.
12176337 Identification of a plasma membrane Raft-associated PKB Ser473 kinase activity that is distinct from ILK and PDK1.
12177059 Regulation of kinase activity of 3-phosphoinositide-dependent protein kinase-1 by binding to 14-3-3.
12177195 Protective role of phosphorylation in turnover of glial fibrillary acidic protein in mice.
12181353 The Shb adaptor protein binds to tyrosine 766 in the FGFR-1 and regulates the Ras/MEK/MAPK pathway via FRS2 phosphorylation in endothelial cells.
12181444 Activation of phospholipase Cgamma2 by tyrosine phosphorylation.
12181742 Caspase cleavage of the nuclear autoantigen LEDGF/p75 abrogates its pro-survival function: implications for autoimmunity in atopic disorders.
12186630 Identification of in vitro and in vivo phosphorylation sites in the catalytic subunit of the DNA-dependent protein kinase.
12186947 A novel chk1-dependent G1/M checkpoint in fission yeast.
12186978 Essential myosin light chain as a target for caspase-3 in failing myocardium.
12191471 Phosphorylation by protein kinase CK2: a signaling switch for the caspase-inhibiting protein ARC.
12193595 Modulation of Smad2-mediated signaling by extracellular signal-regulated kinase.
12194871 cAMP-dependent protein kinase regulates desensitization of the capsaicin receptor (VR1) by direct phosphorylation.
12195704 Metalloproteases cleave the urokinase-type plasminogen activator receptor in the D1-D2 linker region and expose epitopes not present in the intact soluble receptor.
12196520 Protein kinase A site-specific phosphorylation regulates ATP-binding cassette A1 (ABCA1)-mediated phospholipid efflux.
12198130 Phosphorylation of Nrf2 at Ser-40 by protein kinase C regulates antioxidant response element-mediated transcription.
12198159 Tyrosine 221 in Crk regulates adhesion-dependent membrane localization of Crk and Rac and activation of Rac signaling.
12200122 Functional analysis of calcium-binding EF-hand motifs of visinin-like protein-1.
12200128 Interaction of the developmental regulator SALL1 with UBE2I and SUMO-1.
12200134 Processing of native caspase-14 occurs at an atypical cleavage site in normal epidermal differentiation.
12207013 Phosphorylation of threonine 210 and the role of serine 137 in the regulation of mammalian polo-like kinase.
12207903 Molecular cloning of a novel immunoglobulin superfamily gene preferentially expressed by brain and testis.
12208867 Coexpression of ATP-binding cassette proteins ABCG5 and ABCG8 permits their transport to the apical surface.
12209014 Dual localization of human DNA topoisomerase IIIalpha to mitochondria and nucleus.
12213813 Regulation of the ETS transcription factor ER81 by the 90-kDa ribosomal S6 kinase 1 and protein kinase A.
12215447 The long form of FLIP is an activator of caspase-8 at the Fas death-inducing signaling complex.
12215529 Cdc42/Rac1-mediated activation primes PAK2 for superactivation by tyrosine phosphorylation.
12218058 Post-translational modification of bone morphogenetic protein-1 is required for secretion and stability of the protein.
12220227 Reciprocal feedback regulation of insulin receptor and insulin receptor substrate tyrosine phosphorylation by phosphoinositide 3-kinase in primary adipocytes.
12220642 Phosphorylation of the regulatory subunit of smooth muscle protein phosphatase 1M at Thr850 induces its dissociation from myosin.
12221079 Protein kinase C (PKC)-induced phosphorylation of ROMK1 is essential for the surface expression of ROMK1 channels.
12223491 SUMO-1 modification of the C-terminal KVEKVD of Axin is required for JNK activation but has no effect on Wnt signaling.
12223493 Mapping of MST1 kinase sites of phosphorylation. Activation and autophosphorylation.
12223548 A new activity of doublecortin in recognition of the phospho-FIGQY tyrosine in the cytoplasmic domain of neurofascin.
12225289 Differential targeting of the stress mitogen-activated protein kinases to the c-Jun dimerization protein 2.
12226093 Truncation of CDK5 activator p35 induces intensive phosphorylation of Ser202/Thr205 of human tau.
12226103 The extracellular N terminus of the endothelin B (ETB) receptor is cleaved by a metalloprotease in an agonist-dependent process.
12226657 RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO.
12228252 Acyl-enzyme complexes between tissue-type plasminogen activator and neuroserpin are short-lived in vitro.
12231407 Calcitonin induces dephosphorylation of Pyk2 and phosphorylation of focal adhesion kinase in osteoclasts.
12234250 Ionizing radiation induces ataxia telangiectasia mutated kinase (ATM)-mediated phosphorylation of LKB1/STK11 at Thr-366.
12235133 Phosphorylation of tyrosine 291 enhances the ability of WASp to stimulate actin polymerization and filopodium formation. Wiskott-Aldrich Syndrome protein.
12235136 Bi-functional, substrate mimicking RNA inhibits MSK1-mediated cAMP-response element-binding protein phosphorylation and reveals magnesium ion-dependent conformational changes of the kinase.
12235182 The N-linked oligosaccharides at the amino terminus of human apoB are important for the assembly and secretion of VLDL.
12237126 Tyrosine phosphorylation of clathrin heavy chain under oxidative stress.
12237300 Lipopolysaccharide-induced methylation of HuR, an mRNA-stabilizing protein, by CARM1. Coactivator-associated arginine methyltransferase.
12237306 Synapsin I is phosphorylated at Ser603 by p21-activated kinases (PAKs) in vitro and in PC12 cells stimulated with bradykinin.
12237455 The SPOT technique as a tool for studying protein tyrosine phosphatase substrate specificities.
12237775 Biological activity of the thyroid TRK-T3 oncogene requires signalling through Shc.
12239280 A mass spectrometry-based proteomic approach for identification of serine/threonine-phosphorylated proteins by enrichment with phospho-specific antibodies: identification of a novel protein, Frigg, as a protein kinase A substrate.
12241545 Substrate specificity of the metalloproteinase pregnancy-associated plasma protein-A (PAPP-A) assessed by mutagenesis and analysis of synthetic peptides: substrate residues distant from the scissile bond are critical for proteolysis.
12242661 Mammalian Polo-like kinase 3 (Plk3) is a multifunctional protein involved in stress response pathways.
12244095 Activation of STAT3 by the Src family kinase Hck requires a functional SH3 domain.
12244301 PKB/Akt mediates cell-cycle progression by phosphorylation of p27(Kip1) at threonine 157 and modulation of its cellular localization.
12244325 Redox regulatory and anti-apoptotic functions of thioredoxin depend on S-nitrosylation at cysteine 69.
12270932 SHP-2 is a dual-specificity phosphatase involved in Stat1 dephosphorylation at both tyrosine and serine residues in nuclei.
12270943 Casein kinase 1 regulates connexin-43 gap junction assembly.
12297295 Direct identification of PTEN phosphorylation sites.
12297314 Anaphase specific auto-cleavage of separase.
12351631 Protein kinase A negatively modulates the nuclear accumulation of NF-ATc1 by priming for subsequent phosphorylation by glycogen synthase kinase-3.
12351658 Serine phosphorylation of insulin receptor substrate 1 by inhibitor kappa B kinase complex.
12351702 Nuclear export of glucocorticoid receptor is enhanced by c-Jun N-terminal kinase-mediated phosphorylation.
12354693 Induction of cancer cell migration by epidermal growth factor is initiated by specific phosphorylation of tyrosine 1248 of c-erbB-2 receptor via EGFR.
12354770 The aryl hydrocarbon receptor nuclear transporter is modulated by the SUMO-1 conjugation system.
12356731 IEX-1: a new ERK substrate involved in both ERK survival activity and ERK activation.
12356761 Ca2+-stimulated Ca2+ oscillations produced by the Ca2+-sensing receptor require negative feedback by protein kinase C.
12356908 Recombinant human prion protein mutants huPrP D178N/M129 (FFI) and huPrP+9OR (fCJD) reveal proteinase K resistance.
12359212 M6a acts as a nerve growth factor-gated Ca(2+) channel in neuronal differentiation.
12361954 Protein kinase C delta associates with the interleukin-6 receptor subunit glycoprotein (gp) 130 via Stat3 and enhances Stat3-gp130 interaction.
12370821 Tyr-863 phosphorylation enhances focal adhesion kinase autophosphorylation at Tyr-397.
12370829 The transmembrane receptor protein tyrosine phosphatase DEP1 interacts with p120(ctn).
12372285 Fyn and Cdk5 mediate semaphorin-3A signaling, which is involved in regulation of dendrite orientation in cerebral cortex.
12372621 WARTS tumor suppressor is phosphorylated by Cdc2/cyclin B at spindle poles during mitosis.
12372819 Unusual proteolytic activation of pro-hepatocyte growth factor by plasma kallikrein and coagulation factor XIa.
12374744 P21-activated kinase-1 phosphorylates and transactivates estrogen receptor-alpha and promotes hyperplasia in mammary epithelium.
12374746 Control of CBP co-activating activity by arginine methylation.
12374802 Acetylation of interferon regulatory factor-7 by p300/CREB-binding protein (CBP)-associated factor (PCAF) impairs its DNA binding.
12376572 Mapping and structural dissection of human 20 S proteasome using proteomic approaches.
12379128 Beta 2-adrenergic receptor stimulated, G protein-coupled receptor kinase 2 mediated, phosphorylation of ribosomal protein P2.
12379484 Inhibition of histone acetyltransferase function of p300 by PKCdelta.
12379650 Regulation of ionizing radiation-induced Rad52 nuclear foci formation by c-Abl-mediated phosphorylation.
12381726 Definition of the nuclear encoded protein composition of bovine heart mitochondrial complex I. Identification of two new subunits.
12386167 Phosphorylation of the mitotic regulator protein Hec1 by Nek2 kinase is essential for faithful chromosome segregation.
12387813 High-affinity Src-SH2 ligands which do not activate Tyr(527)-phosphorylated Src in an experimental in vivo system.
12387894 Involvement of aberrant glycosylation in phosphorylation of tau by cdk5 and GSK-3beta.
12387897 Beta-helical catalytic domains in glycoside hydrolase families 49, 55 and 87: domain architecture, modelling and assignment of catalytic residues.
12388094 Regulation of the mammalian cell cycle: a model of the G1-to-S transition.
12392720 Phosphorylation of the stress-activated protein kinase, MEKK3, at serine 166.
12393701 Leukemia proto-oncoprotein MLL is proteolytically processed into 2 fragments with opposite transcriptional properties.
12393906 Sumoylation of Mdm2 by protein inhibitor of activated STAT (PIAS) and RanBP2 enzymes.
12397361 The prolyl isomerase Pin1 is a regulator of p53 in genotoxic response.
12399457 Protein kinase A-mediated phosphorylation of the Galpha13 switch I region alters the Galphabetagamma13-G protein-coupled receptor complex and inhibits Rho activation.
12399544 Disruption of the checkpoint kinase 1/cell division cycle 25A pathway abrogates ionizing radiation-induced S and G2 checkpoints.
12400006 Human pEg3 kinase associates with and phosphorylates CDC25B phosphatase: a potential role for pEg3 in cell cycle regulation.
12403768 SHP2 and SOCS3 contribute to Tyr-759-dependent attenuation of interleukin-6 signaling through gp130.
12408818 Control of Smad7 stability by competition between acetylation and ubiquitination.
12408851 Inhibitory autophosphorylation of CaMKII controls PSD association, plasticity, and learning.
12408961 Identification and characterization of novel members of the CREG family, putative secreted glycoproteins expressed specifically in brain.
12411508 Regulation of G(2)/M events by Cdc25A through phosphorylation-dependent modulation of its stability.
12413941 Dissociation of AMPK activity and ACCbeta phosphorylation in human muscle during prolonged exercise.
12414990 A developmentally regulated ARF-like 5 protein (ARL5), localized to nuclei and nucleoli, interacts with heterochromatin protein 1.
12417300 Identification and functional analysis of novel phosphorylation sites in Cx43 in rat primary granulosa cells.
12417592 Phosphorylation of spinophilin modulates its interaction with actin filaments.
12421349 Regulation of tyrosine hydroxylase by stress-activated protein kinases.
12421832 Complex of pregnancy-associated plasma protein-A and the proform of eosinophil major basic protein. Disulfide structure and carbohydrate attachment.
12429743 Tyrosine phosphorylation of I kappa B alpha activates NF kappa B through a redox-regulated and c-Src-dependent mechanism following hypoxia/reoxygenation.
12429746 Oligomerization and trafficking of the human dopamine transporter. Mutational analysis identifies critical domains important for the functional expression of the transporter.
12431783 Phosphorylation of the cell cycle inhibitor p21Cip1/WAF1 by Pim-1 kinase.
12432063 Protein kinase CKII regulates the interaction of beta-catenin with alpha-catenin and its protein stability.
12432067 Lasp-1 binds to non-muscle F-actin in vitro and is localized within multiple sites of dynamic actin assembly in vivo.
12432277 p53 Antiproliferative function is enhanced by aspartate substitution at threonine 18 and serine 20.
12435421 Aberrant glycosylation modulates phosphorylation of tau by protein kinase A and dephosphorylation of tau by protein phosphatase 2A and 5.
12436935 Molecular pharmacology and modeling of vasopressin receptors.
12438239 14-3-3 interacts with the tumor suppressor tuberin at Akt phosphorylation site(s).
12438317 Cell cycle-dependent regulation of pyrimidine biosynthesis.
12438562 Mapping sites of O-GlcNAc modification using affinity tags for serine and threonine post-translational modifications.
12441002 Molecular cloning and subcellular distribution of the novel PDE4B4 cAMP-specific phosphodiesterase isoform.
12441334 The cytokine-inducible Scr homology domain-containing protein negatively regulates signaling by promoting apoptosis in erythroid progenitor cells.
12441343 Structure and activity of human pancreasin, a novel tryptic serine peptidase expressed primarily by the pancreas.
12442257 The spectrum of endogenous human chromogranin A-derived peptides identified using a modified proteomic strategy.
12445832 Phosphorylation of Bruton's tyrosine kinase by c-Abl.
12446680 The p34cdc2-related cyclin-dependent kinase 11 interacts with the p47 subunit of eukaryotic initiation factor 3 during apoptosis.
12447358 Tyrosine phosphorylation of VHR phosphatase by ZAP-70.
12447390 DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1.
12447395 Interaction of FANCD2 and NBS1 in the DNA damage response.
12450396 Prointerleukin-16 contains a functional CcN motif that regulates nuclear localization.
12454019 Mechanism of epidermal growth factor regulation of Vav2, a guanine nucleotide exchange factor for Rac.
12456510 Felic (CIP4b), a novel binding partner with the Src kinase Lyn and Cdc42, localizes to the phagocytic cup.
12457462 Effect of mutation of two critical glutamic acid residues on the activity and stability of human carboxypeptidase M and characterization of its signal for glycosylphosphatidylinositol anchoring.
12458207 Negative regulation of mixed lineage kinase 3 by protein kinase B/AKT leads to cell survival.
12459461 Differential phosphorylation of SNAP-25 in vivo by protein kinase C and protein kinase A.
12459551 The N-terminal truncated isoform of SOCS3 translated from an alternative initiation AUG codon under stress conditions is stable due to the lack of a major ubiquitination site, Lys-6.
12459555 Sialic acid capping of CD8beta core 1-O-glycans controls thymocyte-major histocompatibility complex class I interaction.
12463751 Glycosylation of erythropoietin affects receptor binding kinetics: role of electrostatic interactions.
12464182 Regulation and destabilization of HIF-1alpha by ARD1-mediated acetylation.
12466020 The N-terminus of the human copper transporter 1 (hCTR1) is localized extracellularly, and interacts with itself.
12468530 Tip60 acetyltransferase activity is controlled by phosphorylation.
12468540 The role of C-terminal tyrosine phosphorylation in the regulation of SHP-1 explored via expressed protein ligation.
12468645 Expression and subcellular distribution of the active form of c-Src tyrosine kinase in differentiating human endometrial stromal cells.
12470658 Characterization of the cysteine-rich calcium-binding S100A3 protein from human hair cuticles.
12470661 Identification and characterization of P15RS, a novel P15(INK4b) related gene on G1/S progression.
12475213 S-methylated cysteines in human lens gamma S-crystallins.
12475968 Calcium regulation of GM-CSF by calmodulin-dependent kinase II phosphorylation of Ets1.
12475979 Hepatocyte growth factor receptor tyrosine kinase met is a substrate of the receptor protein-tyrosine phosphatase DEP-1.
12478285 Structural basis of BMP signalling inhibition by the cystine knot protein Noggin.
12478298 Signal-dependent regulation of splicing via phosphorylation of Sam68.
12479974 Biosynthesis and processing of pro CCK: recent progress and future challenges.
12482870 Characterization of sorCS1, an alternatively spliced receptor with completely different cytoplasmic domains that mediate different trafficking in cells.
12482972 Proteolytic cleavage of MLL generates a complex of N- and C-terminal fragments that confers protein stability and subnuclear localization.
12485116 Positive and negative regulation of T-cell activation through kinases and phosphatases.
12488443 J Biol Chem. 2003 Feb 28;278(9):6947-58. Epub 2002 Dec 17.
12488509 Mono-ADP-ribosylation: a tool for modulating immune response and cell signaling.
12492488 Kininogen-derived peptides for investigating the putative vasoactive properties of human cathepsins K and L.
12493754 Polo-like kinase 1 and Chk2 interact and co-localize to centrosomes and the midbody.
12493777 Mechanism of Ca2+-mediated regulation of NDR protein kinase through autophosphorylation and phosphorylation by an upstream kinase.
12496362 Regulation of Lck and Fyn tyrosine kinase activities by transmembrane protein tyrosine phosphatase leukocyte common antigen-related molecule.
12498886 Nitrosopeptide mapping: a novel methodology reveals s-nitrosylation of dexras1 on a single cysteine residue.
12501214 Site-specific dephosphorylation of endothelial nitric oxide synthase by protein phosphatase 2A: evidence for crosstalk between phosphorylation sites.
12502714 Identification and characterization of the autophosphorylation sites of phosphoinositide 3-kinase isoforms beta and gamma.
12504004 Mechanism of recruitment of WASP to the immunological synapse and of its activation following TCR ligation.
12504026 CAND1 binds to unneddylated CUL1 and regulates the formation of SCF ubiquitin E3 ligase complex.
12505983 Cathepsin A regulates chaperone-mediated autophagy through cleavage of the lysosomal receptor.
12507496 GATE-16 and GABARAP are authentic modifiers mediated by Apg7 and Apg3.
12509428 Nitric oxide, NOC-12, and S-nitrosoglutathione modulate the skeletal muscle calcium release channel/ryanodine receptor by different mechanisms. An allosteric function for O2 in S-nitrosylation of the channel.
12509440 Phosphoproteome analysis of capacitated human sperm. Evidence of tyrosine phosphorylation of a kinase-anchoring protein 3 and valosin-containing protein/p97 during capacitation.
12509629 Autoantibodies to dsDNA cross-react with the arginine-glycine-rich domain of heterogeneous nuclear ribonucleoprotein A2 (hnRNP A2) and promote methylation of hnRNP A2.
12511558 A synergy control motif within the attenuator domain of CCAAT/enhancer-binding protein alpha inhibits transcriptional synergy through its PIASy-enhanced modification by SUMO-1 or SUMO-3.
12511603 A central role for Ets-2 in the transcriptional regulation and cyclic adenosine 5'-monophosphate responsiveness of the human chorionic gonadotropin-beta subunit gene.
12514174 JNK1 physically interacts with WW domain-containing oxidoreductase (WOX1) and inhibits WOX1-mediated apoptosis.
12515807 Approaches to define antigen receptor-induced serine kinase signal transduction pathways.
12517957 Lipid raft distribution of CD4 depends on its palmitoylation and association with Lck, and evidence for CD4-induced lipid raft aggregation as an additional mechanism to enhance CD3 signaling.
12519779 Phosphorylation of Munc18 by protein kinase C regulates the kinetics of exocytosis.
12522132 Phosphorylation of tyrosine 319 of the angiotensin II type 1 receptor mediates angiotensin II-induced trans-activation of the epidermal growth factor receptor.
12522270 Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry.
12524442 Identification of the minimal phosphoacceptor site required for in vivo activation of interferon regulatory factor 3 in response to virus and double-stranded RNA.
12524539 Cleaving the oxidative repair protein Ape1 enhances cell death mediated by granzyme A.
12526767 Pathways to Parkinsonism.
12527193 Mammalian Crumbs3 is a small transmembrane protein linked to protein associated with Lin-7 (Pals1).
12527891 Protein kinase CK2 regulates CDC25B phosphatase activity.
12529330 Arsenite-induced phosphorylation of histone H3 at serine 10 is mediated by Akt1, extracellular signal-regulated kinase 2, and p90 ribosomal S6 kinase 2 but not mitogen- and stress-activated protein kinase 1.
12529333 Sumoylation of the progesterone receptor and of the steroid receptor coactivator SRC-1.
12529443 Sam68 RNA binding protein is an in vivo substrate for protein arginine N-methyltransferase 1.
12534294 Phosphorylation of RGS14 by protein kinase A potentiates its activity toward G alpha i.
12538589 Regulation of a transient receptor potential (TRP) channel by tyrosine phosphorylation. SRC family kinase-dependent tyrosine phosphorylation of TRPV4 on TYR-253 mediates its response to hypotonic stress.
12538592 Phosphorylation of the Ras-GRF1 exchange factor at Ser916/898 reveals activation of Ras signaling in the cerebral cortex.
12538644 Multiple splice variants of the human HIF-3 alpha locus are targets of the von Hippel-Lindau E3 ubiquitin ligase complex.
12540842 STAP-2/BKS, an adaptor/docking protein, modulates STAT3 activation in acute-phase response through its YXXQ motif.
12540962 Plasma membrane Ca2+-ATPase isoform 4b is phosphorylated on tyrosine 1176 in activated human platelets.
12546699 Regulation of eukaryotic DNA replication at the initiation step.
12548019 Genotoxic stress-induced activation of Plk3 is partly mediated by Chk2.
12548559 T cell recognition and therapeutic effect of a phosphorylated synthetic peptide of the 70K snRNP protein administered in MR/lpr mice.
12551899 Palmitoylated peptides from the cysteine-rich domain of SNAP-23 cause membrane fusion depending on peptide length, position of cysteines, and extent of palmitoylation.
12551902 Signaling between focal adhesion kinase and trio.
12551923 Phosphorylation of Raf-1 by p21-activated kinase 1 and Src regulates Raf-1 autoinhibition.
12551925 Activation of Raf-1 signaling by protein kinase C through a mechanism involving Raf kinase inhibitory protein.
12551931 The Notch ligands, Delta1 and Jagged2, are substrates for presenilin-dependent "gamma-secretase" cleavage.
12551973 Conserved protein kinases encoded by herpesviruses and cellular protein kinase cdc2 target the same phosphorylation site in eukaryotic elongation factor 1delta.
12552133 The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): liver regeneration and neuronal differentiation.
12554736 Regulation of mammalian STE20-like kinase 2 (MST2) by protein phosphorylation/dephosphorylation and proteolysis.
12554790 Protein tyrosine phosphatase PTP20 induces actin cytoskeleton reorganization by dephosphorylating p190 RhoGAP in rat ovarian granulosa cells stimulated with follicle-stimulating hormone.
12555094 Granzyme A: the road less traveled.
12556484 Human Nudel and NudE as regulators of cytoplasmic dynein in poleward protein transport along the mitotic spindle.
12556497 Regulation of lymphoid enhancer factor 1/T-cell factor by mitogen-activated protein kinase-related Nemo-like kinase-dependent phosphorylation in Wnt/beta-catenin signaling.
12556884 DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation.
12558502 Protein kinase CK2 phosphorylates Hsp105 alpha at Ser509 and modulates its function.
12559972 Mechanism of Janus kinase 3-catalyzed phosphorylation of a Janus kinase 1 activation loop peptide.
12560069 Estrogen regulation of Pak1 and FKHR pathways in breast cancer cells.
12560083 Ezrin is a substrate for Lck in T cells.
12560341 Nuclear localization of the cell cycle regulator CDH1 and its regulation by phosphorylation.
12562768 Molecular evolution by change of function. Alkaloid-specific homospermidine synthase retained all properties of deoxyhypusine synthase except binding the eIF5A precursor protein.
12562775 Specific nitration at tyrosine 430 revealed by high resolution mass spectrometry as basis for redox regulation of bovine prostacyclin synthase.
12563012 Phosphorylation of the myosin phosphatase targeting subunit and CPI-17 during Ca2+ sensitization in rabbit smooth muscle.
12564933 Basal and hydrogen peroxide stimulated sites of phosphorylation in heterogeneous nuclear ribonucleoprotein C1/C2.
12569090 Phosphorylation of serine 1106 in the catalytic domain of topoisomerase II alpha regulates enzymatic activity and drug sensitivity.
12569367 Regulation of the ER81 transcription factor and its coactivators by mitogen- and stress-activated protein kinase 1 (MSK1).
12571245 Actin binding of human LIM and SH3 protein is regulated by cGMP- and cAMP-dependent protein kinase phosphorylation on serine 146.
12573241 Identification of phosphorylation sites within the SH3 domains of Tec family tyrosine kinases.
12574116 Mad2 phosphorylation regulates its association with Mad1 and the APC/C.
12574125 STAT5-induced Id-1 transcription involves recruitment of HDAC1 and deacetylation of C/EBPbeta.
12576312 A predominant role for cAMP-dependent protein kinase in the cGMP-induced phosphorylation of vasodilator-stimulated phosphoprotein and platelet inhibition in humans.
12576423 Tissue microarray analysis of signal transducers and activators of transcription 3 (Stat3) and phospho-Stat3 (Tyr705) in node-negative breast cancer shows nuclear localization is associated with a better prognosis.
12578357 Mutational analysis of the complex of human RNase inhibitor and human eosinophil-derived neurotoxin (RNase 2).
12578970 cAMP-dependent protein kinase phosphorylation of the acid-sensing ion channel-1 regulates its binding to the protein interacting with C-kinase-1.
12582162 The p38 and MK2 kinase cascade phosphorylates tuberin, the tuberous sclerosis 2 gene product, and enhances its interaction with 14-3-3.
12586364 Novel insights into cadherin processing by subtilisin-like convertases.
12586835 Mitotic regulation of ribosomal S6 kinase 1 involves Ser/Thr, Pro phosphorylation of consensus and non-consensus sites by Cdc2.
12586837 Activation of pro-gelatinase B by endometase/matrilysin-2 promotes invasion of human prostate cancer cells.
12588975 The C terminus of initiation factor 4E-binding protein 1 contains multiple regulatory features that influence its function and phosphorylation.
12588979 Phosphorylation of stem-loop binding protein (SLBP) on two threonines triggers degradation of SLBP, the sole cell cycle-regulated factor required for regulation of histone mRNA processing, at the end of S phase.
12589038 Integrin-mediated tyrosine phosphorylation of Shc in T cells is regulated by protein kinase C-dependent phosphorylations of Lck.
12589057 Nup98 localizes to both nuclear and cytoplasmic sides of the nuclear pore and binds to two distinct nucleoporin subcomplexes.
12590919 Functional analysis of site-directed glycosylation mutants of the human equilibrative nucleoside transporter-2.
12591939 The C-terminal domain phosphatase and transcription elongation activities of FCP1 are regulated by phosphorylation.
12591950 JNK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosis.
12594221 Identification of novel ERK2 substrates through use of an engineered kinase and ATP analogs.
12600888 Activation of RhoA and inhibition of myosin phosphatase as important components in hypertension in vascular smooth muscle.
12601080 Signaling initiated by overexpression of the fibroblast growth factor receptor-1 investigated by mass spectrometry.
12604610 The mammalian target of rapamycin (mTOR) partner, raptor, binds the mTOR substrates p70 S6 kinase and 4E-BP1 through their TOR signaling (TOS) motif.
12604689 Selective tryptic cleavage at the tethered ligand site of the amino terminal domain of proteinase-activated receptor-2 in intact cells.
12609826 Endopeptidases 22.214.171.124 and 24.16 in endothelial cells: potential role in vasoactive peptide metabolism.
12609988 Profile-based data base scanning for animal L-type lectins and characterization of VIPL, a novel VIP36-like endoplasmic reticulum protein.
12609995 Activation of cGMP-dependent protein kinase by protein kinase C.
12612081 Regulation of insulin receptor signaling by the protein tyrosine phosphatase TCPTP.
12612082 A novel RING finger protein, human enhancer of invasion 10, alters mitotic progression through regulation of cyclin B levels.
12613668 Regulation of caldesmon activity by Cdc2 kinase plays an important role in maintaining membrane cortex integrity during cell division.
12615929 Sterol regulatory element-binding proteins are negatively regulated through SUMO-1 modification independent of the ubiquitin/26 S proteasome pathway.
12615930 Phosphorylation-dependent regulation of Kv2.1 Channel activity at tyrosine 124 by Src and by protein-tyrosine phosphatase epsilon.
12618428 14-3-3beta is a p90 ribosomal S6 kinase (RSK) isoform 1-binding protein that negatively regulates RSK kinase activity.
12620231 The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase.
12621041 Activation of transforming growth factor-beta signaling by SUMO-1 modification of tumor suppressor Smad4/DPC4.
12621058 Characterization of growth factor-induced serine phosphorylation of tumor necrosis factor-alpha converting enzyme and of an alternatively translated polypeptide.
12621061 Signal transduction pathways regulated by prolactin and Src result in different conformations of activated Stat5b.
12624098 The inhibitory gamma subunit of the type 6 retinal cGMP phosphodiesterase functions to link c-Src and G-protein-coupled receptor kinase 2 in a signaling unit that regulates p42/p44 mitogen-activated protein kinase by epidermal growth factor.
12624099 Adipose-specific expression, phosphorylation of Ser794 in insulin receptor substrate-1, and activation in diabetic animals of salt-inducible kinase-2.
12626415 Glycosylation of human pancreatic ribonuclease: differences between normal and tumor states.
12626422 The underglycosylation of plasma alpha 1-antitrypsin in congenital disorders of glycosylation type I is not random.
12626508 Hypertonicity activates Na+/H+ exchange through Janus kinase 2 and calmodulin.
12628923 Protein kinase CK2 and protein kinase D are associated with the COP9 signalosome.
12630910 Post-synaptic density-95 promotes calcium/calmodulin-dependent protein kinase II-mediated Ser847 phosphorylation of neuronal nitric oxide synthase.
12631277 Disruption of structural and functional integrity of alpha 2-macroglobulin by cathepsin E.
12637327 Ser727/Tyr701-phosphorylated Stat1 is required for the regulation of c-Myc, cyclins, and p27Kip1 associated with ATRA-induced G0/G1 arrest of U-937 cells.
12637502 Regulation of epidermal growth factor-induced connexin 43 gap junction communication by big mitogen-activated protein kinase1/ERK5 but not ERK1/2 kinase activation.
12637511 Specific beta1 integrin site selectively regulates Akt/protein kinase B signaling via local activation of protein phosphatase 2A.
12637538 Tyrosine phosphorylation of protein kinase D in the pleckstrin homology domain leads to activation.
12639913 Regulation of melanocortin-4 receptor signaling: agonist-mediated desensitization and internalization.
12640114 p120 Catenin-associated Fer and Fyn tyrosine kinases regulate beta-catenin Tyr-142 phosphorylation and beta-catenin-alpha-catenin Interaction.
12640123 Structural requirements of SLP-76 in signaling via the high-affinity immunoglobulin E receptor (Fc epsilon RI) in mast cells.
12640464 PKCepsilon is a permissive link in integrin-dependent IFN-gamma signalling that facilitates JAK phosphorylation of STAT1.
12642610 The RasGAP-associated endoribonuclease G3BP assembles stress granules.
12651610 Cathepsin D specifically cleaves the chemokines macrophage inflammatory protein-1 alpha, macrophage inflammatory protein-1 beta, and SLC that are expressed in human breast cancer.
12654918 Serine phosphorylation negatively regulates RhoA in vivo.
12657630 In vivo identification of inducible phosphoacceptors in the IKKgamma/NEMO subunit of human IkappaB kinase.
12659875 Transcriptional activity and DNA binding of heat shock factor-1 involve phosphorylation on threonine 142 by CK2.
12660173 Human Tousled like kinases are targeted by an ATM- and Chk1-dependent DNA damage checkpoint.
12665511 Two motifs in the translational repressor PHAS-I required for efficient phosphorylation by mammalian target of rapamycin and for recognition by raptor.
12665592 Phosphorylation of serine 303 is a prerequisite for the stress-inducible SUMO modification of heat shock factor 1.
12665801 Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.
12668660 Caspase cleavage product of BAP31 induces mitochondrial fission through endoplasmic reticulum calcium signals, enhancing cytochrome c release to the cytosol.
12670890 The proteolytic processing of pro-platelet-derived growth factor-A at RRKR(86) by members of the proprotein convertase family is functionally correlated to platelet-derived growth factor-A-induced functions and tumorigenicity.
12671685 Proteolytic cleavage of PDZD2 generates a secreted peptide containing two PDZ domains.
12672959 Processing, localization, and requirement of human separase for normal anaphase progression.
12676583 Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A.
12676647 Recent advances in mechanisms regulating glucose oxidation at the level of the pyruvate dehydrogenase complex by PDKs.
12676926 Cyclin-dependent kinases phosphorylate p73 at threonine 86 in a cell cycle-dependent manner and negatively regulate p73.
12679040 The polycomb protein Pc2 is a SUMO E3.
12681492 Stimulation of the alpha1A adrenergic receptor inhibits PDGF-induced PDGF beta receptor Tyr751 phosphorylation and PI 3-kinase activation.
12682012 PKA phosphorylates the p75 receptor and regulates its localization to lipid rafts.
12682077 Agonist-induced phosphorylation of the serotonin 5-HT2C receptor regulates its interaction with multiple PDZ protein 1.
12682249 Threonine phosphorylation sites in the beta 2 and beta 7 leukocyte integrin polypeptides.
12682370 Phosphorylation of Kruppel-like factor 5 (KLF5/IKLF) at the CBP interaction region enhances its transactivation function.
12684437 Control of growth cone motility and morphology by LIM kinase and Slingshot via phosphorylation and dephosphorylation of cofilin.
12686604 Functional significance of the specific sites phosphorylated in desmin at cleavage furrow: Aurora-B may phosphorylate and regulate type III intermediate filaments during cytokinesis coordinatedly with Rho-kinase.
12689593 Phosphorylation by aurora B converts MgcRacGAP to a RhoGAP during cytokinesis.
12692561 A method for the comprehensive proteomic analysis of membrane proteins.
12697024 Okadaic acid-induced, naringin-sensitive phosphorylation of glycine N-methyltransferase in isolated rat hepatocytes.
12697768 Accumulation of checkpoint protein 53BP1 at DNA breaks involves its binding to phosphorylated histone H2AX.
12700239 CK2 phosphorylation of the armadillo repeat region of beta-catenin potentiates Wnt signaling.
12709442 Phosphorylation of human Rad9 is required for genotoxin-activated checkpoint signaling.
12714602 Identification of MCM4 as a target of the DNA replication block checkpoint system.
12717439 Chk2 activates E2F-1 in response to DNA damage.
12718890 Methylation of SPT5 regulates its interaction with RNA polymerase II and transcriptional elongation properties.
12724314 Identification and characterization of a novel p300-mediated p53 acetylation site, lysine 305.
12727876 Cdc2-mediated phosphorylation of Kid controls its distribution to spindle and chromosomes.
12729597 Stable isotope phospho-profiling of fibrinogen and fetuin subunits by element mass spectrometry coupled to capillary liquid chromatography.
12730201 Ca2+-dependent phosphorylation of syntaxin-1A by the death-associated protein (DAP) kinase regulates its interaction with Munc18.
12734187 Src-CrkII-C3G-dependent activation of Rap1 switches growth hormone-stimulated p44/42 MAP kinase and JNK/SAPK activities.
12737624 Pigment-epithelium-derived factor (PEDF) occurs at a physiologically relevant concentration in human blood: purification and characterization.
12738778 The activation of matriptase requires its noncatalytic domains, serine protease domain, and its cognate inhibitor.
12738781 Identification of a consensus motif for Plk (Polo-like kinase) phosphorylation reveals Myt1 as a Plk1 substrate.
12740371 AMP-activated protein kinase regulates HNF4alpha transcriptional activity by inhibiting dimer formation and decreasing protein stability.
12740440 Structural and biochemical studies of p21Ras S-nitrosylation and nitric oxide-mediated guanine nucleotide exchange.
12741986 Serine 776 of ataxin-1 is critical for polyglutamine-induced disease in SCA1 transgenic mice.
12743374 The phosphorylation of caveolin-2 on serines 23 and 36 modulates caveolin-1-dependent caveolae formation.
12745091 Expression and phosphorylation of the replication regulator protein geminin.
12747827 TOS motif-mediated raptor binding regulates 4E-BP1 multisite phosphorylation and function.
12748172 Identification and characterization of a nuclear interacting partner of anaplastic lymphoma kinase (NIPA).
12748192 Phosphorylation of threonine 10 on CKBBP1/SAG/ROC2/Rbx2 by protein kinase CKII promotes the degradation of IkappaBalpha and p27Kip1.
12750467 Targeting Ras signaling through inhibition of carboxyl methylation: an unexpected property of methotrexate.
12753909 Heregulin and HER2 signaling selectively activates c-Src phosphorylation at tyrosine 215.
12754301 Protein tyrosine phosphatase epsilon inhibits signaling by mitogen-activated protein kinases.
12754513 AKAP150 signaling complex promotes suppression of the M-current by muscarinic agonists.
12754519 Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry.
12756254 Recruitment of JNK to JIP1 and JNK-dependent JIP1 phosphorylation regulates JNK module dynamics and activation.
12757707 Interaction of Akt-phosphorylated ataxin-1 with 14-3-3 mediates neurodegeneration in spinocerebellar ataxia type 1.
12760422 Thr94 in bovine myelin basic protein is a second phosphorylation site for 42-kDa mitogen-activated protein kinase (ERK2).
12761178 Regulation of type 1 protein phosphatase/inhibitor-2 complex by glycogen synthase kinase-3beta in intact cells.
12763138 Erythropoietin-induced serine 727 phosphorylation of STAT3 in erythroid cells is mediated by a MEK-, ERK-, and MSK1-dependent pathway.
12769842 Increased ezrin expression and activation by CDK5 coincident with acquisition of the senescent phenotype.
12769846 Contingent phosphorylation/dephosphorylation provides a mechanism of molecular memory in WASP.
12769847 Phosphorylation of the WASP-VCA domain increases its affinity for the Arp2/3 complex and enhances actin polymerization by WASP.
12769861 Opposed regulation of corepressor CtBP by SUMOylation and PDZ binding.
12771940 ARHI is a Ras-related small G-protein with a novel N-terminal extension that inhibits growth of ovarian and breast cancers.
12773393 MSK2 and MSK1 mediate the mitogen- and stress-induced phosphorylation of histone H3 and HMG-14.
12777400 Catalase activity is regulated by c-Abl and Arg in the oxidative stress response.
12787665 Functional domains of FOXJ2.
12788913 Reversal of the deoxyhypusine synthesis reaction. Generation of spermidine or homospermidine from deoxyhypusine by deoxyhypusine synthase.
12788955 A docking site in MKK4 mediates high affinity binding to JNK MAPKs and competes with similar docking sites in JNK substrates.
12789267 v-Src induces Shc binding to tyrosine 63 in the cytoplasmic domain of the LDL receptor-related protein 1.
12792650 Inhibition of caspase-9 through phosphorylation at Thr 125 by ERK MAPK.
12794074 Phosphorylation by glycogen synthase kinase-3 beta down-regulates Notch activity, a link for Notch and Wnt pathways.
12794087 Activation of ERK induces phosphorylation of MAPK phosphatase-7, a JNK specific phosphatase, at Ser-446.
12796477 BMPs signal alternately through a SMAD or FRAP-STAT pathway to regulate fate choice in CNS stem cells.
12796778 14-3-3epsilon is important for neuronal migration by binding to NUDEL: a molecular explanation for Miller-Dieker syndrome.
12801888 Phosphorylation of threonine 276 in Smad4 is involved in transforming growth factor-beta-induced nuclear accumulation.
12802062 Membrane targeting of Rab GTPases is influenced by the prenylation motif.
12804768 Occludin phosphorylation: identification of an occludin kinase in brain and cell extracts as CK2.
12805216 The B cell-specific major raft protein, Raftlin, is necessary for the integrity of lipid raft and BCR signal transduction.
12805220 Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD.
12805407 Regulation of the Chk2 protein kinase by oligomerization-mediated cis- and trans-phosphorylation.
12805550 Requirement of AMPA receptor GluR2 phosphorylation for cerebellar long-term depression.
12808093 Protein kinase B/Akt binds and phosphorylates PED/PEA-15, stabilizing its antiapoptotic action.
12808100 Hydrogen peroxide triggers nuclear export of telomerase reverse transcriptase via Src kinase family-dependent phosphorylation of tyrosine 707.
12809493 Hurpin is a selective inhibitor of lysosomal cathepsin L and protects keratinocytes from ultraviolet-induced apoptosis.
12809553 Phosphorylation of BATF regulates DNA binding: a novel mechanism for AP-1 (activator protein-1) regulation.
12810701 The localization and phosphorylation of p47 are important for Golgi disassembly-assembly during the cell cycle.
12812918 Potential role of leucine metabolism in the leucine-signaling pathway involving mTOR.
12815053 M phase-specific phosphorylation of BRCA2 by Polo-like kinase 1 correlates with the dissociation of the BRCA2-P/CAF complex.
12817007 Activation of protein kinase C delta by IFN-gamma.
12818176 JNK-mediated BIM phosphorylation potentiates BAX-dependent apoptosis.
12818188 Identification of interleukin-8 converting enzyme as cathepsin L.
12819028 ASK1 associates with troponin T and induces troponin T phosphorylation and contractile dysfunction in cardiomyocytes.
12819195 Regulation of A + U-rich element-directed mRNA turnover involving reversible phosphorylation of AUF1.
12819209 Threonine 391 phosphorylation of the human prolactin receptor mediates a novel interaction with 14-3-3 proteins.
12824184 Cyclin-dependent kinase-5 is involved in neuregulin-dependent activation of phosphatidylinositol 3-kinase and Akt activity mediating neuronal survival.
12829704 Identification of the p16-Arc subunit of the Arp 2/3 complex as a substrate of MAPK-activated protein kinase 2 by proteomic analysis.
12832492 Cdk5 regulates the organization of Nestin and its association with p35.
12837278 Cofilin phosphorylation and actin polymerization by NRK/NESK, a member of the germinal center kinase family.
12839991 Structure and axon outgrowth inhibitor binding of the Nogo-66 receptor and related proteins.
12840024 A mitotic cascade of NIMA family kinases. Nercc1/Nek9 activates the Nek6 and Nek7 kinases.
12843408 The calpain system.
12851456 Protein kinase A phosphorylation modulates transport of the polypyrimidine tract-binding protein.
12852788 Adaptor signalling proteins Grb2 and Grb7 are recruited by human G6f, a novel member of the immunoglobulin superfamily encoded in the MHC.
12852850 Fertility and taxon-specific sperm binding persist after replacement of mouse sperm receptors with human homologs.
12852856 Polo-like kinase 1 regulates Nlp, a centrosome protein involved in microtubule nucleation.
12852857 A role for Plk1 phosphorylation of NudC in cytokinesis.
12853467 14-3-3s regulate fructose-2,6-bisphosphate levels by binding to PKB-phosphorylated cardiac fructose-2,6-bisphosphate kinase/phosphatase.
12853968 Phosphorylation of human Fen1 by cyclin-dependent kinase modulates its role in replication fork regulation.
12853976 Lats2, a putative tumor suppressor, inhibits G1/S transition.
12855578 PIAS proteins promote SUMO-1 conjugation to STAT1.
12855954 Cdk5 is essential for synaptic vesicle endocytosis.
12857729 Cdk2-dependent phosphorylation of the NF-Y transcription factor and its involvement in the p53-p21 signaling pathway.
12857734 Oxidative damage to mitochondrial complex I due to peroxynitrite: identification of reactive tyrosines by mass spectrometry.
12860119 Phosphorylation of the N-terminal domain regulates subcellular localization and DNA binding properties of the peptidyl-prolyl cis/trans isomerase hPar14.
12860403 Proteolytic cleavage of the EMR2 receptor requires both the extracellular stalk and the GPS motif.
12860980 Multistep autoactivation of asparaginyl endopeptidase in vitro and in vivo.
12861023 Proteomic identification of 14-3-3zeta as a mitogen-activated protein kinase-activated protein kinase 2 substrate: role in dimer formation and ligand binding.
12867358 Mutagenesis of the N-glycosylation site of hNaSi-1 reduces transport activity.
12876286 CHOP transcription factor phosphorylation by casein kinase 2 inhibits transcriptional activation.
12876325 Methylation and carbamylation of human gamma-crystallins.
12878163 Identification of Tyr900 in the kinase domain of c-Kit as a Src-dependent phosphorylation site mediating interaction with c-Crk.
12879005 Cleavage of metastasis suppressor gene product KiSS-1 protein/metastin by matrix metalloproteinases.
12881490 A Ras activation pathway dependent on Syk phosphorylation of protein kinase C.
12881528 Ligand-induced vascular endothelial growth factor receptor-3 (VEGFR-3) heterodimerization with VEGFR-2 in primary lymphatic endothelial cells regulates tyrosine phosphorylation sites.
12885254 Adhesion-associated and PKC-modulated changes in serine/threonine phosphorylation of p120-catenin.
12886014 Polyserase-I, a human polyprotease with the ability to generate independent serine protease domains from a single translation product.
12888487 Mechanisms of P/CAF auto-acetylation.
12888562 Requirement of Cys399 for processing of the human ecto-ATPase (NTPDase2) and its implications for determination of the activities of splice variants of the enzyme.
12888622 Caspase cleavage of tau: linking amyloid and neurofibrillary tangles in Alzheimer's disease.
12888867 Biochemical importance of glycosylation of plasminogen activator inhibitor-1.
12893243 Centaurin-alpha(1) associates with and is phosphorylated by isoforms of protein kinase C.
12893824 Glutathione peroxidase 1 is regulated by the c-Abl and Arg tyrosine kinases.
12897128 p21-Activated kinase 5 (Pak5) localizes to mitochondria and inhibits apoptosis by phosphorylating BAD.
12897141 The N and C termini of the splice variants of the human mitogen-activated protein kinase-interacting kinase Mnk2 determine activity and localization.
12904296 Cleavage of syndecan-1 by membrane type matrix metalloproteinase-1 stimulates cell migration.
12907171 Expression of betaA2-crystallin in human lenses.
12907688 Processing and localization of ADAMTS-1 and proteolytic cleavage of versican during cumulus matrix expansion and ovulation.
12911333 Allowed N-glycosylation sites on the Kv1.2 potassium channel S1-S2 linker: implications for linker secondary structure and the glycosylation effect on channel function.
12911626 Regulation of the glutamate transporter EAAT1 by the ubiquitin ligase Nedd4-2 and the serum and glucocorticoid-inducible kinase isoforms SGK1/3 and protein kinase B.
12912980 Differential contribution of inhibitory phosphorylation of CDC2 and CDK2 for unperturbed cell cycle control and DNA integrity checkpoints.
12912989 Target of rapamycin (TOR)-signaling and RAIP motifs play distinct roles in the mammalian TOR-dependent phosphorylation of initiation factor 4E-binding protein 1.
12914934 S-nitrosation of Cys-800 of HIF-1alpha protein activates its interaction with p300 and stimulates its transcriptional activity.
12917345 Acetylation-mediated transcriptional activation of the ETS protein ER81 by p300, P/CAF, and HER2/Neu.
12923183 T cell receptor engagement leads to the recruitment of IBP, a novel guanine nucleotide exchange factor, to the immunological synapse.
12925766 Exploring the functional interactions between Aurora B, INCENP, and survivin in mitosis.
12926989 Dephosphorylation of histone gamma-H2AX during repair of DNA double-strand breaks in mammalian cells and its inhibition by calyculin A.
12930825 Phosphorylation of SNAP-23 in activated human platelets.
12930845 Phosphorylation of serine 13 is required for the proper function of the Hsp90 co-chaperone, Cdc37.
12931194 Transcription factor IIB acetylates itself to regulate transcription.
12933808 CaMKII-dependent phosphorylation regulates SAP97/NR2A interaction.
12935886 Identification and characterization of novel components of a Ca2+/calmodulin-dependent protein kinase cascade in HeLa cells.
12939163 N-Glycosylation and conserved cysteine residues in RAMP3 play a critical role for the functional expression of CRLR/RAMP3 adrenomedullin receptor.
12939405 Carboxyl-terminal-truncated apolipoprotein E4 causes Alzheimer's disease-like neurodegeneration and behavioral deficits in transgenic mice.
12941695 Functional analysis of C-TAK1 substrate binding and identification of PKP2 as a new C-TAK1 substrate.
12947093 Phosphorylation of serine 337 of NF-kappaB p50 is critical for DNA binding.
12949938 Effect of carbohydrate moieties on the folate hydrolysis activity of the prostate specific membrane antigen.
12950257 Gelatinase B/MMP-9 and neutrophil collagenase/MMP-8 process the chemokines human GCP-2/CXCL6, ENA-78/CXCL5 and mouse GCP-2/LIX and modulate their physiological activities.
12950453 Physiological regulation of Munc18/nSec1 phosphorylation on serine-313.
12953056 The junctional adhesion molecule (JAM) family members JAM-2 and JAM-3 associate with the cell polarity protein PAR-3: a possible role for JAMs in endothelial cell polarity.
12953068 The UIM domain of Hrs couples receptor sorting to vesicle formation.
12955071 Suppression of Tousled-like kinase activity after DNA damage or replication block requires ATM, NBS1 and Chk1.
12962325 Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing.
12962630 The structure of the extracellular region of human hepsin reveals a serine protease domain and a novel scavenger receptor cysteine-rich (SRCR) domain.
12962704 Inhibition of the catalytic activity of rhodanese by S-nitrosylation using nitric oxide donors.
12963847 Regulation of human Cdc25A stability by Serine 75 phosphorylation is not sufficient to activate a S phase checkpoint.
12972425 Src phosphorylates Cas on tyrosine 253 to promote migration of transformed cells.
12972555 Spy1 interacts with p27Kip1 to allow G1/S progression.
12972610 Hes6 promotes cortical neurogenesis and inhibits Hes1 transcription repression activity by multiple mechanisms.
12972619 Phosphorylation of the carboxyl-terminal transactivation domain of c-Fos by extracellular signal-regulated kinase mediates the transcriptional activation of AP-1 and cellular transformation induced by platelet-derived growth factor.
14500673 Eosinophil major basic protein stimulates neutrophil superoxide production by a class IA phosphoinositide 3-kinase and protein kinase C-zeta-dependent pathway.
14500712 PIAS1-mediated sumoylation of focal adhesion kinase activates its autophosphorylation.
14506255 Biochemical properties of the Cdc42-associated tyrosine kinase ACK1. Substrate specificity, authphosphorylation, and interaction with Hck.
14507913 Phosphorylation screening identifies translational initiation factor 4GII as an intracellular target of Ca(2+)/calmodulin-dependent protein kinase I.
14512875 p38 MAPK mediates fibrogenic signal through Smad3 phosphorylation in rat myofibroblasts.
14517306 Tyrosine phosphorylation of plakoglobin causes contrary effects on its association with desmosomes and adherens junction components and modulates beta-catenin-mediated transcription.
14521955 Proteolytic processing of IGFBP-related protein-1 (TAF/angiomodulin/mac25) modulates its biological activity.
14522980 Identification and characterization of GCP16, a novel acylated Golgi protein that interacts with GCP170.
14522994 SHP-2 regulates SOCS-1-mediated Janus kinase-2 ubiquitination/degradation downstream of the prolactin receptor.
14523239 Protein kinase C phosphorylation sensitizes but does not activate the capsaicin receptor transient receptor potential vanilloid 1 (TRPV1).
14527438 Carbon monoxide neurotransmission activated by CK2 phosphorylation of heme oxygenase-2.
14527952 Modification of promyelocytic leukemia zinc finger protein (PLZF) by SUMO-1 conjugation regulates its transcriptional repressor activity.
14532120 SCF(HOS) ubiquitin ligase mediates the ligand-induced down-regulation of the interferon-alpha receptor.
14532170 AMPK activity and isoform protein expression are similar in muscle of obese subjects with and without type 2 diabetes.
14532276 Characterization of recombinant skeletal muscle (Ser-2843) and cardiac muscle (Ser-2809) ryanodine receptor phosphorylation mutants.
14536078 Multisite phosphorylation by Cdk2 and GSK3 controls cyclin E degradation.
14551197 Physical and functional interaction between Hck tyrosine kinase and guanine nucleotide exchange factor C3G results in apoptosis, which is independent of C3G catalytic domain.
14551205 Cell cycle-regulated phosphorylation of hamartin, the product of the tuberous sclerosis complex 1 gene, by cyclin-dependent kinase 1/cyclin B.
14551213 Constitutively active Galpha16 stimulates STAT3 via a c-Src/JAK- and ERK-dependent mechanism.
14557276 The SH3 domain-containing adaptor HIP-55 mediates c-Jun N-terminal kinase activation in T cell receptor signaling.
14559918 PIASgamma represses the transcriptional activation induced by the nuclear receptor Nurr1.
14560030 Molecular mechanism for a role of SHP2 in epidermal growth factor receptor signaling.
14565989 Exercise increases Ca2+-calmodulin-dependent protein kinase II activity in human skeletal muscle.
14573606 Mechanism of p21-activated kinase 6-mediated inhibition of androgen receptor signaling.
14573609 Secretion of heparanase protein is regulated by glycosylation in human tumor cell lines.
14576165 Phosphorylation of presenilin 1 at the caspase recognition site regulates its proteolytic processing and the progression of apoptosis.
14576464 Identification and functional analysis of truncated human glutamic acid decarboxylase 65.
14578350 Role of p38alpha Map kinase in Type I interferon signaling.
14583471 Direct activation of pro-matrix metalloproteinase-2 by leukolysin/membrane-type 6 matrix metalloproteinase/matrix metalloproteinase 25 at the asn(109)-Tyr bond.
14585847 Protein phosphatase 2Cbeta association with the IkappaB kinase complex is involved in regulating NF-kappaB activity.
14592976 Notch-induced E2A ubiquitination and degradation are controlled by MAP kinase activities.
14597612 p42, a novel cyclin-dependent kinase-activating kinase in mammalian cells.
14600148 Cells previously desensitized to type 1 interferons display different mechanisms of activation of stat-dependent gene expression from naïve cells.
14608369 AP-1 recruitment to VAMP4 is modulated by phosphorylation-dependent binding of PACS-1.
14608379 Regulator of G-protein signaling-2 mediates vascular smooth muscle relaxation and blood pressure.
14612398 Positive and negative regulation of the cardiovascular transcription factor KLF5 by p300 and the oncogenic regulator SET through interaction and acetylation on the DNA-binding domain.
14613924 5'-AMP-activated protein kinase activity and protein expression are regulated by endurance training in human skeletal muscle.
14615979 A proteomic approach for quantitation of phosphorylation using stable isotope labeling in cell culture.
14622975 Functional characterization of Narc 1, a novel proteinase related to proteinase K.
14623863 S100C/A11 is a key mediator of Ca(2+)-induced growth inhibition of human epidermal keratinocytes.
14623875 Characterization of cyclin L2, a novel cyclin with an arginine/serine-rich domain: phosphorylation by DYRK1A and colocalization with splicing factors.
14630912 Phosphorylation of vanilloid receptor 1 by Ca2+/calmodulin-dependent kinase II regulates its vanilloid binding.
14633678 Inactivation of a histone methyltransferase by mutations in human cancers.
14633983 The phosphorylation state of an autoregulatory domain controls PACS-1-directed protein traffic.
14633989 Role of acetylated human AP-endonuclease (APE1/Ref-1) in regulation of the parathyroid hormone gene.
14636059 Functional diversity of endothelin pathways in human lung fibroblasts may be based on structural diversity of the endothelin receptors.
14636557 Taspase1: a threonine aspartase required for cleavage of MLL and proper HOX gene expression.
14636580 PKA, PKC, and the protein phosphatase 2A influence HAND factor function: a mechanism for tissue-specific transcriptional regulation.
14641008 Molecular mechanisms regulating hormone-sensitive lipase and lipolysis.
14645242 J Biol Chem. 2004 Feb 13;279(7):5405-12. Epub 2003 Nov 25.
14654844 Protein kinase C switches the Raf kinase inhibitor from Raf-1 to GRK-2.
14654845 Release of eIF6 (p27BBP) from the 60S subunit allows 80S ribosome assembly.
14657023 Growth inhibition by the mammalian SWI-SNF subunit Brm is regulated by acetylation.
14661060 Cbl-c suppresses v-Src-induced transformation through ubiquitin-dependent protein degradation.
14663150 Protein phosphatase 2C binds selectively to and dephosphorylates metabotropic glutamate receptor 3.
14673166 S-nitrosylation of IRP2 regulates its stability via the ubiquitin-proteasome pathway.
14679216 J Biol Chem. 2004 Mar 12;279(11):10765-75. Epub 2003 Dec 16.
14685260 Regulation of InsP3 receptor activity by neuronal Ca2+-binding proteins.
14699159 Underglycosylation of ATF6 as a novel sensing mechanism for activation of the unfolded protein response.
14701738 Phosphorylation of critical serine residues in Gem separates cytoskeletal reorganization from down-regulation of calcium channel activity.
14701748 Negative regulation of histone deacetylase 8 activity by cyclic AMP-dependent protein kinase A.
14701874 SUMO modification of a novel MAR-binding protein, SATB2, modulates immunoglobulin mu gene expression.
14707132 Characterization of OSR1, a member of the mammalian Ste20p/germinal center kinase subfamily.
14709557 Stimulation of the AMP-activated protein kinase leads to activation of eukaryotic elongation factor 2 kinase and to its phosphorylation at a novel site, serine 398.
14711813 Identification of RET autophosphorylation sites by mass spectrometry.
14712216 H4(D10S170), a gene frequently rearranged with RET in papillary thyroid carcinomas: functional characterization.
14729942 Identification of phosphoproteins and their phosphorylation sites in the WEHI-231 B lymphoma cell line.
14729945 Regulation of phosphoinositide 3-kinase by its intrinsic serine kinase activity in vivo.
14734545 Substrate requirements of the oxygen-sensing asparaginyl hydroxylase factor-inhibiting hypoxia-inducible factor.
14739293 Adhesion or plasmin regulates tyrosine phosphorylation of a novel membrane glycoprotein p80/gp140/CUB domain-containing protein 1 in epithelia.
14739304 A novel proteomic approach for specific identification of tyrosine kinase substrates using [13C]tyrosine.
14741103 Cdk5 phosphorylation of doublecortin ser297 regulates its effect on neuronal migration.
14744859 Human mitotic spindle-associated protein PRC1 inhibits MgcRacGAP activity toward Cdc42 during the metaphase.
14749323 Role of glycosylation in the organic anion transporter OAT1.
14749719 p41-Arc subunit of human Arp2/3 complex is a p21-activated kinase-1-interacting substrate.
14751930 A novel plasma proteinase potentiates alpha2-antiplasmin inhibition of fibrin digestion.
14753741 Isolation of a human homolog of osteoclast inhibitory lectin that inhibits the formation and function of osteoclasts.
14760718 Screening for N-glycosylated proteins by liquid chromatography mass spectrometry.
14762214 Improved detection of hydrophilic phosphopeptides using graphite powder microcolumns and mass spectrometry: evidence for in vivo doubly phosphorylated dynamin I and dynamin III.
14764098 Nonlysine-analog plasminogen modulators promote autoproteolytic generation of plasmin(ogen) fragments with angiostatin-like activity.
14766232 Interaction of human MUC1 and beta-catenin is regulated by Lck and ZAP-70 in activated Jurkat T cells.
14871477 Alkylation of protein disulfide isomerase by the episulfonium ion derived from the glutathione conjugate of 1,2-dichloroethane and mass spectrometric characterization of the adducts.
14963018 Evidence of STAT1 phosphorylation modulated by MAPKs, MEK1 and MSK1.
14965474 TIAF1 and p53 functionally interact in mediating apoptosis and silencing of TIAF1 abolishes nuclear translocation of serine 15-phosphorylated p53.
14966296 Site-selective regulation of platelet-derived growth factor beta receptor tyrosine phosphorylation by T-cell protein tyrosine phosphatase.
14970177 N-linked glycosylation is required for optimal function of Kaposi's sarcoma herpesvirus-encoded, but not cellular, interleukin 6.
14970201 p21-activated kinase 1 phosphorylates and regulates 14-3-3 binding to GEF-H1, a microtubule-localized Rho exchange factor.
14970221 Thr2446 is a novel mammalian target of rapamycin (mTOR) phosphorylation site regulated by nutrient status.
14973229 Decreased phosphorylation of NMDA receptor type 1 at serine 897 in brains of patients with Schizophrenia.
14983059 Regulation of canonical transient receptor potential isoform 3 (TRPC3) channel by protein kinase G.
14990569 J Biol Chem. 2004 May 7;279(19):19643-8. Epub 2004 Feb 27.
14996911 EGFR signaling to p120-catenin through phosphorylation at Y228.
14997482 Identification and characterization of phosphorylated proteins in the human pituitary.
15001356 Phage-peptide display identifies the interferon-responsive, death-activated protein kinase family as a novel modifier of MDM2 and p21WAF1.
15003508 Association of CPI-17 with protein kinase C and casein kinase I.
15004546 Regulation of the p300 HAT domain via a novel activation loop.
15010469 Phosphorylation of histone H2A inhibits transcription on chromatin templates.
15012588 Structural analysis and tissue localization of human C4.4A: a protein homologue of the urokinase receptor.
15014043 Phosphorylation of RCC1 in mitosis is essential for producing a high RanGTP concentration on chromosomes and for spindle assembly in mammalian cells.
15016818 Protein phosphatase-2C alpha as a positive regulator of insulin sensitivity through direct activation of phosphatidylinositol 3-kinase in 3T3-L1 adipocytes.
15016915 DAXX interacts with heat shock factor 1 during stress activation and enhances its transcriptional activity.
15024056 Forkhead box M1B transcriptional activity requires binding of Cdk-cyclin complexes for phosphorylation-dependent recruitment of p300/CBP coactivators.
15024086 A novel mTOR-regulated phosphorylation site in elongation factor 2 kinase modulates the activity of the kinase and its binding to calmodulin.
15028714 Regulation of Smad4 sumoylation and transforming growth factor-beta signaling by protein inhibitor of activated STAT1.
15030318 The T-cell protein tyrosine phosphatase is phosphorylated on Ser-304 by cyclin-dependent protein kinases in mitosis.
15037601 YSK1 is activated by the Golgi matrix protein GM130 and plays a role in cell migration through its substrate 14-3-3zeta.
15037656 The interaction of specific peptide aptamers with the DNA binding domain and the dimerization domain of the transcription factor Stat3 inhibits transactivation and induces apoptosis in tumor cells.
15039438 Proteasomal degradation of N-acetyltransferase 1 is prevented by acetylation of the active site cysteine: a mechanism for the slow acetylator phenotype and substrate-dependent down-regulation.
15044018 The islet-specific glucose-6-phosphatase-related protein, implicated in diabetes, is a glycoprotein embedded in the endoplasmic reticulum membrane.
15050367 Alpha- and beta- cleavages of the amino-terminus of the cellular prion protein.
15051728 Formin homology domain protein (FHOD1) is a cyclic GMP-dependent protein kinase I-binding protein and substrate in vascular smooth muscle cells.
15070730 Functional association between Wwox tumor suppressor protein and p73, a p53 homolog.
15070733 M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFbeta-TrCP.
15073171 Insertion sequence 1 of muscle-specific calpain, p94, acts as an internal propeptide.
15073328 Direct regulation of CREB transcriptional activity by ATM in response to genotoxic stress.
15081397 KIBRA is a novel substrate for protein kinase Czeta.
15082798 CK2 controls multiple protein kinases by phosphorylating a kinase-targeting molecular chaperone, Cdc37.
15087450 Proteolysis of the mismatch repair protein MLH1 by caspase-3 promotes DNA damage-induced apoptosis.
15099517 Gene-specific modulation of TAF10 function by SET9-mediated methylation.
15099520 A cathepsin L isoform that is devoid of a signal peptide localizes to the nucleus in S phase and processes the CDP/Cux transcription factor.
15116093 Phosphorylation of p53 on Thr55 by ERK2 is necessary for doxorubicin-induced p53 activation and cell death.
15121872 Tyrosine 813 is a site of JAK2 autophosphorylation critical for activation of JAK2 by SH2-B beta.
15128762 Cutting edge: TREM-like transcript-1, a platelet immunoreceptor tyrosine-based inhibition motif encoding costimulatory immunoreceptor that enhances, rather than inhibits, calcium signaling via SHP-2.
15128871 Phosphorylation of CDC25B by Aurora-A at the centrosome contributes to the G2-M transition.
15138252 VHY, a novel myristoylated testis-restricted dual specificity protein phosphatase related to VHX.
15138260 Transforming growth factor-beta stimulates p300-dependent RUNX3 acetylation, which inhibits ubiquitination-mediated degradation.
15140192 N-linked glycosylation sites of the motor protein prestin: effects on membrane targeting and electrophysiological function.
15143187 Autophosphorylation of JAK2 on tyrosines 221 and 570 regulates its activity.
15143188 Tyrosine phosphorylation of Jak2 in the JH2 domain inhibits cytokine signaling.
15144186 Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.
15147202 Protein phosphorylation of human brain glutamic acid decarboxylase (GAD)65 and GAD67 and its physiological implications.
15150265 Human SAD1 kinase is involved in UV-induced DNA damage checkpoint function.
15152093 Identification of the N-glycosylation sites on glutamate carboxypeptidase II necessary for proteolytic activity.
15158451 Phosphorylation of the mitochondrial protein Sab by stress-activated protein kinase 3.
15159397 BRCA1-BARD1 complexes are required for p53Ser-15 phosphorylation and a G1/S arrest following ionizing radiation-induced DNA damage.
15175427 Acetylation of the human DNA glycosylase NEIL2 and inhibition of its activity.
15178331 Suppression of the caspase cleavage of beta-amyloid precursor protein by its cytoplasmic phosphorylation.
15189448 DREG, a developmentally regulated G protein-coupled receptor containing two conserved proteolytic cleavage sites.
15190079 B23/nucleophosmin serine 4 phosphorylation mediates mitotic functions of polo-like kinase 1.
15192080 Small ubiquitin-like modifier 1 (SUMO-1) modification of the synergy control motif of Ad4 binding protein/steroidogenic factor 1 (Ad4BP/SF-1) regulates synergistic transcription between Ad4BP/SF-1 and Sox9.
15192089 Regulation of insulin signaling through reversible oxidation of the protein-tyrosine phosphatases TC45 and PTP1B.
15192091 Argininosuccinate synthetase is reversibly inactivated by S-nitrosylation in vitro and in vivo.
15193260 Dynein light chain 1, a p21-activated kinase 1-interacting substrate, promotes cancerous phenotypes.
15194694 Phosphorylation and regulation of DNA ligase IV stability by DNA-dependent protein kinase.
15206927 Tyrosine phosphorylation of calponins. Inhibition of the interaction with F-actin.
15210690 Tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone promotes functional cooperation of Bcl2 and c-Myc through phosphorylation in regulating cell survival and proliferation.
15221008 The M-CSF receptor substrate and interacting protein FMIP is governed in its subcellular localization by protein kinase C-mediated phosphorylation, and thereby potentiates M-CSF-mediated differentiation.
15225631 Interaction of filamin A with the integrin beta 7 cytoplasmic domain: role of alternative splicing and phosphorylation.
15225643 The phosphorylation status and anti-apoptotic activity of Bcl-2 are regulated by ERK and protein phosphatase 2A on the mitochondria.
15228384 The plasma membrane translocation of diacylglycerol kinase delta1 is negatively regulated by conventional protein kinase C-dependent phosphorylation at Ser-22 and Ser-26 within the pleckstrin homology domain.
15229287 The phosphorylation of vinculin on tyrosine residues 100 and 1065, mediated by SRC kinases, affects cell spreading.
15234964 Phosphorylation of Mnk1 by caspase-activated Pak2/gamma-PAK inhibits phosphorylation and interaction of eIF4G with Mnk.
15241418 Cyclin-dependent kinases regulate the antiproliferative function of Smads.
15241487 MCL1 is phosphorylated in the PEST region and stabilized upon ERK activation in viable cells, and at additional sites with cytotoxic okadaic acid or taxol.
15247228 Complexity of translationally controlled transcription factor Sp3 isoform expression.
15249683 Binding of platelet glycoprotein Ibalpha to von Willebrand factor domain A1 stimulates the cleavage of the adjacent domain A2 by ADAMTS13.
15251453 Calcium/calmodulin-dependent protein kinase I inhibits neuronal nitric-oxide synthase activity through serine 741 phosphorylation.
15253423 Identification of phosphorylation sites in protein kinase A substrates using artificial neural networks and mass spectrometry.
15253667 Open tubular immobilized metal ion affinity chromatography combined with MALDI MS and MS/MS for identification of protein phosphorylation sites.
15269224 Regulation of SHP-1 tyrosine phosphatase in human platelets by serine phosphorylation at its C terminus.
15271996 Proteomic identification of Bcl2-associated athanogene 2 as a novel MAPK-activated protein kinase 2 substrate.
15272016 In vitro modification of human centromere protein CENP-C fragments by small ubiquitin-like modifier (SUMO) protein: definitive identification of the modification sites by tandem mass spectrometry analysis of the isopeptides.
15273251 Site-specific acetylation of the fetal globin activator NF-E4 prevents its ubiquitination and regulates its interaction with the histone deacetylase, HDAC1.
15273717 Regulation of caspase-6 and FLIP by the AMPK family member ARK5.
15280020 hOLF44, a secreted glycoprotein with distinct expression pattern, belongs to an uncharacterized olfactomedin-like subfamily newly identified by phylogenetic analysis.
15280358 ZNF76, a novel transcriptional repressor targeting TATA-binding protein, is modulated by sumoylation.
15286081 Dok-6, a Novel p62 Dok family member, promotes Ret-mediated neurite outgrowth.
15302935 Large-scale characterization of HeLa cell nuclear phosphoproteins.
15308774 A tagging-via-substrate technology for detection and proteomics of farnesylated proteins.
15322115 Protein kinase Cdelta regulates apoptosis via activation of STAT1.
15324659 aPKC acts upstream of PAR-1b in both the establishment and maintenance of mammalian epithelial polarity.
15327768 Mechanism of phosphorylation-dependent binding of APC to beta-catenin and its role in beta-catenin degradation.
15337770 Phosphorylation and specific ubiquitin acceptor sites are required for ubiquitination and degradation of the IFNAR1 subunit of type I interferon receptor.
15342917 Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase.
15345747 Phosphoproteomic analysis of the developing mouse brain.
15350534 Identification and molecular characterization of Mnk1b, a splice variant of human MAP kinase-interacting kinase Mnk1.
15356145 Phosphorylation of Grb2-associated binder 2 on serine 623 by ERK MAPK regulates its association with the phosphatase SHP-2 and decreases STAT5 activation.
15364919 Protein kinase C Theta inhibits insulin signaling by phosphorylating IRS1 at Ser(1101).
15367659 Protein kinases C and D mediate agonist-dependent cardiac hypertrophy through nuclear export of histone deacetylase 5.
15367677 FANCG is phosphorylated at serines 383 and 387 during mitosis.
15368451 Keratin 8 and 18 hyperphosphorylation is a marker of progression of human liver disease.
15375214 A phosphorylation site in Bruton's tyrosine kinase selectively regulates B cell calcium signaling efficiency by altering phospholipase C-gamma activation.
15379552 Identification of major ERK-related phosphorylation sites in Gab1.
15380617 Regulation of Chk2 phosphorylation by interaction with protein phosphatase 2A via its B' regulatory subunit.
15383283 Selective phosphorylations of the SRC-3/AIB1 coactivator integrate genomic reponses to multiple cellular signaling pathways.
15385675 Prohaptoglobin is proteolytically cleaved in the endoplasmic reticulum by the complement C1r-like protein.
15448144 Arginine 260 of the amino-terminal domain of NR1 subunit is critical for tissue-type plasminogen activator-mediated enhancement of N-methyl-D-aspartate receptor signaling.
15451423 ATR-dependent phosphorylation of ATRIP in response to genotoxic stress.
15454081 The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector.
15459208 Inhibition of gap junction activity through the release of the C1B domain of protein kinase Cgamma (PKCgamma) from 14-3-3: identification of PKCgamma-binding sites.
15461668 Genes Cells. 2004 Oct;9(10):983-92.
15466214 Changes in androgen receptor nongenotropic signaling correlate with transition of LNCaP cells to androgen independence.
15469825 Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin.
15471854 MUC1 membrane trafficking is modulated by multiple interactions.
15485879 Phosphorylation of annexin I by TRPM7 channel-kinase.
15494733 Focal adhesion kinase in netrin-1 signaling.
15498570 N-glycosylation is required for efficient secretion of a novel human secreted glycoprotein, hPAP21.
15504032 Tyrosine phosphorylation of caveolin-2 at residue 27: differences in the spatial and temporal behavior of phospho-Cav-2 (pY19 and pY27).
15507434 Sumoylation of MITF and its related family members TFE3 and TFEB.
15522235 Tyrosine phosphatase epsilonM stimulates migration and survival of porcine aortic endothelial cells by activating c-Src.
15522880 Interleukin-12-induced interferon-gamma production by human peripheral blood T cells is regulated by mammalian target of rapamycin (mTOR).
15525512 Phosphorylation of Cdc20 by Bub1 provides a catalytic mechanism for APC/C inhibition by the spindle checkpoint.
15527798 A novel site of AKT-mediated phosphorylation in the human MDM2 onco-protein.
15534001 The ERBB4/HER4 receptor tyrosine kinase regulates gene expression by functioning as a STAT5A nuclear chaperone.
15537541 Structure of the Cand1-Cul1-Roc1 complex reveals regulatory mechanisms for the assembly of the multisubunit cullin-dependent ubiquitin ligases.
15541388 Characterization of a MAPKK-like protein kinase TOPK.
15545601 Activation of RasGRP3 by phosphorylation of Thr-133 is required for B cell receptor-mediated Ras activation.
15546918 PKA phosphorylation of Src mediates Rap1 activation in NGF and cAMP signaling in PC12 cells.
15549133 Phosphorylation of XPB helicase regulates TFIIH nucleotide excision repair activity.
15549731 IREM-1 is a novel inhibitory receptor expressed by myeloid cells.
15556646 Catalytic domains of tyrosine kinases determine the phosphorylation sites within c-Cbl.
15557335 Src phosphorylation of Alix/AIP1 modulates its interaction with binding partners and antagonizes its activities.
15561713 NF-kappaB- and C/EBPbeta-driven interleukin-1beta gene expression and PAK1-mediated caspase-1 activation play essential roles in interleukin-1beta release from Helicobacter pylori lipopolysaccharide-stimulated macrophages.
15570572 Automated immobilized metal affinity chromatography/nano-liquid chromatography/electrospray ionization mass spectrometry platform for profiling protein phosphorylation sites.
15572666 PIAS-1 is a checkpoint regulator which affects exit from G1 and G2 by sumoylation of p73.
15580310 17beta-Estradiol upregulates and activates WOX1/WWOXv1 and WOX2/WWOXv2 in vitro: potential role in cancerous progression of breast and prostate to a premetastatic state in vivo.
15581361 Requirements for pYXXM motifs in Cbl for binding to the p85 subunit of phosphatidylinositol 3-kinase and Crk, and activation of atypical protein kinase C and glucose transport during insulin action in 3T3/L1 adipocytes.
15581622 Protein kinase Akt/PKB phosphorylates heme oxygenase-1 in vitro and in vivo.
15588985 Substrate-trapping techniques in the identification of cellular PTP targets.
15591058 BMP-1/Tolloid-like metalloproteases process endorepellin, the angiostatic C-terminal fragment of perlecan.
15592455 Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.
15595731 Characterization of phosphorylation sites on histone H1 isoforms by tandem mass spectrometry.
15606899 Beta-amyloid protein converting enzyme 1 and brain-specific type II membrane protein BRI3: binding partners processed by furin.
15610029 Phosphoregulation of mixed-lineage kinase 1 activity by multiple phosphorylation in the activation loop.
15611095 Modulation of erythrocyte membrane mechanical function by protein 4.1 phosphorylation.
15616124 Posttranslational N-glycosylation takes place during the normal processing of human coagulation factor VII.
15616583 Bidirectional signals transduced by DAPK-ERK interaction promote the apoptotic effect of DAPK.
15632081 Coordinated regulation of insulin signaling by the protein tyrosine phosphatases PTP1B and TCPTP.
15632084 Extracellular signal-regulated kinases phosphorylate mitogen-activated protein kinase phosphatase 3/DUSP6 at serines 159 and 197, two sites critical for its proteasomal degradation.
15632193 SIRT1 deacetylation and repression of p300 involves lysine residues 1020/1024 within the cell cycle regulatory domain 1.
15632195 Functional characterization of human RSK4, a new 90-kDa ribosomal S6 kinase, reveals constitutive activation in most cell types.
15637053 Differential regulation of phosphoglucose isomerase/autocrine motility factor activities by protein kinase CK2 phosphorylation.
15644316 Human S-nitroso oxymyoglobin is a store of vasoactive nitric oxide.
15649887 Activation of Stat3 sequence-specific DNA binding and transcription by p300/CREB-binding protein-mediated acetylation.
15652488 GSK-3beta regulates phosphorylation of CRMP-2 and neuronal polarity.
15654952 Breaking the connection: caspase 6 disconnects intermediate filament-binding domain of periplakin from its actin-binding N-terminal region.
15657060 c-Abl tyrosine kinase regulates caspase-9 autocleavage in the apoptotic response to DNA damage.
15659405 CK2 phosphorylates SSRP1 and inhibits its DNA-binding activity.
15659558 Phosphotyrosine proteomic study of interferon alpha signaling pathway using a combination of immunoprecipitation and immobilized metal affinity chromatography.
15664191 Regulation of Raf-1 by direct feedback phosphorylation.
15665856 The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair.
15670817 Differentiative pathway activated by 3-aminobenzamide, an inhibitor of PARP, in human osteosarcoma MG-63 cells.
15670829 Identification of proteins interacting with the RNAPII FCP1 phosphatase: FCP1 forms a complex with arginine methyltransferase PRMT5 and it is a substrate for PRMT5-mediated methylation.
15677445 Distinct turnover of alternatively spliced isoforms of the RET kinase receptor mediated by differential recruitment of the Cbl ubiquitin ligase.
15687492 Protein kinase CK1alpha regulates mRNA binding by heterogeneous nuclear ribonucleoprotein C in response to physiologic levels of hydrogen peroxide.
15688026 Cooperation and selectivity of the two Grb2 binding sites of p52Shc in T-cell antigen receptor signaling to Ras family GTPases and Myc-dependent survival.
15689152 Mechanism of CDK5/p25 binding by CDK inhibitors.
15696159 JNK phosphorylation of 14-3-3 proteins regulates nuclear targeting of c-Abl in the apoptotic response to DNA damage.
15696169 Selective regulation of tumor necrosis factor-induced Erk signaling by Src family kinases and the T cell protein tyrosine phosphatase.
15723659 Ataxia-telangiectasia-mutated dependent phosphorylation of Artemis in response to DNA damage.
15728359 Phosphorylation of spinophilin by ERK and cyclin-dependent PK 5 (Cdk5).
15733869 Serum/glucocorticoid-inducible kinase can phosphorylate the cyclic AMP response element binding protein, CREB.
15738637 Receptor-type protein tyrosine phosphatase epsilon (PTPepsilonM) is a negative regulator of insulin signaling in primary hepatocytes and liver.
15743820 Removal of C-terminal SRC kinase from the immune synapse by a new binding protein.
15744310 Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1.
15752768 Characterization of two non-testis-specific CABYR variants that bind to GSK3beta with a proline-rich extensin-like domain.
15754012 Molecular evolution of Wnt2b orthologs.
15781465 Channel function is dissociated from the intrinsic kinase activity and autophosphorylation of TRPM7/ChaK1.
15782174 Identifying and quantifying in vivo methylation sites by heavy methyl SILAC.
15788536 Phosphorylation of Hdmx mediates its Hdm2- and ATM-dependent degradation in response to DNA damage.
15791647 Involvement of protein kinase PKN1 in G2/M delay caused by arsenite.
15800651 3',5'-cyclic nucleotide phosphodiesterase 11A: localization in human tissues.
15805470 Histone deacetylase 3 (HDAC3) activity is regulated by interaction with protein serine/threonine phosphatase 4.
15807535 N-Linked glycosylation of the human ABC transporter ABCG2 on asparagine 596 is not essential for expression, transport activity, or trafficking to the plasma membrane.
15835917 Phosphorylation of the human Fhit tumor suppressor on tyrosine 114 in Escherichia coli and unexpected steady state kinetics of the phosphorylated forms.
15837948 Phosphorylation of GATA2 by Akt increases adipose tissue differentiation and reduces adipose tissue-related inflammation: a novel pathway linking obesity to atherosclerosis.
15845350 Src kinase regulation by phosphorylation and dephosphorylation.
15851026 Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis.
15851471 Platelet endothelial aggregation receptor 1 (PEAR1), a novel epidermal growth factor repeat-containing transmembrane receptor, participates in platelet contact-induced activation.
15878163 The death domain-associated protein modulates activity of the transcription co-factor Skip/NcoA62.
15879431 Post-translational modification of nuclear co-repressor receptor-interacting protein 140 by acetylation.
15886098 RIN1 is an ABL tyrosine kinase activator and a regulator of epithelial-cell adhesion and migration.
15894802 Protein kinase C phosphorylation of the metabotropic glutamate receptor mGluR5 on Serine 839 regulates Ca2+ oscillations.
15899889 Phosphorylation of mammalian target of rapamycin (mTOR) at Ser-2448 is mediated by p70S6 kinase.
15905173 Identification of S6 kinase 1 as a novel mammalian target of rapamycin (mTOR)-phosphorylating kinase.
15905176 Phosphorylation of claudin-3 at threonine 192 by cAMP-dependent protein kinase regulates tight junction barrier function in ovarian cancer cells.
15910747 Determination of site-specificity of S-glutathionylated cellular proteins.
15951569 Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules.
15951807 S-nitrosylated GAPDH initiates apoptotic cell death by nuclear translocation following Siah1 binding.
15952790 Identification of tyrosine residues on ELMO1 that are phosphorylated by the Src-family kinase Hck.
15952796 Phosphorylation of Grb10 by mitogen-activated protein kinase: identification of Ser150 and Ser476 of human Grb10zeta as major phosphorylation sites.
15963462 Phosphorylation and binding partner analysis of the TSC1-TSC2 complex.
15964553 TSSK5, a novel member of the testis-specific serine/threonine kinase family, phosphorylates CREB at Ser-133, and stimulates the CRE/CREB responsive pathway.
15987703 LKB1 interacts with and phosphorylates PTEN: a functional link between two proteins involved in cancer predisposing syndromes.
16001085 HIV-1 Tat targets Tip60 to impair the apoptotic cell response to genotoxic stresses.
16006563 Sequential phosphorylation mediates receptor- and kinase-induced inhibition of TREK-1 background potassium channels.
16007225 Adhesion signaling by a novel mitotic substrate of src kinases.
16014719 Tyrosine 394 is phosphorylated in Alzheimer's paired helical filament tau and in fetal tau with c-Abl as the candidate tyrosine kinase.
16024724 Regulation of human methylenetetrahydrofolate reductase by phosphorylation.
16027158 Phosphorylation of coronin 1B by protein kinase C regulates interaction with Arp2/3 and cell motility.
16027164 Dephosphorylation of Ser-226 facilitates plasma membrane retention of Ntcp.
16045749 BCR kinase phosphorylates 14-3-3 Tau on residue 233.
16051222 Endosomal proteolysis of insulin-like growth factor-I at its C-terminal D-domain by cathepsin B.
16055064 PICK1 interacts with ABP/GRIP to regulate AMPA receptor trafficking.
16055720 WW domains provide a platform for the assembly of multiprotein networks.
16061179 Phosphorylation of FADD at serine 194 by CKIalpha regulates its nonapoptotic activities.
16061477 B-aggressive lymphoma family proteins have unique domains that modulate transcription and exhibit poly(ADP-ribose) polymerase activity.
16083266 Extended Range Proteomic Analysis (ERPA): a new and sensitive LC-MS platform for high sequence coverage of complex proteins with extensive post-translational modifications-comprehensive analysis of beta-casein and epidermal growth factor receptor (EGFR).
16083285 Global phosphoproteome of HT-29 human colon adenocarcinoma cells.
16087181 The role of PKCalpha and RLIP76 in transport-mediated doxorubicin-resistance in lung cancer.
16094384 Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry.
16094730 Protein kinase activity of phosphoinositide 3-kinase regulates beta-adrenergic receptor endocytosis.
16097765 Mapping of phosphorylation sites by a multi-protease approach with specific phosphopeptide enrichment and NanoLC-MS/MS analysis.
16098147 Transcriptional activity of megakaryoblastic leukemia 1 (MKL1) is repressed by SUMO modification.
16098514 Analysis of mTOR signaling by the small G-proteins, Rheb and RhebL1.
16105548 Pleiotrophin stimulates tyrosine phosphorylation of beta-adducin through inactivation of the transmembrane receptor protein tyrosine phosphatase beta/zeta.
16107690 Phosphatidylinositol 3-kinase/Akt induced by erythropoietin renders the erythroid differentiation factor GATA-1 competent for TIMP-1 gene transactivation.
16123041 Cleavage of claspin by caspase-7 during apoptosis inhibits the Chk1 pathway.
16123141 Molecular characterization of ring finger protein 11.
16129408 Phosphorylation inhibits DNA-binding of alternatively spliced aryl hydrocarbon receptor nuclear translocator.
16131083 Identification of phosphorylation sites in insulin receptor substrate-1 by hypothesis-driven high-performance liquid chromatography-electrospray ionization tandem mass spectrometry.
16135791 Epidermal growth factor-dependent phosphorylation of the GGA3 adaptor protein regulates its recruitment to membranes.
16135815 Rapid estrogen-induced phosphorylation of the SRC-3 coactivator occurs in an extranuclear complex containing estrogen receptor.
16138080 Phosphorylation of EEA1 by p38 MAP kinase regulates mu opioid receptor endocytosis.
16139227 Akt/PKB regulates actin organization and cell motility via Girdin/APE.
16141410 Glycogen synthase kinase 3beta inhibits myocardin-dependent transcription and hypertrophy induction through site-specific phosphorylation.
16153436 Direct phosphorylation of proliferative and survival pathway proteins by RET.
16156666 Identification and characterization of ERK MAP kinase phosphorylation sites in Smad3.
16157583 A protein kinase C/Ras/ERK signaling pathway activates myeloid fibronectin receptors by altering beta1 integrin sialylation.
16162500 Features of the catalytic domains and C termini of the MAPK signal-integrating kinases Mnk1 and Mnk2 determine their differing activities and regulatory properties.
16163388 ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage.
16179258 Higher-order substrate recognition of eIF2alpha by the RNA-dependent protein kinase PKR.
16179349 Tyrosine phosphorylation of sam68 by breast tumor kinase regulates intranuclear localization and cell cycle progression.
16186108 Tyrosine 740 phosphorylation of discoidin domain receptor 2 by Src stimulates intramolecular autophosphorylation and Shc signaling complex formation.
16186805 The 44 kDa Pim-1 kinase directly interacts with tyrosine kinase Etk/BMX and protects human prostate cancer cells from apoptosis induced by chemotherapeutic drugs.
16188906 Regulation of HSL serine phosphorylation in skeletal muscle and adipose tissue.
16195223 Hyperphosphorylation of JNK-interacting protein 1, a protein associated with Alzheimer disease.
16199863 Abl kinases regulate actin comet tail elongation via an N-WASP-dependent pathway.
16199882 Phosphorylation of beta-catenin by cyclic AMP-dependent protein kinase stabilizes beta-catenin through inhibition of its ubiquitination.
16204230 Regulation of the interaction of Pak2 with Cdc42 via autophosphorylation of serine 141.
16210244 Mapping post-translational modifications of the histone variant MacroH2A1 using tandem mass spectrometry.
16212419 Phosphoproteome analysis of HeLa cells using stable isotope labeling with amino acids in cell culture (SILAC).
16212962 HIPK2 inhibits both MDM2 gene and protein by, respectively, p53-dependent and independent regulations.
16223362 Nur77 is phosphorylated in cells by RSK in response to mitogenic stimulation.
16224021 Akt-mediated phosphorylation of EZH2 suppresses methylation of lysine 27 in histone H3.
16247472 Phosphorylation of the cytokinesis regulator ECT2 at G2/M phase stimulates association of the mitotic kinase Plk1 and accumulation of GTP-bound RhoA.
16252004 Critical role of novel Thr-219 autophosphorylation for the cellular function of PKCtheta in T lymphocytes.
16253990 Increased proliferation and altered growth factor dependence of human mammary epithelial cells overexpressing the Gab2 docking protein.
16272144 Regulation of intracellular localization and transcriptional activity of FOXO4 by protein kinase B through phosphorylation at the motif sites conserved among the FOXO family.
16278218 Phosphorylation of HSF1 by MAPK-activated protein kinase 2 on serine 121, inhibits transcriptional activity and promotes HSP90 binding.
16280322 In vitro transport of membrane proteins to peroxisomes by shuttling receptor Pex19p.
16286467 Interleukin-1beta induction of NFkappaB is partially regulated by H2O2-mediated activation of NFkappaB-inducing kinase.
16286470 Cooperation of ERK and SCFSkp2 for MKP-1 destruction provides a positive feedback regulation of proliferating signaling.
16287866 Regulation of caspase 9 through phosphorylation by protein kinase C zeta in response to hyperosmotic stress.
16291744 Phosphorylated alpha-actinin and protein-tyrosine phosphatase 1B coregulate the disassembly of the focal adhesion kinase x Src complex and promote cell migration.
16293623 DNA replication stress-induced phosphorylation of cyclic AMP response element-binding protein mediated by ATM.
16293633 The AT-hook of the chromatin architectural transcription factor high mobility group A1a is arginine-methylated by protein arginine methyltransferase 6.
16299313 Ectophosphorylation of CD36 regulates cytoadherence of Plasmodium falciparum to microvascular endothelium under flow conditions.
16306228 14-3-3 cooperates with LKB1 to regulate the activity and localization of QSK and SIK.
16319058 Binding of manumycin A inhibits IkappaB kinase beta activity.
16325853 Phosphorylation on Ser106 modulates the cellular functions of the SHOX homeodomain protein.
16326706 Shp-1 mediates the antiproliferative activity of tissue inhibitor of metalloproteinase-2 in human microvascular endothelial cells.
16330544 Chaperoning checkpoint kinase 1 (Chk1), an Hsp90 client, with purified chaperones.
16338927 Identification of p122RhoGAP (deleted in liver cancer-1) Serine 322 as a substrate for protein kinase B and ribosomal S6 kinase in insulin-stimulated cells.
16342939 Prevention of MKK6-dependent activation by binding to p38alpha MAP kinase.
16351573 Biochem J. 2006 Mar 1;394(Pt 2):379-87.
16354680 Nutrients suppress phosphatidylinositol 3-kinase/Akt signaling via raptor-dependent mTOR-mediated insulin receptor substrate 1 phosphorylation.
16354698 Akt-mediated YB-1 phosphorylation activates translation of silent mRNA species.
16362057 Histone demethylation by a family of JmjC domain-containing proteins.
16364302 P70 S6 kinase mediates tau phosphorylation and synthesis.
16365045 The low density lipoprotein receptor-related protein 6 interacts with glycogen synthase kinase 3 and attenuates activity.
16373505 Tyrosine phosphorylation acts as a molecular switch to full-scale activation of the eIF2alpha RNA-dependent protein kinase.
16374512 DNA-damage-responsive acetylation of pRb regulates binding to E2F-1.
16376338 Protein kinase A phosphorylates and regulates dimerization of 14-3-3 epsilon.
16397300 Functional role of NF-IL6beta and its sumoylation and acetylation modifications in promoter activation of cyclooxygenase 2 gene.
16399764 Identification of sites of mannose 6-phosphorylation on lysosomal proteins.
16403219 Pim kinases phosphorylate multiple sites on Bad and promote 14-3-3 binding and dissociation from Bcl-XL.
16407227 Phosphorylation and transactivation of Pax6 by homeodomain-interacting protein kinase 2.
16407301 Phosphorylation of serine 526 is required for MEKK3 activity, and association with 14-3-3 blocks dephosphorylation.
16413544 Induction of apoptosis by p110C requires mitochondrial translocation of the proapoptotic BCL-2 family member BAD.
16415881 Structural basis for the methylation site specificity of SET7/9.
16426576 CK2-dependent C-terminal phosphorylation at T300 directs the nuclear transport of TSPY protein.
16427064 Analysis on heat stress-induced hyperphosphorylation of stathmin at serine 37 in Jurkat cells by means of two-dimensional gel electrophoresis and tandem mass spectrometry.
16428449 Inhibition of DNA binding by differential sumoylation of heat shock factors.
16428860 Phosphorylation of RanGAP1 stabilizes its interaction with Ran and RanBP1.
16429130 Regulation of ubiquitin-binding proteins by monoubiquitination.
16442531 Repression of SOX6 transcriptional activity by SUMO modification.
16456540 P38MAPK-dependent phosphorylation and degradation of SRC-3/AIB1 and RARalpha-mediated transcription.
16461343 Identification of substrates of human protein-tyrosine phosphatase PTPN22.
16478538 Phosphorylation-facilitated sumoylation of MEF2C negatively regulates its transcriptional activity.
16482222 Ubiquitylation of leptin receptor OB-Ra regulates its clathrin-mediated endocytosis.
16488976 Proteinase 3 is an IL-32 binding protein.
16511560 Regulation of MDMX nuclear import and degradation by Chk2 and 14-3-3.
16511572 14-3-3gamma binds to MDMX that is phosphorylated by UV-activated Chk1, resulting in p53 activation.
16512921 The protein kinase DYRK1A phosphorylates the splicing factor SF3b1/SAP155 at Thr434, a novel in vivo phosphorylation site.
16517729 Signaling through mutants of the IgA receptor CD89 and consequences for Fc receptor gamma-chain interaction.
16519687 Site-specific phosphorylation of MCM4 during the cell cycle in mammalian cells.
16537915 Uncleaved TFIIA is a substrate for taspase 1 and active in transcription.
16540648 Phosphorylation of nucleotide excision repair factor xeroderma pigmentosum group A by ataxia telangiectasia mutated and Rad3-related-dependent checkpoint pathway promotes cell survival in response to UV irradiation.
16543145 Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1.
16543730 DOCA-induced phosphorylation of glycogen synthase kinase 3beta.
16552184 CDK9 phosphorylates p53 on serine residues 33, 315 and 392.
16554819 The prolyl isomerase Pin1 regulates amyloid precursor protein processing and amyloid-beta production.
16556605 Posttranslational N-myristoylation is required for the anti-apoptotic activity of human tGelsolin, the C-terminal caspase cleavage product of human gelsolin.
16565220 Phosphoproteome analysis of the human mitotic spindle.
16582606 Phosphorylation of RIalpha by cyclin-dependent kinase CDK 2/cyclin E modulates the dissociation of the RIalpha-RFC40 complex.
16582879 Interaction with Grb14 results in site-specific regulation of tyrosine phosphorylation of the insulin receptor.
16603397 Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB.
16636147 Activity of TSC2 is inhibited by AKT-mediated phosphorylation and membrane partitioning.
16648260 Identification of S-nitrosylation motifs by site-specific mapping of the S-nitrosocysteine proteome in human vascular smooth muscle cells.
16648821 c-Abl acetylation by histone acetyltransferases regulates its nuclear-cytoplasmic localization.
16669787 Functional interactions of the SPAK/OSR1 kinases with their upstream activator WNK1 and downstream substrate NKCC1.
16682416 Reversible post-translational modification of proteins by nitrated fatty acids in vivo.
16723391 Regulation of hypermutation by activation-induced cytidine deaminase phosphorylation.
16729043 Phosphotyrosine interactome of the ErbB-receptor kinase family.
16753148 Polo-like kinase 1 regulates mitotic arrest after UV irradiation through dephosphorylation of p53 and inducing p53 degradation.
16760428 Phosphorylation- and polo-box-dependent binding of Plk1 to Bub1 is required for the kinetochore localization of Plk1.
16760434 Phosphorylation of focal adhesion kinase (FAK) on Ser732 is induced by rho-dependent kinase and is essential for proline-rich tyrosine kinase-2-mediated phosphorylation of FAK on Tyr407 in response to vascular endothelial growth factor.
16763549 Glycosaminoglycan modification of neuropilin-1 modulates VEGFR2 signaling.
16763566 The mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and activity.
16777849 Physical and functional interaction of Fyn tyrosine kinase with a brain-enriched Rho GTPase-activating protein TCGAP.
16782707 Huntingtin phosphorylation sites mapped by mass spectrometry. Modulation of cleavage and toxicity.
16785428 Phosphoproteomic analysis of Her2/neu signaling and inhibition.
16794575 Trans-activation of the DNA-damage signalling protein kinase Chk2 by T-loop exchange.
16799092 Dynamic profiling of the post-translational modifications and interaction partners of epidermal growth factor receptor signaling after stimulation by epidermal growth factor using Extended Range Proteomic Analysis (ERPA).
16803888 Rheb inhibits C-raf activity and B-raf/C-raf heterodimerization.
16807684 Phosphoproteomic analysis of the human pituitary.
16810323 FGF-2 protects small cell lung cancer cells from apoptosis through a complex involving PKCepsilon, B-Raf and S6K2.
16825424 Identification of phosphorylation sites in GIT1.
16825425 Cortactin phosphorylation sites mapped by mass spectrometry.
16837009 A dimeric kinase assembly underlying autophosphorylation in the p21 activated kinases.
16837464 STOP-like protein 21 is a novel member of the STOP family, revealing a Golgi localization of STOP proteins.
16843263 HER2 kinase domain mutation results in constitutive phosphorylation and activation of HER2 and EGFR and resistance to EGFR tyrosine kinase inhibitors.
16858395 The amino-terminal B-Raf-specific region mediates calcium-dependent homo- and hetero-dimerization of Raf.
16858402 Involvement of novel autophosphorylation sites in ATM activation.
16858404 Histone methyltransferase Suv39h1 represses MyoD-stimulated myogenic differentiation.
16862120 Phosphorylation of WAVE1 regulates actin polymerization and dendritic spine morphology.
16862148 FilGAP, a Rho- and ROCK-regulated GAP for Rac binds filamin A to control actin remodelling.
16874301 A novel mitochondrial ubiquitin ligase plays a critical role in mitochondrial dynamics.
16895919 CFBP is a novel tyrosine-phosphorylated protein that might function as a regulator of CIN85/CD2AP.
16899217 Magicin associates with the Src-family kinases and is phosphorylated upon CD3 stimulation.
16906133 Autophosphorylation at serine 1987 is dispensable for murine Atm activation in vivo.
16917505 Direct binding of p85 to sst2 somatostatin receptor reveals a novel mechanism for inhibiting PI3K pathway.
16917507 Roles of HIPK1 and HIPK2 in AML1- and p300-dependent transcription, hematopoiesis and blood vessel formation.
16921383 Orai1 is an essential pore subunit of the CRAC channel.
16938345 Evidence of LAT as a dual substrate for Lck and Syk in T lymphocytes.
16956611 CRM1 mediates nuclear export of HDAC7 independently of HDAC7 phosphorylation and association with 14-3-3s.
16963136 An ITIM-like motif within the CCK2 receptor sequence required for interaction with SHP-2 and the activation of the AKT pathway.
16963448 Repeated phosphopeptide motifs in human Claspin are phosphorylated by Chk1 and mediate Claspin function.
16966330 Phosphorylation of Tyr1214 within VEGFR-2 triggers the recruitment of Nck and activation of Fyn leading to SAPK2/p38 activation and endothelial cell migration in response to VEGF.
16977309 A PACS-1, GGA3 and CK2 complex regulates CI-MPR trafficking.
17000644 Distinct and overlapping sets of SUMO-1 and SUMO-2 target proteins revealed by quantitative proteomics.
17006543 Mdm2 is involved in the ubiquitination and degradation of G-protein-coupled receptor kinase 2.
17024177 The phosphorylation status of PAS-B distinguishes HIF-1alpha from HIF-2alpha in NBS1 repression.
17027227 The N-terminal SH2 domain of the tyrosine phosphatase, SHP-2, is essential for Jak2-dependent signaling via the angiotensin II type AT1 receptor.
17043054 Mass spectrometric mapping of linker histone H1 variants reveals multiple acetylations, methylations, and phosphorylation as well as differences between cell culture and tissue.
17053781 Suppression of receptor interacting protein 140 repressive activity by protein arginine methylation.
17053782 C-terminal phosphorylation controls the stability and function of p27kip1.
17066076 Regulation of MBD1-mediated transcriptional repression by SUMO and PIAS proteins.
17078951 PKA modulates GSK-3beta- and cdk5-catalyzed phosphorylation of tau in site- and kinase-specific manners.
17081983 Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
17088250 Phosphorylation of a threonine unique to the short C-terminal isoform of betaII-spectrin links regulation of alpha-beta spectrin interaction to neuritogenesis.
17097642 Regulation of RKIP binding to the N-region of the Raf-1 kinase.
17098746 FBXO11 promotes the Neddylation of p53 and inhibits its transcriptional activity.
17108971 Repression of p53 activity by Smyd2-mediated methylation.
17110336 E4F1 is an atypical ubiquitin ligase that modulates p53 effector functions independently of degradation.
17110929 MDMX regulation of p53 response to ribosomal stress.
17116872 Phosphorylation and cleavage of presenilin-associated rhomboid-like protein (PARL) promotes changes in mitochondrial morphology.
17139249 GSK-3beta-regulated interaction of BICD with dynein is involved in microtubule anchorage at centrosome.
17157788 Che-1 phosphorylation by ATM/ATR and Chk2 kinases activates p53 transcription and the G2/M checkpoint.
17159907 Palmitoylation of CD95 facilitates formation of SDS-stable receptor aggregates that initiate apoptosis signaling.
17159908 Palmitoylation is required for efficient Fas cell death signaling.
17192257 Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry.
17203073 aPKC-mediated phosphorylation regulates asymmetric membrane localization of the cell fate determinant Numb.
17205062 The role of proline-rich protein tyrosine kinase 2 in differentiation-dependent signaling in human epidermal keratinocytes.
17208333 Modulation of beta-catenin by cyclin-dependent kinase 6 in Wnt-stimulated cells.
17210579 Apoptosis signal-regulating kinase (ASK) 2 functions as a mitogen-activated protein kinase kinase kinase in a heteromeric complex with ASK1.
17215513 Aurora-B regulates RNA methyltransferase NSUN2.
17218255 Modeling of a human circadian mutation yields insights into clock regulation by PER2.
17220478 Proteomics analysis of the interactome of N-myc downstream regulated gene 1 and its interactions with the androgen response program in prostate cancer cells.
17229891 DYRK1A autophosphorylation on serine residue 520 modulates its kinase activity via 14-3-3 binding.
17245430 A specific PP2A regulatory subunit, B56gamma, mediates DNA damage-induced dephosphorylation of p53 at Thr55.
17254966 Cdk-inhibitory activity and stability of p27Kip1 are directly regulated by oncogenic tyrosine kinases.
17254967 p27 phosphorylation by Src regulates inhibition of cyclin E-Cdk2.
17254968 PRAK is essential for ras-induced senescence and tumor suppression.
17274640 A limited screen for protein interactions reveals new roles for protein phosphatase 1 in cell cycle control and apoptosis.
17290217 Role of activation of PIP5Kgamma661 by AP-2 complex in synaptic vesicle endocytosis.
17290218 Death effector domain DEDa, a self-cleaved product of caspase-8/Mch5, translocates to the nucleus by binding to ERK1/2 and upregulates procaspase-8 expression via a p53-dependent mechanism.
17290227 Subcellular localization of Grb2 by the adaptor protein Dok-3 restricts the intensity of Ca2+ signaling in B cells.
17290288 Interferons induce tyrosine phosphorylation of the eIF2alpha kinase PKR through activation of Jak1 and Tyk2.
17293345 Biochemical and functional characterization of Orai proteins.
17310145 A ubiquitin ligase transfers preformed polyubiquitin chains from a conjugating enzyme to a substrate.
17318175 Protein phosphatase 1 regulates assembly and function of the beta-catenin degradation complex.
17322306 Phosphopeptide enrichment by aliphatic hydroxy acid-modified metal oxide chromatography for nano-LC-MS/MS in proteomics applications.
17363905 Phosphorylation and ubiquitination of the IkappaB kinase complex by two distinct signaling pathways.
17380123 A new p38 MAP kinase-regulated transcriptional coactivator that stimulates p53-dependent apoptosis.
17382325 Modulation of p300 binding by posttranslational modifications of the C-terminal activation domain of hypoxia-inducible factor-1alpha.
17408621 Cyclin B1/Cdk1 binds and phosphorylates Filamin A and regulates its ability to cross-link actin.
17426253 Growth stimulation of non-small cell lung cancer cell lines by antibody against epidermal growth factor receptor promoting formation of ErbB2/ErbB3 heterodimers.
17460694 FANCI is a second monoubiquitinated member of the Fanconi anemia pathway.
17486112 Roles of ATM and NBS1 in chromatin structure modulation and DNA double-strand break repair.
17525332 ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.
17525340 Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response.
17540171 Proinflammatory stimuli induce IKKalpha-mediated phosphorylation of PIAS1 to restrict inflammation and immunity.
17540172 L3MBTL1, a histone-methylation-dependent chromatin lock.
17540176 The tumor suppressor PP2A Abeta regulates the RalA GTPase.
17558413 Determination of the sites of tyrosine O-sulfation in peptides and proteins.
17662948 Regulation of Pax3 by proteasomal degradation of monoubiquitinated protein in skeletal muscle progenitors.
17684059 Calcineurin is essential for depolarization-induced nuclear translocation and tyrosine phosphorylation of PYK2 in neurons.
18083107 Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer.
18691969 Ubc9 sumoylation regulates SUMO target discrimination.
18707152 Phosphorylation of SUMO-1 occurs in vivo and is conserved through evolution.
19117447 Profiling of endogenous serum phosphorylated peptides by titanium (IV) immobilized mesoporous silica particles enrichment and MALDI-TOFMS detection.
19508227 Glycosylation of tetraspanin Tspan-1 at four distinct sites promotes its transition through the endoplasmic reticulum.
27803192 Interchromosomal core duplicons drive both evolutionary instability and disease susceptibility of the Chromosome 8p23.1 region.
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